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Kansas City Chiefs at Buffalo Bills odds, picks and predictions

Analyzing Sunday’s Kansas City Chiefs at Buffalo Bills odds and lines, with expert NFL picks and predictions.

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The Kansas City Chiefs (9-0) renew their rivalry with the Buffalo Bills (8-2) Sunday. Kickoff from Highmark Stadium is set for 4:25 p.m. EST (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Chiefs vs. Bills odds, and make our expert NFL picks and predictions.

The Chiefs remain undefeated after cashing in a miracle last week in a 16-14 victory over the Denver Broncos. Denver rushed down the field and milked the clock to stage a 35-yard chip shot to win it as 7-point dogs, but KC blocked it to keep their streak alive. QB Patrick Mahomes threw for 266 yardsand a TD.

Buffalo won its fifth straight, covering as 4.5-point favorites in Indianapolis, to beat the Colts 30-20. QB Josh Allen was 22-for-37 for 280 yards, 0 TDs and 2 INTs, but ran in his first score in 4 weeks. RB James Cook added 80 rushing yards and a score.

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Chiefs at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated at 12:33 a.m. ET.

Moneyline (ML): Chiefs +110 (bet $100 to win $110) | Bills -130 (bet $130 to win $100)
Against the spread (ATS): Chiefs +2 (-110) | Bills -2 (-110)
Over/Under (O/U): 46 (O: -110 | U: -110)

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Chiefs at Bills key injuries

Chiefs

DE Charles Omenihu (knee) out
RB Isiah Pacheco (ankle) out

Bills

OT Spencer Brown (ankle) questionable
WR Keon Coleman (wrist) out
WR Amari Cooper (wrist) questionable
TE Dalton Kincaid (knee) out
LB Matt Milano (biceps) out

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Chiefs at Bills picks and predictions

Prediction

Bills 24, Chiefs 20

Moneyline

The Bills are missing a couple of key starters in Coleman and Kincaid, but Mahomes is really gimpy in the pocket with ankle and hip issues for KC. WR DeAndre Hopkins also popped up on the injury report this week with a knee issue.

This is going to be a gritty game where the running backs will be key. Allen’s legs to extend plays and get out of the pocket while Mahomes is a bit compromised physically is what turns the tables here.

You can take the Bills -130, but I prefer the spread. I would shift gears to JAMES COOK OVER 58.5 RUSHING YARDS (-120) or PATRICK MAHOMES UNDER 20.5 RUSHING YARDS (-110).

Against the spread

I’m all over BILLS -2 (-110) here. The Bills have won the last 3 regular-season meetings, but the Chiefs disposed of them in the last 3 playoff meetings. This is the number to strike at. The weather is going to be a little iffy (see below), and the running game + Allen’s legs will be the difference maker.

Over/Under

It’s expected to be in the high 40s with winds picking up to over 20 mph later in the game. There could also be light showers early on.

As such, take the UNDER 46.5 (-110). The last 5 finals in the regular season have been: 37, 44, 58, 43 and 26.

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Miami Dolphins at Buffalo Bills odds, picks and predictions

Analyzing Sunday’s Miami Dolphins at Buffalo Bills odds and lines, with expert NFL picks and predictions.

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The Buffalo Bills (6-2) welcome the Miami Dolphins (2-5) to Highmark Stadium on Sunday. Kickoff is scheduled for 1 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Dolphins vs. Bills odds, and make our expert NFL picks and predictions.

The Dolphins have lost back-to-back games after falling 28-27 to the Arizona Cardinals last Sunday and failing to cover as 4.5-point home favorites. QB Tua Tagovailoa went 28-of-38 for 234 yards and a TD while RB Raheem Mostert added 2 TDs on the ground.

The Bills have won 3 games in a row after taking down the Seattle Seahawks 31-10 in Week 8 as 3-point road favorites. QB Josh Allen went 24-of-34 for 283 yards with 2 TDs and a pick while RB James Cook carried the ball 17 times for 111 yards and 2 TDs.

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Dolphins at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 8:05 p.m.

Moneyline (ML): Dolphins +220 (bet $100 to win $220) | Bills -275 (bet $275 to win $100)
Against the spread (ATS): Dolphins +6 (-110) | Bills -6 (-110)
Over/Under (O/U): 49.5 (O: -110 | U: -110)

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Dolphins at Bills key injuries

Dolphins

WR River Cracraft (shoulder) questionable
CB Storm Duck (ankle) questionable
TE Julian Hill (shoulder) out
S Jevon Holland (hand, knee) doubtful
FB Alec Ingold (calf) questionable
CB Kader Kohou (neck) out
DT Zach Sieler (eye) out

Bills

CB Christian Benford (wrist) questionable
WR Amari Cooper (wrist) questionable
FB Reggie Gilliam (hip) out
WR Curtis Samuel (pectoral) questionable

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Dolphins at Bills picks and predictions

Prediction

Bills 24, Dolphins 13

Moneyline

PASS.

There is no value on the Bills (-275) to take down the Dolphins.

Against the spread

BET BILLS -6 (-110).

The Bills have won back-to-back games by 21 or more points and have covered the spread in 5 of their last 7 games. Miami has dropped 5 of its last 6 games with 4 of the 5 losses coming by 6 or more points. Buffalo will handle Tagovailoa and the Dolphins with ease.

Over/Under

BET UNDER 49.5 (-110).

While the Dolphins scored 27 points last Sunday with the return of Tagovailoa, they have scored 15 or fewer points in 5 of their last 6 games while their defense has allowed 16 or fewer points in 2 of their last 3 games. Buffalo’s defense has allowed 10 points in back-to-back weeks and in 4 of their last 7 weeks overall.

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Buffalo Bills at Seattle Seahawks odds, picks and predictions

Analyzing Sunday’s Buffalo Bills at Seattle Seahawks odds and lines, with expert NFL picks and predictions.

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The Buffalo Bills (5-2) and Seattle Seahawks (4-3) meet in Week 8 Sunday. Kickoff from Lumen Field is set for 4:05 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Bills vs. Seahawks odds, and make our expert NFL picks and predictions..

The Bills dominated the visiting Tennessee Titans 34-10 Oct. 20, covering as 10-point favorites as the Over (41) hit. QB Josh Allen threw for 323 yards — his first 300-yard game of the season — with 2 TDs, including one to new target WR Amari Cooper. Buffalo’s run game contributed as well, with RBs James Cook and Ray Davis each scoring a rushing TD. The win showcased a balanced attack, helping the Bills secure a comfortable victory at home.

The Seahawks snapped their 3-game skid with a 34-14 victory as 3-point underdogs at the Atlanta Falcons Oct. 20 while the Under (51.5) hit. RB Kenneth Walker III scored 2 total TDs (1 receiving, 1 rushing), and WR DK Metcalf added 99 receiving yards and a TD. Seattle’s defense played a key role, forcing 3 turnovers from the Falcons, helping secure the win and getting the Seahawks back on track.

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Bills at Seahawks odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated at 1:32 a.m. ET.

Moneyline (ML): Bills -160 (bet $160 to win $100) | Seahawks +135 (bet $100 to win $135)
Against the spread (ATS): Bills -3 (-110) | Seahawks +3 (-110)
Over/Under (O/U): 45.5 (O: -110 | U: -110)

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Bills at Seahawks key injuries

Bills

LB Terrel Bernard (ankle/pectoral/personal) out
DL DeWayne Carter (wrist) out
RB Darrynton Evans (hamstring) doubtful
WR Curtis Samuel (pec) out

Seahawks

CB Tre Brown (ankle) questionable
OL George Fant (knee) questionable
OL Abraham Lucas (knee) out
WR DK Metcalf (calf) doubtful
DL Mike Morris (ankle) questionable
CB Nehemiah Pritchett (ankle) questionable
DL Cameron Young (knee) doubtful

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Bills at Seahawks picks and predictions

Prediction

Bills 26, Titans 13

Moneyline

PASS.

The Bills (-160) will get it done in Seattle Sunday. I’ve got enough confidence that they will cover the line, as well, which is why I’ll take my bet to the spread.

Against the spread

BET BILLS -3 (-110).

The Bills are 22-13 on the road over the last 5 seasons and have started this year 2-2 away from home. They excel against NFC teams, boasting a 19-5 record in the same period. In contrast, the Seahawks are just 2-2 at home this season and have a concerning -38 point differential overall. Buffalo’s offense should take advantage of Seattle’s vulnerabilities, leveraging Cooper’s addition along with Allen and Cook on the ground.

The Seahawks have a capable offense, but face a Bills defense that ranks 8th in scoring and 5th against the pass. With Metcalf dealing with an MCL strain and listed as week-to-week, the Bills have a great chance to create distance in the AFC East with a road victory in Seattle.

Over/Under

BET UNDER 45.5 (-110).

The last 4 encounters between the Bills and Seahawks have all gone over the total, and both teams are currently riding hot streaks.

The Bills have exceeded the total in their last 2 games, while the Seahawks have done so in 5 of their 7 matchups this season. Buffalo is averaging over 28 points in its last 2 victories, while Seattle has scored more than 26 points in its previous 4 outings. With both offenses clicking, Sunday’s showdown in Seattle promises to be a high-scoring affair.

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Tennessee Titans at Buffalo Bills odds, picks and predictions

Analyzing Sunday’s Tennessee Titans at Buffalo Bills odds and lines, with expert NFL picks and predictions.

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The Tennessee Titans (1-4) and Buffalo Bills (4-2) meet in Week 7 Sunday. Kickoff from Highmark Stadium is set for 1:00 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Titans vs. Bills odds, and make our expert NFL picks and predictions..

The Titans remained winless at home after a 20-17 loss to the Colts, failing to cover as 2.5-point favorites, with the game hitting the under on a 41.5 total. Quarterback Will Levis struggled, throwing for just 95 yards with a touchdown and an interception. The bright spot was RB Tony Pollard, who rushed for 93 yards, including a 23-yard touchdown run. However, Pollard’s efforts weren’t enough to lift the Titans past their offensive struggles, as they fell short once again.

The Buffalo Bills ended their 2-game losing streak with a 23-20 win over division rival Jets, covering the 1-point spread as the game went over the 42 total. QB Josh Allen was efficient, completing 19 of 25 passes for 215 yards and 2 touchdowns. Rookie RB Ray Davis stepped up in place of the injured James Cook, racking up 152 total yards on 23 touches. The Bills also bolstered their offense with the addition of WR Amari Cooper.

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Titans at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 2:15 p.m. ET.

Moneyline (ML): Titans +380 (bet $100 to win $380) | Bills -500 (bet $500 to win $100)
Against the spread (ATS): Titans +9.5 (-110) | Bills -9.5 (-110)
Over/Under (O/U): 41 (O: -110 | U: -110)

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Titans at Bills key injuries

Titans

WR Treylon Burks (knee) out
DE Keondre Coburn (knee) out
LB Cedric Gray (shoulder) out
QB Will Levis (shoulder) questionable
CB L’Jarius Sneed (quad) questionable
RB Tyjae Spears (hamstring) out

Bills

RB Ray Davis (calf) questionable
S Mike Edwards (illness) questionable
RB Darrynton Evans (hamstring) doubtful

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Titans at Bills picks and predictions

Prediction

Bills 26, Titans 13

Moneyline

PASS.

No doubt in my mind that the Bills (-500) win this game and cover Sunday, which is why they are such heavy favorites. So, I’ll take my wager to the spread.

Against the spread

BET BILLS -9.5 (-110).

Sunday’s game at Highmark Stadium marks the first meeting between the Bills and Titans in over 2 years. Buffalo dominated their last matchup in Sept. 2022, winning 41-7, and has won 4 of the past 6 meetings, including consecutive home victories. While this matchup might look tough for Buffalo on paper, coming off a close Monday Night Football win over the Jets, their acquisition of Cooper provides a boost to their offense. The Bills have thrived against weaker opponents, and with Cooper in the mix, their passing attack should flourish.

The Titans face a tough challenge, particularly with their struggling passing game. Levis is questionable with a shoulder injury. Furthermore, he has the worst interception rate in the league and struggles to protect the ball, which could spell trouble against Buffalo’s solid pass defense. Tennessee’s road woes are also a concern, having averaged just 9.5 points per game during a 2-game losing streak at Highmark Stadium. While Buffalo has struggled to cover large spreads recently, the Titans’ offense lacks firepower to keep pace. Given Buffalo’s home dominance and Tennessee’s road struggles, I’m backing the Bills -9.5 to control this matchup, expecting a performance similar to their earlier blowout win over Jacksonville.

Over/Under

BET UNDER 41 (-110).

The Titans have struggled offensively, particularly in the passing game, with Levis managing only 3.8 yards per attempt in their recent loss to the Colts. Meanwhile, Tennessee’s defense has been a bright spot, allowing the fewest yards per attempt in the NFL, which could limit Allen and Buffalo’s passing attack.

The Bills’ defense has also been effective, ranking 9th in EPA per pass, with a strong secondary that could challenge the Titans’ struggling offense. With a tough road game in Seattle up next, Buffalo might lean on a run-heavy game plan to control the pace and limit scoring opportunities. Considering these factors, this game seems likely to be a slow-paced, defensive battle, making the Under 41 a good bet.

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Alex’s best bet: Buffalo Bills at New York Jets prediction

SportsbookWire.com’s Alex White likes a side in the Buffalo Bills-New York Jets Week 6 Monday Night Football game.

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Alex White of SportsbookWire.com set her focus on the Monday Night Football game featuring the Buffalo Bills (3-2) at the New York Jets (2-3).

It’s Josh Allen vs. Aaron Rodgers. Kickoff from MetLife Stadium in East Rutherford, New Jersey, is slated for 8:15 p.m. ET (ABC/ESPN).

Both teams are looking to turn things around — as they battle for 1st place in the AFC East.

The Bills are on a 2-game skid after starting the season 3-0.

The Jets fired coach Robert Saleh Tuesday, claiming disappointment in the direction the team appeared headed. New York is also on a 2-game slide.

Will the Jets respond in front of the home crowd against the 4-time defending AFC East champs?

The Bills are favored by 1 point (-110), per BetMGM Sportsbook’s NFL odds as of Sunday at 10:18 p.m. ET — the line was 2.5 points earlier in the day.

Listen below to why Alex is on this play.

🏈🏈Monday night showdown🏈🏈

Week 6 wraps up in New Jersey at @MetLifeStadium 🏟️and @alexwhitee has a 💰best bet 💰when the @BuffaloBills visit the @nyjets on 🏈Monday Night Football 🏈Who do you like? 💸 pic.twitter.com/d5NoW2t62R

— SportsBookWire (@SportsBookWire) October 14, 2024

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Make sure to catch Alex on Sports By the Book Saturday 11 a.m.-noon ET, and Sunday through Wednesday noon-1 p.m. ET, and on Punch Lines every Monday and Wednesday 3 p.m.-4 p.m. ET — live from the South Point Sportsbook in Las Vegas. Follow @alexwhitee on Twitter/X.

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Buffalo Bills at New York Jets odds, picks and predictions

Analyzing Monday’s Buffalo Bills at New York Jets odds and lines, with expert NFL picks and predictions.

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The Buffalo Bills (3-2) meet the New York Jets (2-3) for Monday Night Football in Week 6 at MetLife Stadium. Kickoff is scheduled for 8:15 p.m. ET (ESPN/ABC). Let’s analyze BetMGM Sportsbook’s NFL odds around the Bills vs. Jets odds, and make our expert NFL picks and predictions.

The Bills were humming right along through the 1st 3 games, going 2-1 against the spread (ATS), while going for 31 or more points. However, Buffalo was humbled 35-10 on Sunday Night Football in Week 4 in Baltimore, and it had some injuries and clock management issues in Houston in Week 5 for a disappointing 23-20 loss.

The Jets are coming home after losing 23-17 in London last week against the Minnesota Vikings, a 2nd straight loss. That was enough for team owner Woody Johnson, as the team relieved Robert Saleh of his coaching duties. Jeff Ulbrich takes over as interim coach, and he replaced Nathaniel Hackett with Todd Downing as the offensive play caller.

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Bills at Jets odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Sunday at 7:02 p.m. ET.

Moneyline (ML): Bills -130 (bet $130 to win $100) | Jets +110 (bet $100 to win $110)
Against the spread: Bills -2 (-110) | Jets +2 (-110)
Over/Under (O/U): 41 (O: -110 | U: -110)

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Bills at Jets key injuries

Bills

RB James Cook (toe) questionable
OT Austin Johnson (oblique) questionable
CB Taron Johnson (forearm) questionable
DT Ed Oliver (hamstring) out
WR Khalil Shakir (ankle) questionable

Jets

CB Michael Carter II (back) out
TE Tyler Conklin (hip) questionable
LB C.J. Mosley (toe) questionable

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Bills at Jets picks and predictions

Prediction

Bills 25, Jets 19

Moneyline

BILLS (-130) is a good play with this moderate price tag, if you want to just pick a winner without fiddling around with the little bit of points due to the uncertainty with Buffalo’s injury report.

The best order of business would be to wait to finalize your wager, though. With Cook and Shakir both carrying questionable tags, Buffalo is a bit of a risk. If at least one or both are active and ready to roll, the Bills are a strong play.

Against the spread

The BILLS -2 (-110) are looking for a bounce-back game, and what better place to get it than against the Jets +2 (-110).

The organization is a mess yet again, as it always seems to be something. Last season, they lost QB Aaron Rodgers to an Achilles injury 4 snaps into the Monday night opener against the Bills. The rest of the season was a hot mess with a turnstile of QBs. This season figured to have more stability, but Rodgers has looked really old, the offense isn’t able to move the ball, and now there is an interim head coach and new play caller.

Roll with the more stable team, and the stud quarterback on MNF.

Over/Under

OVER 41 (-110) is worth a look, but don’t get too carried away. Again, like we mentioned in the moneyline section, wait to see if Cook and Shakir are active before proceeding. If Allen has all of his weapons, Buffalo could do a lot of the heavy lifting on its own.

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Buffalo Bills at Houston Texans odds, picks and predictions

Analyzing Sunday’s Buffalo Bills at Houston Texans odds and lines, with expert NFL picks and predictions.

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The Buffalo Bills (3-1) and Houston Texans (3-1) meet Sunday. Kickoff from NRG Stadium is set for 1 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Bills vs. Texans odds, and make our expert NFL picks and predictions.

Buffalo was dismantled 35-10 at the Baltimore Ravens on Sunday Night Football as a 2.5-point underdog. The Bills allowed a whopping 427 yards of total offense, including 199 rushing yards to Ravens RB Derrick Henry. The loss marked the 1st game without a passing TD for QB Josh Allen this year.

Houston escaped with a 24-20 win over the visiting Jacksonville Jaguars Sunday, but failed to cover as a 5.5-point favorite. QB C.J. Stroud completed 27 of his 40 passes for 345 yards with 2 TDs as the Texans amassed 435 yards of offense. WR Nico Collins hauled in 12 receptions for 151 yards and 1 TD.

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Bills at Texans odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 3 p.m. ET.

Moneyline (ML): Bills +100 (bet $100 to win $100) | Texans -120 (bet $120 to win $100)
Against the spread (ATS): Bills +1 (-110) | Texans -1 (-110)
Over/Under (O/U): 47 (O: -110 | U: -110)

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Bills at Texans key injuries

Bills

LB Terrel Bernard (pectoral) questionable
CB Taron Johnson (forearm) questionable
DT Ed Oliver (hamstring) out
S Taylor Rapp (concussion) out
WR Khalil Shakir (ankle) out

Texans

DE Derek Barnett (shoulder) out
RB Joe Mixon (ankle) out
RB Dameon Pierce (hamstring) questionable

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Bills at Texans picks and predictions

Prediction

Bills 24, Texans 21

Moneyline

LEAN BILLS (+100).

Houston has the more talented roster, especially offensively, but in close matchups like these, I tend to go with the better quarterback to win. I expect this Buffalo team to see some success in the trenches on both sides of the ball.

This is a lean because, as stated, this is a very tight matchup, and I find it very difficult to gauge either team at this time.

Against the spread

PASS.

I like the Bills to cover here, but I am backing them on the ML and am not a fan of doubling down on 1-point underdogs.

Over/Under

BET UNDER 47 (-110).

The Under has hit in each of Houston’s last 3 games and is 2-1 in Buffalo’s last 3. Both Buffalo and Houston have solid defenses, and I am not sold on Buffalo’s offense, which currently scores 30.5 points per game, as I expect that number to decrease as the Bills play more competition.

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Buffalo Bills at Baltimore Ravens odds, picks and predictions

Analyzing Sunday’s Buffalo Bills at Baltimore Ravens odds and lines, with expert NFL picks and predictions.

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The Buffalo Bills (3-0) visit the Baltimore Ravens (1-2) on Sunday Night Football. Kickoff from M&T Bank Stadium is set for 8:20 p.m. ET (NBC/Peacock). Let’s analyze BetMGM Sportsbook’s NFL odds around the Bills vs. Ravens odds, and make our expert NFL picks and predictions.

Buffalo demolished the Jacksonville Jaguars 47-10 on Monday while covering as a 4.5-point favorite. QB Josh Allen completed 23-of-30 passes for 263 yards and 4 TDs while the Bills also rushed for 122 yards and 2 TDs.

Baltimore escaped with a 28-25 victory over the Dallas Cowboys Sunday while covering as a 1-point favorite. The Ravens ran for 274 yards and 3 TDs to avoid blowing what was a 28-6 lead with 9 minutes left in the game.

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Bills at Ravens odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated at 12:51 a.m. ET.

Moneyline (ML): Bills +120 (bet $100 to win $120) | Ravens -145 (bet $145 to win $100)
Against the spread (ATS): Bills +2.5 (-105) | Ravens -2.5 (-115)
Over/Under (O/U): 46.5 (O: -110 | U: -110)

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Bills at Ravens key injuries

Bills

LB Terrel Bernard (pectoral) out
OT Tylan Grable (groin) IR
CB Taron Johnson (forearm) out

Ravens

CB Jalyn Armour-Davis (hamstring) out
C Tyler Linderbaum (knee) questionable
G Andrew Vorhees (ankle) questionable

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Bills at Ravens picks and predictions

Prediction

Ravens 28, Bills 27

Moneyline

BET RAVENS (-145).

Baltimore comes into this game with a sense of desperation after starting the season 1-2 and nearly blowing a 28-6 lead in the 4th-quarter last week.

Buffalo has been hotter and has looked better to start the season, but the Ravens will be the team that is more motivated and has a chip on its shoulder. Combine that with Baltimore’s talent on both sides of the ball and you’ve got an unstoppable force.

Against the spread

LEAN BILLS +2.5 (-105).

Buffalo has been the better team to start the season, and its NFL-leading offense that averages 37.3 points per game will be enough to keep the Bills close, especially with how uncharacteristically bad the Ravens’ defense has looked so far.

But a spread of +2.5 leaves very little margin for error, so this is a fairly risky bet.

Over/Under

BET OVER 46.5 (-110).

Buffalo’s offense has been phenomenal with QB Josh Allen playing at an MVP level and the offensive line firing on all cylinders. On the other side, the Ravens also have yet to put up less than 20 points in a game.

The Over has also hit in each of Baltimore’s 1st 3 games this year and is 2-1 on the season for the Bills.

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Jacksonville Jaguars at Buffalo Bills odds, picks and predictions

Analyzing Monday’s Jacksonville Jaguars at Buffalo Bills odds and lines, with expert NFL picks and predictions.

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The Jacksonville Jaguars (0-2) and the Buffalo Bills (2-0) meet for a Week 3 game Monday. Kickoff at Highmark Stadium is set for 7:30 p.m. ET (ESPN). Let’s analyze BetMGM Sportsbook’s NFL odds around the Jaguars vs. Bills odds, and make our expert NFL picks and predictions.

The Jaguars lost 18-13 at home to the Cleveland Browns last week. Jacksonville has had issues on offense, averaging just 15.0 points per game (PPG) in 2 games, while allowing just 19.0 PPG.

QB Trevor Lawrence has completed just 51.0% of his pass attempts for 382 yards, 1 TD and 0 INT in 2 outings, while RB Travis Etienne leads the team with just 96 rushing yards, although he has 2 scores.

The Bills have scored 31 or more points in both games. That includes a 31-10 win at the Miami Dolphins last Thursday as a 2.5-point underdog as the Under (49.5) cashed.

The weather forecast for Western New York is rather ominous, although things have improved in the past couple of days. The forecast is calling for a 40% chance of precipitation, with showers off and on throughout the game. Winds will be blowing from 8-11 MPH, too, perhaps limiting the aerial attack with the slippery conditions.

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Jaguars at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Sunday at 4:07 p.m. ET.

Moneyline (ML): Jaguars +200 (bet $100 to win $220) | Bills -250 (bet $250 to win $100)
Against the spread (ATS): Jaguars +5.5 (-110) | Bills -5.5 (-110)
Over/Under (O/U): 45.5 (O: -110 | U: -110)

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Jaguars at Bills key injuries

Jaguars

RB Tank Bigsby (shoulder) questionable
TE Evan Engram (hamstring) out
OT Cam Robinson (knee) questionable
DB Darnell Savage (quadriceps) questionable

Bills

LB Terrel Bernard (pectoral) out
CB Taron Johnson (forearm) out

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Jaguars at Bills picks and predictions

Prediction

Bills 24, Jaguars 17

Moneyline

The Bills (-250) will cost you 2 1/2 times your potential return, and that’s quite risky despite the fact Buffalo has won both its games, while the Jaguars (+200) have lost both outings.

Jacksonville could easily have won both of its 1st 2 games, losing each by a single score. This is a pesky team with some impressive skill-position players and an above-average defense. It won’t be an easy game for the home side.

PASS.

Against the spread

The BILLS -5.5 (-110) are the lean, but go very, very lightly.

Buffalo covered handily last week in Miami in Week 2, but it failed to cover at home against Arizona despite a 34-28 victory. You can expect a similar result here, especially if it is a soggy game with plenty of running.

The Jaguars +5.5 (-110) have the tools to hang with the Bills if the aerial game is limited by the weather, especially if RB Tank Bigsby is healthy enough to join Etienne in the backfield.

Over/Under

UNDER 45.5 (-110) is a solid play in the 1st of this MNF double dip.

We’re going to have a wet track, and that might mean more running, and less aerials. A ground-based offensive attack keeps the clock running, which is beneficial to Under bettors.

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Buffalo Bills at Miami Dolphins odds, picks and predictions

Analyzing Thursday’s Buffalo Bills at Miami Dolphins odds and lines, with expert NFL picks and predictions.

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The Buffalo Bills (1-0) and Miami Dolphins (1-0) meet at Hard Rock Stadium Thursday. Kickoff is scheduled for 8:20 p.m. ET (Prime Video). Below, we analyze BetMGM Sportsbook’s NFL odds around the Bills vs. Dolphins odds, and make our expert NFL picks and predictions.

The Bills opened their season with a 34-28 win over the visiting Arizona Cardinals Sunday. Buffalo rallied back from a 14-point deficit, but failed to cover as a 7-point favorite as the Over (45) easily hit. QB Josh Allen was 18-of-23 passing for 232 yards with 2 TDs and rushed for another 2 scores. Allen appeared to injure his left hand on a rushing TD in the 4th quarter, but has been cleared to play Thursday.

Miami also overcame a 14-point deficit in a 20-17 home victory over the Jacksonville Jaguars Sunday. It was unable to cover as a 3.5-point favorite, and the Under (49) cashed. WR Tyreek Hill — who was detained by Miami-Dade Police officers earlier in the day for a traffic violation — ignited the Dolphins offense in the 3rd quarter with an 80-yard TD. K Jason Sanders made 2 FGs in the 4th, including a go-ahead 52-yarder as time expired.

Miami will be without RB Raheem Mostert (chest) Thursday, and RB De’Von Achane (ankle) is a game-time decision. Mostert and Achane led the Dolphins in rushing yards in the 2023 regular season with 1,012 and 800, respectively.

Bills at Dolphins odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Wednesday at 9:04 p.m. ET.

Moneyline (ML): Bills +115 (bet $100 to win $115) | Dolphins -135 (bet $135 to win $100)
Against the spread (ATS): Bills +2.5 (-110) | Dolphins -2.5 (-110)
Over/Under (O/U): 49 (O: -110 | U: -110)

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Bills at Dolphins key injuries

Bills

CB Taron Johnson (forearm) out
DE Dawuane Smoot (toe) out

Dolphins

RB De’Von Achane (ankle) questionable
WR Odell Beckham Jr. (undisclosed) out
RB Raheem Mostert (chest) out
WR Malik Washington (quadricep) out

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Bills at Dolphins picks and predictions

Prediction

Bills 31, Dolphins 23

Moneyline

The Dolphins have struggled against Allen recently. The BILLS (+115) are 4-0 in the last 4 meetings between these teams, with Allen averaging 333.8 passing yards over the 4-game sample.

Dolphins QB Tua Tagovailoa is just 1-6 in 7 career starts vs. the Bills and went 2-3 in the 2023 regular season in standalone games, not including a 28-27 loss to the Tennessee Titans in a MNF doubleheader Dec. 11. Tagovailoa is faced with the pressure of ending his team’s 4-game skid against the Bills, but he’ll have to do so in a standalone game, a situation he was mediocre in last season.

To make matters worse, Miami may potentially be without its top 2 RBs Thursday — not a great sitution for a team that was 3rd in rushing TDs per game (1.5) last season.

BET BILLS (+115).

Against the spread

Buffalo +2.5 (-110) should cover, but this number isn’t very enticing unless it hits a flat 3. If you have a book that offers 2-team, 6-point teasers at -120 or cheaper, Buffalo +8.5 is a good teaser leg going through the key numbers of 3 and 7.

Otherwise, PASS on the spread. Bet the ML and/or total instead.

Over/Under

The Over is 3-1 in the last 4 meetings, with the Dolphins struggling to contain Allen (3.5 total TDs per game). The Bills started slowly in their season opener vs. Arizona, but still scored 24 points in the 2nd half once they got more comfortable in their offense.

Miami’s offense was disappointing in Week 1, but it’s expected that the Dolphins, who were 2nd in the NFL last season with 6.4 yards per play, will look more like last year’s high-powered offense in Week 2.

BET OVER 49 (-110).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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