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The No. 9 Duke Blue Devils (6-2) and the Louisville Cardinals (5-3) meet Sunday in the ACC opener for both teams. Tip-off at KFC Yum! Center is set for 6 p.m. ET (ACC Network). Let’s analyze BetMGM Sportsbook’s college basketball odds around the Duke vs. Louisville odds, and make our expert college basketball picks and predictions.
Duke won 84-78 in a marquee game last time out against the No. 2 Auburn Tigers at Cameron Indoor Stadium on Wednesday. The Blue Devils covered as a 3.5-point favorite as the Over (146.5) cashed. Duke had hit the Under in the previous 5 outings.
Louisville enters with back-to-back losses to the Oklahoma Sooners and Ole Miss Rebels in the SEC/ACC Challenge. The Cardinals are just 1-3 against the spread (ATS) in the past 4 home games, while the Under is on a 5-0 run, and the total has gone low in 7 of 8 games this season.
Duke has won 5 in a row in this series, while including the past 3 trips to Louisville. The Cardinals have cashed in 2 of the past 3 in the series, while the Over is also 2-1 in that span.
– Rankings: USA TODAY Sports Men’s Basketball Coaches Poll
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Duke at Louisville odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college basketball odds. Lines last updated at 7:51 a.m. ET.
- Moneyline (ML): Duke -450 (bet $350 to win $100) | Louisville +340 (bet $100 to win $340)
- Against the spread: Duke -9.5 (-106) | Louisville +9.5 (-114)
- Over/Under (O/U): 144.5 (O: -105 | U: -115)
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Duke at Louisville picks and predictions
Prediction
Duke 79, Louisville 64
Moneyline
Duke (-450) will set you back 4 1/2 times your potential return, and that’s too expensive for a straight up wager or as part of a multi-leg parlay.
AVOID, and look to the spread instead.
Against the spread
PLAY DUKE -9.5 (-110), and pray it doesn’t have a hangover game after its big win over Auburn earlier in the week.
The Blue Devils are an experienced team, and this is the conference opener in hostile territory, so Cooper Flagg and company should have no problem getting up for this one.
Louisville +9.5 (-110) limps into this game with consecutive losses to Oklahoma and Ole Miss, and it is 1-3 ATS in the previous 4 outings at home.
Over/Under
UNDER 144.5 (-115) is worth a look in this conference opener for both sides.
The Under has cashed in 5 in a row, and 7 of 8 games on the season, for the Cardinals. Against power conference teams at home, Louisville is averaging just 59.0 PPG, while allowing 81.5 PPG.
For Duke, the Over did cash in the marquee matchup with Auburn, but the Under is still 5-1 across the previous 6 outings.
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