San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Saturday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (83-65) face the San Francisco Giants (72-76) in the 2nd game of their 3-game series Saturday. First pitch from Oracle Park is at 9:05 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 6-5.

The Padres won the opener Friday night 5-0 and retook the Wild Card lead over the Arizona Diamondbacks by a half game. They are 6-4 in  their last 10 games.

The Giants were shut out for the 2nd straight game Friday and have lost 3 of their last 4 games. They are 4-8 in their last 12 games.

Padres at Giants projected starters

RHP Joe Musgrove vs. RHP Mason Black

Musgrove (5-5, 4.54 ERA) makes his 17th start. He has a 1.28 WHIP, 2.4 BB/9 and 8.6 K/9 through 81 1/3 innings.

  • Last start: Loss, 4 1/3 IP, 6 ER, 8 H, 1 BB, 7 K in 7-6 home loss to the Giants Sunday
  • Had allowed only 4 ER in previous 5 starts combined
  • 4-5 with 4.46 ERA in 15 career starts vs. Giants

Black (0-3, 7.50 ERA) makes his 6th start and 7th appearance. He has a 1.63 WHIP, 3.0 BB/9 and 8.3 K/9 through 24 innings.

  • Last start: Loss, 4 2/3 IP, 4 ER, 6 H, 1 BB, 6 K in 5-1 road loss to the Padres last Friday, his only career game against the them
  • Has allowed 4+ ER in 3 of 5 starts

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Padres at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of MLB odds. Lines last updated at 12:40 p.m. ET.

  • Moneyline (ML): Padres -160 (bet $160 to win $100) | Giants +135 (bet $100 to win $135)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+105) | Giants +1.5 (-125)
  • Over/Under (O/U): 7.5 (O: -115 | U: -105)

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Padres at Giants picks and predictions

Prediction

Padres 5, Giants 2

Moneyline

The Giants have scored 2 or fewer runs in their last 4 losses. They beat Musgrove last week, but Black has not been great thus far,

Musgrove got lit up for 6 runs in his last start, but his ERA was 1.16 in his previous 4.

He will bounce back, but the run line is the better bet for the Padres.

PASS. 

Run line/Against the spread

Seven of the Padres’ last 9 wins have been by more than 1 run. All 5 of their wins over the Giants this season have been by 2+ runs.

Seven of the Giants’ last 10 losses have been my multiple runs.

BET PADRES -1.5 (+105). 

Over/Under

Six of the 11 games they have played against each other this season have had 8 or more runs.

The Giants’ last 4 losses have not reached 8 total runs.

Six of the Padres’ last 10 games have not reached 8 total runs.

BET UNDER 7.5 (-105). 

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Friday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (82-65) and San Francisco Giants (72-75) open a 3-game series Friday. First pitch from Oracle Park is at 10:15 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 6-4

The Padres were off Thursday after Wednesday’s 5-2 loss at the Seattle Mariners for a 2-game series split. They have lost 3 of their last 4 games and trail the Arizona Diamondbacks by a half-game for the top NL Wild Card spot.

The Giants are coming off a 2-1 series loss to the visiting Milwaukee Brewers, dropping the Thursday finale 3-0. They are 4-7 in their last 11 games.

Padres at Giants projected starters

RHP Dylan Cease vs. RHP Logan Webb

Cease (12-11, 3.71 ERA) makes his 31st start. He has a 1.09 WHIP, 3.2 BB/9 and 10.9 K/9 through 170 innings.

  • Last start: Loss, 6 IP, 4 ER, 6 H, 2 BB, 4 K in 6-3 home defeat to Giants Saturday; Webb was San Francisco’s starter
  • 2024 vs. Giants: 0-2, 4.32 ERA (16 2/3 IP, 8 ER), 1.08 WHIP, 9.2 K/9 in 3 starts
  • Career vs. Giants: 2-2, 3.38 ERA (26 2/3 IP, 10 ER), 1.16 WHIP, 9.8 K/9 in 5 starts

Webb (12.9, 3.46 ERA) makes his 31st start. He has a 1.23 WHIP, 2.2 BB/9 and 7.4 K/9 through 189 2/3 innings.

  • Last start: Win, 6 IP, 3 ER, 10 H, 2 BB, 3 K Saturday
  • 2024 vs. Padres: 1-0, 3.32 ERA (19 IP, 7 ER), 1.53 WHIP, 5.2 K/9 in 3 starts
  • Career vs. Padres: 4-2, 2.70 ERA (76 2/3 IP, 23 ER), 1.19 WHIP, 7.2 K/9 in 13 appearances (12 starts)

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Padres at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of MLB odds. Lines last updated at 11 a.m. ET.

  • Moneyline (ML): Padres -115 (bet $115 to win $100) | Giants -105 (bet $105 to win $100)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+155) | Giants +1.5 (-190)
  • Over/Under (O/U): 7 (O: -105 | U: -115)

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Padres at Giants picks and predictions

Prediction

Giants 5, Padres 3

Moneyline

The GIANTS (-105) are 6-2 in Webb’s last 8 starts. They took 2 out of 3 games last weekend in San Diego over the Padres. They have held opponents to 3 or fewer runs in 5 of their last 7 games.

The Padres are 2-7 in their last 9 games when they allow 4 or more runs.

The Giants have scored 4 or more in 6 of their last 10 games.

BET GIANTS (-105).

Run line/Against the spread

The Giants are 4-1 ATS in their last 5 games. The Padres are 4-9 ATS in their last 13 games.

The Padres are 14-17 ATS as road favorites.

But If you like the Giants +1.5, the -190 odds aren’t it. With -105 odds for them to win outright, go with the ML.

PASS.

Over/Under

Six of 10 games between the 2 teams have had more than 7 total runs.

Seven of the Giants’ last 11 games have had at least 7 total runs. Webb’s last 4 starts have all had more than 7 total runs.

Nine of the last 11 for the Padres have had totals of 7 or more.

BET OVER 7 (-105).

Play our free daily Pick’em Challenge and win! Play now!

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Jess Root on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

Fantasy baseball help from BaseballHQ.com:
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San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Wednesday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (78-80) and San Francisco Giants (78-80) meet for the final time this season on Wednesday. First pitch from Oracle Park is 9:45 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 7-5

The Padres lost the opener 2-1, but bounced back Tuesday night with a 4-0  win. They have won 10 of their last 12 games, but are 1 game from being eliminated from Wild Card contention.

The Giants are 3-9 in their last 12 games. They also are 1 game from being eliminated.

Padres at Giants projected starters

RHP Matt Waldron vs. LHP Sean Manaea

Waldron (1-3, 4.58 ERA) makes his 6th start and 8th appearance. He has a 1.25 WHIP, 2.5 BB/9 and 7.4 K/9 in 35 1/3 innings.

  • Last start: No-decision, 5 2/3 IP, 1 ER, 3 H, 2 BB, 9 K in 4-2 home win over St. Louis Cardinals on Friday
  • Allowed 1 ER in 5 IP in a no-decision vs. Giants Aug. 31

Manaea (7-6, 4.51 ERA) makes his 10th start and 37th appearance. He has a 1.25 WHIP, 3.4 BB/9 and 9.7 K/9 in 111 2/3 innings.

  • Last start: Win, 7 IP, 0 R, 3 H, 0 BB, 2 K in 5-1 victory at the Los Angeles Dodgers on Friday
  • Is 2-1 with 2.00 ERA in 3 starts since rejoining the rotation

Play our free daily Pick’em Challenge and win! Play now!

Padres at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:21 p.m. ET.

  • Moneyline (ML): Padres -110 (bet $110 to win $100) | Giants -110 (bet $110 to win $100)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+150) | Giants +1.5 (-185)
  • Over/Under (O/U): 8.5 (O: -105 | U: -115)

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Padres at Giants picks and predictions

Prediction

Padres 5, Giants 2

Moneyline

The Padres have won 10 of their last 12 games and, while they are only 34-43 on the road this season, they have won 5 of their last 6 road games. Also, Waldron has only allowed 3 runs in his last 2 starts (11 IP).

You can take Padres straight up and it isn’t a bad play but you have win more on the spread, based on their recent play.

PASS.

Run line/Against the spread

Thirty of the Padres’ last 31 wins have been by 2 or more runs. They have covered the spread in 9 of their last 12 games. Meanwhile, 7 of the Giants’ last 8 losses have been by 2 or more runs.

BET PADRES -1.5 (+150).

Over/Under

Half of the 12 games between the  teams have not reached 9 runs. The last 4 meetings have had fewer than 9. And 6 of the Padres’ last 7 games have not reached 9 runs.

BET UNDER 8.5 (-115).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Jess Root on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

Additional MLB coverage:
BaseballHQ Fantasy Baseball

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