Chicago White Sox vs. Cleveland Guardians odds predictions pick betting line spread

Chicago White Sox at Cleveland Guardians odds, picks and predictions

Analyzing Wednesday’s Chicago White Sox at Cleveland Guardians odds and lines, with MLB expert picks, predictions and best bets.

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The Chicago White Sox (24-63) and Cleveland Guardians (53-30) play the middle contest of a 3-game series Wednesday. First pitch from Progressive Field is scheduled for 6:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Guardians odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 4-4

The Guardians walked it off with a sacrifice fly from pinch-hitter Bo Naylor in the bottom of the 9th inning for a 7-6 win over the last-place White Sox in a wild seesaw battle in Tuesday’s series opener. Despite the win, Cleveland is just 4-4 this season against Chicago.

Cleveland is 13-9 inside the AL Central, while going only 2-4 in the past 6 tries inside the division. The Under has a 12-10 edge in 22 divisional matchups.

Guardians RHP Gavin Williams (elbow) was reinstated from the 60-day injured list after recovering from right elbow discomfort and will start Wednesday. He posted a 10:2 K:BB ratio in his final 2 rehab starts for Triple-A Columbus after a sluggish start to his assignment.

Chicago has dropped back-to-back road games after winning 3 in a row from June 27-29. The White Sox are just 3-14 in the past 17 road outings. The Over has cashed in 3 straight, with the offense averaging 7.0 runs per game (RPG), while allowing 5.0 RPG in the span.

White Sox at Guardians projected starters

RHP Erick Fedde vs. RHP Gavin Williams

Fedde (5-3, 3.23 ERA) makes his 18th start. He has a 1.14 WHIP, 2.2 BB/9 and 8.2 K/9 in 100 1/3 IP.

Last start: Loss, 6 IP, 4 ER, 5 H (1 HR), 1 BB, 5 K in 4-0 home loss vs. Los Angeles Dodgers June 26
2024 road splits: 1-2, 4.47 ERA (56 1/3 IP, 28 ER), 1.31 WHIP, .257 opponents’ batting average (OBA), 7 HR, 17 BB, 50 K in 10 starts
2024 vs. Guardians: 1-0, 3.27 ERA (11 IP, 5 R – 4 ER), 3 HR, 3 BB, 6 K in 2 starts
Career vs. Guardians: 1-0, 2.77 ERA (13 IP, 5 R – 4 ER), 1.08 WHIP, 3 HR, 4 BB, 6 K in 3 appearances (2 starts)

Williams makes his 1st start of 2024. He was 3-5, 3.29 ERA (82 IP, 30 ER), 8 HR, 37 BB, 81 K in 16 starts in 2023

Last start: Win, 6 IP, 1 ER, 4 H, 2 BB, 8 K in 9-2 home win vs. Texas Rangers Sept. 17, 2023
2023 home splits: 3-3, 3.74 ERA (53 IP, 22 ER), 1.32 WHIP, .234 OBA, 23 BB, 53 K in 10 starts
Has never faced White Sox

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White Sox at Guardians odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday at 10:42 p.m. ET.

Moneyline (ML): White Sox +145 (bet $100 to win $145) | Guardians -175 (bet $175 to win $100)
Run line (RL)/Against the spread (ATS): White Sox +1.5 (+140) | Guardians -1.5 (+115)
Over/Under (O/U): 8.5 (O: -105 | U: -115)

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White Sox at Guardians picks and predictions

Prediction

White Sox 4, Guardians 3

Moneyline

The WHITE SOX (+145) aren’t a bad play as a moderate underdog against the Guardians (-175), especially since Williams could be a little rusty after a lengthy layoff due to his elbow ailment.

The ChiSox have handled the Guardians pretty well this season, splitting 8 games to date. Tuesday’s series opener was a seesaw affair, too, and it easily could have gone Chicago’s way.

Run line/Against the spread

The WHITE SOX +1.5 (-140) aren’t priced out of line, if you’d like a little insurance, and you just can’t bring yourself to back Chicago straight up as the moderate underdog.

The White Sox have dropped back-to-back games, but both losses are by a single run. Chicago is a respectable 6-3 on the run line in the past 9 as an underdog, including outright wins in 3 of the outings.

Over/Under

UNDER 8.5 (-115) is the lean in Wednesday’s battle at Progressive Field.

The Over cashed in a wild affair Tuesday, but Fedde has been pretty effective, and he should be able to help keep score down. And while the Over is 3-0 in the past 3 for the White Sox, the Under is still 10-4 across the past 14 outings, including Fedde’s past 2 starts.

For the Guardians, the Over is 3-1 in the past 4 games, but the Over-Under has split 5-5-1 in the past 11 outings since June 21. The Over-Under is 4-4 in the 8 meetings these season, too.

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Chicago White Sox at Cleveland Guardians odds, picks and predictions

Analyzing Monday’s Chicago White Sox at Cleveland Guardians odds and lines, with MLB expert picks, predictions and best bets.

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The Chicago White Sox (1-8) take on the Cleveland Guardians (7-2) Monday in the opener of a 3-game set at Progressive Field at 5:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Guardians odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; White Sox won 8-5 last season

The Sox have gotten off to a rough start in what is expected to be a long season. It got worse when they lost OF Luis Robert to the 10-day IL with a strained adductor muscle Friday. They were swept in 4 games by the Kansas City Royals over the weekend and are last with 1.8 runs per game and 27th with a .196 team batting average. The Sox haven’t announced a starter Monday, but they’re expected to recall someone from the minors.

The Guardians were also dealt a tough blow as RHP Shane Bieber was lost for the season requiring Tommy John surgery. They have won 4 straight, though, and 7 of 9 to open the campaign. The Guardians, who will be playing in their home opener, had an extra day of rest Sunday after they were rained out against the Minnesota Twins.

White Sox at Guardians projected starters

LHP Jared Shuster vs. RHP Triston McKenzie

Shuster (4-3, 5.81 ERA) made 11 starts with the Atlanta Braves last season and had a 1.50 WHIP, 4.4 BB/9 and 5.1 K/9 in 52 2/3 IP.

Allowed 7 ER on 6 H and 1 BB with 4 K in 4 IP in 1 start March 30 at Charlotte (AAA)
2023 home/road splits: 1-3 with a 7.52 ERA, 1.71 WHIP, 4.1 K/9 in 6 road GS vs. 3-0, 4.10 ERA, 1.29 WHIP and 6.2 K/9 in 5 home GS

McKenzie (0-1, 10.80 ERA) allowed 4 ER on 4 H and 2 BB while fanning 2 in 3 1/3 IP in a loss to Seattle April 1.

Made only 4 starts in 2023 due to a strained ulnar collateral ligament in his elbow; he went 0-3 with a 5.06 ERA
Last 5 starts vs. White Sox: 2-1, 2.96 ERA, 1.13 WHIP, 38 K over 27 1/3 IP

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White Sox at Guardians odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10 a.m. ET.

Moneyline (ML): White Sox +180 (bet $100 to win $180) | Guardians -225 (bet $225 to win $100)
Run line (RL)/Against the spread (ATS): White Sox +1.5 (-120) | Guardians -1.5 (+100)
Over/Under (O/U): 7.5 (O: -120 | U: +100)

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White Sox at Guardians picks and predictions

Prediction

Guardians 5, White Sox 1

Moneyline

The Guardians are tied for 4th in MLB with 5.9 R/game and allow the fewest at 2.3 R/game. I look for those trends to continue Monday. If the Sox indeed roll with the lefty, the Guardians are hitting .323 with a .446 slugging percentage and .841 OPS in 65 ABs against left-handed pitchers.

There’s too much juice on the ML, though. PASS and look to the spread.

Run line/Against the spread

All of Cleveland’s 7 wins have been multi-run winners. With a rested bullpen, the GUARDIANS -1.5 (+105) is the best bet on the board Monday.

Over/Under

The weather shouldn’t impact the game much tonight, as it’s projected to be 66 degrees with just a 5-mph breeze blowing out to right-center.

Cleveland is 5-4-1 O/U thus far, and the Sox are 2-7. This one will be close, but for the price, I’ll take the UNDER 7.5 (+100).

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Chicago White Sox at Cleveland Guardians odds, picks and predictions

Analyzing Friday’s Chicago White Sox at Cleveland Guardians odds and lines, with MLB expert picks, predictions and best bets.

The Cleveland Guardians (53-56) welcome the Chicago White Sox (43-67) to Progressive Field Friday. First pitch is set for 7:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the White Sox at Guardians odds and make our expert MLB picks and predictions for the best bets.

Season series: White Sox lead 6-4

Cleveland was swept in a 3-game series by the Houston Astros from Monday-Wednesday, losing 3-2 in the finale. The Guardians are 2 1/2 games behind the Minnesota Twins in the AL Central. They are 28-24 at home this season but just 4-6 over their last 10 games.

Chicago was swept by in a 3-game series by the Texas Rangers to kick off the week, losing 5-3 Thursday. The White Sox are just 20-38 on the road this season and 2-8 over their last 10 contests and trail the Twins by 12 1/2 games.

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White Sox at Guardians projected starters

RHP Mike Clevinger vs. LHP Logan Allen

Clevinger (4-4, 3.59 ERA) makes his 14th start. He has a 1.29 WHIP, 3.5 BB/9 and 7.4 K/9 through 67 2/3 IP.

Last start: Win, 5 IP, 0 ER, 2 H, 0 BB, 3 K in 7-2 win vs. Guardians Saturday
2023 road stats: 2-3, 4.78 ERA (37 2/3 IP, 20 ER) over 7 starts
Career vs. Guardians: 2-1, 21 2/3 IP, 7 ER, 14 H, 8 BB, 16 K across 4 starts

Allen (4-4, 3.70 ERA) makes his 16th start. He has a 1.37 WHIP, 3.1 BB/9 and 9.0 K/9 through 80 1/3 IP.

Last start: Loss, 6 IP, 5 ER, 8 H, 3 BB, 4 K opposite Clevinger Saturday
2023 home stats: 1-2, 4.15 ERA (39 IP, 18 ER) in 7 starts
Career vs. White Sox: 0-2, 17 2/3 IP, 9 ER, 22 H, 5 BB, 13 K in 3 starts, all this year

White Sox at Guardians odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:14 a.m. ET.

Moneyline (ML): White Sox +135 (bet $100 to win $135) | Guardians -160 (bet $160 to win $100)
Run line (RL)/Against the spread (ATS): White Sox +1.5 (-150) | Guardians -1.5 (+125)
Over/Under (O/U): 8.5 (O: -120 | U: +100)

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White Sox at Guardians picks and predictions

Prediction

Guardians 4, White Sox 3

Moneyline

PASS.

Considering the splits for each team in this situation (home vs. away), there isn’t much reasoning to bet on Chicago to go into Cleveland and win, being 18 games under .500 on the road.

However, with Clevinger, it should keep things close though. Nonetheless, I’d pass on both sides of the equation here and look for better value on the run line and/or total.

Run line/Against the spread

LEAN WHITE SOX +1.5 (-150).

The White Sox haven’t been great on the road, but they have been great against the Guardians this season. Chicago is 40-35 on the run line as an underdog, and Cleveland is 23-37 on the run line as a favorite.

Despite the juice, those records make this playable. Clevinger has also had a great season and dominated the Guardians the last time he was on the mound. Chicago is 20-13 on the run line in its division as well, whereas Cleveland is 17-16.

Take WHITE SOX +1.5 (-150).

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Over/Under

BET UNDER 8.5 (+100).

If there’s one trend both teams can get behind, it is backing the Under. Chicago is 49-55-6 O/U this season while Cleveland is 45-61-3 O/U.

Both teams have strong starters going. The Guardians are 1-2-1 O/U in Clevinger’s last 4 games and are 1-4-1 O/U in their last 6 games. Cleveland has gone Under in 3 of its last 4 games and in 4 of its last 6 outings.

Take UNDER 8.5 (+100).

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Chicago White Sox at Cleveland Guardians odds, picks and predictions

Analyzing Wednesday’s Chicago White Sox at Cleveland Guardians odds and lines, with MLB expert picks, predictions and best bets.

The Chicago White Sox (20-30) and Cleveland Guardians (21-27) play the finale of a 3-game set at Progressive Field Wednesday. First pitch is at 1:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Guardians odds and make our expert MLB picks and predictions for the best bets.

Season series: White Sox lead 3-2

The White Sox took Game 2 of the series Tuesday 4-2. C Yasmany Grandal homered, and RHP Dylan Cease allowed 2 ER over 6 innings. The White Sox are now 7-3 over the last 10 games. Chicago is 10-8 against the AL Central and sits 5.5 games back in the division despite being 10 games under .500.

The Guardians have lost 6 of their last 8 games, and they managed 4 runs in a game just twice in that stretch. They are also just 2-5 in the last 7 home games against the White Sox. Cleveland is 12-18 over the last 30 games, but because it plays in arguably the weakest division in baseball, it sits 3.5 games out of 1st place.

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White Sox at Guardians projected starters

RHP Michael Kopech vs. RHP Cal Quantrill

Kopech (2-4, 4.83 ERA) makes his 10th start. He has a 1.33 WHIP, 5.0 BB/9 and 9.1 K/9 in 50 1/3 innings.

Dominated the Kansas City Royals in last start Friday: 8 IP, 0 ER, 1 H, 0 BB, 10 K
2 career starts vs. Cleveland: 0-0, 0 ER and 11 K in 8 IP

Quantrill (2-2, 4.06 ERA) makes his 10th start. He has a 1.31 WHIP, 2.6 BB/9 and 5.1 K/9 in 51 innings.

Last start: No-decision, 5 2/3 IP, 3 ER, 6 H, 0 BB, 6 K, against the New York Mets Friday
Last 5 starts vs. White Sox: 2-1, 3.67 ERA, 1.33 WHIP, 21 K in 27 IP

White Sox at Guardians odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:16 a.m. ET.

Moneyline (ML): White Sox +115 (bet $100 to win $115) | Guardians -135 (bet $135 to win $100)
Run line (RL)/Against the spread (ATS): White Sox +1.5 (-175) | Guardians -1.5 (+145)
Over/Under (O/U): 8 (O: -105 | U: -115)

White Sox at Guardians picks and predictions

Prediction

White Sox 4, Guardians 2

Moneyline

We have gone 5-1 on picks in this series, and there looks to be value in this afternoon affair. I like the White Sox here because of Cleveland’s inability to score runs and because Kopech is coming off the best start of his career.

Kopech has always been a guy that threw hard, but you could count on him to walk 2 hitters a start, but he has not done so in 2 of his last 3 starts. We’ll need him to get 2 outs into the 6th inning, and he has gone 6 innings in 3 of 4 starts and did so in his last one against Cleveland.

Take MICHAEL KOPECH OVER 16.5 OUTS RECORDED (-110).

Run line/Against the spread

Each game has been decided by more than 1 run between these clubs this year, and they haven’t had a 1-run game in the last 12 meetings. So we’ll use this as a de facto moneyline bet and LEAN WHITE SOX -1.5 (+190) for a chance to nearly double up.

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Over/Under

The wind is blowing in at 11 mph on a 72-degree day for this Wednesday matinee. The Under is 7-1 in the last 8 meetings between these teams in Cleveland. The Under is 7-0-1 in the last 8 for Cleveland against a team under .500. The Under has cashed in Chicago’s last 6 games overall and its last 4 outings following a win.

Only go a HALF-UNIT here because things could get messy on getaway day, but take the UNDER 8 (-115).

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Chicago White Sox at Cleveland Guardians odds, picks and predictions

Analyzing Tuesday’s Chicago White Sox at Cleveland Guardians odds and lines, with MLB expert picks, predictions and best bets.

The Chicago White Sox (19-30) and Cleveland Guardians (21-26) play the 2nd of a 3-game set at Progressive Field Tuesday. First pitch is at 6:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Guardians odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 2-2

The White Sox fell to the Guardians 3-0 Monday as they mustered just 3 hits. Chicago had won 5 of its last 6 games to crawl back to 10 games under .500 before the series opener. The Pale Hose are just 7-17 on the road and are 2-7 against left-handed pitchers — which they’ll face Tuesday.

The Guardians snapped a 3-game losing skid Monday, and C Mike Zunino’s 2-run homer snapped a 1-for-31 slump. He had recently struck out in 17 straight games and has 46 K’s in 90 at-bats this season. The Guardians are now 4-6, 8-12 and 12-18 over the last 10, 20 and 30 games, respectively.

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White Sox at Guardians projected starters

RHP Dylan Cease vs. LHP Logan Allen

Cease (2-3, 4.78 ERA) makes his 11th start. He has a 1.39 WHIP, 3.9 BB/9 and 9.7 K/9 in 52 2/3 innings.

Last start: Loss, 6 1/3 IP, 3 ER, 5 H, 1 BB, 3 K, in a 3-1 loss to the Guardians Thursday
Last 5 starts vs. Cleveland: 2-2, 2.45 ERA, 1.33 WHIP, 22 K in 29 1/3 IP

Allen (1-1, 3.04 ERA) makes his 6th start. He has a 1.46 WHIP, 2.7 BB/9 and 9.8 K/9 in 26 2/3 innings.

Last start: No-decision, 5 2/3 IP, 1 ER, 7 H, 1 BB, 5 K, in a 3-1 road win vs. White Sox Thursday
In 3 home starts: 1-0, 3.38 ERA, 1.56 WHIP, 9.0 K/9 vs. 0-1, 2.53 ERA, 1.31 WHIP and 11.0 K/9 in 2 away starts

White Sox at Guardians odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9 a.m. ET.

Moneyline (ML): White Sox +110 (bet $100 to win $110) | Guardians -135 (bet $135 to win $100)
Run line (RL)/Against the spread (ATS): White Sox +1.5 (-185) | Guardians -1.5 (+150)
Over/Under (O/U): 8 (O: -120 | U: +100)

White Sox at Guardians picks and predictions

Prediction

Guardians 3, White Sox 1

Moneyline

We cashed all 3 bets here Monday, and we’ll look for the same success Tuesday. Cease has been out of whack with a 6.19 ERA over his last 7 starts and the White Sox aren’t scoring runs. The Guardians strike out the fewest times per game in the league (7.11), and that’s what Cease relies most on. They’ll survive the tide and get to the bullpen once he’s out.

However, I like CEASE OVER 17.5 OUTS RECORDED (-110) instead of the moneyline. He has gone 6 innings in his last 2 starts overall and his last 3 against Cleveland. The lack of K’s will keep his pitch count low enough to stick around.

Run line/Against the spread

The White Sox are 24-25 (11-13 on the road) on the RL this year, and Cleveland is 21-26 (9-13 at home). Each game has been decided by more than 1 run between these clubs this year, and they haven’t had a 1-run game in the last 11 meetings. If you’re feeling the Guardians, it’s worth sprinkling GUARDIANS -1.5 (+150) once again.

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Over/Under

The White Sox are 2-8 O/U in the last 10, and Cleveland is 5-4-1. Chicago is 23rd (4.23) in runs/9, and Cleveland is 29th (3.57). The weather shouldn’t be a factor with 76-degree skies and a slight 3-mph breeze coming in from right-center field.

The Under is 5-0 in the last 5 overall for Chicago and in its last 5 against the AL Central. The Under is 3-0-1 in Allen’s last 4 starts and is 6-1 in the last 7 meetings between these teams in Cleveland.

Take the UNDER 8 (+100).

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Chicago White Sox at Cleveland Guardians odds, picks and predictions

Analyzing Monday’s Chicago White Sox at Cleveland Guardians odds and lines, with MLB expert picks, predictions and best bets.

The Chicago White Sox (19-29) and Cleveland Guardians (20-26) open up a 3-game set at Progressive Field Monday. First pitch is at 6:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Guardians odds and make our expert MLB picks and predictions for the best bets.

Season series: White Sox lead 2-1

The White Sox just swept the Kansas City Royals over the weekend and have won 5 of their last 6 games — including 2 of 3 against Cleveland. Chicago is now just 6.5 games out of 1st the AL Central after a miserable start to the year. 3B Jake Burger is hitting .409 (9-for-22) with 2 homers and 7 RBIs in the last 7 days.

Cleveland was swept by the New York Mets over the weekend and has dropped 5 of its last 6 outings and 7 of its last 10. The Guardians have dropped to 3rd place in the division, 4.5 games back. They are also just 9-12 at home on the season. 3B Jose Ramirez homered in both slates of a doubleheader Sunday.

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White Sox at Guardians projected starters

RHP Jesse Scholtens vs. RHP Hunter Gaddis

Scholtens (0-0, 3.00 ERA) makes his 1st start and 3rd appearance. He has a 2.00 WHIP, 6.0 BB/9 and 12.0 K/9 in 3 innings.

The White Sox have not announced a starter Monday after RHP Mike Clevinger (wrist) went on the IL. Scholtens is a logical choice to come up from Triple-A Charlotte to make the start.
Last start May 14 vs. Triple-A Durham: 6 2/3 IP, 0 ER, 5 H, 1 BB, 4 K

Gaddis (0-1, 6.86 ERA) makes his 5th start and 6th appearance. He has a 1.42 WHIP, 2.7 BB/9 and 5.9 K/9 in 19 2/3 innings.

Being recalled from Triple-A Columbus for this start after being sent down following a relief appearance on April 22
Last MLB start: No-decision, 5 IP, 3 ER, 8 H, 1 BB, 1 K on April 18 at Detroit Tigers
1 career start vs. White Sox on Sept. 15, 2022: Loss, 4 IP, 7 ER, 8 H, 1 BB, 3 K

White Sox at Guardians odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:21 a.m. ET.

Moneyline (ML): White Sox +105 (bet $100 to win $105) | Guardians -125 (bet $125 to win $100)
Run line (RL)/Against the spread (ATS): White Sox +1.5 (-190) | Guardians -1.5 (+155)
Over/Under (O/U): 9 (O: -105 | U: -115)

White Sox at Guardians picks and predictions

Prediction

Guardians 4, White Sox 2

Moneyline

The Indians’ bullpen is in good shape despite playing a doubleheader Sunday as they only had to cover 2 innings. The Guardians were 12-7 against the Pale Hose last season and are a decent run-prevention team at 11th with 4.33 runs/9. They have the 6th-ranked ‘pen with a 3.50 ERA, compared to the White Sox’s next-to-last at 5.41.

Take the GUARDIANS (-125) at a solid price.

Run line/Against the spread

The White Sox are 24-24 (11-12 on the road) on the RL this year, and Cleveland is 20-26 (8-13 at home). Each game has been decided by more than 1 run between these clubs this year, and they haven’t had a 1-run game in the last 10 meetings. If you’re feeling the Guardians, it’s worth sprinkling GUARDIANS -1.5 (+155).

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Over/Under

The White Sox are 2-8 O/U in the last 10, and Cleveland is 5-4-1. Chicago is 22nd (4.31) in runs/9, and Cleveland is 29th (3.59). There is a lot to like about the Under, and the total is steamed up because of a couple of unknowns on the mound. The Under has cashed in the last 4 overall, the last 4 on grass and the last 4 against the AL Central for the White Sox. The Under is 5-1 in the last 6 in Cleveland.

Take the UNDER 9 (-115).

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Chicago White Sox at Cleveland Guardians odds, picks and predictions

Analyzing Thursday’s Chicago White Sox at Cleveland Guardians odds and lines, with MLB expert picks and predictions.

The Chicago White Sox (73-70) and the Cleveland Guardians (76-65) play a makeup game Thursday at Progressive Field. First pitch is scheduled for 1:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the White Sox at Guardians odds with MLB picks and predictions.

Season series: Guardians lead 9-6

The White Sox meet the Guardians in a makeup game due to a rainout Aug. 21. Chicago currently trails Cleveland by 4 games in the AL Central. It’s dropped 2 of the past 3 to fall a little further off the pace.

The Guardians completed their second consecutive sweep, topping the Los Angeles Angels Wednesday by a 5-3 count. Cleveland has won 6 in a row dating back to Sept. 9, and it has cashed the Over in 4 of its last 6 outings.

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White Sox at Guardians projected starters

RHP Lance Lynn vs. RHP Hunter Gaddis

Lynn (6-5, 4.07 ERA) makes his 18th start. He has a 1.07 WHIP, 1.4 BB/9 and 9.9 K/9 through 97 1/3 IP.

Is 2-3 with a 4.14 ERA and .251 opponent batting average with 53 K and just 9 BB across 50 IP in 9 road starts
Has not allowed a run across 13 IP in 2 starts in September, striking out 16 batters
Is 0-1 with a 5.17 ERA across 15 2/3 IP in 3 starts vs. Cleveland in 2022

Gaddis (0-1, 21.60 ERA) makes his 2nd career start. He was pounded for 8 ER on 7 H and 2 BB with 2 K in just 3 1/3 IP in a loss against the Houston Astros in his MLB debut Aug. 5.

Posted a 3-2 record with a 3.93 ERA and 1.05 WHIP across 34 1/3 IP in 7 starts with Triple-A Columbus

White Sox at Guardians odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:05 a.m. ET.

Money line (ML): White Sox -155 (bet $155 to win $100) | Guardians +125 (bet $100 to win $125)
Run line (RL)/Against the spread (ATS): White Sox -1.5 (+110) | Guardians +1.5 (-135)
Over/Under (O/U): 8.5 (O: -105 | U: -120)

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White Sox at Guardians picks and predictions

Prediction

White Sox 6, Guardians 2

Money line

The WHITE SOX (-155) are the play here, as this is not an even pitching matchup. The veteran right-hander Lynn has been absolutely on fire lately, and he is opposed by a guy making just his 2nd-career start. That’s not a recipe for success for the first-place Guardians.

Run line/Against the spread

The WHITE SOX -1.5 (+110) are worth playing on the run line, basically as a play against Gaddis, who was tattooed by the Astros in his first MLB start over a month ago.

Cleveland is due to get cooled off, too, coming off its 2nd consecutive 3-game sweep. The runs will be hard to come by against the red-hot Lynn.

Over/Under

UNDER 8.5 (-120) is a risky play with a rookie on the bump for Cleveland. However, the good news for Under bettors is that Lynn hasn’t allowed a run in September — he’s been absolutely red hot. In addition, the wind is blowing in directly from center field into the face of the batters at a 6-9 mph clip, keeping the ball in the park.

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Chicago White Sox at Cleveland Guardians odds, picks and predictions

Analyzing Saturday’s Chicago White Sox at Cleveland Guardians odds and lines, with MLB expert picks and predictions.

The Chicago White Sox (61-59) take on the Cleveland Guardians (64-55) Saturday in the 2nd game of a 3-game set at Progressive Field. First pitch is set for 6:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the White Sox vs. Guardians odds with MLB picks and predictions.

Season series: Guardians lead 9-5

The tides keep turning for the White Sox, who have dropped 3 in a row after a 5-game win streak. They are 26-26 within the division and 3½ games back of the 1st-place Guardians. If there was a must-win game in August, this is it.

The Guardians took care of business 5-2 in Friday’s opener behind RHP Triston McKenzie’s career-high 14 strikeouts. They’re in a good position with their ace on the hill Saturday. Cleveland has won 10 of 13 and boast a 32-24 home record.

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White Sox at Guardians projected starters

RHP Johnny Cueto vs. RHP Shane Bieber

Cueto (5-5, 2.78 ERA) makes his 17th start and 18th appearance. He has a 1.20 WHIP, 2.0 BB/9 and 5.8 K/9 in 110 IP.

Allowed 1 ER on 6 H and 1 BB with 3 K in 8 IP last time out to beat the visiting Houston Astros 4-2 Monday
No-decision at home against Cleveland July 23 after allowing 3 ER on 8 H and 1 BB with 0 K in 7 IP

Bieber (8-6, 3.18 ERA) makes his 23rd start. He has a 1.10 WHIP, 1.9 BB/9 and 9.1 K/9 in 138 2/3 IP.

Owns a 3.21 ERA (47 2/3 IP, 17 ER) and 5-2 record over the last 7 starts
Allowed 6 ER in 6 IP in 6-3 loss at the White Sox July 24 but held them to 2 ER in 15 IP, including complete-game victory, in other 2 starts against them this year, both wins

White Sox at Guardians odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:38 p.m. ET.

Money line (ML): White Sox +145 (bet $100 to win $145) | Guardians -180 (bet $180 to win $100)
Run line (RL)/Against the spread (ATS): White Sox +1.5 (-155) | Guardians -1.5 (+125)
Over/Under (O/U): 7.5 (O: -107 | U: -115)

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White Sox at Guardians picks and predictions

Prediction

Guardians 4, White Sox 2

Money line

It’s possible that Chicago steals this one as Cueto was awesome against Houston last time out. However, I think Bieber holds it down at home. Cleveland has scored 4 or more runs in 7 of 9 games, and that’s what it will take to get it done Saturday.

Instead of paying the -180 juice, let’s go with GUARDIANS TOTAL RUNS OVER 3.5 (-150).

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Run line/Against the spread

I’m not confident enough in the Guardians offense, despite picking a 4-2 win to throw down on the RL. One way we can go is to read into Bieber’s last 2 starts at home against the White Sox. He allowed 3 hits in 9 innings (July 12) and 4 hits in 6 innings (April 20).

So, let’s go with WHITE SOX UNDER 4.5 HITS FIRST 5 INNINGS (-145) for a HALF UNIT.

Over/Under

The Over is just 3-7 in the Guardians’ last 10 games, and they’ve won 7 of those.

The Under is 4-0 in the last 4 meetings between these teams in Cleveland.

The Under is 5-0 in Bieber’s last 5 home starts when the total was between 7.0-8.5.

UNDER 7.5 (-115) looks good Saturday.

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Chicago White Sox at Cleveland Guardians odds, picks and predictions

Analyzing Friday’s Chicago White Sox at Cleveland Guardians odds and lines, with MLB expert picks and predictions.

The Chicago White Sox (61-58) and Cleveland Guardians (63-55) open a 3-game set at Progressive Field. Friday’s series opener is slated for a 7:05 p.m. ET first pitch. Let’s analyze Tipico Sportsbook‘s lines around the White Sox vs. Guardians odds with MLB picks and predictions.

Season series: Cleveland leads 8-5

The White Sox have lost 2 straight after winning 5 in a row from Aug. 12-16. Chicago had a fine 2nd-half ERA of 3.39 until coughing up 21 runs in Thursday’s loss to the Houston Astros.

The Guardians have pitched themselves to a 12-6 record since July 31. Cleveland owns a 3.24 ERA, 1.09 WHIP over that productive stretch.

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White Sox at Guardians projected starters

RHP Lance Lynn vs. RHP Triston McKenzie

Lynn (3-5, 5.62 ERA) owns a 1.25 WHIP, 1.5 BB/9 and 9.5 K/9 through 65 2/3 IP in 12 starts.

Has a 3.34 ERA, 0.91 WHIP over his last 5 starts
Owns a 6.92 ERA in 5 starts against Cleveland since last May

McKenzie (8-9, 3.14 ERA) has a 0.97 WHIP, 2.3 BB/9 and 8.3 K/9 through 134 2/3 IP in 22 games (21 starts).

Owns a 6.65 ERA in his last 5 starts against Chicago
Has come on strong in July and August with a 1.82 ERA in his last 8 starts
Has a 2.82 ERA at home

White Sox at Guardians odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:37 a.m. ET.

Money line: White Sox +110 (bet $100 to win $110) | Guardians -135 (bet $135 to win $100)
Run line (RL)/Against the spread (ATS): White Sox +1.5 (-190) | Guardians -1.5 (+155)
Over/Under (O/U): 7.5 (O: -107 | U: -115)

White Sox at Guardians picks and predictions

Prediction

White Sox 4, Guardians 3

Money line

Lynn has been undone by a .312 batting average on balls in play and a very low strand rate. The veteran righty has yielded a .355 BABIP with runners in scoring position.

McKenzie has some BABIP numbers that sway the other way, and he’s been more fortunate in 3rd-time around situations.

It all spells some leverage for the visiting team in a series of 2 teams closely matched when it comes to pitting real production against expected production based on analytics.

TAKE CHICAGO (+110).

Run line/Against the spread

Bettors not scared off buy the bullpen disparity of late between these clubs (last 30 days: Cleveland 2.31 ERA , Chicago 5.11) should consider the WHITE SOX +1.5 (-190).

Over/Under

PASS. No leverage on either side of this total and these prices.

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Chicago White Sox at Cleveland Guardians odds, picks and predictions

Analyzing Wednesday’s Chicago White Sox at Cleveland Guardians odds and lines, with MLB expert picks and predictions.

The Chicago White Sox (42-45) and Cleveland Guardians (43-43) meet Wednesday to finalize a 4-game AL Central series. First pitch at Progressive Field is set for 7:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the White Sox vs. Guardians odds with MLB picks and predictions.

Season series: Cleveland leads 6-2.

The White Sox and Guardians split in Tuesday doubleheader. Chicago shut out Cleveland 7-0 in the nightcap after losing the opener 4-1. The White Sox have registered a fine 3.70 ERA in their last 17 games. For the season, Chicago ranks 21st in MLB with a 4.11 ERA.

On June 22, the Guardians were 8 games over .500 (36-28) and in 1st place in the AL Central. Since that date, Cleveland is just 7-15 and has been outscored 116-70.

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White Sox at Guardians projected starters

RHP Lucas Giolito vs. RHP Aaron Civale

Giolito (5-5, 5.05 ERA) has logged a 1.44 WHIP, 3.4 BB/9 and 10.7 K/9 through 82 IP in 15 starts.

Has allowed 4 ER or more in 5 of his last 8 starts, but owns a 1.15 ERA in his last 5 starts against Cleveland.
Has held lefty bats to a .675 OPS over his career (.608 this season), and that figures as a big key against a Cleveland club mashing right-handers from that side.

Civale (2-5, 6.28 ERA) is making his 12th start. He has a 1.45 WHIP, 2.6 BB/9 and 8.7 K/9 in 53 IP.

Has a 5.06 ERA in his last 5 starts against Chicago.
Took a Boeing 7.04 ERA into his last start (July 8 at Kansas City). Held the Royals to 1 run on 6 hits in 7 IP (0 BB, 6K).

White Sox at Guardians odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated 10:17 a.m. ET.

Money line: White Sox -115 (bet $100 to win $115) | Guardians -105 (bet $105 to win $100)
Run line (RL): White Sox -1.5 (+145) | Guardians +1.5 (-180)
Over/Under (O/U): 8.5 (O: +100 | U: -125)

White Sox at Guardians picks and predictions

Prediction

White Sox 5, Guardians 3

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