49ers Rams odds lines money line against the spread Over Under

First look: San Francisco 49ers at LA Rams odds and lines

Looking at Sunday’s San Francisco 49ers at LA Rams Week 3 NFL odds, lines and trends. Here’s what you need to know.

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The San Francisco 49ers (1-1) and LA Rams (0-2) will renew their rivalry Sunday in an NFC West matchup. Kickoff from SoFi Stadium in Inglewood, Calif., is set for 4:25 p.m. ET (FOX).

Below, we look at 49ers vs. Rams odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

Both teams are coming off losses in Week 2. The 49ers were upset by the Minnesota Vikings as 4.5-point favorites, losing 23-17 on the road in Minneapolis. They now sit at 1-1 and will look to avoid a dreaded 1-2 start as the defending NFC champions. RB Christian McCaffrey (calf/Achilles) remains out after being placed on injured reserve.

The Rams are 0-2 for the first time since 2011 after losing back-to-back games to the Detroit Lions and Arizona Cardinals. They were blown out by the Cardinals Sunday, 41-10, the 2nd-worst loss of Sean McVay’s head-coaching career. WR Puka Nacua (knee) is on injured reserve, and in Sunday’s loss, WR Cooper Kupp exited early with an ankle injury.

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49ers at Rams odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list NFL odds. Lines last updated Monday at 9:51 a.m. ET.

Moneyline (ML): 49ers -375 (bet $375 to win $100) | Rams +300 (bet $100 to win $300)
Against the spread (ATS): 49ers -7.5 (-110) | Rams +7.5 (-110)
Over/Under (O/U): 44.5 (O: -115 | U: -105)

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2024 betting stats

ML: 49ers 1-1 | Rams 0-2
ATS: 49ers 1-1 | Rams 0-2
O/U: 49ers 1-1 | Rams 1-1

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49ers vs. Rams head-to-head

The 49ers have owned the Rams in recent years, winning 9 of their last 11 meetings. Their only 2 losses were in Week 18 last season when both teams rested their starters and in the NFC title game 3 years ago, which punched the Rams’ ticket to the Super Bowl.

The Rams are 2-0 ATS in their last 2 games against the 49ers but previously failed to cover the spread in 7 straight. The total has gone Over in 3 consecutive meetings between these teams and is 5-5 in their last 10 games.

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First look: San Francisco 49ers at Los Angeles Rams odds and lines

Looking at Xday’s VFullname at HFullname Week X NFL odds, lines and trends. Here’s what you need to know.

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After blowing out each of their opponents in Week 1, the Los Angeles Rams (1-0) and the San Francisco 49ers (1-0) will square off on Sunday afternoon at SoFi Stadium in Inglewood, Calif. Kickoff is set for 4:05 p.m. ET (FOX). Below, we look at 49ers vs. Rams odds from BetMGM Sportsbook. Also see: SportsbookWire’s NFL picks and predictions.

The 49ers crushed the Pittsburgh Steelers on Sunday, cruising to a 30-7 win after jumping out to a 20-0 lead in the 1st half. QB Brock Purdy had 220 yards and 2 TDs, both to WR Brandon Aiyuk.

The Rams also made a statement in the season opener, dominating the Seattle Seahawks in a 30-13 victory. LA allowed just 12 second-half yards to the Seahawks and outscored them 23-0 in the final 30 minutes, showing the defense may be better than expected.

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49ers at Rams odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 9:45 a.m. ET.

Moneyline (ML): 49ers -300 (bet $300 to win $100) | Rams +240 (bet $100 to win $240)
Against the spread (ATS): 49ers -7 (-110) | Rams +7 (-110)
Over/Under (O/U): 42.5 (O: -110 | U: -110)

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2023 betting stats

ML: 49ers 1-0 | Rams 1-0
ATS: 49ers 1-0 | Rams 1-0
O/U: 49ers 0-1 | Rams 0-1

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49ers vs. Rams head-to-head

The 49ers and Rams meet twice a year, sometimes 3 times if both make the playoffs. But in the last 4 seasons, the 49ers have owned the Rams in the regular season. The 49ers are 8-0 in their last 8 regular-season games against the Rams, which dates back to the 2019 season.

The Rams have 1 win since then, which came in the NFC Championship Game in January 2022, but the 49ers have had their number in regular-season meetings.

In their last 10 matchups, the 49ers are 8-2 straight-up and ATS while the Under is 6-4. The 49ers have covered the spread in 7 straight games against LA.

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First look: San Francisco 49ers at Los Angeles Rams odds and lines

Looking at Sunday’s San Francisco 49ers at Los Angeles Rams Week 8 NFL odds, lines and trends. Here’s what you need to know.

It’s only Week 8, but the Los Angeles Rams (3-3) and San Francisco 49ers (3-4) will square off for the 2nd time this season Sunday. Kickoff from SoFi Stadium will be at 4:25 p.m. ET (FOX). Below, we look at 49ers vs. Rams odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

The 49ers have lost 2 games in a row, falling at the Atlanta Falcons in Week 6 and at home to the Kansas City Chiefs Sunday. The Chiefs made the win look easy, too, winning 44-23 thanks to 30 second-half points. The 49ers acquired RB Christian McCaffrey last week and he played Sunday in a somewhat of a limited role — 8 carries for 38 yards and 2 receptions for 24 yards. Expect him to get more touches against the Rams.

Los Angeles is coming off a bye for this division matchup at home. In the Rams’ last game, they beat the Carolina Panthers 24-10 in L.A. to snap a 2-game losing streak. The Rams lost their first meeting with the 49ers 24-9 back in Week 4 in Santa Clara. Los Angeles ranks 28th in points per game (17.3) this season.

Also see: All Week 8 odds and lines

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49ers at Rams odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 2:30 p.m. ET.

Moneyline (ML): 49ers -135 (bet $135 to win $100) | Rams +110 (bet $100 to win $110)
Against the spread (ATS): 49ers -2.5 (-110) | Rams +2.5 (-110)
Over/Under (O/U): 42.5 (O: -112 | U: -108)

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2022 betting stats

ML: 49ers 3-4 | Rams 3-3
ATS: 49ers 3-4 | Rams 2-4
O/U: 49ers 2-5 | Rams 1-5

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49ers vs. Rams head-to-head

There’s no question which team has owned this rivalry in recent years. The 49ers have won 7 of the last 8 meetings dating back to 2019, including their most recent meeting in Week 4. San Francisco has won 7 straight regular-season meetings, too.

The Rams’ only win against the 49ers in their last 8 attempts was in the NFC title game in January behind a 20-17 victory at home. The 49ers are a perfect 6-0 ATS in the last 6 meetings of this series, with the total going Under in 5 of those 6 games.

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First look: San Francisco 49ers at Los Angels Rams odds and lines

Looking at Sunday’s San Francisco 49ers at Los Angels Rams Week 18 NFL odds, lines and trends. Here’s what you need to know.

The San Francisco 49ers (9-7) visit the Los Angeles Rams (12-4) for a regular-season finale Sunday in Week 18. Kickoff is scheduled for 4:25 p.m. ET at SoFi Stadium. Below, we look at the 49ers vs. Rams odds and lines; check back for our NFL picks and predictions.

San Francisco can clinch its second postseason appearance in three seasons with a win or tie against the Rams or a loss or tie by the New Orleans Saints (8-8), who play at the Atlanta Falcons (7-9) Sunday, also at 4:25 p.m. ET.

The Rams, who already wrapped up a playoff berth, win the NFC West with a win or tie vs. the 49ers or a loss or tie by the Arizona Cardinals (11-5), who host the Seattle Seahawks (6-10) Sunday at 4:25 p.m. ET.

The 49ers beat the visiting Houston Texans 23-7 Sunday. Rookie QB Trey Lance, starting in place of injured QB Jimmy Garoppolo (thumb), threw for 249 yards with 2 second-half touchdowns and the defense tossed a shutout in the second half as the 49ers covered as 14-point favorites.

The Rams rallied for a 20-19 victory at the Baltimore Ravens in Week 17. L.A., which won its fifth in a row, trailed 16-7 with 4:42 to go in the third quarter before scoring 2 touchdowns in the fourth for the win. QB Matthew Stafford and WR Odell Beckham Jr. hooked up for a 7-yard TD pass with 57 seconds to go for the winning score — the Rams missed the ensuing two-point conversion attempt.

Also see: All Week 18 odds and lines

49ers at Rams odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 8 a.m. ET.

Money line: 49ers +190 (bet $100 to win $190) | Rams -240 (bet $240 to win $100)
Against the spread (ATS): 49ers +5.5, -112 (bet $112 to win $100) | Rams -5.5, -108 (bet $108 to win $100)
Over/Under (O/U): 44.5, O: -110 (bet $110 to win $100) | U: -110 (bet $110 to win $100)

Also see: Betting 101

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2021 betting stats:

ML: 49ers 9-7 | Rams 12-4
ATS: 49ers 8-8 | Rams 8-8
O/U: 49ers 7-9 | Rams 8-7-1

49ers at Rams head-to-head

The 49ers lead the all-time series 74-67-3, including 1-0 in the postseason, a 30-3 rout at home in the 1989-90 NFC Championship Game.

San Francisco took the first meeting of the season, cruising to a 31-10 home victory in Week 10 as a 3.5-point underdog.

The 49ers have actually won the last five in this series. They swept both games last season with a 24-16 home win in Week 6 as 2.5-point underdogs and a 23-20 squeaker in Week 12 as 5-point road ‘dogs.

The underdog is 5-0 ATS in the last five, while the Under is 4-1.

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