Notre Dame at Syracuse odds, picks and predictions

Analyzing Saturday’s Notre Dame at Syracuse odds and lines, with college football expert picks, predictions and best bets.

The Notre Dame Fighting Irish (4-3) and the No. 16 Syracuse Orange (6-1) play Saturday at JMA Wireless Dome. Kickoff is scheduled for noon ET (ABC). Below, we analyze Tipico Sportsbook‘s lines around the Notre Dame vs. Syracuse odds, and make our expert college football picks and predictions.

The Fighting Irish picked up the 44-21 win over UNLV last weekend at home, bouncing back from an embarrassing 16-14 setback against Stanford as a 16.5-point favorite. While Notre Dame is 4-1 SU in the last 5 games, it is just 2-4 ATS over the previous 6 outings.

The Orange looked like they had it in the bag last week against Clemson in a showdown of unbeatens. Syracuse led 21-10 heading to the 4th quarter, but  outscored by Clemson 17-0 in the final 15 minutes.

Check out: AFCA Coaches Poll powered by USA TODAY sports

Stream select live college football games and full replays: Get ESPN+

Notre Dame at Syracuse odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 12:03 a.m. ET.

  • Moneyline (ML): Notre Dame +115 (bet $100 to win $115) | Syracuse -140 (bet $140 to win $100)
  • Against the spread: Notre Dame +2.5 (-108) | Syracuse -2.5 (-112)
  • Over/Under (O/U): 47.5 (O: -115 | U: -107)

Claim your risk-free bet up to $350. Catch the excitement and start betting with Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Bet now!

Notre Dame at Syracuse picks and predictions

Prediction

Syracuse 27, Notre Dame 20

Moneyline

SYRACUSE (-140) isn’t priced out of line if you just want to pick a winner on the moneyline and not worry about the points.

The Orange have had a nice season, and they’re not going to suffer a 2nd consecutive setback. Syracuse played well enough to win on the road at Clemson, they’re not coming back home and losing to a mediocre Notre Dame side.

Against the spread

SYRACUSE -2.5 (-112) is solid play. This should be a 1-score game, but it will go in the favor of the home side.

The Orange have covered 16 of the last 21 games overall dating back to last season, while hitting in 9 of the last 11 games at home. Syracuse has a perfect 8-0 ATS mark in the last eight games in the month of October, too.

While the Fighting Irish are an impressive 21-8-1 ATS in the last 30 road games, and 5-0 ATS in the last 5 against ACC teams, this is a mediocre team at best. Notre Dame has particularly struggled with the pass on offense, while Syracuse has allowed just 171.4 yards per game through the air, 10th in the nation. Notre Dame is going to have a lot of trouble moving the sticks.

Over/Under

UNDER 47.5 (-107) is the lean here, ever so slightly.

The Under is 5-2 in the last 7 games overall for Notre Dame, while the Under is perfect for Syracuse in the last 4 games. In addition, the Under has cashed in 7 of the last 8 home games for ‘Cuse, while hitting in 4 in a row against teams with a winning overall mark.

Play our free daily Pick’em Challenge and win! Play now!

Want action on this game or any other NCAA football matchup? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

[mm-video type=playlist id=01fb7dafw2b08817yr player_id=none image=https://sportsbookwire.usatoday.com/wp-content/plugins/mm-video/images/playlist-icon.png]

Follow Kevin J. Erickson on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

College sports coverage from USA TODAY Sports Media Group:

Alabama / Arkansas / Auburn / Clemson / Colorado / Florida / Georgia / Iowa / LSU / Michigan / Michigan State / Nebraska / North Carolina / Notre Dame / Ohio State / Oklahoma / Oregon / Penn State / Rutgers / Tennessee / Texas / Texas A&M / USC / Wisconsin / College Football News

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1622]

First look: Notre Dame at Syracuse odds and lines

Looking at Saturday’s Notre Dame at Syracuse college football odds, lines and trends. Here’s what you need to know.

The Notre Dame Fighting Irish (4-3) and Syracuse Orange (6-1) meet Saturday at JMA Wireless Dome in Syracuse, N.Y. Kickoff is scheduled for noon ET (ABC). Below, we look at Notre Dame vs. Syracuse odds from Tipico Sportsbook; check back for all our college football picks and predictions.

The Fighting Irish had little trouble with UNLV at home, posting a 44-21 win as the Over (45.5) cashed. Notre Dame (-25.5) failed to cover for the 2nd straight game, and 4th time in the last 6 games.

The Orange suffered their 1st loss of the season, falling 27-21 at Clemson in a heartbreaker. Syracuse led 21-10 heading to the final quarter before it was outscored 17-0 in the final 15 minutes.

Syracuse is No. 16 in the AFCA Coaches Poll powered by USA TODAY Sports.

Stream select live college football games and full replays: Get ESPN+

Notre Dame at Syracuse odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 10:52 a.m. ET.

  • Moneyline (ML): Off the board.
  • Against the spread (ATS): Notre Dame +2.5 (-108) | Syracuse -2.5 (-112)
  • Over/Under (O/U): 45.5 (O: -115 | U: -107)

2022 betting stats

  • ML: Notre Dame 4-3 | Syracuse 6-1
  • ATS: Notre Dame 3-4 | Syracuse 6-1
  • O/U: Notre Dame 2-5 | Syracuse 2-5

Claim your risk-free bet up to $350. Catch the excitement and start betting with Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Bet now!

Notre Dame at Syracuse head-to-head

These schools have met 10 times on the gridiron, with the Irish holding a 7-3 all-time lead. Notre Dame has won the last 4 meetings, with the last win for Syracuse coming in 2008 in South Bend 24-23. The Irish won the most recent meeting, also at Notre Dame Stadium, 45-21 win in 2020.

Play our free daily Pick’em Challenge and win! Play now!

Want action on this game or any other NCAA football matchup? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

Follow Kevin J. Erickson on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

College sports coverage from USA TODAY Sports Media Group:

Alabama / Arkansas / Auburn / Clemson / Colorado / Florida / Georgia / Iowa / LSU / Michigan / Michigan State / Nebraska / North Carolina / Notre Dame / Ohio State / Oklahoma / Oregon / Penn State / Rutgers / Tennessee / Texas / Texas A&M / USC / Wisconsin / College Football News

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1622]