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The Stanford Cardinal (1-0) take a trip to Los Angeles to visit the USC Trojans (2-0) Saturday. Kickoff from Los Angeles Memorial Coliseum is set for 10:30 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook’s lines around the Stanford vs. USC odds, and make our expert college football picks and predictions.
Stanford beat the Hawaii Rainbow Warriors 37-24 in Week 1 as QB Ashton Daniels completed 25 of 36 passes (69%) for 248 yards and 2 TDs. Stanford’s run game was solid as well, rushing for 158 yards and 2 TDs, averaging 4.6 yards per carry. What put Stanford over the top was its special teams play as K Joshua Karty was 3/3 on field goals and 4/4 on extra points.
The USC Trojans rolled to a 66-14 win over the Nevada Wolf Pack last week as QB Caleb Williams showed why is the favorite to repeat as the Heisman Trophy winner. Williams completed 75% of his passes (18 of 24) for 319 yards and 5 TDs. His leading receiver was Tahj Washington, who caught 3 passses for 75 yards and 2 TDs. The Trojans had 4 receivers with 50-plus receiving yards and 5 receivers caught a TD pass.
USC is No. 6 in the USA TODAY Sports AFCA Coaches Poll.
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Stanford at USC odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 1:03 a.m. ET.
- Moneyline (ML): Stanford +2000 (bet $100 to win $2000) | USC -10000 (bet $10000 to win $100)
- Against the spread (ATS): Stanford +29.5 (-115) | USC -29.5 (-105)
- Over/Under (O/U): 69.5 (O: -115 | U: -105)
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Stanford at USC picks and predictions
Prediction
USC 49, Stanford 28
Moneyline
PASS.
The Trojans should win here but they are far too heavy of a favorite to bet on at (-10000). Bet on the spread and/or total instead.
Against the spread
BET STANFORD +29.5 (-110).
I am a fan of Williams and this USC offense, but their defense is still a concern. The Trojans should win this game pretty comfortably, but I am not sure they will win by 30 points. The Trojans have not dominated Stanford recently, only being 2-2 in the last 4 meetings since 2018. USC showed last season that their defense was a huge liability, and I expect that to begin to show yet again in this matchup.
Over/Under
LEAN OVER 69.5 (-115).
Defense is not a staple in college football, especially not in the PAC-12, and that will show in this game. Stanford has already shown that their defense is lackluster as they allowed Hawaii to score 24 points, so they have no chance of containing Williams and this explosive USC offense. I expect Williams to further his Heisman campaign and throw for at least 5 TDs.
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