Chicago Cubs at San Francisco Giants odds, picks and predictions

Analyzing Saturday’s Chicago Cubs at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

The Chicago Cubs (27-36) and San Francisco Giants (32-31) meet Saturday for the 2nd game of a 3-game series. First pitch from Oracle Park is set for 7:35 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s lines around the Cubs vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Cubs lead 1-0

Chicago won 3-2 as a +103 road underdog Friday in the series opener. San Francisco held a 1-0 lead off the back of an RBI double in the 3rd inning from 2B Thairo Estrada but the Cubs capitalized on a 3-run 7th inning to secure the victory.

Friday’s game snapped a 4-game losing skid for Chicago and 3-game win streak for San Francisco. The Cubs have won 4 of their last 10 games and are 12-20 on the road while the Giants are 5-5 in their last 10 outings and 17-16 at home.

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Cubs at Giants projected starters

RHP Kyle Hendricks vs. RHP John Brebbia

Hendricks (0-2, 4.70 ERA) makes his 4th start. He has a 1.50 WHIP, 2.9 BB/9 and 7.0 K/9 through 15 1/3 IP.

  • Last outing: Loss, 6 IP, 4 ER, 6 H, 0 BB, 4 K in a 5-0 road loss vs. the San Diego Padres Monday
  • Career vs. San Francisco: 5-2 with a 2.29 ERA (63 IP, 16 ER), 1.00 WHIP, 19 BB, 53 K across 10 starts

Brebbia (2-0, 3.65 ERA) makes his 6th start and 27th appearance. He has a 1.14 WHIP, 2.9 BB/9 and 12.0 K/9 through 24 2/3 IP.

  • Last outing: No-decision, 1 IP, 0 ER, 2 H, 1 BB, 0 K in a 10-4 road win Tuesday vs. Colorado Rockies as an opener
  • Career vs. Chicago: 1-2 with a 4.66 ERA (19 1/3 IP, 10 ER), 8 BB, 18 K, 1.40 WHIP across 1 start and 19 relief appearances
  • Has yet to pitch more than 1 1/3 inning in any of his 5 starts

Cubs at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:30 a.m. ET.

  • Moneyline (ML): Cubs +125 (bet $100 to win $125) | Giants -150 (bet $150 to win $100)
  • Run line (RL)/Against the spread (ATS): Cubs +1.5 (-160) | Giants 1.5 (+135)
  • Over/Under (O/U): 8.5 (O: -115 | U: -105)

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Cubs at Giants picks and predictions

Prediction

Giants 4, Cubs 3

Moneyline

LEAN GIANTS (-150).

The Giants are 7-3 in the last 10 meetings with the Cubs and have won two of the last 3 times they’ve squared off. The Cubs have struggled on the road and while the Giants are not a great home team it is still hard for me to believe that they will allow Chicago to come away with back-to-back road games.

Run line/Against the spread

PASS.

The line here simply isn’t worth the juice, bet on the moneyline and/or O/U instead.

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Over/Under

BET UNDER 8.5 (-105).

Chicago has played to 3 straight Unders and the Under is 9-1 in its last 10 games. The Under is 6-4 in San Francisco’s last 10 games and 3-0 in their last 3 as well.

The Under is also 7-3 in the last 10 meetings overall and 5-0 in the last 5 meetings overall.

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Chicago Cubs at San Francisco Giants odds, picks and predictions

Analyzing Friday’s Chicago Cubs at San Francisco Giants odds and lines, with expert MLB picks, predictions and best bets.

The Chicago Cubs (26-36) and the San Francisco Giants (32-30) kick off a 3-game series Friday at Oracle Park. First pitch is scheduled for 10:15 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Cubs vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting of 2023; Giants won the season series 5-2 in 2022

The Cubs have dropped 4 in a row, and Chicago is just 2-5 in the first 7 games of a 10-game road trip. Chicago is averaging just 1.8 runs per game across the past 4 losses and has 2 or fewer runs in 4 of the 7 games on the trip so far — including a pair of shutout setbacks.

The Giants are coming off a 3-game sweep of the division rival Colorado Rockies on the road Tuesday through Thursday. San Francisco has averaged 5.5 runs per game across its last 17 outings but has allowed 4 or more runs in each of the past 4 contests.

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Cubs at Giants projected starters

RHP Marcus Stroman vs. RHP Anthony DeSclafani

Stroman (6-4, 2.39 ERA) makes his 14th start. He has a 1.00 WHIP, 3.1 BB/9 and 7.7 K/9 in 79 IP.

  • Last start: Win, 6 IP, 1 R (0 ER), 4 H, 3 BB, 6 K in a 7-1 road win vs. the San Diego Padres Sunday
  • 2023 Road splits: 2-1, 2.73 ERA (33 IP, 10 ER – 1 HR) with a .221 OBA in 6 starts

DeSclafani (4-5, 3.97 ERA) makes his 13th start. He has a 1.12 WHIP, 1.5 BB/9 and 6.5 K/9 in 70 1/3 innings.

  • Last start: Loss, 3 IP, 6 R (5 ER), 5 H, 3 BB, 2 K in an 8-3 home loss vs. the Baltimore Orioles Sunday
  • 2023 Home splits: 2-3, 4.99 ERA (39 2/3 IP, 22 ER – 4 HR) with a .280 OBA in 7 starts

Cubs at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:32 a.m. ET.

  • Moneyline (ML): Cubs +100 (bet $100 to win $100) | Giants -120 (bet $120 to win $100)
  • Run line (RL)/Against the spread (ATS): Cubs +1.5 (-210) | Giants -1.5 (+170)
  • Over/Under (O/U): 7.5 (O: -110 | U: -110)

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Cubs at Giants picks and predictions

Prediction

Cubs 6, Giants 4

Moneyline

It’s bit of a leap of faith, but back the CUBS (+100) as the short ‘dogs at even money.

Chicago has lost 4 in a row coming in, but Stroman has pitched well lately, and the pitching advantage is in the favor of the visitors over DeSclafani and the Giants.

Run line/Against the spread

The Cubs +1.5 (-210) will cost you over 2 times your potential return if you require a little insurance and you cannot back Chicago straight up. While the Cubs are just 5-18 in the past 23 games on the road, they have won 20 of the previous 28 series openers.

The Giants -1.5 (+170) have dropped 4 of the past 5 at home, while going 1-4 in the past 5 at home against a right-handed starting pitcher, too.

PASS.

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Over/Under

OVER 7.5 (-110) is easily my favorite wager in this series opener.

The winds are usually gusting out to straightaway center field or the power alleys at Oracle Park, and Friday is no exception. We’ll have a jet stream blowing 20-23 mph, aiding the batters and making life miserable for both of the starting hurlers. I have more faith in Stroman being able to keep the ball down and inside the yard than DeSclafani.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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Chicago Cubs at San Francisco Giants odds, picks and predictions

Analyzing Sunday’s Chicago Cubs at San Francisco Giants odds and lines, with MLB expert picks and predictions.

The Chicago Cubs (41-59) and San Francisco Giants (50-51) tangle in a Sunday night affair on ESPN at Oracle Park. Game 4 of the Cubs-Giants series is slated to begin at 7 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Cubs vs. Giants odds with MLB picks and predictions.

Season series: San Francisco leads 2-1

Chicago pitching has been on a roll of late. The Cubs have registered a 1.77 ERA while going 6-2 so far in the 2nd half. Both losses over that stretch have been in close games.

The Giants have struggled offensively in going 2-8 in their last 10 games. San Francisco owns a mere .613 OPS in those 10 games.

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Cubs at Giants projected starters

RHP Adrian Sampson vs. LHP Carlos Rodon

Sampson (0-1, 3.20 ERA) has appeared in 8 games (6 as a starter). He has posted a 1.17 WHIP, 2.1 BB/9 and 6.0 K/9 in 39 1/3 IP.

  • Has done well to limit hard contact (22.8%) overall and has not allowed a HR in his last 2 starts.
  • Facing a left-leaning S.F. lineup. Has thus far held lefty bats in check this season (.617 OPS allowed).

Rodon (8-6, 3.18 ERA) has authored a 1.12 WHIP, 3.0 BB/9 and 11.5 K/9 through 116 IP in 20 starts.

  • Owns a 1.57 ERA, 0.93 WHIP in his last 3 starts at home. For the season, has logged a 2.05 ERA across 44 home innings.
  • Has held right-handed batters to an OPS under-.600 over the last 2 seasons.

Cubs at Giants odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:53 a.m. ET.

  • Money line: Cubs +155 (bet $100 to win $155) | Giants -190 (bet $190 to win $100)
  • Run line (RL)/Against the spread (ATS): Cubs +1.5 (-135) | Giants -1.5 (+110)
  • Over/Under (O/U): 7.5 (O: -107 | U: -115)

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Cubs at Giants picks and predictions

Prediction

Giants 4, Cubs 2

Money line

The Giants’ 12-19 record in 1-run games somewhat unfairly colors bettors’ current opinions of a club that has underplayed its 4.62 runs per game and 4.36 RPG allowed.

PASS on the current tag, But a Giants play closer to -180 makes sense.

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Run line/Against the spread

TAKE SAN FRANCISCO -1.5 (+110).

Expect a bounce-back from Rodon, who has struggled in 2 second-half starts after going into the break on a hot streak.

Over/Under

Both clubs have some Under lean in their overall runs-versus-expected runs figures. But peg Sampson as being overrated in the Chicago starter’s slot and the S.F. bullpen being in need of a day off.

PASS.

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Chicago Cubs at San Francisco Giants odds, picks and predictions

Analyzing Saturday’s Chicago Cubs at San Francisco Giants odds and lines, with MLB expert picks and predictions.

The Chicago Cubs (41-58) and San Francisco Giants (49-51) meet Saturday at 9:05 p.m. ET for the 3rd game of their 4-game series at Oracle Park. Let’s analyze Tipico Sportsbook‘s lines around the Cubs vs. Giants odds with MLB picks and predictions.

Season series: tied 1-1

Chicago pitching has been on a roll of late. The Cubs have registered a 1.38 ERA while going 7-1 over their last 8 games. Both games of this series have been 4-2 pitchers’ duels.

The Giants have struggled offensively in going 1-8 over their last 9 games. San Francisco has just 3 home runs over its last 8 games; it owns a mere .596 OPS over its 1-8 tailspin.

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Cubs at Giants projected starters

LHP Drew Smyly vs. RHP Jakob Junis

Smyly (3-5, 3.93 ERA) has made 12 starts this season. He has a 1.27 WHIP, 2.0 BB/9 and 7.0 K/9 through 55 IP.

  • Was solid in his last start June 24 at the Philadelphia Phillies where he allowed 2 runs (1 earned) on 4 hits through 6 innings.
  • Draws a San Francisco club swung around to its best platoon splits: the Giants own a .751 OPS against southpaws (9th MLB).

Junis (4-2, 2.98 ERA) has made 8 starts and 3 relief appearances. He’s clocked a 1.01 WHIP, 1.8 BB/9 and 7.3 K/9 through 54 1/3 IP.

  • Struggled with hamstring issues in June and July and will be making his 3rd start since a return from the IL July 17.
  • Has pitched through a tough slate as 6 of his 11 appearances have been against clubs that rank in the current top-12 in overall OPS.

Cubs at Giants odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:56 a.m. ET.

  • Money line: Cubs +115 (bet $100 to win $115) | Giants -140 (bet $140 to win $100)
  • Run line (RL)/Against the spread (ATS): Cubs +1.5 (-180) | Giants -1.5 (+145)
  • Over/Under (O/U): 8.5 (O: -105 | U: -120)

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Cubs at Giants picks and predictions

Prediction

Giants 4, Cubs 3

Money line

The lefty-righty matchup on the mound plays into an S.F. advantage in platoon splits. The Giants’ 12-19 record in 1-run games somewhat unfairly colors bettors’ current opinions.

Consider a partial-unit play on SAN FRANCISCO (-140).

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Run line/Against the spread

PASS: the San Francisco and Under leans don’t mix.

Over/Under

Both clubs have some Under lean in their overall runs-versus-expected runs figures. On a 55-degree night, both starters have shown just enough of late to tilt than lean into action.

BACK THE UNDER 8.5 (-120).

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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Chicago Cubs at San Francisco Giants odds, picks and predictions

Analyzing Thursday’s Chicago Cubs at San Francisco Giants odds and lines, with MLB expert picks and predictions.

The Chicago Cubs (40-57) and San Francisco Giants (48-50) meet Thursday for the opener of a 4-game series. First pitch from Oracle Park in San Francisco is scheduled for 9:45 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Cubs vs. Giants odds with MLB picks and predictions.

Season series: First meeting of the season. Giants won the season series 6-1 in 2021.

The Cubs have won 6 straight games, outscoring the opposition 35-13. The win streak comes after a 9-game skid from July 7-16.

The Giants enter on a 7-game slide, all on the road, last winning July 17 at home against the Milwaukee Brewers. San Francisco has won 5 of its last 6 at Oracle Park.

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Cubs at Giants projected starters

LHP Justin Steele vs. LHP Alex Wood

Steele (4-6, 4.02 ERA) makes his 19th start. He has a 1.42 WHIP, 4.2 BB/9 and 8.3 K/9 through 87 1/3 IP.

  • Is just 1-2 with a 5.23 ERA and .257 opponent batting average with 39 K across 32 2/3 IP over 7 road outings.
  • Has a solid 1-1 record with a 2.55 ERA and .188 opponent BA across 3 starts in July, his lowest marks in either of those categories in any month this season.

Wood (6-8, 4.21 ERA) makes his 20th start. He has a 1.26 WHIP, 2.2 BB/9 and 9.2 K/9 through 94 IP.

  • Is 2-3 with a 3.95 ERA and 40 K across 41 IP over 8 home starts.
  • Has allowed just 3 HR at home vs. 7 HR through 53 IP across 11 road outings.

Cubs at Giants odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 5:28 a.m. ET.

  • Money line (ML): Cubs +122 (bet $100 to win $122) | Giants -150 (bet $150 to win $100)
  • Run line (RL)/Against the spread (ATS): Cubs +1.5 (-175) | Giants -1.5 (+140)
  • Over/Under (O/U): 7.5 (O: -125 | U: +100)

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Cubs at Giants picks and predictions

Prediction

Giants 6, Cubs 4

Money line

The GIANTS -1.5 (+140) are a bit of a risky play based on the fact they’re on a major losing skid while the Cubs have been hot. However, San Francisco is not only 5-1 across its last 6 home games, but it outscored the opposition 38-17 during that span.

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Run line/Against the spread

The GIANTS -1.5 (+140) are the lean here given the juicy payout. There is definitely some risk considering the opposing streaks these two teams have been on of late, but San Francisco should get to Steele on the road in its return home from a road trip.

Over/Under

The OVER 7.5 (-125) is the lean, as the wind will be blowing out to the left-center field power alley. With a pair of left-handed hurlers on the bump, right-handed hitters have to be licking their collective chops.

Bet legally online with a trusted partner: Tipico Sportsbook, Sportsbook Wire’s official sportsbook partner in CO, NJ and soon IA. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

Follow Kevin J. Erickson on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

Additional MLB coverage:
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BaseballPress.com: Your source for every MLB lineup

Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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