Clemson at Duke odds, picks and predictions

Analyzing Monday’s Clemson at Duke odds and lines, with college football expert picks, predictions and best bets.

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The Clemson Tigers and the Duke Blue Devils open their regular seasons on Monday night at Wallace Wade Stadium in Durham, N.C. Kickoff is scheduled for 8 p.m. ET (ESPN). Below, we analyze BetMGM Sportsbook’s lines around the Clemson at Duke odds, and make our expert college football picks and predictions.

The Tigers roll into the Triangle looking to come away with yet another win over the Blue Devils. Clemson has won 5 straight meetings in the series since Duke won at Wallace Wace on Nov. 13, 2004. This is the 1st meeting between the school since Nov. 17, 2008, a 35-6 Tigers win in the upstate.

Clemson QB Cade Klubnik begins his 1st full season as the starter under center, as QB D.J. Uiagalelei transferred to Oregon State after losing his starting job late in the season to the prospect.

Duke won 9 games last season under new coach Mike Elko, including a bowl victory. The Blue Devils will be hard-pressed to repeat the showing, as the schedule is extremely difficult. Duke managed to go 5-1 straight-up (SU) at home last season, and it was 5-0 against the spread (ATS) at Wallace Wade Stadium vs. FBS opponents in 2022.

Clemson is No. 9 in the USA TODAY Sports AFCA Coaches Poll.

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Clemson at Duke odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 6:17 p.m. ET.

  • Moneyline (ML): Clemson -500 (bet $500 to win $100) | Duke +375 (bet $100 to win $375)
  • Against the spread (ATS): Clemson -13 (-110) | Duke +13 (-110)
  • Over/Under (O/U): 55.5 (O: -110 | U: -110)

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Clemson at Duke picks and predictions

Prediction

Clemson 38, Duke 17

Moneyline

Clemson (-500) will cost you 5 times your potential return, and that’s quite a large amount of risk for not enough reward.

While Duke (+375) isn’t traditionally a national power, it did win 9 games, and it exceeded expectations by miles. QB Riley Leonard and the offense could be quite formidable again.

PASS.

Against the spread

CLEMSON -13 (-110) might begin this game a little on the sluggish side before talent takes over and the Tigers pull away in the 2nd half.

Duke +13 (-110) protected its field well last season, winning 5 of 6 games, while covering all 5 games vs. FBS opponents. However, Leonard and the offense won’t be able to answer Klubnik and the Tigers all evening long.

Over/Under

UNDER 55.5 (-110) might be the most dramatic part of this entire game, as I expect the total to go low by a slim margin.

The Under went 3-1-1 in Duke’s 5 home games against FBS opponents in 2022. Clemson has held Duke to 83 total points in the past 7 meetings, or 11.8 points per game (PPG). The Blue Devils aren’t likely to exceed that total by very much in this one, either.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Kevin J. Erickson on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

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First look: Clemson at Duke odds and lines

Looking at Monday’s Clemson at Duke college football odds, lines and trends. Here’s what you need to know.

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The Clemson Tigers and the Duke Blue Devils open the regular season on Monday. Sept. 4, at Wallace Wade Stadium in Durham, N.C. Kickoff is scheduled for 8 p.m. ET (ESPN). Below, we look at Clemson at Duke odds from BetMGM Sportsbook. Also see: SportsbookWire’s college football picks and predictions.

The Tigers posted 11 victories last season, which gives Clemson 12 straight campaigns with 10 or more wins. It was a season of transition, as QB D.J. Uiagalelei started as the signal caller, but prospect QB Cade Klubnik finished as the starter. Klubnik is the future, and Uiagalelei is now at Oregon State. Klubnik must take another step forward if the team wants to get back in the national title picture.

The Blue Devils hired a new coach last season, as Mike Elko replaced the popular David Cutcliffe. Duke surprisingly won 8 regular-season games and its bowl in Elko’s debut, led by QB Riley Leonard. The schedule is brutal for the Blue Devils this season, including the opener against a top-10 team.

Clemson is No. 9 in the USA TODAY Sports AFCA Coaches Poll.

Stream select live college football games and full replays: Get ESPN+

Clemson at Duke odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 11:42 p.m. ET.

  • Moneyline (ML): Clemson -450 (bet $450 to win $100) | Duke +333 (bet $100 to win $333)
  • Against the spread (ATS): Clemson -13 (-110) | Duke +13 (-110)
  • Over/Under (O/U): 55.5 (O: -110 | U: -110)

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2022 betting stats

  • ML: Clemson 11-3 | Duke 9-4
  • ATS: Clemson 7-7 | Duke 9-4
  • O/U: Clemson 7-7 | Duke 5-7-1

Clemson at Duke head-to-head

Clemson leads the all-time series 37-16-1, and it has won 5 straight meetings in the series.

These teams last met Nov. 17, 2018, in “Death Valley” with Clemson coming away with the 35-6 home win. Clemson won its 2 most recent trips to Durham, posting a 56-20 win on Nov. 3, 2012, and a 47-10 win on Nov. 3, 2007.

Duke’s last win in the series was at home, as the Blue Devils edged the Tigers 16-13 back on Nov. 13, 2004. Prior to that, Duke hadn’t won in the series since Oct. 24, 1998, a 28-23 home victory.

Play our free daily Pick’em Challenge and win! Play now!

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Kevin J. Erickson on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

College sports coverage from USA TODAY Sports Media Group:
Alabama / Arkansas / Auburn / Clemson / Colorado / Florida / Georgia / Iowa / LSU / Michigan / Michigan State / Nebraska / North Carolina / Notre Dame / Ohio State / Oklahoma / Oregon / Penn State / Rutgers / Tennessee / Texas / Texas A&M / USC / Wisconsin / Recruiting / Transfer portal / College Football Playoffs / College Sports Wire

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