San Francisco Giants at Cincinnati Reds odds, picks and predictions

Analyzing Wednesday’s San Francisco Giants at Cincinnati Reds odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (54-41) and Cincinnati Reds (50-46) meet Wednesday for the 3rd game of a 4-game series. First pitch from Great American Ball Park is set for 7:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Reds odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 2-0

San Francisco won 11-10 as a -130 road favorite Tuesday night. Cincinnati held a 4-1 lead through 2nd innings but a 3-run HR from Giants IF Wilmer Flores tied the game at 4 in the top of the 3rd. From there it was a back-and-forth game the rest of the way until a 3-run top of the 7th inning put the Giants up for good.

The victory extended the Giants’ win streak to 7 games and improved their record to 28-19 away from home. Cincinnati has lost 6 straight games and slipped to 23-26 at home on the year.

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Giants at Reds projected starters

RHP Ross Stripling vs. RHP Graham Ashcraft

Stripling (0-2, 6.11 ERA) makes his 9th start and 14th appearance. He has a 1.42 WHIP, 2.2 BB/9 and 7.9 K/9 through 45 2/3 IP.

  • Last start: No-decision, 4 2/3 IP, 2 ER, 5 H, 0 BB, 6 K in a 6-4 road win vs. the Pittsburgh Pirates Friday
  • Career vs. Cincinnati: 0-0, 4.63 ERA (11 2/3 IP, 6 ER), 15 H, 1 BB, 12 K through 2 starts and 2 relief appearances

Ashcraft (4-7, 5.95 ERA) makes his 18th start. He has a 1.56 WHIP, 3.8 BB/9 and 6.5 K/9 through 87 2/3 IP.

  • Last outing: Loss, 6 IP, 1 ER, 5 H, 2 BB, 2 K in a 1-0 home loss Friday vs. Milwaukee Brewers
  • Career vs. San Francisco: 2-0, 1.26 ERA (14 1/3 IP, 2 ER), 10 H, 2 BB, 9 K across 2 starts

Giants at Reds odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:35 a.m. ET.

  • Moneyline (ML): Giants -115 (bet $115 to win $100) | Reds -105 (bet $105 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants -1.5 (+135) | Reds +1.5 (-160)
  • Over/Under (O/U): 10.5 (O: -115 | U: -105)

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Giants at Reds picks and predictions

Prediction

Giants 4, Reds 3

Moneyline

BET GIANTS (-115).

What makes me so confident in the Giants here is their 7-game win streak combined with the Reds’ 6-game losing streak. San Francisco also holds a 6-4 edge in the last 10 meetings between these clubs. What puts this bet over the top for me is the Giants’ stellar road record and the Reds’ poor home record.

Run line/Against the spread

LEAN REDS +1.5 (-160).

This line is a little rich so if you feel the risk is not worth the reward then you should pass on this bet.

Recent matchups between these teams have been close and neither has the clear pitching advantage, with both teams being 2-3 in their starters’ last 5 overall. I like the Giants to win just because they are so hot but I would expect the Reds to put up a fight here just as they did in game 2 on Tuesday.

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Over/Under

LEAN UNDER 10.5 (-105).

The Under is 7-3 in San Francisco’s last 10 games overall, including a 5-game stretch of hitting on the Under.

The Under has cashed in 5 of Cincinnati’s last 6 outings and is and 2-0 in each of Ashcraft’s 2 career starts vs. San Francisco.

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