Toronto Blue Jays at San Francisco Giants odds, picks and predictions

Analyzing Wednesday’s Toronto Blue Jays at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The Toronto Blue Jays (41-50) and San Francisco Giants (45-47) play the 2nd game of a 3-game set at Oracle Park Wednesday. First pitch is scheduled for 9:45 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Blue Jays vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 1-0

The Giants won 4-3 in the series opener Tuesday as the Under (7.5) hit.

Toronto had a 91.1% win probability, according to ESPN, when Giants PH Mike Yastrzemski flew out with a runner on 1st for the 2nd out of the 9th inning. SS Brett Wisely tied it with an RBI single later in the inning, and CF Tyler Fitzgerald scored the winning run soon after on a wild pitch.

Toronto is 6-14 in its last 20 games, while San Francisco is 9-5 in its last 14.

Blue Jays at Giants projected starters

RHP Chris Bassitt vs. RHP Logan Webb

Bassitt (7-7, 3.43 ERA) makes his 19th start. He has a 1.42 WHIP, 3.6 BB/9 and 8.3 K/9 in 102 1/3 IP.

  • Last start: Loss, 5 IP, 4 ER, 8 H, 4 BB, 3 K in 5-3 home loss vs. Houston Astros Thursday
  • 2024 road stats: 2-3, 2.93 ERA (46 IP, 15 ER), 1.30 WHIP, 7.8 K/9 in 8 starts
  • Career vs. Giants: 2-2, 4.41 ERA (34 2/3 IP, 17 ER), 1.18 WHIP, 9.9 K/9 in 6 starts, including 1-0 with 0.00 ERA (6 IP) in 1 start last year

Webb (7-6, 3.09 ERA) makes his 20th start. He has a 1.22 WHIP, 2.0 BB/9 and 7.8 K/9 in an MLB-leading 119 1/3 IP.

  • Last start: Win, 7 IP, 2 ER, 7 H, 1 BB, 6 K in 4-2 victory at Atlanta Braves Thursday
  • 2024 home stats: 4-2, 2.13 ERA (55 IP, 13 ER), 1.07 WHIP, 6.5 K/9 in 8 starts
  • Career vs. Blue Jays: 0-1, 9.00 ERA (5 IP, 5 ER), 8 H, 0 BB, 5 K in 1 start, a 6-1 road loss June 28, 2023

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Blue Jays at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:37 p.m. ET.

  • Moneyline (ML): Blue Jays +130 (bet $100 to win $130) | Giants -155 (bet $155 to win $100)
  • Run line (RL)/Against the spread (ATS): Blue Jays +1.5 (-175) | Giants -1.5 (+145)
  • Over/Under (O/U): 7 (O: -120 | U: +100)

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Blue Jays at Giants picks and predictions

Prediction

Giants 5, Blue Jays 3

Moneyline

The Giants (-155) should hand Toronto its 15th loss in 21 games, but with Webb taking the mound at home, the run line at plus money is the better play.

PASS. Bet the run line and/or total instead.

Run line/Against the spread

The Giants have won 5 of Webb’s last 7 home starts by 2 or more runs.

The Blue Jays scored 5 runs in the 1st inning when they faced Webb last year, but he regained control and pitched 4 scoreless frames right after. It’s unlikely that Toronto will score that many runs this time around.

Bassitt had 12 K’s in 6 shutout IP in his start last year against San Francisco, but the 2023 version of the Giants struck out a lot more than this year’s team. San Francisco had the 7th-highest strikeout rate last season (9.21 per game), while this year’s Giants are middle of the pack with the 15th-highest rate (8.35).

Don’t expect Bassitt, or the Blue Jays offense, to replicate last year’s dominance.

BET GIANTS -1.5 (+145).

Over/Under

Bassitt is coming off a disappointing performance against Houston Thursday, allowing 4 ER on 8 hits in 5 IP. After an impressive June (1.95 ERA across 6 starts), there’s a chance the 35-year-old Blue Jays pitcher is regressing toward the mean.

However, it’s tough to bet the Over when Webb is starting at home, where he has allowed 2 ER or fewer in 6 of his 8 starts.

LEAN OVER 7 (-120).

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