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The Cleveland Guardians (90-66) and the St. Louis Cardinals (78-77) wrap up a 3-game interleague series Sunday. First pitch from Busch Stadium is set for 2:15 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Guardians vs. Cardinals odds and make our expert MLB picks and predictions for the best bets.
Season series: Tied 1-1
The Guardians clinched a playoff spot Thursday, and they secured the AL Central Division title on Saturday despite a loss to the Cardinals. It is Cleveland’s 2nd division title in the past 3 seasons, and 1st for 1st-year skipper Stephen Vogt.
Cleveland is 6-2 in the past 8 games after Saturday’s 6-5 loss. The Over (7.5) cashed in that loss, and that was a rarity, too. The Under is still 15-3-3 across the previous 21 contests.
The Cardinals have been eliminated from the postseason hunt, but they’re not tossing in the towel. St. Louis has won 4 of the past 6 games, while going 6-2 in the previous 8 outings at home. The Under is 9-3 in the past 12 outings, and 10-3-1 across the past 14 home contests.
The win Saturday snapped a 5-game skid in interleague play for the Cards. St. Louis is still just 2-6 in the past 8 tries against the AL.
Guardians at Cardinals projected starters
RHP Gavin Williams vs. RHP Andre Pallante
Williams (3-10, 5.12 ERA) makes his 16th start. He has a 1.39 WHIP, 3.8 BB/9 and 9.7 K/9 in 70 1/3 IP.
- Last start: Loss, 5 IP, 2 ER, 5 H, 2 BB, 7 K in 4-1 home setback vs. Minnesota Twins Tuesday
- 2024 road splits: 3-3, 3.86 ERA, 37 1/3 IP, 16 ER, 2 HR, 1.13 WHIP, .190 opponents’ batting average (OBA), 16 BB, 34 K in 8 starts
- Last 7 games: 1-6, 6.03 ERA, 31 1/3 IP, 21 ER, 28 H, 17 BB, 34 K, 1.44 WHIP
- Has never faced Cardinals
Pallante (7-8, 3.87 ERA) makes his 19th start and 28th appearance. He has a 1.35 WHIP, 3.8 BB/9 and 7.1 K/9 in 109 1/3 IP.
- Last start: Win, 7 IP, 0 ER, 4 H, 1 BB, 9 K in 4-0 home victory vs. Pittsburgh Pirates Monday
- 2024 home splits: 5-5, 4.18 ERA, 60 1/3 IP, 28 ER, 3 HR, 1.43 WHIP, .262 OBA, 24 BB, 51 K in 10 starts (14 appearances)
- Last 7 games: 3-2, 2.98 ERA, 42 1/3 IP, 14 ER, 21 BB, 35 K, 1.32 WHIP
- Career vs. Guardians: 0-0, 1 2/3 IP, 0 ER, 3 H, 1 BB, 1 K in 2 relief appearances
Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.
Guardians at Cardinals odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of MLB odds. Lines last updated at 6:47 a.m. ET.
- Moneyline: Guardians -115 (bet $115 to win $100) | Cardinals -105 (bet $105 to win $100)
- Run line (RL)/Against the spread (ATS): Guardians -1.5 (+155) | Cardinals +1.5 (-190)
- Over/Under (O/U): 7.5 (O: -115 | U: -105)
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Guardians at Cardinals picks and predictions
Prediction
Cardinals 4, Guardians 3
Moneyline
It’s worth playing the CARDINALS (-105) lightly in the interleague series finale.
The Guardians (-115) aren’t likely to be terribly motivated after having clinched the division Saturday night. In addition, Williams is on the mound, and he has struggled for the entirety of the season.
Be careful, though, as the Cards are still just 4-5 in the past 9 contests, while cashing in 2 of the previous 6 home interleague battles.
Run line/Against the spread
The Cardinals +1.5 (-190) will cost you nearly 2 times your potential return, and that’s just a little too risky for a standalone play. It’s OK to toss St. Louis into a multi-leg parlay, though.
Williams just can’t be trusted for the Guardians -1.5 (+155), especially to pitch the team to a win by 2 or more runs.
AVOID.
Over/Under
UNDER 7.5 (-105) is quite risky with Williams, although his splits are much better on the road. Pallante actually has some surprisingly good numbers, though.
The Under is 5-2 across the past 7 games for the Cardinals, while going 11-4-1 in the previous 15 contests.
And, for the Guardians, the Under has dominated lately. Cleveland has hit the Under at a 15-3-3 pace in the past 21 contests, while going 8-2-2 in the previous 12 outings away from home.
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