First look: Clemson at Duke odds and lines

Looking at Monday’s Clemson at Duke college football odds, lines and trends. Here’s what you need to know.

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The Clemson Tigers and the Duke Blue Devils open the regular season on Monday. Sept. 4, at Wallace Wade Stadium in Durham, N.C. Kickoff is scheduled for 8 p.m. ET (ESPN). Below, we look at Clemson at Duke odds from BetMGM Sportsbook. Also see: SportsbookWire’s college football picks and predictions.

The Tigers posted 11 victories last season, which gives Clemson 12 straight campaigns with 10 or more wins. It was a season of transition, as QB D.J. Uiagalelei started as the signal caller, but prospect QB Cade Klubnik finished as the starter. Klubnik is the future, and Uiagalelei is now at Oregon State. Klubnik must take another step forward if the team wants to get back in the national title picture.

The Blue Devils hired a new coach last season, as Mike Elko replaced the popular David Cutcliffe. Duke surprisingly won 8 regular-season games and its bowl in Elko’s debut, led by QB Riley Leonard. The schedule is brutal for the Blue Devils this season, including the opener against a top-10 team.

Clemson is No. 9 in the USA TODAY Sports AFCA Coaches Poll.

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Clemson at Duke odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 11:42 p.m. ET.

  • Moneyline (ML): Clemson -450 (bet $450 to win $100) | Duke +333 (bet $100 to win $333)
  • Against the spread (ATS): Clemson -13 (-110) | Duke +13 (-110)
  • Over/Under (O/U): 55.5 (O: -110 | U: -110)

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2022 betting stats

  • ML: Clemson 11-3 | Duke 9-4
  • ATS: Clemson 7-7 | Duke 9-4
  • O/U: Clemson 7-7 | Duke 5-7-1

Clemson at Duke head-to-head

Clemson leads the all-time series 37-16-1, and it has won 5 straight meetings in the series.

These teams last met Nov. 17, 2018, in “Death Valley” with Clemson coming away with the 35-6 home win. Clemson won its 2 most recent trips to Durham, posting a 56-20 win on Nov. 3, 2012, and a 47-10 win on Nov. 3, 2007.

Duke’s last win in the series was at home, as the Blue Devils edged the Tigers 16-13 back on Nov. 13, 2004. Prior to that, Duke hadn’t won in the series since Oct. 24, 1998, a 28-23 home victory.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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