San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Tuesday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (77-80) and San Francisco Giants (78-79) play the 2nd game of a 3-game set Tuesday at Oracle Park. First pitch is scheduled for 9:45 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 6-5

The Padres lost 2-1 as -114 favorites as the Under (7) hit in the series opener Monday. San Diego has lost 2 of 3 and has fallen to 5½ games back of the Arizona Diamondbacks and the Chicago Cubs, who are tied for the final 2 NL Wild Cards.

Giants LF Michael Conforto batted in both runs for San Francisco with a 2-run single in the 8th inning. The Giants have won just 3 of their last 11 outings and are 4½ games out of the final NL Wild Card spot.

Padres at Giants projected starters

RHP Seth Lugo vs. LHP Kyle Harrison

Lugo (7-7, 3.79 ERA) makes his 26th start. He has a 1.24 WHIP, 2.2 BB/9 and 8.7 K/9 in 137 2/3 innings.

  • Last start: No-decision, 6 IP, 2 ER, 7 H, 2 BB, 7 K in 3-2 home victory vs. Colorado Rockies Wednesday
  • 2023 road stats: 3-3, 3.91 ERA (73 2/3 IP, 32 ER) in 13 starts
  • 2023 vs. Giants: 1-0, 0.82 ERA (11 IP, 1 ER) in 2 starts — Most recent: Win, 6 IP, 0 ER, 3 H, 1 BB, 4 K in 4-0 home victory Sept. 3
  • Career vs. Giants: 3-2, 2.52 ERA (35 2/3 IP, 10 ER) across 4 starts and 11 relief appearances

Harrison (1-1, 4.85 ERA) makes his 7th start. The rookie has a 1.28 WHIP, 2.7 BB/9 and 9.4 K/9 in 29 2/3 innings.

  • Last start: No-decision, 5 1/3 IP, 2 ER, 3 H, 1 BB, 2 K in 7-2 loss at Los Angeles Dodgers Thursday
  • 2023 home stats: 1-0, 3.52 ERA (15 1/3 IP, 6 ER) in 3 starts
  • Career vs. Padres: Loss, 5 2/3 IP, 6 ER, 6 H, 2 BB, 5 K in 1 start, a 6-1 road loss Sept. 2

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Padres at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:21 a.m. ET.

  • Moneyline (ML): Padres -125 (bet $125 to win $100) | Giants +105 (bet $100 to win $105)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+135) | Giants +1.5 (-160)
  • Over/Under (O/U): 8.5 (O: -105 | U: -115)

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Padres at Giants picks and predictions

Prediction

Padres 5, Giants 4

Moneyline

The PADRES (-125) will get eliminated with 1 more loss this season. They would also get eliminated by 1 more win for the Diamondbacks and Cubs, but that is out of their control. San Diego scored 6 runs on Harrison the 1st time they saw him, and I expect it to have a similar performance Tuesday in a must-win scenario.

BET PADRES (-125).

Run line/Against the spread

The Giants are 19-7 on the run line this season as home underdogs. San Francisco +1.5 (-160) will probably hit, but there’s no need to pay the higher price on the run line when San Diego ML is the better play.

PASS. Bet the moneyline and/or the total instead.

Over/Under

The Over is 22-19-4 (53.7%) this season when the Padres are road favorites. San Diego scored just 1 run Monday, and I expect it to bounce back vs. the rookie Harrison.

The Under has hit in 4 straight games for San Francisco, but its last Over cashed in Harrison’s most recent start.

BET OVER 8.5 (-105).

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