WATCH: Isaiah Simmons makes one-handed INT and takes it to the house!

Isaiah Simmons made a play that maybe only Isaiah Simmons can make!

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The Arizona Cardinals picked off New Orleans Saints quarterback Andy Dalton three times in the first half Thursday night.

The first was by Antonio Hamilton in the end zone. The second was a 38-yard pick-six by Marco Wilson.

The third happened just moments after the Wilson interception. It was another pick-six, but this time it was linebacker Isaiah Simmons.

Dalton dropped back, was pressured and contacted as he threw it. Simmons made a one-handed grab and showed off his sub-4.4 speed, running it 56 yards for a touchdown.

With the two-point conversion, it gave the Cardinals a 28-14 first-half lead.

It was Simmons’ first interception of 2022 and the third of his career.

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