Boston Red Sox at Cleveland Guardians odds, picks and predictions

Analyzing Saturday’s Boston Red Sox at Cleveland Guardians odds and lines, with MLB expert picks and predictions

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The Boston Red Sox (40-31) and Cleveland Guardians (36-30) meet Saturday for the middle contest of a 3-game set at Progressive Field in Cleveland. First pitch is scheduled for 6:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Red Sox vs. Guardians odds with MLB picks and predictions.

Season series: Red Sox lead 1-0 after doubling up the Guardians 6-3 in Friday’s opener with the Over (8.5) cashing

The Red Sox enter Saturday’s game on a 5-game win streak, while posting victories in 10 of their previous 12 games away from home.

The Guardians are basically tied for 1st place with the Minnesota Twins in the AL Central but are actually percentage points ahead. They’re also 16-11 at home this season, including 8-3 in the previous 11 despite Friday’s setback.

Red Sox at Guardians projected starters

RHP Josh Winckowski vs. RHP Shane Bieber

Winckowski (2-1, 3.68 ERA) makes his 4th start. The rookie has a 1.50 WHIP, 3.1 BB/9 and 5.5 K/9 through 14 2/3 IP.

  • Recorded 1st-career quality start last time out, allowing 2 ER on 7 H and 1 BB across 6 2/3 IP against the Detroit Tigers Monday
  • Will be making his 1st-career MLB road start

Bieber (3-3, 3.00 ERA) makes his 14th start. He has a 1.17 WHIP, 2.1 BB/9 and 9.7 K/9 through 78 IP.

  • Winless in past 3 starts, posting 3 consecutive no-decisions
  • 1-0 with a 2.59 ERA across 24 1/3 IP in 4 June starts – Cleveland won all 4 games
  • Career vs. Red Sox: 2-2, 6.95 ERA (22 IP, 17 ER) in 3 starts, including 1 relief appearance – last faced Boston in 2019

Red Sox at Guardians odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 5:1 a.m. ET.

  • Money line (ML): Red Sox +135 (bet $100 to win $135) | Guardians -170 (bet $170 to win $100)
  • Run line (RL)/Against the spread (ATS): Red Sox +1.5 (-150) | Guardians -1.5 (+122)
  • Over/Under (O/U): 8.5 (O: -120 | U: -105)

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Red Sox at Guardians picks and predictions

Prediction

Red Sox 5, Guardians 4

Money line

The value is with the RED SOX (+135), as laying the big number with the Guardians (-170) isn’t a good idea. Cleveland’s bats have gone cold, totaling 3 runs in the past 2 outings, both losses.

Yes, Bieber is on the hill, and yes, he hasn’t faced the Red Sox since 2019. However, when he has faced Boston, he has been rather uneven, and the prospect Winckowski has come up to the majors and is building confidence. The rook will outpitch the savvy veteran.

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Run line/Against the spread

The RED SOX +1.5 (-150) aren’t a terrible play if you don’t trust the rookie hurler to get it done in his 1st-career road start, and you’d like a little insurance. Boston is on a 5-game heater, however, therefore it’s best to play the Sox straight up for a much better value.

Over/Under

The OVER 8.5 (-120) just came through in Friday’s series opener, with 9 total runs and an O/U line of 8.5. Both teams scored a run in the 9th to inch this one across the finish line.

Over bettors might be in for another sweat job Saturday, but the lean is to the Over, yet again.

Bet legally online with a trusted partner: Tipico Sportsbook, Sportsbook Wire’s official sportsbook partner in CO, NJ and soon IA. Bet now!

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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Cleveland Guardians at Minnesota Twins odds, picks and predictions

Analyzing Thursday’s Cleveland Guardians at Minnesota Twins odds and lines, with MLB expert picks and predictions

The Cleveland Guardians (36-28) and Minnesota Twins (38-32) meet Thursday for the finale of a 3-game set at Target Field in Minneapolis, Minn. First pitch is scheduled for 1:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Guardians vs. Twins odds with MLB picks and predictions.

Season series: The Guardians hold a 3-2 season series edge, including the first 2 contests of this 3-game set.

The Guardians faced a 10-7 deficit in the 9th inning Wednesday, but RPs Emilio Pagan and Griffin Jax coughed up 4 runs as Minnesota fell 11-10.

The Twins have fallen 1 game back of the 1st-place Guardians as a result of that blown opportunity in the 9th, as well as Tuesday’s 6-5 setback in the 11th inning to Cleveland.

Guardians at Twins projected starters

RHP Zach Plesac vs. LHP Devin Smeltzer

Plesac (2-4, 4.41 ERA) makes his 13th start. He has a 1.28 WHIP, 2.0 BB/9 and 5.9 K/9 through 67 1/3 IP.

  • Has a 3.34 ERA in 35 IP across 6 home starts, but a dismal 5.57 ERA in 32 1/3 IP over 6 road outings.
  • Is 1-0 with a 2.19 ERA in 4 starts (none vs. MIN) across 24 2/3 IP vs. AL Central teams this season.

Smeltzer (3-1, 3.52 ERA) makes his 8th start. He has a 1.15 WHIP, 2.6 BB/9 and 4.5 K/9 through 38 1/3 IP.

  • Allowed a career-high 7 R (6 ER) across just 4 1/3 IP in a loss last time out at Arizona Friday.
  • Is 1-0 with a 2.00 ERA across 18 IP with a .150 opponent batting average over 3 home starts.

Guardians at Twins odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:40 a.m. ET.

  • Money line (ML): Guardians +110 (bet $100 to win $110) | Twins -135 (bet $135 to win $100)
  • Run line (RL)/Against the spread (ATS): Guardians +1.5 (-175) | Twins -1.5 (+140)
  • Over/Under (O/U): 10.5 (O: +100 | U: -125)

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Guardians at Twins picks and predictions

Prediction

Twins 6, Guardians 5

Money line

I expect the TWINS (-135) to salvage the series finale on getaway day, getting back to a tie for 1st place with the Guardians (+110) in the AL Central.

These teams have had two 1-run games so far in this series and will likely have plenty more close battles this season. They have a 5-game set in Cleveland from June 27-30.

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Run line/Against the spread

The GUARDIANS +1.5 (-175) have found a way to win when it appeared all was lost, or hope was dismal. It’s reminiscent of teams from the 1990’s from the great city of Cleveland. This team has just had something special during the early going. They might not win, but they’ll keep it close to the end.

Over/Under

The OVER 10.5 (+100) is a value play at even-money.

These teams combined for 21 total runs in Wednesday’s wild and wacky 11-10 Cleveland win, and the Over has cashed in each of the first 2 in the series. While the Under is 3-1 in Plesac’s past four outings, the Over has hit at a 3-0-1 clip across Smeltzer’s previous 4 starts.

Bet legally online with a trusted partner: Tipico Sportsbook, Sportsbook Wire’s official sportsbook partner in CO, NJ and soon IA. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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Kansas City Royals at Cleveland Guardians odds, picks and predictions

Analyzing Tuesday’s Kansas City Royals at Cleveland Guardians odds and lines, with MLB expert picks and predictions.

The Kansas City Royals (16-31) and Cleveland Guardians (20-24) face off Tuesday for the second game of a three-game set at Progressive Field. First pitch is scheduled for 6:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Royals vs. Guardians odds with MLB picks and predictions.

Season series: The Guardians lead the season series against the Royals 3-2, including Monday’s 7-3 victory in Cleveland.

The Royals have dropped nine of the past 11 games overall. The exact score of the past three games for Kansas City has been 7-3, with back-to-back losses by that score.

The Guardians have picked up two wins in the past three games, and Cleveland has been a respectable 6-4 across the past 10 at home.

Royals at Guardians projected starters

LHP Daniel Lynch vs. RHP Cal Quantrill

Lynch (2-3, 3.92 ERA) makes his ninth start. He has a 1.41 WHIP, 3.92 BB/9 and 8.54 K/9 through 39 IP.

  • Is winless in the past five starts, going 0-2 with a 4.30 ERA across 23 IP in 5 outings in the month of May.
  • Posted a 1-2 record with a 3.55 ERA across 25.1 IP over five starts on the road.

Quantrill (1-3, 3.42 ERA) makes his ninth start. He has a 1.23 WHIP, 3.61 BB/9 and 5.32 K/9 through 47.1 IP.

  • Faced the Royals in Kansas City April 10, allowing two runs, four hits and a walk across 5 IP for his only win of the campaign.
  • Has walked three or more batters in five of his past seven outings, while lasting at least 6 IP in six consecutive starts.

Royals at Guardians odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:45 a.m. ET.

  • Money line (ML): Royals +120 (bet $100 to win $120) | Guardians -145 (bet $145 to win $100)
  • Run line (RL)/Against the spread (ATS): Royals +1.5 (-170) | Guardians -1.5 (+135)
  • Over/Under (O/U): 9.5 (O: -107 | U: -115)

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Royals at Guardians picks and predictions

Prediction

Guardians 7, Royals 4

Money line

The GUARDIANS (-145) are the play as moderate favorites. Cleveland opened this three-game set with a convincing 7-3 win, posting eight hits, including a triple and two home runs.

It’s not just about offense for Cleveland, however, as it enters seventh in the majors with a 1.18 WHIP, and third in the league with a 7.27 strikeouts per game. Conversely, Kansas City struggles to put up runs, ranking just 25th with 3.81 runs per game.

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Run line/Against the spread

The GUARDIANS -1.5 (+135) are worth a small-unit play on the run line. That’s because the Royals have been yielding runs at an alarming rate, posting a 5.02 ERA to rank 28th. They’re also 29th with a 1.48 WHIP. Cleveland’s offense should be able to post plenty of runs like it did in Monday’s opener.

Over/Under

The OVER 9.5 (-107) is worth playing, as again, Kansas City has struggled in the pitching department. But it’s not a slam-dunk play, as the Royals have also struggled plating runs. Still, the Guardians have averaged 11.3 runs per game in the past three meetings with the Royals.

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If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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San Diego Padres at Cleveland Guardians odds, picks and predictions

Analyzing Tuesday’s San Diego Padres at Cleveland Guardians odds and lines, with MLB expert picks and predictions.

The San Diego Padres (15-8) open a two-game interleague series with the Cleveland Guardians (10-12) on Tuesday at Progressive Field. First pitch is scheduled for 6:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Padres vs. Guardians odds with MLB picks and predictions.

These two teams haven’t met since July 4-6, 2017 in Cleveland, when San Diego won the series with two victories in three games.

The Padres, tied for first place in the National League West, have picked up nine victories in 13 games on the road. Overall, the Padres have a plus-20 run differential, too.

The Guardians are in second place in the American League Central, just 3.5 games off the pace despite a sub-.500 record. They also have a division-best 101 runs scored, and enter on a three-game win streak.

Padres at Guardians projected starters

RHP Mike Clevinger vs. RHP Zach Plesac

Clevinger will make his first start since Oct. 6, 2020, a playoff appearance against the Los Angeles Dodgers.

  • Clevinger is making his way back from Tommy John surgery, which shuttered his entire 2021 campaign.
  • Clevinger came up with the Cleveland organization, and went 41-20 with a 2.96 ERA and 1.15 WHIP with 10.2 K/9 from 2017-20.

Plesac (1-2, 3.80 ERA) makes his fifth start. He has a 1.31 WHIP, 1.69 BB/9 and 5.06 K/9 through 21.1 IP.

  • Plesac makes his third start at Progressive Field. He has a 1-1 record and 2.25 ERA across 12 IP in two home outings, while posting a 5.79 ERA in two road starts.
  • Plesac has just one win in five decisions across eight interleague starts during his career, including a loss to San Francisco on April 15.

Padres at Guardians odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8 a.m. ET.

  • Money line (ML): Padres -140 (bet $140 to win $100) | Guardians +115 (bet $100 to win $115)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+120) | Guardians +1.5 (-140)
  • Over/Under (O/U): 7.5 (O: -130 | U: +105)

Exclusive USA TODAY Network offer: Deposit $10 or more, get $200 in instant bet credits at Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Place your legal, online sports bets at Tipico. Let’s make this interesting. Bet now!

Padres at Guardians picks and predictions

Prediction

Guardians 5, Padres 4

Money line

The GUARDIANS (+115) are a solid value at home in this interleague series opener. Clevinger was once a dominant pitcher, and he still very well could be for the Padres (-140). But you can expect some jitters, and a little bit of rust, too, as he faces his former team.

Cleveland is aiming to equal its season best with four straight victories, and it will do just that as short ‘dogs at home.

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Run line/Against the spread

If you’re not feeling the GUARDIANS +1.5 (-140) straight up, and would like some insurance, the price isn’t out of line to bet the home side catching a run-and-a-half.

Cleveland won in Plesac’s most-recent start at home against the Chicago White Sox April 21, cashing as underdogs with a similar number in a 6-3 win. Look for more of the same here.

Over/Under

The OVER 7.5 (-130) has cashed in three of the past four home games for the Guardians. And while the Padres hit the Under in Sunday’s series finale in Pittsburgh, the Over is 6-1 across the past seven overall for San Diego.

Bet legally online with a trusted partner: Tipico Sportsbook, Sportsbook Wire’s official sportsbook partner in CO, NJ and soon IA. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

Follow Kevin J. Erickson on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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Chicago White Sox at Cleveland Guardians odds, picks and predictions

Analyzing Wednesday’s Chicago White Sox at Cleveland Guardians odds and lines, with MLB expert picks and predictions.

The Chicago White Sox (6-3) play the Cleveland Guardians (4-5) in the first of a traditional doubleheader Wednesday at Progressive Field. First pitch of Game 1 is set for 2:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the White Sox vs. Guardians odds with MLB picks and predictions.

The White Sox-Guardians games Monday and Tuesday were rained out, which led to Wednesday’s doubleheader.

Chicago won its first three series, all 2-1, at the Detroit Tigers Opening Day weekend and then at home versus the Seattle Mariners and the Tampa Bay Rays last week.

Cleveland rode a 4-game winning streak into its previous series with San Francisco, but was swept at home last weekend by the Giants and outscored 16-4 in the series.

The White Sox won last season’s regular-season series over the Guardians 10-9 and Chicago outscored Cleveland 81-74.

White Sox at Guardians: Projected starters

LHP Dallas Keuchel vs. RHP Shane Bieber

Keuchel (1-0, 5.40 ERA) won his first start last Wednesday versus the Mariners 12-11, throwing 5 1/3 IP with 5 ER on 5 H and 1 BB with 4 K.

  • 2021 vs. Guardians: 0-1 with. 6.61 ERA (16 1/3 IP, 12 ER), 12 H, 7 BB and 10 K in 3 starts.
  • vs. Guardians on the current roster: 4.92 FIP with a .270 batting average (BA), .332 wOBA, .459 expected slugging percentage (xSLG), 12.7 K% and 89.4 mph exit velocity (EV) in 79 plate appearances (PA).

Bieber (0-0) has two straight no-decisions on the road, versus the Kansas City Royals and Cincinnati Reds to open the season. He went 5 1/3 IP with 3 ER on 2 H and 3 BB with 5 K in Cleveland’s 10-5 win April 12 at the Reds.

  • 2021 vs. White Sox: 3-0 with a 1.80 ERA (25 IP, 5 ER), 0.76 WHIP and 11.5 K/9 in 4 starts.
  • vs. White Sox on the current roster: 2.53 FIP with a .215 BA, .252 wOBA, .375 xSLG, 33.1 K% and 91.5 mph EV in 124 PA.

White Sox at Guardians and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:37 a.m. ET.

  • Money line (ML): White Sox +115 (bet $100 to win $115) | Guardians -140 (bet $140 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (-180) | Guardians -1.5 (+145)
  • Over/Under (O/U): 7.5 (O: -122 | U: -102)

Exclusive USA TODAY Network offer: Deposit $10 or more, get $200 in instant bet credits at Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Place your legal, online sports bets at Tipico. Let’s make this interesting. Bet now!

White Sox at Guardians picks and predictions

Prediction

Guardians 6, White Sox 3

Money line

LEAN to the GUARDIANS (-140) mostly because Bieber is on the mound,  but this is a little pricey considering the White Sox (+115) are one of the best teams in the American League.

However, Chicago has lost five straight games as road underdogs with Keuchel on the bump. In Keuchel’s only start last season in Progressive Field, the Guardians had a 50% hard-hit rate but just a. .222 BABIP.

If you can find a price for Cleveland’s first 5-inning ML then I’d take that since Bieber is one of the best starters in baseball and Keuchel is a middle-of-the-rotation guy.

But, I LEAN GUARDIANS (-140) for the full game.

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Run line/Against the spread

LEAN to the GUARDIANS -1.5 (+145) because their lineup should rough up Keuchel and Cleveland’s bullpen is good enough to hold any lead Bieber turns over to them.

Furthermore, the Guardians are 48-32 RL in division games since the beginning of last season while the White Sox are just 37-42 RL versus divisional foes and 12-15 RL as road underdogs.

My hesitation with Cleveland’s RL is Chicago has a MLB top-5 lineup and bullpen and I’d prefer the Over as my favorite play in the White Sox-Guardians.

Over/Under

BET the OVER 7.5 (-122) for 1 unit because the Guardians are 5-1 O/U in Bieber’s last 6 starts versus teams with a winning record and there’s some logic to fading the market betting the Under with Bieber is on the mound.

Also, 7 or more runs have been scored in 7 of Keuchel’s last 9 starts dating back to last year.

Lastly, Bieber and Keuchel’s ERAs are higher when starting with 6 or more rest days than any other rest split, Bieber actually has a worse home ERA whereas Keuchel pitches worse on the road throughout his career.

The OVER 7.5 (-122) is my favorite wager in this game.

Bet legally online with a trusted partner: Tipico Sportsbook, Sportsbook Wire’s official sportsbook partner in CO, NJ and soon IA. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

Follow Geoff Clark on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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Chicago White Sox at Cleveland Guardians odds, picks and predictions

Analyzing Tuesday’s Chicago White Sox at Cleveland Guardians odds and lines, with MLB expert picks and predictions.

The Chicago White Sox (6-3) face the Cleveland Guardians (4-5) Tuesday in the opener of what is now a three-game set. First Pitch from Progressive Field in Cleveland is scheduled for 6:10 p.m. ET (ESPN+). Let’s analyze Tipico Sportsbook‘s lines around the White Sox vs. Guardians odds with MLB picks and predictions.

Season series: White Sox won the 2021 series 10-9

These teams were expected to open a four-game set Monday, but a chilly rain/snow mix washed out the opener which has been rescheduled for July 12. The White Sox won five of the nine meetings in Cleveland last season.

The Guardians opened the season with wins in four of their first six games — all on the road — but were swept in a three-game interleague set against the San Francisco Giants over the weekend, so they’re still looking for the first home win of 2022.

White Sox at Guardians: Projected starters

LHP Dallas Keuchel vs. RHP Shane Bieber

Keuchel (1-0, 5.40 ERA) makes his second start. He allowed 3 ER on 6 H and 0 BB with 5 K across 5 IP in his first start versus the Seattle Mariners Wednesday.

  • Posted a 4-7 record and 5.75 ERA with a .310 opponent batting average across 81 1/3 IP in 16 road starts in 2021.
  • Managed a 0-1 record, 6.61 ERA and 4 home runs allowed in just 16 1/3 IP across three starts versus Cleveland last season.

Bieber (0-0, 2.70 ERA) allowed 3 ER on 2 H and 3 BB with 5 K in 5 1/3 IP at the Cincinnati Reds in his second start of the season last Tuesday. This will be his first home outing of 2022.

  • Went 2-2 with a 3.51 ERA with 53 strikeouts over 41 IP across seven starts at Progressive Field in 2021.
  • Managed a tremendous 3-0 record, 1.80 ERA and .169 OBA with 32 K and no HR allowed across 25 IP in four starts against the White Sox last season.

White Sox at Guardians odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:20 a.m. ET.

  • Money line (ML): White Sox +120 (bet $100 to win $120) | Guardians -145 (bet $145 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (-180) | Guardians -1.5 (+145)
  • Over/Under (O/U): 7.5 (O: -115 | U: -107)

Exclusive USA TODAY Network offer: Deposit $10 or more, get $200 in instant bet credits at Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Place your legal, online sports bets at Tipico. Let’s make this interesting. Bet now!

White Sox at Guardians picks and predictions

Prediction

Guardians 4, White Sox 2

Money line

The GUARDIANS (-145) are worth playing as moderate favorites at home. The home side caught a break with the weather Monday, as they’ll now be able to use their ace for this series opener.

While Cleveland hasn’t really supported its Opening Day starter with a lot of offense, he’ll break through against a team he showed well against in 2021.

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Run line/Against the spread

GUARDIANS -1.5 (+145) are worth playing very lightly on the run line. Bieber had a tremendous hold on the White Sox last season, racking up three of his seven victories against the Pale Hose. The offense has struggled a bit lately after flying high in Kansas City and Cincinnati, so be careful.

Over/Under

The UNDER 7.5 (-107) might be the best play on the board here.

The Under is 5-1 in the past six games for the ChiSox against a right-handed starting pitcher, while going 7-2-1 in the past 10 as an underdog going back to last season. The Under is also 11-5-1 in the past 17 road games for Chicago.

While the Over is 5-2 in the past seven for Cleveland, the Under is 5-2 in the past seven at Progressive Field, including 2-1 this season. Cleveland’s offense scratched out just 4 total runs in the three-game sweep at the hands of San Francisco.

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San Francisco Giants at Cleveland Guardians odds, picks and predictions

Analyzing Saturday’s San Francisco Giants at Cleveland Guardians odds and lines, with MLB expert picks and predictions.

The San Francisco Giants (5-2) face the Cleveland Guardians (4-3) in the second game of a three-game interleague set Saturday at Progressive Field in Cleveland. First pitch is scheduled for 6:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Giants vs. Guardians odds with MLB picks and predictions.

Season series: Giants lead 1-0

The Giants spoiled the Guardians’ home opener with a 4-1 victory Friday. Former White Sox LHP Carlos Rodon helped keep the Cleveland bats cool for his new squad, as he limited the home side to just 3 hits.

The Guardians had rolled up 44 total runs in the previous four games before the offense ground to a halt against the southpaw Rodon. The Under result was the first for Cleveland since their second game of the regular season at Kansas City April 9.

Giants at Guardians: Projected starters

RHP Anthony DeSclafani vs. RHP Cal Quantrill

DeSclafani (0-0, 4.91 ERA) makes his second start. He allowed 2 ER on 8 H and 1 BB with 5 K across 3 2/3 IP in his first start versus the Miami Marlins Sunday.

  • Posted a 5-4 record, 3.22 ERA and .225 opponent batting average across 95 IP in 17 road starts last season.
  • Allowed 2 runs on 7 hits and 2 walks with 6 strikeouts across 6 innings in a no-decision as a member of the Cincinnati Reds when he last faced Cleveland July 6, 2019.

Quantrill (1-0, 3.60 ERA) allowed 2 ER on 4 H and 1 BB with 2 K in 5 IP at the Kansas City Royals Sunday in his season debut.

  • The Guardians supported Quantrill with 17 runs of offense in his first outing of the season at Kauffman Stadium Sunday.
  • Was outstanding at Progressive Field in 2021, posting a 6-0 record, 2.35 GAA and .224 OBA with 76 strikeouts across 92 IP in 14 starts and eight relief appearances.

Giants at Guardians odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:55 a.m. ET.

  • Money line (ML): Giants -108 (bet $108 to win $100) | Guardians -112 (bet $112 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants -1.5 (+145) | Guardians +1.5 (-180)
  • Over/Under (O/U): 8.5 (O: +100 | U: -125)

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Giants at Guardians picks and predictions

Prediction

Giants 5, Guardians 3

Money line

The GIANTS (-108) have been interleague beasts, winning five of the past six against the American League, and they have handled the Cleveland franchise with nine victories in the past 10 tries.

While Quantrill failed to lose a decision in 2021 at home, he will struggle against a Giants team that won 107 games last season.

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Run line/Against the spread

GIANTS -1.5 (+145) are worth playing lightly, as they covered the run line in Friday’s interleague series opener. While three of their five victories so far have been 1-run wins, their pitching has been excellent lately. The Giants have yielded just 4 total runs in the past three games while piling up 19 runs scored. Look for more of the same Saturday.

Over/Under

The lean is to the UNDER 8.5 (-125), mostly due to San Francisco’s pitching. The Giants have cashed the Under in five of their last six games, allowing 2 or fewer runs in five of their previous six outings.

The Guardians had four straight Over results before Friday’s low-scoring loss. The offense has overshadowed the pitching, which has turned in a 2.90 ERA, ranking sixth in the majors during the early going.

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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San Francisco Giants at Cleveland Guardians odds, picks and predictions

Analyzing Friday’s San Francisco Giants at Cleveland Guardians odds and lines, with MLB expert picks and predictions.

The San Francisco Giants (4-2) start a 3-game interleague series with the Cleveland Guardians (4-2) Friday at Progressive Field. First pitch is scheduled for 7:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Giants vs. Guardians odds with MLB picks and predictions.

The Guardians and Giants have not played each other since 2017. The Giants lead 5-14 in the regular season and have won 10 of the last 12 meetings between the teams.

San Francisco won back-to-back games over the San Diego Padres to win their 3-game series 2-1. The Giants outscored the Padres 17-7.

Cleveland has won 4 consecutive games after dropping its first two of the season, which includes a split in their 4-game set with the Royals and a sweep in the 2-game interleague miniseries with the Reds earlier this week.

Giants at Guardians: Projected starters

San Francisco RHP Carlos Rodon vs. Cleveland LHP Zach Plesac 

Rodon (0-0, 1.80 ERA) picked up a no-decision in San Francisco’s 2-1 home loss to the Marlins Saturday. He went for 5 IP, allowing just 1 ER on 3 H and 2 BB with 12 K.

  • 2021 vs. Guardians: 2-0 with a 2.70 ERA (20 IP, 6 ER), 0.90 WHIP and 10.4 K/9 in 3 starts for the Chicago White Sox.
  • vs. Guardians on the current roster: 3.05 FIP with a .176 batting average, .257 wOBA, .309 expected slugging percentage, 24.1 K% and 90.0 mph exit velocity in 83 plate appearances.

Plesac (0-0, 0.00 ERA), also earned a no-decision in Cleveland’s 1-0 loss in K.C. Saturday. He gave up 0 ER on 3 H, 0 BB and 5 K in 5 2/3 IP.

  • April splits: 1-3 with a 4.78 ERA (32 IP, 17 ER), 1.06 WHIP and 5.9 K/9 in 6 starts.

Giants at Guardians odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:12 a.m. ET.

  • Money line (ML): Giants -155 (bet $155 to win $100) | Guardians +125 (bet $100 to win $125)
  • Run line (RL)/Against the spread (ATS): Giants -1.5 (+110) | Guardians +1.5 (-135)
  • Over/Under (O/U): 7.5 (O: -125 | U: +100)

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Giants at Guardians picks and predictions

Prediction

Guardians 4, Giants 2

Money line

SPRINKLE on the GUARDIANS (+125), if at all, because I see more value in Cleveland’s RL, which is going for a relatively cheap price.

The Guardians have the hottest bats in baseball through the first week, Friday is their home opener and Progressive Field is a hitter-friendly ballpark. Also, Cleveland’s lineup is familiar with Rodon who was a divisional foe and played for the Chicago White Sox from 2015-21.

This Giants (-155) lineup has yet to face Plesac, who I expect to be one of the best middle-of-the-rotation starters in MLB. Cleveland’s organization is a pitching factory and the rotation alone can put the Guardians in playoff contention.

However, San Francisco is somehow underrated coming into this year despite winning the NL West last season and I prefer Cleveland’s RL.

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Run line/Against the spread

Definitely BET the GUARDIANS +1.5 (-135) instead of or heavier than their ML because Cleveland should beat the Giants -1.5 (+110) outright. but the RL is just too cheap to pass up.

Furthermore, there’s reverse line movement in Cleveland’s direction as nearly two-thirds of the money is on San Francisco but the line has moved slightly towards the Guardians. This suspicious line movement tells us the oddsmakers are trying to entice more pro-Giants action.

A Cleveland ML bet should cash but my preferred play is the GUARDIANS +1.5 (-135).

Over/Under

LEAN to the UNDER 7.5 (+100)

This is a sharp total and there are two quality starters on the mound. Plesac is due for a breakout season and Rodon was an AL Cy Young contender last season and his pitching peripherals versus this Cleveland lineup are solid.

But Cleveland’s lineup is hot and powered by Guardians 3B Jose Rameriz, who was recently given a hefty contract extension and is dialed in at the plate.

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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Cleveland Guardians at Cincinnati Reds odds, picks and predictions

Analyzing Tuesday’s Cleveland Guardians at Cincinnati Reds odds and lines, with MLB expert picks and predictions.

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The Cleveland Guardians (2-2) take on the Cincinnati Reds (2-2) Tuesday at Great American Ball Park in Cincinnati. First pitch is scheduled for 4:10 p.m. Let’s analyze Tipico Sportsbook‘s lines around the Guardians vs. Reds odds with MLB picks and predictions.

The Guardians split their wraparound 4-game series against the Kansas City Royals. Cleveland won its final 2 games of the set to gain the split, outscoring Kansas City 27-10 after being outscored in the first two games 4-1.

The Reds also split a 4-game set in their opening series, playing well against the Atlanta Braves. Cincinnati scored exactly 6 runs in 3 of the 4 outings.

Guardians at Reds: Projected starters

RHP Shane Bieber vs. RHP Tyler Mahle

Bieber did not factor into the decision in his first start against Kansas City Thursday, allowing a run with 3 hits and no walks while striking out 4 across 4.2 IP.

  • Went 5-2 with a 2.91 ERA with a .211 opponent batting average in 9 road starts across 55.2 IP on the road last season.
  • Allowed 3 runs, 6 hits and 2 walks with 13 strikeouts over 8 innings in a win at GABP April 18 last season in his only appearance against the Reds.

Mahle picked up the win in his initial start of the season Thursday, allowing 1 unearned run, 3 hits and 2 walks with 7 strikeouts across 5 innings.

  • Went 5-4 with a 5.63 ERA across 78.1 IP over 15 starts at home last season, striking out 98 batters with 19 home runs allowed.
  • Last faced Cleveland Aug. 4, 2020, allowing just 1 hit and 2 walks with 6 strikeouts across 6 scoreless innings in a no-decision.

Guardians at Reds odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:30 a.m. ET.

  • Money line (ML): Guardians -120 (bet $120 to win $100) | Reds +100 (bet $100 to win $100)
  • Run line (RL)/Against the spread (ATS): Guardians -1.5 (+135) | Reds +1.5 (-170)
  • Over/Under (O/U): 8.5 (O: -105 | U: -120)

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Guardians at Reds prediction and picks

Prediction

Guardians 4, Reds 2

Money line

The GUARDIANS (-120) failed to win in Bieber’s first start in Kansas City. He probably saw the offense break out in the past 2 games and wondered where the run support was in his outing. The Cleveland bats will likely struggle a little against Cincinnati’s opening-day starter, but it’ll do enough to get the win for its ace.

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Run line/Against the spread

The GUARDIANS -1.5 (+135) are worth a small-unit play in this one. In its 2 wins, Cleveland also won by 3 or more runs each time. If you like Cleveland to win, you should like it on the run line, too.

Over/Under

The UNDER 8.5 (-120) is the best play on the board in this battle between the aces of these teams. Cincinnati pitching has allowed 15 total runs across 4 games so far, while Cleveland pitching has allowed 3 or fewer runs in 3 of 4 games to date.

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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Cleveland Guardians at Kansas City Royals odds, picks and predictions

Analyzing Thursday’s Cleveland Guardiansat Kansas City Royals odds and lines, with MLB expert picks and predictions.

The Cleveland Guardians open the regular season against the Kansas City Royals Thursday at Kauffman Stadium in Kansas City. First pitch is scheduled for 4:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Guardians vs. Royals odds with MLB picks and predictions.

Season series: Guardians won the 2021 regular-season series vs. Royals 14-5, including 8-2 in Kansas City.

It’s a new era of baseball in Cleveland, changing from the Indians to the Guardians. The Royals hope their fortunes change against the Cleveland baseball team, too, as Kansas City really struggled against them in 2021.

The Royals went 74-88 in 2021, including 39-42 at home. But Kansas City was 69-74 against everyone but Cleveland, including 37-34 at home. The Royals also had a dismal run differential of minus-102, compared to just minus-10 for the Guardians in ’21.

Guardians at Royals: Projected starters

RHP Shane Bieber vs. RHP Zack Greinke

Bieber (7-4, 3.17 ERA in 2021) did not factor into the decision in three starts against the Royals in ’21, pitching 15 1/3 innings and striking out 22 batters.

  • Bieber will make his third consecutive Opening Day start, becoming the 12th player in franchise history to work in three or more straight openers.
  • Bieber was actually better on the road in 2021, posting a 5-2 record, 2.91 ERA and .211 OBA in 55 2/3 IP in nine starts.

Greinke (11-6, 4.16 ERA in 2021) posted a 1-0 record, 3.46 ERA and .213 OBA with 12 strikeouts in 13 IP in two starts vs. Cleveland in 2021.

  • Greinke returns to where it all started, as he spent his first seven seasons in the majors from 2004-10 with Kansas City, winning 60 games in 169 starts and 41 relief appearances.
  • Greinke posted a 2-1 record with a 3.44 ERA in six April starts in 2021. That ERA was his lowest month ERA of the entire season.

Guardians at Indians odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:01 p.m. ET.

  • Money line (ML): Guardians -120 (bet $120 to win $100) | Royals +100 (bet $100 to win $100)
  • Run line (RL)/Against the spread (ATS): Guardians -1.5 (+135) | Royals +1.5 (-170)
  • Over/Under (O/U): 7.5 (O: -122 | U: -102)

Exclusive USA TODAY Network offer: Deposit $10 or more, get $200 in instant bet credits at Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Place your legal, online sports bets at Tipico. Let’s make this interesting. Bet now!

Guardians at Royals prediction and picks

Prediction

Guardians 4, Royals 2

Money line

The GUARDIANS (-120) are the play behind Bieber, who is the Cleveland ace. He might be the next player the team decides to lock up long term after securing All-Star Jose Ramirez to an extension prior to the 2022 opener.

The Guardians have won 16 of the past 21 visits to Kauffman Stadium, making them a solid value in this opener until the Royals prove anything is different.

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Run line/Against the spread

Take a chance on GUARDIANS -1.5 (+135) on the run line at plus-money. In 12 of the 14 victories over Kansas City in 2021, Cleveland won by two or more runs.

If you like the Guardians to win, you should also like them to do so by at least two runs.

Over/Under

The UNDER 7.5 (-102) is worth a look, but play it lightly. The Under cashed in the final two starts for Bieber in 2021, including his final outing of the season on Sept. 30 in Kansas City.

Greinke is getting settled back in with the Royals, and gives them a bona fide ace and veteran who should also keep crooked numbers off the board early.

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If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

Follow Kevin J. Erickson on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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