WATCH: Pittsburgh Steelers At Buffalo Bills, Week 1, Key Facts, Stats

See betting lines, statistical trends and relevant facts for the 2021 NFL season opener between the Pittsburgh Steelers and Buffalo Bills.

The Buffalo Bills reached the AFC championship game last season for the first time since 1993, and taking care of business at home was a key to their success.

Including the playoffs, the Bills have won seven consecutive home games. They also have a nine-game winning streak as home favorites, and they are favored for their season opener against the visiting Pittsburgh Steelers. Go to Tipico Sportsbook for the most updated odds.

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