The San Francisco 49ers reached the Super Bowl two years ago, thanks to a powerful running game and a stout defense. Despite the intriguing quarterback situation with Jimmy Garoppolo and first-round pick Trey Lance during training camp, that is expected to be their identity again.
Garoppolo gets the call for the season opener on the road against the Detroit Lions. This is one of those early Eastern Time Zones that West Coast teams often dread, and additionally, the 49ers have lost five consecutive games when favored, which they are against the Lions. Go to Tipico Sportsbook for the most updated odds.
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