Indianapolis Colts at New Orleans Saints odds, picks and best bets

Previewing Monday’s Colts at Saints Week 15 NFL matchup, with NFL betting odds, picks and best bets

The Indianapolis Colts (6-7) will try to snap their three-game losing streak on Monday night against the New Orleans Saints (10-3), who are coming off a loss to the 49ers in Week 14.

These two cross-conference foes will square off at 8:15 p.m. ET from the Mercedes-Benz Superdome in New Orleans.

Colts at Saints: Week 15 preview, betting trends and notes


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  • The Colts have lost five of their last six games this season, going 2-3-1 against the spread in that span.
  • The Saints are 9-2 straight up and 8-3 ATS in their last 11 games. Their only SU losses this season were to the Rams, Falcons and 49ers.
  • New Orleans is 15-5 SU in its last 20 games at home (including playoffs).
  • The Saints are 8-2 SU in their last 10 games against the Colts
  • In the last five games between these teams in New Orleans, the total has gone over four times.
  • The Colts are 11-2 ATS in their last 13 games against teams above .500.
  • The Saints are 4-1 ATS against teams with a losing record.

Colts at Saints: Key injuries

Colts WR T.Y. Hilton has a calf injury and is questionable to play on Monday night.

Saints DT Sheldon Rankins (ankle) and DE Marcus Davenport (foot) were both placed on injured reserve this week. TE Jared Cook suffered a concussion against the 49ers and will be monitored.

Colts at Saints: Odds, betting lines and prediction

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Thursday at 12:40 p.m. ET.

Prediction

Saints 31, Colts 20

Moneyline (?)

It’s hard to fathom a way in which the Saints lose this game, especially being at home and coming off a 48-46 loss to the 49ers. The Colts are really struggling right now and shouldn’t pose much of a threat to the Saints.

Bet the SAINTS (-455) to win outright on Monday night and defend their home turf.

New to sports betting? A successful $10 wager on the Saints to win would return a profit of $2.20.

Against the Spread (?)

The Saints come into this one as 9.5-point home favorites over the Colts. Three of the Saints’ last five wins have come by at least 11 points, so they’re plenty capable of winning handily.

Take the SAINTS -9.5 (-106) to cover the spread and beat the Colts by at least 10 points.

Over/Under (?)

The over/under of 45.5 points is certainly a reachable number, considering the Saints have scored at least 26 points in each of their last four games, and just put up 46 on the 49ers’ top defense.

Take the OVER (-125) because this game has a good chance of topping 50 total points.

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