San Francisco 49ers betting odds lines ML ATS OU – Page 2

First look: Arizona Cardinals at San Francisco 49ers odds and lines

Looking at Sunday’s Arizona Cardinals at San Francisco 49ers Week 5 NFL odds, lines and trends. Here’s what you need to know.

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The Arizona Cardinals (1-3) are on the road in Week 5 to take on the San Francisco 49ers (2-2) on Sunday. Kickoff from Levi’s Stadium is at 4:05 p.m. ET (FOX). Below, we look at Cardinals vs. 49ers odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

The Cardinals have lost 2 straight games after a 41-10 win over the LA Rams in Week 2. They lost 42-14 on Sunday at home to the Washington Commanders, allowing 449 total yards and 216 on the ground. The Cardinals were 3.5-point favorites and the Over (49) hit in the loss.

The 49ers evened their record on Sunday, beating the New England Patriots 30-13, covering the 10.5-point spread as home favorites. The Over (42.5) cashed in.

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Cardinals at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Monday at 10:46 a.m. ET.

Moneyline (ML): Cardinals +300 (bet $100 to win $300) | 49ers -375 (bet $375 to win $100)
Against the spread (ATS): Cardinals +7.5 (-110) | 49ers -7.5 (-110)
Over/Under (O/U): 49.5 (O: -110 | U: -110)

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2024 betting stats

ML: Cardinals 1-3 | 49ers 2-2
ATS: Cardinals 2-2 | 49ers 2-2
O/U: Cardinals 3-1 | 49ers 3-1

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Cardinals vs. 49ers head-to-head

The Cardinals and 49ers have played each other 75 times. The Niners lead 36-29 and won the last 4 meetings and 7 of the last 10.

In 8 career starts against San Francisco, Cardinals QB Kyler Murray is 2-6, but has through 10 TD passes and only 3 INTs. He has also rushed for 2 TDs against them.

The 49ers beat Arizona 45-29 in Arizona and 35-16 in Santa Clara last season. 49ers QB Brock Purdy is 4-0 against Arizona with 8 TD passes and no INTs.

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First look: New England Patriots at San Francisco 49ers odds and lines

Looking at Sunday’s New England Patriots at San Francisco 49ers Week 4 NFL odds, lines and trends. Here’s what you need to know.

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The New England Patriots (1-2) and San Francisco 49ers (1-2) meet Sunday in Week 4. Kickoff from Levi’s Stadium is scheduled for 4:05 p.m. ET (FOX). Below, we look at Patriots vs. 49ers odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

The Patriots had a tough outing Thursday night, losing 24-3 to the New York Jets. The failed to cover the 6.5-point spread, and the game stayed under the 39-point total. QB Jacoby Brissett had a rough night, barely hitting 100 passing yards, and the entire offense only managed 139 total yards. It was a forgettable performance from New England’s offense, to say the least.

The 49ers let a 10-point lead slip away in the 4th quarter and lost 27-24 to the division rival LA Rams. Even without key playmakers RB Christian McCaffrey, WR Deebo Samuel, and TE George Kittle, QB Brock Purdy still impressed, going 22-of-30 for 292 yards and 3 TDs. WR Jauan Jennings had a career day, catching 11 passes for 175 yards and all 3 of Purdy’s TD throws.

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Patriots at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Monday at 12:18 a.m. ET.

Moneyline (ML): Patriots +450 (bet $100 to win $450) | 49ers -600 (bet $600 to win $100)
Against the spread (ATS): Patriots +10.5 (-110) | 49ers -10.5 (-110)
Over/Under (O/U): 40.5 (O: -110 | U: -110)

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2024 betting stats

ML: Patriots 1-2 | 49ers 1-2
ATS: Patriots 1-1-1 | 49ers 1-2
O/U: Patriots 1-2 | 49ers 2-1

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Patriots at 49ers head-to-head

The teams 1st met in 1971 and the 49ers lead the series 9-5. The last 4 meetings have been a real back-and-forth battle with each team winning twice, covering the spread twice, and splitting the Over/Under right down the middle at 2-2.

The last meeting was on Oct. 25, 2020, in New England. The 49ers shocked everyone by dominating the game and winning 33-6 as 1.5-point underdogs while the Under (45.5) hit.

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First look: San Francisco 49ers at LA Rams odds and lines

Looking at Sunday’s San Francisco 49ers at LA Rams Week 3 NFL odds, lines and trends. Here’s what you need to know.

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The San Francisco 49ers (1-1) and LA Rams (0-2) will renew their rivalry Sunday in an NFC West matchup. Kickoff from SoFi Stadium in Inglewood, Calif., is set for 4:25 p.m. ET (FOX).

Below, we look at 49ers vs. Rams odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

Both teams are coming off losses in Week 2. The 49ers were upset by the Minnesota Vikings as 4.5-point favorites, losing 23-17 on the road in Minneapolis. They now sit at 1-1 and will look to avoid a dreaded 1-2 start as the defending NFC champions. RB Christian McCaffrey (calf/Achilles) remains out after being placed on injured reserve.

The Rams are 0-2 for the first time since 2011 after losing back-to-back games to the Detroit Lions and Arizona Cardinals. They were blown out by the Cardinals Sunday, 41-10, the 2nd-worst loss of Sean McVay’s head-coaching career. WR Puka Nacua (knee) is on injured reserve, and in Sunday’s loss, WR Cooper Kupp exited early with an ankle injury.

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49ers at Rams odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list NFL odds. Lines last updated Monday at 9:51 a.m. ET.

Moneyline (ML): 49ers -375 (bet $375 to win $100) | Rams +300 (bet $100 to win $300)
Against the spread (ATS): 49ers -7.5 (-110) | Rams +7.5 (-110)
Over/Under (O/U): 44.5 (O: -115 | U: -105)

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2024 betting stats

ML: 49ers 1-1 | Rams 0-2
ATS: 49ers 1-1 | Rams 0-2
O/U: 49ers 1-1 | Rams 1-1

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49ers vs. Rams head-to-head

The 49ers have owned the Rams in recent years, winning 9 of their last 11 meetings. Their only 2 losses were in Week 18 last season when both teams rested their starters and in the NFC title game 3 years ago, which punched the Rams’ ticket to the Super Bowl.

The Rams are 2-0 ATS in their last 2 games against the 49ers but previously failed to cover the spread in 7 straight. The total has gone Over in 3 consecutive meetings between these teams and is 5-5 in their last 10 games.

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First look: San Francisco 49ers at Minnesota Vikings odds and lines

Looking at Sunday’s San Francisco 49ers at Minnesota Vikings Week 2 NFL odds, lines and trends. Here’s what you need to know.

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The San Francisco 49ers (1-0) and the Minnesota Vikings (1-0) meet in Week 2 at U.S. Bank Stadium in Minneapolis. Kickoff is scheduled for 1 p.m. ET (CBS). Below, we look at 49ers vs. Vikings odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

The 49ers were without RB Christian McCaffrey for Week 1 due to Achilles’ and calf injuries, but RB Jordan Mason stepped in for his 1st NFL start, and his 1st NFL 100-yard game. Mason ended up with 147 rushing yards and a score in a 32-19 victory over the New York Jets, which was a Scorigami, by the way.

There are reports McCaffrey might sit again in Week 2 due to the artificial turf at U.S. Bank Stadium, so that’s something to watch during the week.

The Vikings paddled the hapless New York Giants 28-6 on the road Sunday in their opener, as QB Sam Darnold tossed 2 TDs, including 1 to superstar WR Justin Jefferson. Unlike the 49ers, the Vikings cashed low on the total in Week 1. Now, Darnold makes his home debut for the Vikings against his 2023 team.

49ers at Vikings odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Tuesday at 6:11 a.m. ET.

Moneyline (ML): 49ers -275 (bet $275 to win $100) | Vikings +220 (bet $100 to win $220)
Against the spread (ATS): 49ers -6 (-110) | Vikings +6 (-110)
Over/Under (O/U): 45.5 (O: -110 | U: -110)

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2024 betting stats

ML: 49ers 1-0 | Vikings 1-0
ATS: 49ers 1-0 | Vikings 1-0
O/U: 49ers 1-0 | Vikings 0-1

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49ers vs. Vikings head-to-head

This will be the 10th meeting since 2006. Minnesota holds a 5-4 edge in the series during the span. The home side has won 7 straight meetings, with the home team also 6-0 ATS in the previous 6 in this series.

These teams met last season in the Twin Cities, with Minnesota winning 22-17 as a 6.5-point underdog as the Under (44) cashed on Oct. 23, 2023. The Under is 5-1 in the past 6 meetings, and 7-2 in the previous 9 in the series, including the past 3 battles in the Twin Cities.

The teams have played 50 times (6 in the postseason) with the 49ers ahead 25-24-1.

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First look: New York Jets at San Francisco 49ers odds and lines

Looking at Monday’s New York Jets at San Francisco 49ers Week 1 NFL odds, lines and trends. Here’s what you need to know.

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The New York Jets visit the San Francisco 49ers at Levi’s Stadium for Monday Night Football. Kickoff in this Week 1 battle is set for 8:15 p.m. ET (ESPN). Below, we look at Jets vs. 49ers odds from BetMGM Sportsbook before making our expert NFL picks and predictions later in the week.

QB Aaron Rodgers‘ Jets career got off to a rocky start after he tore his Achilles 4 plays into the 2023 season. The Jets went 7-10 and finished 3rd in the AFC East. They signed longtime Dallas Cowboys OT Tyron Smith to shore up the offensive line. Gang Green also signed former LA Chargers WR Mike Williams to play opposite of dynamite WR Garrett Wilson. They took LB Will McDonald IV from Iowa State with the 15th overall pick.

The 49ers went 12-5 in the regular season last year and came up just short, falling 25-22 in overtime to the Kansas City Chiefs in Super Bowl LVIII. QB Brock Purdy emerged from Mr. Irrelevant to lead the team to its 2nd Super Bowl appearance in 4 years. After a drama-laden offseason, the team retained and extended WR Brandon Aiyuk and took WR Ricky Pearsall 31st overall in the 2024 NFL Draft, although he is recovering after being shot during a robbery against him.

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Jets at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 1:01 p.m. ET.

Moneyline (ML): Jets +165 (bet $100 to win $165) | 49ers -200 (bet $200 to win $100)
Against the spread (ATS): Jets +3.5 (-110) | 49ers -3.5 (-110)
Over/Under (O/U): 43.5 (O: -115 | U: -105)

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2023 betting stats

ML: Jets 7-10 | 49ers 12-5
ATS: Jets 6-10-1 | 49ers 9-7
O/U: Jets 7-10 | 49ers 9-6-2

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Jets vs. 49ers head-to-head

The 49ers are 11-3 all-time against the Jets. They have only played 4 times since 2008 with the Niners winning 3 of the 4.

The most-recent meeting resulted in a 31-13 road win for the Niners as they covered as 7-point favorites while the Over 41.5 hit. That game took place Sept. 20, 2020.

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First look: Cincinnati Bengals at San Francisco 49ers odds and lines

Looking at Sunday’s Cincinnati Bengals at San Francisco 49ers Week 8 NFL odds, lines and trends. Here’s what you need to know.

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The Cincinnati Bengals (3-3) and San Francisco 49ers (5-2) meet for a Week 8 matchup at Levi’s Stadium in Santa Clara, Calif. Kickoff is scheduled for 4:25 p.m. ET (CBS). Below, we look at Bengals vs. 49ers odds from FanDuel Sportsbook. Also see: SportsbookWire’s NFL picks and predictions.

The Bengals opened 0-2 straight up (SU), before winning 3 of the past 4 games. That includes a 17-13 win over the Seattle Seahawks prior to the bye in Week 7. Cincinnati is 3-0 SU and 2-0-1 against the spread (ATS) in 3 games against the NFC West Division, and 0-3 SU/ATS against all other teams.

The 49ers were on the short end of a 22-17 road loss on Monday night in Minnesota, and now they face the short week. San Francisco opened 5-0 SU, but it has dropped 2 in a row, losing by a combined total of 7 points while failing to cover in each as a favorite.

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Bengals at 49ers odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday at 5:35 a.m. ET.

Moneyline (ML): Bengals +180 (bet $100 to win $180) | 49ers -215 (bet $215 to win $100)
Against the spread (ATS): Bengals +5.5 (-115) | 49ers -5.5 (-105)
Over/Under (O/U): 45.5 (O: -110 | U: -110)

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2023 betting stats

ML: Bengals 3-3 | 49ers 5-2
ATS: Bengals 2-3-1 | 49ers 4-3
O/U: Bengals 2-4 | 49ers 3-3-1

Bengals at 49ers head-to-head

These teams last met Dec. 12, 2021, in Cincinnati, with the 49ers picking up a 26-23 overtime win as a 1-point favorite. The road team has won each of the past 4 meetings since 2011, while the road team is also 4-0 ATS during that span.

The last time these teams played in the Bay Area was Dec. 20, 2015, and the Bengals came away with a 24-14 win behind 2 TD runs by Jeremy Hill, and a TD reception from QB A.J. McCarron to TE Tyler Kroft. It’s been a while since the Bengals have visited the 49ers at home.

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First look: San Francisco 49ers at Minnesota Vikings odds and lines

Looking at Monday’s San Francisco 49ers at Minnesota Vikings Week 7 NFL odds, lines and trends. Here’s what you need to know.

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The San Francisco 49ers (5-1) and the Minnesota Vikings (2-4) meet for Monday Night Football in Week 7 at U.S. Bank Stadium in Minneapolis. Kickoff is scheduled for 8:15 p.m. ET (ABC/ESPN). Below, we look at 49ers vs. Vikings odds from FanDuel Sportsbook. Also see: SportsbookWire’s NFL picks and predictions.

The 49ers took their 1st loss of the season Sunday in Cleveland, falling by a 19-17 score to the Browns. Rookie PK Jake Moody misfired on a a 41-yard game-winning field goal attempt with :06 left in regulation, as the Browns won outright as an 8.5-point underdog.

To make matters worse, the Niners saw both RB Christian McCaffrey (oblique, ribs) and WR Deebo Samuel (shoulder) exit early, and each player is a question mark for Week 7. At least they have an extra day to heal.

The 49ers saw a 3-game cover streak snapped, while the total pushed at most shops. The Over is still 3-1-1 in the past 5 games overall, while going 1-1-1 in 3 outings on the road.

The Vikings scratched out a 19-13 victory in the rain and wind in Chicago, covering a 3-point number. Minnesota has done its best work on the road, going 2-1 SU and 2-0-1 ATS. At home, the Vikings are 0-3 SU/ATS. The Under cashed Sunday, and it is 5-1 overall, including 3-0 at home.

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49ers at Vikings odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 11:51 a.m. ET.

Moneyline (ML): 49ers -300 (bet $300 to win $100) | Vikings +240 (bet $100 to win $240)
Against the spread (ATS): 49ers -7 (-110) | Vikings +7 (-110)
Over/Under (O/U): 44 (O: -110 | U: -110)

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2023 betting stats

ML: 49ers 5-1 | Vikings 2-4
ATS: 49ers 4-2 | Vikings 2-3-1
O/U: 49ers 3-2-1 | Vikings 1-5

49ers at Vikings head-to-head

The last meeting in this series was Nov. 28, 2021, in Santa Clara, as the 49ers won 34-26 as a 4-point favorite. The Over (49) cashed in that matchup, snapping a 4-game Under streak in the series.

San Francisco has won 3 of the past 4 meetings outright, while also covering 3 of the past 4 in the series. The home team has won and covered 5 straight meetings, too, with the home team winning 6 in a row. The road team last won outright when the Vikings won 27-7 at Candlestick Park on Dec. 9, 2007.

This will be the 50th meeting with the 49ers ahead 25-23-1, including 5-1 in the postseason.

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First look: San Francisco 49ers at Cleveland Browns odds and lines

Looking at Sunday’s San Francisco 49ers at Cleveland Browns Week 6 NFL odds, lines and trends. Here’s what you need to know.

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The San Francisco 49ers (5-0) and the Cleveland Browns (2-2) meet on Sunday for a Week 6 matchup at Cleveland Browns Stadium. Kickoff is scheduled for 1 p.m. ET (FOX). Below, we look at 49ers vs. Browns odds from FanDuel Sportsbook. Also see: SportsbookWire’s NFL picks and predictions.

The 49ers remain 1 of 2 unbeaten teams in the NFL after dismantling the Dallas Cowboys 42-10 on Sunday Night Football. RB Christian McCaffrey scored a touchdown in his 14th straight game.

The Niners have scored 30 or more points in every game this season, including a 30-7 road win against the Pittsburgh Steelers in Week 1, an AFC North Division opponent.

The 49ers easily covered against the Cowboys, and they’re now 4-1 against the spread (ATS), with covers in 3 straight. The Over has cashed in back-to-back games, and 3 of the past 4 outings. The Under cashed in Week 1 in the 1st meeting vs. an AFC opponent.

The Browns are coming off a bye week. QB Deshaun Watson missed the game prior to the bye due to a shoulder injury. He is expected to be ready for Week 6. Cleveland has alternated wins and losses in the first 4 weeks, while also alternating covers and non-covers. The Under is 3-1 in 4 outings. This is Cleveland’s 1st game vs. an NFC foe this season.

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49ers at Browns odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 6:11 a.m. ET.

Moneyline (ML): 49ers -188 (bet $188 to win $100) | Browns +158 (bet $100 to win $158)
Against the spread (ATS): 49ers -3.5 (-110) | Browns +3.5 (-110)
Over/Under (O/U): 41.5 (O: -105 | U: -115)

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2023 betting stats

ML: 49ers 5-0 | Browns 2-2
ATS: 49ers 4-1 | Browns 2-2
O/U: 49ers 3-2 | Browns 1-3

49ers at Browns head-to-head

These teams haven’t met since Oct. 7, 2019, a 31-3 victory by the 49ers at Levi’s Stadium in Santa Clara.

The last time these teams met at Cleveland Browns Stadium, the Browns picked up a 24-10 win with Johnny Manziel at QB as 2.5-point favorites as the Under (43) cashed on Dec. 13, 2015.

The home team has won and covered each of the past 4 games in the series. The last time the road team won was a 13-12 win by the Browns in Candlestick Park on Sept. 21, 2003.

This will the 30th all-time meeting with the Browns leading 19-10.

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First look: Dallas Cowboys at San Francisco 49ers odds and lines

Looking at Sunday’s Dallas Cowboys at San Francisco 49ers Week 5 NFL odds, lines and trends. Here’s what you need to know.

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The Dallas Cowboys (3-1) pay a visit to the San Francisco 49ers (4-0) Sunday in a battle of NFC powerhouses. Kickoff from Levi’s Stadium is set for 8:20 p.m. ET (NBC). Below, we look at Cowboys vs. 49ers odds from FanDuel Sportsbook. Also see: SportsbookWire’s NFL picks and predictions.

Dallas routed the New England Patriots 38-3 as 6-point favorites on Sunday as QB Dak Prescott completed 28 of 34 passes for 261 yards and 1 TD. But it was the Dallas defense that took the game over. The Cowboys’ defensive unit scored TDs on a fumble return and an interception while forcing 3 turnovers and 2 sacks.

San Francisco stayed undefeated by picking up a 35-16 win Sunday vs. the Arizona Cardinals as 14-point favorites. RB Christian McCaffrey had a career-high 4 TDs. QB Brock Purdy hit 20 of 21 passes for 283 yards and had 2 TDs. His 95% completion percentage vs. Arizona set a franchise record.

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Cowboys at 49ers odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 11:54 p.m. ET.

Moneyline (ML): Cowboys +146 (bet $100 to win $146) | 49ers -174 (bet $174 to win $100)
Against the spread (ATS): Cowboys +3.5 (-115) | 49ers -3.5 (-105)
Over/Under (O/U): 45.5 (O: -110 | U: -110)

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2023 betting stats

ML: Cowboys 3-1 | 49ers 4-0
ATS: Cowboys 3-1 | 49ers 3-1
O/U: Cowboys 2-2 | 49ers 2-2

Cowboys vs. 49ers head-to-head

The all-time series between these 2 storied franchises is 19-19-1. The Niners have won the last 2 meetings, both in the playoffs. San Francisco beat Dallas 19-12 in 2023’s NFC Divisional round and 23-17 in 2022’s NFC Wild Card round.

The Cowboys lead 6-4 in the last 10 meetings and are 4-1 in the last 5 meetings in San Francisco.

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First look: Arizona Cardinals at San Francisco 49ers odds and lines

Looking at Sunday’s Arizona Cardinals at San Francisco 49ers Week 4 NFL odds, lines and trends. Here’s what you need to know.

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The Arizona Cardinals (1-2) visit the San Francisco 49ers (3-0) Sunday in Week 4. Kickoff from Levi’s Stadium is at 4:25 p.m. ET (FOX). Below, we look at Cardinals vs. 49ers odds from BetMGM Sportsbook. Also see: SportsbookWire’s NFL picks and predictions.

The Cardinals picked up their first win of the season in Week 3, defeating the Dallas Cowboys 28-16 as 11-point home underdogs. Arizona rushed for 222 yards in its 3rd straight game vs. the NFC East.

The 49ers improved to 3-0 with a 30-12 win over the New York Giants as 10.5-point favorites on Thursday Night Football. QB Brock Purdy has thrown 4 touchdown passes without an interception so far this season.

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Cardinals at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 12:53 p.m. ET.

Moneyline (ML): Cardinals +600 (bet $100 to win $600) | 49ers -900 (bet $900 to win $100)
Against the spread (ATS): Cardinals +14 (-110) | 49ers -14 (-xxx)
Over/Under (O/U): 43.5 (O: -110 | U: -110)

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2023 betting stats

ML: Cardinals 1-2 | 49ers 3-0
ATS: Cardinals 3-0 | 49ers 2-1
O/U: Cardinals 2-1 | 49ers 1-2

Cardinals vs. 49ers head-to-head

Dating back to 1961, the 49ers lead the all-time series 34-29. They won both meetings last season and have won 4 of the last 7 meetings.

Purdy is 2-0 in 2 career starts against the Cardinals and has 3 touchdown passes with no interceptions.

Cardinals QB Josh Dobbs has never played against the 49ers.

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