The San Francisco Giants (5-2) face the Cleveland Guardians (4-3) in the second game of a three-game interleague set Saturday at Progressive Field in Cleveland. First pitch is scheduled for 6:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Giants vs. Guardians odds with MLB picks and predictions.
Season series: Giants lead 1-0
The Giants spoiled the Guardians’ home opener with a 4-1 victory Friday. Former White Sox LHP Carlos Rodon helped keep the Cleveland bats cool for his new squad, as he limited the home side to just 3 hits.
The Guardians had rolled up 44 total runs in the previous four games before the offense ground to a halt against the southpaw Rodon. The Under result was the first for Cleveland since their second game of the regular season at Kansas City April 9.
Giants at Guardians: Projected starters
RHP Anthony DeSclafani vs. RHP Cal Quantrill
DeSclafani (0-0, 4.91 ERA) makes his second start. He allowed 2 ER on 8 H and 1 BB with 5 K across 3 2/3 IP in his first start versus the Miami Marlins Sunday.
- Posted a 5-4 record, 3.22 ERA and .225 opponent batting average across 95 IP in 17 road starts last season.
- Allowed 2 runs on 7 hits and 2 walks with 6 strikeouts across 6 innings in a no-decision as a member of the Cincinnati Reds when he last faced Cleveland July 6, 2019.
Quantrill (1-0, 3.60 ERA) allowed 2 ER on 4 H and 1 BB with 2 K in 5 IP at the Kansas City Royals Sunday in his season debut.
- The Guardians supported Quantrill with 17 runs of offense in his first outing of the season at Kauffman Stadium Sunday.
- Was outstanding at Progressive Field in 2021, posting a 6-0 record, 2.35 GAA and .224 OBA with 76 strikeouts across 92 IP in 14 starts and eight relief appearances.
Giants at Guardians odds and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:55 a.m. ET.
- Money line (ML): Giants -108 (bet $108 to win $100) | Guardians -112 (bet $112 to win $100)
- Run line (RL)/Against the spread (ATS): Giants -1.5 (+145) | Guardians +1.5 (-180)
- Over/Under (O/U): 8.5 (O: +100 | U: -125)
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Giants at Guardians picks and predictions
Prediction
Giants 5, Guardians 3
Money line
The GIANTS (-108) have been interleague beasts, winning five of the past six against the American League, and they have handled the Cleveland franchise with nine victories in the past 10 tries.
While Quantrill failed to lose a decision in 2021 at home, he will struggle against a Giants team that won 107 games last season.
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Run line/Against the spread
GIANTS -1.5 (+145) are worth playing lightly, as they covered the run line in Friday’s interleague series opener. While three of their five victories so far have been 1-run wins, their pitching has been excellent lately. The Giants have yielded just 4 total runs in the past three games while piling up 19 runs scored. Look for more of the same Saturday.
Over/Under
The lean is to the UNDER 8.5 (-125), mostly due to San Francisco’s pitching. The Giants have cashed the Under in five of their last six games, allowing 2 or fewer runs in five of their previous six outings.
The Guardians had four straight Over results before Friday’s low-scoring loss. The offense has overshadowed the pitching, which has turned in a 2.90 ERA, ranking sixth in the majors during the early going.
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