First look: Dallas Cowboys at San Francisco 49ers odds and lines

Looking at Sunday’s Dallas Cowboys at San Francisco 49ers Week 5 NFL odds, lines and trends. Here’s what you need to know.

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The Dallas Cowboys (3-1) pay a visit to the San Francisco 49ers (4-0) Sunday in a battle of NFC powerhouses. Kickoff from Levi’s Stadium is set for 8:20 p.m. ET (NBC). Below, we look at Cowboys vs. 49ers odds from FanDuel Sportsbook. Also see: SportsbookWire’s NFL picks and predictions.

Dallas routed the New England Patriots 38-3 as 6-point favorites on Sunday as QB Dak Prescott completed 28 of 34 passes for 261 yards and 1 TD. But it was the Dallas  defense that took the game over. The Cowboys’ defensive unit scored TDs on a fumble return and an interception while forcing 3 turnovers and 2 sacks.

San Francisco stayed undefeated by picking up a 35-16 win Sunday vs. the Arizona Cardinals as 14-point favorites. RB Christian McCaffrey had a career-high 4 TDs. QB Brock Purdy hit 20 of 21 passes for 283 yards and had 2 TDs. His 95% completion percentage vs. Arizona set a franchise record.

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Cowboys at 49ers odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 11:54 p.m. ET.

  • Moneyline (ML): Cowboys +146 (bet $100 to win $146) | 49ers -174 (bet $174 to win $100)
  • Against the spread (ATS): Cowboys +3.5 (-115) | 49ers -3.5 (-105)
  • Over/Under (O/U): 45.5 (O: -110 | U: -110)

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2023 betting stats

  • ML: Cowboys 3-1 | 49ers 4-0
  • ATS: Cowboys 3-1 | 49ers 3-1
  • O/U: Cowboys 2-2 | 49ers 2-2

Cowboys vs. 49ers head-to-head

The all-time series between these 2 storied franchises is 19-19-1. The Niners have won the last 2 meetings, both in the playoffs. San Francisco beat Dallas 19-12 in 2023’s NFC Divisional round and 23-17 in 2022’s NFC Wild Card round.

The Cowboys lead 6-4 in the last 10 meetings and are 4-1 in the last 5 meetings in San Francisco.

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