Chicago Cubs at San Francisco Giants odds, picks and predictions

Analyzing Saturday’s Chicago Cubs at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

The Chicago Cubs (27-36) and San Francisco Giants (32-31) meet Saturday for the 2nd game of a 3-game series. First pitch from Oracle Park is set for 7:35 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s lines around the Cubs vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Cubs lead 1-0

Chicago won 3-2 as a +103 road underdog Friday in the series opener. San Francisco held a 1-0 lead off the back of an RBI double in the 3rd inning from 2B Thairo Estrada but the Cubs capitalized on a 3-run 7th inning to secure the victory.

Friday’s game snapped a 4-game losing skid for Chicago and 3-game win streak for San Francisco. The Cubs have won 4 of their last 10 games and are 12-20 on the road while the Giants are 5-5 in their last 10 outings and 17-16 at home.

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Cubs at Giants projected starters

RHP Kyle Hendricks vs. RHP John Brebbia

Hendricks (0-2, 4.70 ERA) makes his 4th start. He has a 1.50 WHIP, 2.9 BB/9 and 7.0 K/9 through 15 1/3 IP.

  • Last outing: Loss, 6 IP, 4 ER, 6 H, 0 BB, 4 K in a 5-0 road loss vs. the San Diego Padres Monday
  • Career vs. San Francisco: 5-2 with a 2.29 ERA (63 IP, 16 ER), 1.00 WHIP, 19 BB, 53 K across 10 starts

Brebbia (2-0, 3.65 ERA) makes his 6th start and 27th appearance. He has a 1.14 WHIP, 2.9 BB/9 and 12.0 K/9 through 24 2/3 IP.

  • Last outing: No-decision, 1 IP, 0 ER, 2 H, 1 BB, 0 K in a 10-4 road win Tuesday vs. Colorado Rockies as an opener
  • Career vs. Chicago: 1-2 with a 4.66 ERA (19 1/3 IP, 10 ER), 8 BB, 18 K, 1.40 WHIP across 1 start and 19 relief appearances
  • Has yet to pitch more than 1 1/3 inning in any of his 5 starts

Cubs at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:30 a.m. ET.

  • Moneyline (ML): Cubs +125 (bet $100 to win $125) | Giants -150 (bet $150 to win $100)
  • Run line (RL)/Against the spread (ATS): Cubs +1.5 (-160) | Giants 1.5 (+135)
  • Over/Under (O/U): 8.5 (O: -115 | U: -105)

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Cubs at Giants picks and predictions

Prediction

Giants 4, Cubs 3

Moneyline

LEAN GIANTS (-150).

The Giants are 7-3 in the last 10 meetings with the Cubs and have won two of the last 3 times they’ve squared off. The Cubs have struggled on the road and while the Giants are not a great home team it is still hard for me to believe that they will allow Chicago to come away with back-to-back road games.

Run line/Against the spread

PASS.

The line here simply isn’t worth the juice, bet on the moneyline and/or O/U instead.

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Over/Under

BET UNDER 8.5 (-105).

Chicago has played to 3 straight Unders and the Under is 9-1 in its last 10 games. The Under is 6-4 in San Francisco’s last 10 games and 3-0 in their last 3 as well.

The Under is also 7-3 in the last 10 meetings overall and 5-0 in the last 5 meetings overall.

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