Tag: Carolina Panthers betting odds line spread pick predictions best bets

San Francisco 49ers at Carolina Panthers odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at Carolina Panthers Week 5 odds and lines, with expert NFL picks, predictions and best bets.

The San Francisco 49ers (2-2) and the Carolina Panthers (1-3) meet Sunday at Bank of America Stadium in Charlotte. Kickoff is scheduled for 4:05 p.m. ET (CBS). Below, we analyze Tipico Sportsbook‘s lines around the 49ers vs. Panthers odds, and make our expert NFL picks and predictions.

The 49ers pasted the Rams 24-9, using their top-ranked defense to confuse and frustrate the defending champs all game long.

San Francisco ranks No. 1 with just 234.5 total yards allowed and 11.5 points allowed per game, while ranking No. 2 with 161.3 passing yards allowed and 73.3 rushing yards allowed per game.

The Panthers offense ranks dead-last in total yards per game with 262.3, and facing the 49ers’ top-ranked D isn’t the cure for their ills. Carolina is averaging just 19.5 PPG, ranking 17th in the NFL, and 2 of the team’s 4 touchdowns in the past 2 games have come on defensive scores.

Also see: All Week 5 odds and lines

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49ers at Panthers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 11:45 a.m. ET.

  • Moneyline (ML): 49ers -260 (bet $260 to win $100) | Panthers +215 (bet $100 to win $215)
  • Against the spread (ATS): 49ers -5.5 (-115) | Panthers +5.5 (-105)
  • Over/Under (O/U): 39.5 (O: -110 | U: -110)

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49ers at Panthers key injuries

49ers

  • DL Arik Armstead (foot, ankle) out
  • RB Tyrion Davis-Price (ankle) out
  • TE Tyler Kroft (knee) knee
  • OT Trent Williams (ankle) out

Panthers

  • LB Frankie Luvu (shoulder) questionable
  • WR Laviska Shenault Jr. (hamstring) out

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49ers at Panthers picks and predictions

Prediction

49ers 17, Panthers 12

Moneyline

The 49ers (-260) are more than likely going to win this game, but risking nearly 3 times your potential return on a road team is risky business in the NFL. Even when something looks like a sure thing, it’s not.

PASS.

Against the spread

PANTHERS +5.5 (-105) is risky, as the offense has shown no signs of life across the first 4 games. This was expected to be an improved unit with QB Baker Mayfield, but the offense is actually worse than the 2021 team. In fact, it’s much worse.

Still, even though Carolina is facing the top-ranked 49ers -5.5 (-115) defense at home, it has a decent kicker and should be able to keep this to 1 score. The 49ers don’t exactly light the world afire on offense, either.

Over/Under

UNDER 39.5 (-110) is the best bet on the board, even though it might seem like a low number at first glance.

Remember, this is a 49ers team that went into Denver and lost 11-10. It is also a San Francisco D that has allowed 27 total points across the past 3 games. We could easily see a game that rivals the Thursday night yawner between the Indianapolis Colts and Denver Broncos. Oh, please, not again!

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Arizona Cardinals at Carolina Panthers odds, picks and predictions

Analyzing Sunday’s Arizona Cardinals at Carolina Panthers odds and lines, with expert NFL picks, predictions and best bets.

The Arizona Cardinals (1-2) and the Carolina Panthers (1-2) meet Sunday at Bank of America Stadium in Charlotte, N.C. Kickoff is scheduled for 4:05 p.m. ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Cardinals vs. Panthers odds, and make our expert NFL picks and predictions.

The Cardinals have been very Jekyll and Hyde to date. They were pounded 44-21 in Week 1 against the Kansas City Chiefs, won 29-23 at the Las Vegas Raiders in OT in Week 2, and then lost 20-12 against the Los Angeles Rams in Week 3.

The Panthers lost 26-24 at home in Week 1 to the Cleveland Browns. After a 19-16 loss at N.Y. Giants in Week 2, Carolina found success at home against the New Orleans Saints last week, winning 22-14.

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Cardinals at Panthers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:12 a.m. ET.

  • Moneyline (ML): Cardinals -103 (bet $103 to win $100) | Panthers -115 (bet $115 to win $100)
  • Against the spread (ATS): Cardinals +1.5 (-115) | Panthers -1.5 (-107)
  • Over/Under (O/U): 43.5 (O: -112 | U: -108)

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Cardinals at Panthers key injuries

Cardinals

  • WR Marquis Brown (foot) questionable
  • WR A.J. Green (knee) out
  • PK Matt Prater (hip) questionable
  • DE J.J. Watt (calf) questionable

Panthers

  • DE Marquis Haynes (knee) questionable
  • RB Christian McCaffrey (thigh) questionable
  • WR Laviska Shenault Jr. (hamstring) questionable

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Cardinals at Panthers picks and predictions

Prediction

Cardinals 27, Panthers 20

Moneyline

The CARDINALS (-103) are the play in this road game. The Panthers (-115) could potentially be without McCaffrey, but even if he plays, he hasn’t been a difference maker so far for Carolina. This team is still very middling.

QB Kyler Murray should find plenty of room to operate in Sunday’s game, as the Panthers rank 22nd against the run, and 18th in the NFL in total yards allowed (348.7). Look for Murray to be a difference maker.

Against the spread

CARDINALS +1.5 (-107) doesn’t really make sense, paying slightly more than the money line. Unless you are feeling a tie or 1-point game will happen, just play the ML.

And if you like the tie, then you like the Game To Go To Overtime (+900). Play that lightly instead. I don’t like it, though.

Over/Under

OVER 43.5 (-112) is the best play on the board.

Arizona is going to be able to move the ball up and down the field on this defense. On the other side, even the ineffective QB Baker Mayfield should find plenty of open spaces against a Cardinals defense which ranks 30th in the NFL against the pass, allowing 281.0 yards per game, while coughing up 29.0 PPG. It’s not or never for the Bake Show in Charlotte.

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New Orleans Saints at Carolina Panthers odds, picks and predictions

Analyzing Sunday’s New Orleans Saints at Carolina Panthers odds and lines, with expert NFL picks, predictions and best bets.

The New Orleans Saints (1-1) and the Carolina Panthers (0-2) meet in a Week 3 matchup Sunday at Bank of America Stadium. Kickoff is scheduled 1 p.m. ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Saints vs. Panthers odds, and make our expert NFL picks and predictions.

The Saints played a defensive battle in their home opener against the Tampa Bay Buccaneers, coming up short in Week 2 by a 20-10 score. New Orleans has failed to cover both games to start the year.

The Panthers are 0-2 SU/ATS, losing both games outright as a small-number favorite. Carolina has lost its 2 games by a combined 5 total points.

These NFC South teams split their meetings last season, with the home team winning and covering each meeting. The Under has cashed in 3 in a row in the series.

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Saints at Panthers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:12 a.m. ET.

  • Money line (ML): Saints -135 (bet $135 to win $100) | Panthers +115 (bet $100 to win $115)
  • Against the spread (ATS): Saints -2.5 (-117) | Panthers +2.5 (-103)
  • Over/Under (O/U): 41.5 (O: -108 | U: -112)

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Saints at Panthers key injuries

Saints

  • CB Paulson Adebo (ankle) questionable
  • TE Taysom Hill (rib) questionable
  • RB Alvin Kamara (rib) questionable
  • S Marcus Maye (rib) questionable
  • OT Ryan Ramczyk (elbow) questionable)
  • QB Jameis Winston (back, ankle) questionable

Panthers

  • CB Donte Jackson (hamstring) questionable

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Saints at Panthers picks and predictions

Prediction

Saints 21, Panthers 18

Money line

The SAINTS (-135) are worth a play but circle back around Sunday before finalizing your wager. With Winston on the injury report, and a 50-50 proposition to play, this could turn into a huge risk in a hurry if he is inactive.

Winston has 4 of his 33 vertebrae fractured, and now he is dealing with an ankle injury, too. If Winston is sidelined, veteran QB Andy Dalton would get the starting nod, so New Orleans would still be in decent hands.

Against the spread

The Saints -2.5 (-117) aren’t terribly overpriced, but there is just so much risk based on the QB situation. In addition, Kamara is also on the injury report and a 50-50 proposition. The Saints could go from Winston and Kamara playing, to Dalton and RB Mark Ingram II.

PASS, just play the money line instead.

Over/Under

UNDER 41.5 (-112) is worth playing lightly, regardless of the healthy of Winston and Kamara. Even if they play, the Under has hit in each of the past 3 meetings in this series.

The Under is 9-4 in the past 13 games inside the NFC South for New Orleans and is 7-2 in its last 9 games overall. The Under is 5-2 in the past 7 games for the Panthers inside the division, too.

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Carolina Panthers at New York Giants odds, picks and predictions

Analyzing Sunday’s Carolina Panthers at New York Giants odds and lines, with expert NFL picks, predictions and best bets.

The Carolina Panthers (0-1) and the New York Giants (1-0) meet in a Week 2 matchup Sunday at MetLife Stadium. Kickoff is scheduled 1 p.m. ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Panthers vs. Giants odds, and make our expert NFL picks and predictions.

The Panthers had a chance to win last week against the Cleveland Browns, but allowed a 58-yard game-winning field goal in the final 10 seconds to come up just a little bit short at home, 26-24.

Down 20-13, the Giants scored a late touchdown to make it 20-19, pending the extra point. Head coach Brian Daboll — in his debut in that role – ended up calling for the 2-point conversion and RB Saquon Barkley got it done. The Titans missed a field goal at the buzzer, and the Giants held on for the solid 21-20 road win as the Under cashed.

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Panthers at Giants odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 8:06 a.m. ET.

  • Money line (ML): Panthers +110 (bet $100 to win $110) | Giants -130 (bet $130 to win $100)
  • Against the spread (ATS): Panthers +2.5 (-110) | Giants -2.5 (-110)
  • Over/Under (O/U): 43.5 (O: -112 | U: -108)

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Panthers at Giants key injuries

Panthers

  • LB Frankie Luvu (shoulder) questionable
  • OL Taylor Moton (knee) questionable
  • LB Brandon Smith (thigh) questionable

Giants

  • C Joe Fellciano (lower leg) questionable
  • DL/LB Azeez Ojulari (calf) questionable
  • CB Aaron Robinson (appendicitis) questionable
  • WR Wan’Dale Robinson (knee) questionable
  • LB Kayvon Thibodeaux (knee) questionable
  • WR Kadarius Toney (hamstring) questionable

[the_huddle]

Panthers at Giants picks and predictions

Prediction

Giants 27, Panthers 24

Money line

The GIANTS (-130) aren’t a bad play if you don’t want to fiddle around with the points, and just want to declare a winner. It isn’t that much more juice to take the home side.

The G-Men established the run last week, as Barkley is finally 100 percent and looks like his former self. The Giants won 25-3 last season against the Panthers without Barkley, while RB Christian McCaffrey also missed that meeting. CMC is back, too, and this game should be a lot more interesting.

Against the spread

GIANTS -2.5 (-110) is a strong play on their home field. This team won by 22 against a McCaffrey-less Panthers offense last season. Carolina’s offense should be much better, especially with QB Baker Mayfield now in the fold, but it won’t have enough to upend Barkley and the Giants on the road.

Over/Under

The OVER 43.5 (-112) might be the best play on the board. McCaffrey and Barkley are both playing in this game after missing last season’s matchup. The run game is obviously better with them on the field, but that opens things up more downfield in the pass game, too.

Expect to see a lot more fireworks in this battle in New Jersey, with the Giants coming out ahead late.

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Cleveland Browns at Carolina Panthers odds, picks and predictions

Analyzing Sunday’s Cleveland Browns at Carolina Panthers Week 1 odds and lines, with expert NFL picks, predictions and best bets.

The Cleveland Browns and the Carolina Panthers open their regular seasons Sunday at Bank of America Stadium. Kickoff is scheduled for 1 p.m. ET (CBS). Below, we analyze Tipico Sportsbook‘s lines around the Browns vs. Panthers odds, and make our expert NFL picks and predictions.

The Browns made big headlines by signing QB Deshaun Watson during the offseason. He is suspended for the first 11 games, so QB Jacoby Brissett will make the start in the opener.

The Browns also made headlines when they traded QB Baker Mayfield to the Panthers in the wake of the Watson signing. As luck has it, the Panthers are first on the schedule, and he gets a crack at his former team after winning the starting job during the preseason.

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Browns at Panthers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 10 a.m. ET.

  • Money line (ML): Browns -108 (bet $108 to win $100) | Panthers -110 (bet $110 to win $100)
  • Against the spread (ATS): Browns +0.5 (-108) | Panthers -0.5 (-112)
  • Over/Under (O/U): 41.5 (O: -112 | U: -108)

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Browns at Panthers key injuries

Browns

  • OT Jack Conklin (knee) questionable

Panthers

  • None

[the_huddle]

Browns at Panthers picks and predictions

Prediction

Panthers 23, Browns 20

Money line

This is a very important start for Mayfield, as he gets a revenge game in Week 1. He wants to show the Browns that they made a huge mistake parting ways with him, going with Watson instead.

The PANTHERS (-108) are a good play since Mayfield has a chip on his shoulder.

Against the spread

Playing the Panthers -0.5 (-112) isn’t necessary given it provides worse odds than the money line. This actually should be a pretty close game with scoring at a premium, but if you think the Panthers are going to win just play the money line for the better payout.

PASS.

Over/Under

OVER 41.5 (-112) is worth playing lightly. I expect both teams to try to establish the run early, easing their new quarterbacks into action, but we still won’t see a defensive slog.

There are plenty of home run hitters on both sides, including RB Christian McCaffrey and WR DJ Moore for Carolina, and WR Amari Cooper and RB Nick Chubb for Cleveland. We could see a surprising number of big plays.

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Buffalo Bills at Carolina Panthers odds, picks and prediction

Analyzing Friday’s Buffalo Bills at Carolina Panthers odds and lines, with expert NFL picks, predictions and best bets.

The Buffalo Bills (2-0) and Carolina Panthers (1-1) wrap up their preseason schedule Friday. Kickoff from Bank of America Stadium is scheduled for 7 p.m. ET. Below, we analyze Tipico Sportsbook‘s lines around the Bills vs. Panthers odds, and make our best NFL picks, predictions and bets.

The Bills throttled the visiting Denver Broncos 42-15 last weekend, playing the starters for most of the 1st quarter. But the run game continued to be impressive well after the 1st unit was out of there, showing some tremendous organizational depth.

Coach Sean McDermott confirmed early this week that most of his 1st-team players will not play Friday in Charlotte, including star QB Josh Allen.

The Panthers were on the short end of a 20-10 loss at New England after joint practices with the Patriots last week. The only touchdown came via pick-6 from DB Tae Hayes, too.

Carolina made headlines this week, officially naming QB Baker Mayfield as the starter, while also announcing rookie QB Matt Corral (foot) suffered a long-term injury. Mayfield is expected to play into the 2nd quarter Friday, with QBs Sam Darnold and PJ Walker finishing up.

Bills at Panthers odds

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 4:01 p.m. ET.

  • Money line (ML): Bills +220 (bet $100 to win $220) | Panthers -280 (bet $280 to win $100)
  • Against the spread (ATS): Bills +6.5 (-115) | Panthers -6.5 (-105)
  • Over/Under (O/U): 39.5 (O: -117 | U: -103)

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Bills at Panthers picks and predictions

Prediction

Panthers 22, Bills 16

Money line

The Panthers (-280) will use the 1st-team offense well into the 2nd quarter, while the Bills (+220) will take a low-key approach to this preseason finale, using mostly reserves.

The advantage is to the home side, but you can’t risk nearly 3 times your potential return on a favorite in a preseason game.

AVOID.

Against the spread

The PANTHERS -6.5 (-105) are worth playing lightly, as the starters on offense should feature well into the 2nd quarter in front of the home fans. Coach Matt Rhule will give us a glimpse of what to expect from the Panthers, and it might be a little better than the regular season, since they’ll be facing a Bills team using mostly reserves.

[the_huddle]

Over/Under

The UNDER 39.5 (-103) is the way to go here, as no Allen means the offense is likely to be a little slower for Buffalo. Of course, that wasn’t the case at home against Denver last week even after Allen exited.

Still, the Panthers offense managed just a field goal last weekend, and it is still a work in progress.

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Carolina Panthers at New England Patriots odds, picks and prediction

Analyzing Friday’s Carolina Panthers at New England Patriots odds and lines, with expert NFL picks, predictions and best bets.

The New England Patriots (0-1) welcome the Carolina Panthers (1-0) to Gillette Stadium Friday. Kickoff is scheduled for 7 p.m. ET. Below, we analyze Tipico Sportsbook‘s lines around the Panthers vs. Patriots odds, and make our best NFL picks, predictions and bets.

The Patriots didn’t give 2nd-year QB Mac Jones any plays in their opening preseason loss to the New York Giants. After ending the 1st quarter up 7-3, the Patriots eventually lost 23-21.

The combination of Jones, QB Bailey Zappe and QB Brian Hoyer will be what New England goes with in Week 1. Fans may get a better glimpse at the running back committee they’re destined to use as well.

The Panthers, who have a quarterback competition on their hands, beat the Washington Commanders. RB Christian McCaffrey did not play.

In the 23-21 victory last week, QB Baker Mayfield and QB Sam Darnold both got a series with the former going 4-for-7 for 45 yards and the latter going 2-for-3 for 16 yards and a touchdown. A report Thursday said Mayfield would be named the starter for Week 1.

Panthers at Patriots odds

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 2:44 p.m. ET.

  • Money line (ML): Panthers +133 (bet $100 to win $133) | Patriots -160 (bet $160 to win $100)
  • Against the spread (ATS): Panthers +3.5 (-130) | Patriots -3.5 (+105)
  • Over/Under (O/U): 40.5 (O: -103 | U: -117)

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Panthers at Patriots picks and predictions

Prediction

Panthers 24, Patriots 20

Money line

BET PANTHERS (+115).

The Panthers have been in a heated quarterback battle, and I wouldn’t be shocked if they opted to play Darnold and Mayfield for the entirety of the first half. On the other hand, Jones may be too valuable to give multiple series to.

Even the Patriots backfield, which is a 3-headed monster, should see limited time.

The Panthers played well in the first quarter against Washington, jumping out to a 10-0 lead while the Giants beat the Patriots at Gillette and took a 10-7 lead into the half.

Carolina has more figuring out to do with its first string than New England, and in turn, I think it’ll want to see what it is working with. Against Washington, its top players thrived, and I expect the same on Friday evening.

Against the spread

PASS.

If you feel more comfortable playing Carolina +3.5, then by all means go that route, but I would suggest the plus-money play on the money line instead given the value.

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Over/Under

LEAN OVER 40.5 (-103).

Both teams went over this amount in their first preseason matchup with both teams totaling 44 points on identical 23-21 scores.

The Panthers are expected to name Mayfield their starter, which could mean more time on the field for Darnold. Similarly, fans should get to see Jones in action. The stars should be able to aid the scoring.

Given the scuffle that went on in a joint practice, the teams should be primed to give a little added effort which could also help the game keep a high pace. Nonetheless, betting NFL overs was a solid option in Week 1 and that should keep up as the preseason progresses.

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Carolina Panthers at Washington Commanders odds, picks and prediction

Analyzing Saturday’s Carolina Panthers at Washington Commanders preseason odds and lines, with expert NFL picks, predictions and best bets.

The Carolina Panthers and Washington Commanders meet in their preseason opener Saturday. Kickoff from FedEx Field is scheduled for 1 p.m. ET. Below, we analyze Tipico Sportsbook‘s lines around the Panthers vs. Commanders odds, and make our best NFL picks, predictions and bets.

The Panthers acquired QB Baker Mayfield from the Cleveland Browns to come in and compete with QB Sam Darnold for the starting job. Both quarterbacks are expected to see action Saturday in D.C. Rookie QB Matt Corral is also expected to debut.

Like the Panthers, the Commanders have 3 capable QBs in Carson Wentz, Taylor Heinicke and Sam Ehlinger, and all are expected to see some snaps against Carolina. The level of play on offense for both sides could be good.

Panthers at Commanders odds

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 11:07 p.m. ET.

  • Money line (ML): Panthers +125 (bet $100 to win $125) | Commanders -155 (bet $155 to win $100)
  • Against the spread (ATS): Panthers +2.5 (+105) | Commanders -2.5 (-130)
  • Over/Under (O/U): 37.5 (O: +100 | U: -120)

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Panthers at Commanders picks and predictions

Prediction

Panthers 19, Commanders 13

Money line

The PANTHERS (+125) are likely to keep oft-injured RB Christian McCaffrey on the sidelines, but they have 2 NFL starting QBs in Mayfield and Darnold, and both are likely to see at least a handful of series. That gives the visitors the edge, although Washington’s defense is fierce.

For the Commanders (-155), Wentz has had a woeful training camp with his new team, and it is going to be a work in progress this preseason to get him hitting on all cylinders before Week 1.

Against the spread

The PANTHERS +2.5 (+105) is the play, although playing ATS vs. ML really makes no sense unless you strongly believe there is going to be a tie. Just play the money line.

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Over/Under

The UNDER 37.5 (-120) is the way to go.

While these teams are each deep at the QB position, these teams still are among the lowest ranked overall clubs in the NFL. The Washington defense will make things particularly difficult on the Carolina offense, and the Panthers D isn’t too shabby, either. Expect many field goals, not so many  touchdowns.

Play our free daily Pick’em Challenge and win! Play now!

Bet legally online with a trusted partner: Tipico Sportsbook, Sportsbook Wire’s official sportsbook partner in CO and NJ. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO).

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Tampa Bay Buccaneers at Carolina Panthers odds, picks and prediction

Analyzing Sunday’s Tampa Bay Buccaneers at Carolina Panthers odds and lines, with expert NFL picks, predictions and best bets.

The Tampa Bay Buccaneers (10-4) travel to meet the Carolina Panthers (5-9) for a Week 16 game Sunday at Bank of America Stadium. Kickoff is scheduled for 1 p.m. ET. Below, we look at the Buccaneers vs. Panthers odds and lines, and make our best NFL picks, predictions and bets.

The Buccaneers are coming off a stunning 9-0 loss to the New Orleans Saints at home last Sunday night, although they’re still 4-1 SU/ATS across the past five outings.

The Panthers are in freefall, losing four straight games while also going 0-4 ATS. All four of those games were with QB Cam Newton back under center. The Over has cashed in five in a row for Carolina, with the defense allowing 27 or more points in each of the past four outings.

Buccaneers at Panthers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10 a.m. ET.

  • Money line: Buccaneers -550 (bet $550 to win $100) | Panthers +400 (bet $100 to win $400)
  • Against the spread (ATS): Buccaneers -10.5 (+100) | Panthers +10.5 (-120)
  • Over/Under (O/U): 43.5 (O: -108 | U: -112)

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Buccaneers at Panthers key injuries

Buccaneers

  • WR Jaelon Darden (reserve/COVID) out
  • CB Jamel Dean (illness/non-COVID) questionable
  • WR Mike Evans (hamstring) out
  • WR Breshad Perriman (reserve/COVID) questionable
  • LB Jason Pierre-Paul (shoulder) doubtful
  • CB Richard Sherman (Achilles) questionable
  • S Antoine Winfield Jr. (foot) out

Panthers

  • C Pat Elflein (reserve/COVID) out
  • OT Cam Erving (calf) questionable
  • WR DJ Moore (hamstring) questionable

Let’s Make This Interesting

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Buccaneers at Panthers odds, lines, predictions and picks

Prediction

Buccaneers 29, Panthers 13

Money line

The Buccaneers (-550) are furious after getting blanked at home last week by the mediocre Saints, and they’ll likely take out their aggressions on the poor Panthers (+400).

However, PASS, as risking more than five times your return is just too much, especially with Evans joining WR Chris Godwin (knee) and RB Leonard Fournette (hamstring) on the shelf. Returning WR Antonio Brown is the de facto WR1, and he could be rusty after returning from suspension. If the Panthers D can slow TE Rob Gronkowski, they have a puncher’s chance.

Against the spread

The BUCCANEERS -10.5 (+100) are warranted being at least 10 points better than the skidding Panthers +10.5 (-120), although I don’t like all of the injuries on the offensive side of the ball for Tampa. As such, go lightly.

Over/Under

The lean is to the UNDER 43.5 (-112) in this NFC South battle. Again, the Bucs are racked with injuries on offense, but the Panthers defense has still been unable to stop anyone lately. It will be close. A small-unit bet is warranted, but don’t get carried away.

Also see: All Week 16 odds and lines

Bet legally online with a trusted partner: Tipico Sportsbook, Sportsbook Wire’s official sportsbook partner in CO, NJ and, soon, IA. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

Follow Kevin J. Erickson on Twitter and SportsbookWire on Twitter and like us on Facebook.

Access more NFL coverage:

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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Carolina Panthers at Buffalo Bills odds, picks and prediction

Analyzing Sunday’s Carolina Panthers at Buffalo Bills odds and lines, with expert NFL picks, predictions and best bets.

The Carolina Panthers (5-8) travel to face the Buffalo Bills (7-6) in a Week 15 matchup Sunday. Kickoff is scheduled for 1 p.m. ET. Below, we look at the Panthers vs. Bills odds and lines, and make our best NFL picks, predictions and bets.

The Panthers are skidding, dropping three in a row while failing to cover each. The defense has been an issue, allowing 27 or more points in each of the losses, and the Over has hit in four consecutive games for Carolina.

The Bills dropped a 33-27 overtime heartbreaker at Tampa Bay last week, which was like losing twice. The Bills erased a late 27-10 deficit to force overtime, but couldn’t stop the Bucs in OT. Buffalo enters on a 2-5-1 ATS slide.

Panthers at Bills odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 2:25 p.m. ET.

  • Money line: Panthers +470 (bet $100 to win $470) | Bills -700 (bet $700 to win $100)
  • Against the spread (ATS): Panthers +10.5 (-105) | Bills -10.5 (-115)
  • Over/Under (O/U): 44.5 (O: -105 | U: -115)

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Panthers at Bills key injuries

Panthers

  • CB A.J. Bouye (foot) out
  • WR DJ Moore (hamstring) questionable
  • OG Michael Jordan (hamstring) questionable
  • OG John Miller (ankle) questionable

Bills

  • WR Emmanuel Sanders (knee) doubtful
  • DT Star Lotulelei (toe) questionable

Panthers at Bills odds, lines, predictions and picks

Prediction

Bills 29, Panthers 13

Money line

The Bills (-700) are going to snap back on track with a win over head coach Sean McDermott’s old team, but you can’t lay seven times your potential winnings on a team that is just one game over .500. Don’t do it.

PASS.

Against the spread

The BILLS -10.5 (-115) are 2-1-1 ATS as a double-digit favorite this season, and they’re 2-1 SU/ATS against three NFC opponents.

Buffalo is 6-1-1 ATS in the past eight against teams with a losing record, so expect the Bills to finally pull it together and put a performance together worthy of a playoff team.

Over/Under

The UNDER 44.5 (-115) hit in Buffalo’s most recent home game, but blustering, wintry conditions played a huge part in its 14-10 loss to New England on Monday night in Week 13.

The temperature will be around freezing with winds of 13-16 mph, but not too terribly for this time of year in western New York.

The Under is 5-2 in the past seven at home for the Bills and 4-1 in the past five against teams with a losing record. The Panthers’ offense has been mediocre, and the Bills’ D should shut them down for a convincing win.

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

Follow Kevin J. Erickson on Twitter and SportsbookWire on Twitter and like us on Facebook.

Access more NFL coverage:

TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWire | TitansWire | VikingsWire | WashingtonFootballWire | DraftWire | TouchdownWire | TheListWire

Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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