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The Clemson Tigers and the Duke Blue Devils open their regular seasons on Monday night at Wallace Wade Stadium in Durham, N.C. Kickoff is scheduled for 8 p.m. ET (ESPN). Below, we analyze BetMGM Sportsbook’s lines around the Clemson at Duke odds, and make our expert college football picks and predictions.
The Tigers roll into the Triangle looking to come away with yet another win over the Blue Devils. Clemson has won 5 straight meetings in the series since Duke won at Wallace Wace on Nov. 13, 2004. This is the 1st meeting between the school since Nov. 17, 2008, a 35-6 Tigers win in the upstate.
Clemson QB Cade Klubnik begins his 1st full season as the starter under center, as QB D.J. Uiagalelei transferred to Oregon State after losing his starting job late in the season to the prospect.
Duke won 9 games last season under new coach Mike Elko, including a bowl victory. The Blue Devils will be hard-pressed to repeat the showing, as the schedule is extremely difficult. Duke managed to go 5-1 straight-up (SU) at home last season, and it was 5-0 against the spread (ATS) at Wallace Wade Stadium vs. FBS opponents in 2022.
Clemson is No. 9 in the USA TODAY Sports AFCA Coaches Poll.
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Clemson at Duke odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 6:17 p.m. ET.
- Moneyline (ML): Clemson -500 (bet $500 to win $100) | Duke +375 (bet $100 to win $375)
- Against the spread (ATS): Clemson -13 (-110) | Duke +13 (-110)
- Over/Under (O/U): 55.5 (O: -110 | U: -110)
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Clemson at Duke picks and predictions
Prediction
Clemson 38, Duke 17
Moneyline
Clemson (-500) will cost you 5 times your potential return, and that’s quite a large amount of risk for not enough reward.
While Duke (+375) isn’t traditionally a national power, it did win 9 games, and it exceeded expectations by miles. QB Riley Leonard and the offense could be quite formidable again.
PASS.
Against the spread
CLEMSON -13 (-110) might begin this game a little on the sluggish side before talent takes over and the Tigers pull away in the 2nd half.
Duke +13 (-110) protected its field well last season, winning 5 of 6 games, while covering all 5 games vs. FBS opponents. However, Leonard and the offense won’t be able to answer Klubnik and the Tigers all evening long.
Over/Under
UNDER 55.5 (-110) might be the most dramatic part of this entire game, as I expect the total to go low by a slim margin.
The Under went 3-1-1 in Duke’s 5 home games against FBS opponents in 2022. Clemson has held Duke to 83 total points in the past 7 meetings, or 11.8 points per game (PPG). The Blue Devils aren’t likely to exceed that total by very much in this one, either.
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