Washington Nationals at San Francisco Giants odds, picks and predictions

Analyzing Wednesday’s Washington Nationals at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

The Washington Nationals (15-21) close out a 6-game road with the finale of a 3-game series against the San Francisco Giants (16-19) Wednesday. First pitch from Oracle Park is at 3:45 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Nationals vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 1-1

The Nationals had a 2-game win streak snapped with a 4-1 loss Tuesday. Washington had won Monday’s series opener 5-2. The Nats are just 2-3 on their road trip but 5-3 in their last 8 contests.

The Giants got 7 innings of 1-run ball from RHP Alex Cobb Tuesday as they snapped a 2-game skid. San Francisco is 5-2 in its last 7 games.

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Nationals at Giants projected starters

RHP Josiah Gray vs. LHP Sean Manaea

Gray (2-5, 3.03 ERA) makes his 8th start. He has a 1.35 WHIP, 3.5 BB/9 and 8.6 K/9 through 38 2/3 IP.

  • Had 5 consecutive starts allowing 2 or fewer ER before giving up 3 ER at the Arizona Diamondbacks last time out on Friday
  • 1-0 with 3.60 ERA in 1 start and 1 relief appearance in his career vs. Giants

Manaea (1-1, 7.33 ERA) makes his 6th start and 8th appearance. He has a 1.63 WHIP, 5.4 BB/9 and 10.4 K/9 through 23 1/3 IP.

  • 8.80 ERA over 15 1/3 IP in his last 5 appearances
  • 1-0 with a 1.29 ERA over 7 IP in 1 career start vs. Nationals

Nationals at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:45 a.m. ET.

  • Moneyline (ML): Nationals +125 (bet $100 to win $125) | Giants -155 (bet $155 to win $100)
  • Run line (RL)/Against the spread (ATS): Nationals +1.5 (-155) | Giants -1.5 (+125)
  • Over/Under (O/U): 8.5 (O: -115 | U: -105)

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Nationals at Giants picks and predictions

Prediction

Nationals 6, Giants 4

Moneyline

The Nationals have a better record on the road (9-9) than at home (6-12).

The Giants are 10-9 at home this season.

Before Gray allowed 3 earned runs over 5 innings in his last outing, he had a 1.61 ERA in his previous 5 starts. Five of his 13 earned runs allowed this season came in his first start.

Manaea has an 8.80 ERA in his last 5 appearances.

BET NATIONALS (+125).

Run line/Against the spread

The plus-money moneyline is the bet to make considering a predicted Nationals outright win.

Fourteen of the Nationals’ 21 losses have been by at least 2 runs, so they will generally either win outright or lose to the spread.

PASS.

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Over/Under

Seven of the Nationals’ last 9 games have had 7 or fewer total runs.

Five of the last 7 for the Giants have had 8 or fewer runs.

Only 1 of Gray’s starts has had more than 8 total runs this season

However, all 7 of Manaea’s games have had 9 or more runs.

BET OVER 8.5 (-115).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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