Big 12 week 1 predictions: West Virginia with a tough road matchup vs. Penn State

West Virginia goes on the road in week one to take on the Penn State Nittany Lions in a pivotal nonconference matchup. Here are this week’s Big 12 picks.

There aren’t a lot of big-time matchups in the Big 12 in week one, but there are a few intriguing contests. West Virginia goes on the road to take on Penn State. Texas Tech is the only other Big 12 team playing away from home this week, but take on Wyoming in what could be an interesting contest.

Houston hosts UTSA, a team that’s started to gain national recognition among Group of Five teams.

UCF got the Big 12 started off right with a huge win over Kent State on Thursday night. John Rhys Plumlee had 371 combined passing and rushing yards and four total touchdowns in their 56-6 win over Kent State.

Can the conference keep things going starting Friday night with Kansas hosting Missouri State?

There will be some big-time performances this week. Here are our Big 12 predictions for week one.