San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Friday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (82-65) and San Francisco Giants (72-75) open a 3-game series Friday. First pitch from Oracle Park is at 10:15 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 6-4

The Padres were off Thursday after Wednesday’s 5-2 loss at the Seattle Mariners for a 2-game series split. They have lost 3 of their last 4 games and trail the Arizona Diamondbacks by a half-game for the top NL Wild Card spot.

The Giants are coming off a 2-1 series loss to the visiting Milwaukee Brewers, dropping the Thursday finale 3-0. They are 4-7 in their last 11 games.

Padres at Giants projected starters

RHP Dylan Cease vs. RHP Logan Webb

Cease (12-11, 3.71 ERA) makes his 31st start. He has a 1.09 WHIP, 3.2 BB/9 and 10.9 K/9 through 170 innings.

  • Last start: Loss, 6 IP, 4 ER, 6 H, 2 BB, 4 K in 6-3 home defeat to Giants Saturday; Webb was San Francisco’s starter
  • 2024 vs. Giants: 0-2, 4.32 ERA (16 2/3 IP, 8 ER), 1.08 WHIP, 9.2 K/9 in 3 starts
  • Career vs. Giants: 2-2, 3.38 ERA (26 2/3 IP, 10 ER), 1.16 WHIP, 9.8 K/9 in 5 starts

Webb (12.9, 3.46 ERA) makes his 31st start. He has a 1.23 WHIP, 2.2 BB/9 and 7.4 K/9 through 189 2/3 innings.

  • Last start: Win, 6 IP, 3 ER, 10 H, 2 BB, 3 K Saturday
  • 2024 vs. Padres: 1-0, 3.32 ERA (19 IP, 7 ER), 1.53 WHIP, 5.2 K/9 in 3 starts
  • Career vs. Padres: 4-2, 2.70 ERA (76 2/3 IP, 23 ER), 1.19 WHIP, 7.2 K/9 in 13 appearances (12 starts)

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Padres at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of MLB odds. Lines last updated at 11 a.m. ET.

  • Moneyline (ML): Padres -115 (bet $115 to win $100) | Giants -105 (bet $105 to win $100)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+155) | Giants +1.5 (-190)
  • Over/Under (O/U): 7 (O: -105 | U: -115)

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Padres at Giants picks and predictions

Prediction

Giants 5, Padres 3

Moneyline

The GIANTS (-105) are 6-2 in Webb’s last 8 starts. They took 2 out of 3 games last weekend in San Diego over the Padres. They have held opponents to 3 or fewer runs in 5 of their last 7 games.

The Padres are 2-7 in their last 9 games when they allow 4 or more runs.

The Giants have scored 4 or more in 6 of their last 10 games.

BET GIANTS (-105).

Run line/Against the spread

The Giants are 4-1 ATS in their last 5 games. The Padres are 4-9 ATS in their last 13 games.

The Padres are 14-17 ATS as road favorites.

But If you like the Giants +1.5, the -190 odds aren’t it. With -105 odds for them to win outright, go with the ML.

PASS.

Over/Under

Six of 10 games between the 2 teams have had more than 7 total runs.

Seven of the Giants’ last 11 games have had at least 7 total runs. Webb’s last 4 starts have all had more than 7 total runs.

Nine of the last 11 for the Padres have had totals of 7 or more.

BET OVER 7 (-105).

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