The Virginia Tech Hokies (1-0) and Duke Blue Devils (0-3) square off at Wallace Wade Stadium in Durham, N.C. for a 4 p.m. ET kickoff Saturday. Below, we analyze the Virginia Tech-Duke college football betting odds and lines, with picks and best bets.
The Hokies are the No. 23 team in the Amway Coaches Poll powered by USA TODAY Sports.
Virginia Tech at Duke: Betting odds and lines
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 4:30 p.m. ET.
- Money line: Virginia Tech -400 (bet $400 to win $100) | Duke +300 (bet $100 to win $300)
- Against the spread/ATS: Virginia Tech -10.5 (-110) | Duke +10.5 (-110)
- Over/Under: 53.5 (O: -110 | U: -110)
Virginia Tech at Duke: Three things to know
- The beginning of Virginia Tech’s season was postponed a couple of times due to COVID, including a coronavirus case spike in Blacksburg, VA, They finally got underway last week against N.C. State, and they were down 23 players due to COVID-19 concerns, including starting QB Hendon Hooker. They still were able to win handily, 45-24.
- With Hooker unavailable, QB Braxton Burmeister started. However, he was injured in the first half, so third-string QB Quincy Patterson II took the reins, tossing two touchdowns while also running for another score, showing off the team’s depth.
- Duke has really struggled, posting just 342.3 total yards per game, including only 88.3 yards per game on the ground. As such, they have posted 13.0 PPG, 67th in the nation. They also have a ridiculous 14 turnovers, including seven last week in a loss to Virginia, while posting an FBS-worst minus-9 turnover ratio.
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Virginia Tech at Duke: Odds, betting lines and picks
Prediction
Virginia Tech 34, Duke 16
Money line (ML)
Virginia Tech (-400) will cost you four times your potential return if they hit the road and pick up the victory against Duke (+300). It’s just not worth the risk, especially if Hooker isn’t cleared to play. He was in quarantine until last Friday before the Duke game, and he has reportedly missed extended practice time, so even if he does play, it’s unclear how sharp he will be. He could be eased into action. AVOID.
Against the spread (ATS)
VIRGINIA TECH -10.5 (-110) is an attractive play, even if Burmeister and/or Patterson see time under center. They played well against N.C. State, although Duke’s defense figures to give the Hokies a bit more of a test. Still, the Hokies will also have revenge on their minds after getting boat raced by the Blue Devils at Lane Stadium last September, 45-10.
Over/Under (O/U)
UNDER 53.5 (-110) is worth a small-unit play, although Virginia Tech should be able to generate plenty of offense. The Under is 2-1 in Duke’s three games so far, and they’re averaging just 13.0 PPG. It won’t be a defensive slog, but it won’t be a track meet, either.
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