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San Francisco Giants at Cleveland Guardians odds, picks and predictions

Analyzing Sunday’s San Francisco Giants at Cleveland Guardians odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (44-46) and Cleveland Guardians (55-32) wrap up a 3-game interleague series Sunday. First pitch from Progressive Field is scheduled for 1:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Guardians odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 1-1

After winning Friday’s opener 4-2, the Giants lost 5-4 on Saturday as the Guardians (-123) cashed as home favorites with the Over (8.5) just coming in. San Francisco tries for the series win Sunday. The Giants have won 3 straight series, going 8-4 across the past 12 outings. The Over on Saturday halted a 3-0 run to the Under.

The Guardians have alternated wins and losses in the past 8 games dating back to June 28, going 4-4 in the previous 8 contests. The Over has hit in 4 of the past 5 outings, and 6 of the past 8 games.

In interleague play, San Francisco have won 6 of the past 11 games, while the Over is 4-2 in the past 6 outings against the AL.

For Cleveland, it is 7-5 in the past 12 interleague battles, while going 6-2 at home this season against NL foes. The Under is 4-3-1 in 8 home games vs. NL teams.

Giants at Guardians projected starters

RHP Hayden Birdsong vs. RHP Carlos Carrasco

Birdsong (1-0, 4.66 ERA) makes his 3rd career start. He has a 1.55 WHIP, 2.2 BB/9 and 8.2 K/9 in 9 2/3 IP.

  • Last start: Win, 5 IP, 2 ER, 4 H (2 solo HR), 2 BB, 5 K in 5-3 road victory vs. Atlanta Braves Tuesday in 1st career road start
  • Made 38 starts (8-7, 3.02 ERA) in 3 minor league seasons

Carrasco (3-6, 5.21 ERA) makes his 16th start. He has a 1.36 WHIP, 2.8 BB/9 and 7.2 K/9 in 76 IP.

  • Last start: No-decision, 6 IP, 3 ER, 4 H (2 HR), 1 BB, 7 K in 7-6 home win vs. Chicago White Sox Tuesday
  • 2024 home splits: 2-3, 4.55 ERA (31 2/3 IP, 16 ER), 1.42 WHIP, .294 OBA, 10 BB, 28 K in 6 starts
  • Career vs. Giants: 1-2, 2.95 ERA (39 2/3 IP, 13 ER), 0.88 WHIP, 7.7 K/9 in 6 starts (1 CG)

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Giants at Guardians odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 2:09 a.m. ET.

  • Moneyline (ML): Giants +110 (bet $100 to win $110) | Guardians -135 (bet $135 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-175) | Guardians -1.5 (+145)
  • Over/Under (O/U): 9 (O: -110 | U: -110)

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Giants at Guardians picks and predictions

Prediction

Guardians 5, Giants 4

Moneyline

The GUARDIANS (-135) are worth a look in Sunday’s finale against the Giants (+110), but be careful and go lightly.

Carrasco has been slightly better at home, although he is still fairly giving. He has served up 6 HR with a .294 OBA in 31 2/3 IP across 6 starts.

However, Birdsong is making just his 3rd career start, and 2nd on the road. He is facing the best team in the AL, at least in terms of win percentage, and that’s a tough assignment for the 22-year-old rookie.

Run line/Against the spread

If you’re a little more on the conservative side, GIANTS +1.5 (-175) isn’t priced out of line if you want a little bit of insurance.

The Guardians -1.5 (+145) haven’t won consecutive games since June 24-25 in Baltimore, and 2 of the team’s past 3 victories have been by a single run.

Over/Under

PASS on the total 9, as it should come right down on the number.

If there was a lean, it would be to go high, as Carrasco has been hit for plenty of crooked numbers this season. And the Over is 6-2 in the past 8 games for Cleveland.

The Giants have hit the Under at a 3-1 pace in the past 4 games, but the Over is still 14-7-1 across the previous 22 contests.

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San Francisco Giants at Cleveland Guardians odds, picks and predictions

Analyzing Friday’s San Francisco Giants at Cleveland Guardians odds and lines, with MLB expert picks, predictions and best bets.

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The Cleveland Guardians (54-31) welcome the San Francisco Giants (43-45) to Progressive Field Friday for the opener of their 3-game series. First pitch is set for 7:10 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Giants vs. Guardians odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Giants took 2 of 3 games in 2023

The Giants beat the Atlanta Braves 4-2 Thursday, closing at +111 on the moneyline. They won 2 of 3 in the series and have won 4 of their last 6 games. San Francisco has been awful on the road this season at just 18-26, the 7th-worst road record in the majors. It is 42-46 against the spread (ATS).

The Guardians beat the Chicago White Sox 8-4 at home Thursday, closing as a sizable -214 favorite. They have traded off winning and losing over their last 6 games and are 3-5 straight up over their last 8 games. Cleveland is 7-1 in its last 8 at home and 28-10 at home on the season. It is 48-37 ATS.

Giants at Guardians projected starters

Undecided vs. RHP Tanner Bibee

Giants pitcher has yet to be named with no inclination as to who will start.

Bibee (7-2, 3.47 ERA) makes his 18th start. He has a 1.09 WHIP, 2.1 BB/9 and 10.5 K/9 in 93 1/3 IP.

  • Last start: Win, 6 IP, 2 R, 4 H, 0 BB, 3 K in 7-2 road win over the Kansas City Royals Saturday
  • 2024 home splits: 3-1, 4.36 ERA (43 1/3 IP, 21 ER), 1.15 WHIP, 5 HR, 11.0 K/9 in 8 starts
  • Has never faced Giants

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Giants at Guardians odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:13 a.m. ET.

  • Moneyline (ML): Giants +144 (bet $100 to win $144) | Guardians -172 (bet $172 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-156) | Guardians -1.5 (+130)
  • Over/Under (O/U): 8.5 (O: -110 | U: -110)

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Giants at Guardians picks and predictions

Prediction

Guardians 6, Giants 3

Moneyline

PASS.

The Guardians have been so good at home that they are a strong favorite here, but they are also unplayable as a straight-up moneyline favorite. They are too expensive while the Giants are too risky.

Avoid this play.

Run line/Against the spread

BET GUARDIANS -1.5 (+130).

The Guardians have been almost unbeatable when Bibee takes the mound. They are 14-3 in his starts and have won 8 of those games by more than 1 run. Cleveland is 5-3 ATS in its last 5 home games. It is 21-17 ATS at home, the 3rd-best home ATS record in the majors.

Meanwhile, the Giants are 22-21 ATS on the road. While above .500, that still sits in the bottom 3rd of the league. San Fran is 2-3 ATS in its last 5 on the road. Considering Bibee’s strength and the Giants’ struggles in away games, back GUARDIANS -1.5 (+130).

Over/Under

BET OVER 8.5 (-110).

The Giants are 4-2-1 O/U in their last 7 games and 48-37-3 O/U on the season. They have scored at least 5 runs in 4 of their last 6 games.

The Guardians, who are 2-1 O/U in Bibee’s last 3 starts, have gone north of the total in 3 straight games and in 5 of their last 6. They have scored at least 7 runs in 3 of their last 5 games while allowing at least 6 runs in 3 of their last 4.

Considering those trends, back OVER 8.5 (-110).

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San Francisco Giants at Cleveland Guardians odds, picks and predictions

Analyzing Saturday’s San Francisco Giants at Cleveland Guardians odds and lines, with MLB expert picks and predictions.

The San Francisco Giants (5-2) face the Cleveland Guardians (4-3) in the second game of a three-game interleague set Saturday at Progressive Field in Cleveland. First pitch is scheduled for 6:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Giants vs. Guardians odds with MLB picks and predictions.

Season series: Giants lead 1-0

The Giants spoiled the Guardians’ home opener with a 4-1 victory Friday. Former White Sox LHP Carlos Rodon helped keep the Cleveland bats cool for his new squad, as he limited the home side to just 3 hits.

The Guardians had rolled up 44 total runs in the previous four games before the offense ground to a halt against the southpaw Rodon. The Under result was the first for Cleveland since their second game of the regular season at Kansas City April 9.

Giants at Guardians: Projected starters

RHP Anthony DeSclafani vs. RHP Cal Quantrill

DeSclafani (0-0, 4.91 ERA) makes his second start. He allowed 2 ER on 8 H and 1 BB with 5 K across 3 2/3 IP in his first start versus the Miami Marlins Sunday.

  • Posted a 5-4 record, 3.22 ERA and .225 opponent batting average across 95 IP in 17 road starts last season.
  • Allowed 2 runs on 7 hits and 2 walks with 6 strikeouts across 6 innings in a no-decision as a member of the Cincinnati Reds when he last faced Cleveland July 6, 2019.

Quantrill (1-0, 3.60 ERA) allowed 2 ER on 4 H and 1 BB with 2 K in 5 IP at the Kansas City Royals Sunday in his season debut.

  • The Guardians supported Quantrill with 17 runs of offense in his first outing of the season at Kauffman Stadium Sunday.
  • Was outstanding at Progressive Field in 2021, posting a 6-0 record, 2.35 GAA and .224 OBA with 76 strikeouts across 92 IP in 14 starts and eight relief appearances.

Giants at Guardians odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:55 a.m. ET.

  • Money line (ML): Giants -108 (bet $108 to win $100) | Guardians -112 (bet $112 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants -1.5 (+145) | Guardians +1.5 (-180)
  • Over/Under (O/U): 8.5 (O: +100 | U: -125)

Exclusive USA TODAY Network offer: Deposit $10 or more, get $200 in instant bet credits at Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Place your legal, online sports bets at Tipico. Let’s make this interesting. Bet now!

Giants at Guardians picks and predictions

Prediction

Giants 5, Guardians 3

Money line

The GIANTS (-108) have been interleague beasts, winning five of the past six against the American League, and they have handled the Cleveland franchise with nine victories in the past 10 tries.

While Quantrill failed to lose a decision in 2021 at home, he will struggle against a Giants team that won 107 games last season.

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Run line/Against the spread

GIANTS -1.5 (+145) are worth playing lightly, as they covered the run line in Friday’s interleague series opener. While three of their five victories so far have been 1-run wins, their pitching has been excellent lately. The Giants have yielded just 4 total runs in the past three games while piling up 19 runs scored. Look for more of the same Saturday.

Over/Under

The lean is to the UNDER 8.5 (-125), mostly due to San Francisco’s pitching. The Giants have cashed the Under in five of their last six games, allowing 2 or fewer runs in five of their previous six outings.

The Guardians had four straight Over results before Friday’s low-scoring loss. The offense has overshadowed the pitching, which has turned in a 2.90 ERA, ranking sixth in the majors during the early going.

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San Francisco Giants at Cleveland Guardians odds, picks and predictions

Analyzing Friday’s San Francisco Giants at Cleveland Guardians odds and lines, with MLB expert picks and predictions.

The San Francisco Giants (4-2) start a 3-game interleague series with the Cleveland Guardians (4-2) Friday at Progressive Field. First pitch is scheduled for 7:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Giants vs. Guardians odds with MLB picks and predictions.

The Guardians and Giants have not played each other since 2017. The Giants lead 5-14 in the regular season and have won 10 of the last 12 meetings between the teams.

San Francisco won back-to-back games over the San Diego Padres to win their 3-game series 2-1. The Giants outscored the Padres 17-7.

Cleveland has won 4 consecutive games after dropping its first two of the season, which includes a split in their 4-game set with the Royals and a sweep in the 2-game interleague miniseries with the Reds earlier this week.

Giants at Guardians: Projected starters

San Francisco RHP Carlos Rodon vs. Cleveland LHP Zach Plesac 

Rodon (0-0, 1.80 ERA) picked up a no-decision in San Francisco’s 2-1 home loss to the Marlins Saturday. He went for 5 IP, allowing just 1 ER on 3 H and 2 BB with 12 K.

  • 2021 vs. Guardians: 2-0 with a 2.70 ERA (20 IP, 6 ER), 0.90 WHIP and 10.4 K/9 in 3 starts for the Chicago White Sox.
  • vs. Guardians on the current roster: 3.05 FIP with a .176 batting average, .257 wOBA, .309 expected slugging percentage, 24.1 K% and 90.0 mph exit velocity in 83 plate appearances.

Plesac (0-0, 0.00 ERA), also earned a no-decision in Cleveland’s 1-0 loss in K.C. Saturday. He gave up 0 ER on 3 H, 0 BB and 5 K in 5 2/3 IP.

  • April splits: 1-3 with a 4.78 ERA (32 IP, 17 ER), 1.06 WHIP and 5.9 K/9 in 6 starts.

Giants at Guardians odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:12 a.m. ET.

  • Money line (ML): Giants -155 (bet $155 to win $100) | Guardians +125 (bet $100 to win $125)
  • Run line (RL)/Against the spread (ATS): Giants -1.5 (+110) | Guardians +1.5 (-135)
  • Over/Under (O/U): 7.5 (O: -125 | U: +100)

Exclusive USA TODAY Network offer: Deposit $10 or more, get $200 in instant bet credits at Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Place your legal, online sports bets at Tipico. Let’s make this interesting. Bet now!

Giants at Guardians picks and predictions

Prediction

Guardians 4, Giants 2

Money line

SPRINKLE on the GUARDIANS (+125), if at all, because I see more value in Cleveland’s RL, which is going for a relatively cheap price.

The Guardians have the hottest bats in baseball through the first week, Friday is their home opener and Progressive Field is a hitter-friendly ballpark. Also, Cleveland’s lineup is familiar with Rodon who was a divisional foe and played for the Chicago White Sox from 2015-21.

This Giants (-155) lineup has yet to face Plesac, who I expect to be one of the best middle-of-the-rotation starters in MLB. Cleveland’s organization is a pitching factory and the rotation alone can put the Guardians in playoff contention.

However, San Francisco is somehow underrated coming into this year despite winning the NL West last season and I prefer Cleveland’s RL.

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Run line/Against the spread

Definitely BET the GUARDIANS +1.5 (-135) instead of or heavier than their ML because Cleveland should beat the Giants -1.5 (+110) outright. but the RL is just too cheap to pass up.

Furthermore, there’s reverse line movement in Cleveland’s direction as nearly two-thirds of the money is on San Francisco but the line has moved slightly towards the Guardians. This suspicious line movement tells us the oddsmakers are trying to entice more pro-Giants action.

A Cleveland ML bet should cash but my preferred play is the GUARDIANS +1.5 (-135).

Over/Under

LEAN to the UNDER 7.5 (+100)

This is a sharp total and there are two quality starters on the mound. Plesac is due for a breakout season and Rodon was an AL Cy Young contender last season and his pitching peripherals versus this Cleveland lineup are solid.

But Cleveland’s lineup is hot and powered by Guardians 3B Jose Rameriz, who was recently given a hefty contract extension and is dialed in at the plate.

Bet legally online with a trusted partner: Tipico Sportsbook, Sportsbook Wire’s official sportsbook partner in CO, NJ and soon IA. Bet now!

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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