Chicago White Sox at San Francisco Giants odds, picks and predictions

Analyzing Wednesday’s Chicago White Sox at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The Chicago White Sox (30-97) and San Francisco Giants (65-63) wrap up a 3-game series Wednesday. First pitch from Oracle Park is set for 3:45 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the White Sox vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 2-0

The White Sox look to avoid an interleague series sweep after suffering a 4-1 loss as +212 underdogs Tuesday as the Under (7.5) cashed. The Giants have outscored the ChiSox 9-4 in the first 2 games of the series, and the Chicago offense has been limited to just 5 runs in the past 4 games for a 1.25 runs per game (RPG) average. It’s no surprise the Under is 3-0-1 in that span.

The Giants have rattled off 3 consecutive wins to get above the .500 mark, while allowing just 8 runs in the previous 5 outings for a 1.6 RPG average. Like Chicago, the Under is 3-0-1 in San Francisco’s past 4 contests.

Chicago heads into this game just 12-53 on the road, while posting a league-worst minus-263 run differential. The ChiSox are also an MLB-worst 10-29 in interleague play.

San Francisco has managed a 38-27 record at home, while going 17-19 against the American League.

White Sox at Giants projected starters

LHP Garrett Crochet vs. RHP Logan Webb

Crochet (6-9, 3.61 ERA) makes his 26th start. He has a 1.07 WHIP, 2.2 BB/9 and 12.7 K/9 in 124 2/3 innings.

  • Last start: No-decision, 4 IP, 1 ER, 4 H, 0 BB, 9 K in 5-4 win at Houston Astros Friday
  • 2024 road splits: 2-3, 3.91 ERA (53 IP, 23 ER), 1.09 WHIP, .205 opponents’ batting average (OBA), 8 HR, 11.5 K/9 in 11 starts
  • Has never faced Giants

Webb (11-8, 3.17 ERA) makes his 26th start. He has a 1.22 WHIP, 2.2 BB/9 and 7.7 K/9 in 164 2/3 innings.

  • Last start: Win, 7 2/3 IP, 0 ER, 4 H, 1 BB, 7 K in 6-0 home shutout of Atlanta Braves Thursday
  • 2024 home splits: 7-3, 2.26 ERA (83 2/3 IP, 21 ER), 1.00 WHIP, .223 OBA, 1 complete game, 3 HR, 7.0 K/9, in 12 starts
  • Career vs. White Sox: 0-2, 5.73 ERA (11 IP, 7 ER), 1.45 WHIP, 1 BB, 9 K in 2 starts

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to scor5e a $1,500 first-bet offer.

White Sox at Giants odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 2:59 a.m. ET.

  • Moneyline (ML): White Sox +190 (bet $100 to win $190) | Giants -230 (bet $230 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (-118) | Giants -1.5 (-102)
  • Over/Under (O/U): 7 (O: -110 | U: -110)

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White Sox at Giants picks and predictions

Prediction

Giants 4, White Sox 2

Moneyline

The Giants (-230) will cost 2.3 times the potential return. That’s quite risky …  even against a 97-loss team.

San Francisco covered the run line in the first 2 games of this series, winning each contest by 2 or more runs as the favorite. However, there is still plenty of risk.

PASS and look to the favorite on the run line instead.

Run line/Against the spread

The GIANTS -1.5 (-102) are a solid play as favorites, although be careful, as Crochet is easily the best White Sox starting pitcher.

It isn’t going to be easy, but once San Francisco gets to the Chicago bullpen, the Giants should have enough offense to pull ahead by at least 2 runs to complete the series sweep.

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Over/Under

UNDER 7 (-110) is the lean but only for a half-unit play to be on the safe side.

We’ve seen the Under go 1-0-1 in the first 2 games of this series, with Chicago averaging 2.0 RPG and San Francisco scoring 4.5 RPG. If this finale follows along the same lines, we’ll get another Under result, even if just barely.

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Chicago White Sox at San Francisco Giants odds, picks and predictions

Analyzing Tuesday’s Chicago White Sox at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The Chicago White Sox (30-96) and San Francisco Giants (64-63) play the middle contest of a 3-game series Tuesday. First pitch from Oracle Park is set for 9:45 p.m. ET (MLB Network). Let’s analyze FanDuel Sportsbook’s lines around the White Sox vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 1-0

The White Sox dropped the interleague series opener 5-3 on Monday night, the team’s 3rd consecutive setback. Chicago, already eliminated from the playoffs, is just 4 losses away from hitting 100 for the 2nd straight season.

With Monday’s loss, Chicago is now just 12-52 on the road, while going 10-28 in interleague play. Facing southpaws has been a chore, too, as the White Sox are just 6-19 against left-handed starting pitchers.

The Giants have won 3 of the past 4 outings, outscoring the opposition 15-7. The Under is 3-0-1 in that span, while going 5-1-1 in the past 7 outings.

San Francisco is 16-19 in interleague play, but 45-40 against a right-handed starting pitcher. The Giants are 37-27 at home, too.

White Sox at Giants projected starters

RHP Davis Martin vs. LHP Robbie Ray

Martin (0-1, 3.00 ERA) makes his 4th start and 5th appearance. He has a 1.39 WHIP, 5.0 BB/9 and 8.5 K/9 in 18 IP.

  • Last start: No-decision, 5 2/3 IP, 1 ER, 4 H (solo HR), 3 BB, 5 K in 10-2 home setback vs. New York Yankees last Wednesday
  • 2024 road splits: 0-1, 3.72 ERA (9 2/3 IP, 4 ER), 1.24 WHIP, .229 opponents’ batting average (OBA), 4 BB, 9 K in 2 starts
  • Has never faced Giants

Ray (2-2, 6.00 ERA) makes his 6th start. He has a 1.33 WHIP, 5.1 BB/9 and 12.9 K/9 in 21 IP.

  • Last start: Loss, 2/3 IP, 5 ER, 1 H (1 HR), 3 BB, 2 K in 13-2 home loss vs. Atlanta Braves last Wednesday
  • 2024 home splits: 0-2, 9.00 ERA (11 IP, 11 ER), 2.00 WHIP, .317 OBA, 4 HR, 9 BB, 13 K in 3 starts
  • Career vs. White Sox: 0-1, 3.66 ERA (19 2/3 IP, 8 ER), 3 BB, 31 K in 3 starts

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

White Sox at Giants odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:34 a.m. ET.

  • Moneyline (ML): White Sox +215 (bet $100 to win $215) | Giants -260 (bet $260 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (+100) | Giants -1.5 (+120)
  • Over/Under (O/U): 7.5 (O: -128 | U: +104)

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White Sox at Giants picks and predictions

Prediction

Giants 6, White Sox 2

Moneyline

The Giants (-260) will cost you more than 2 1/2 times your potential return, and that’s way too much risk for standalone wager, even if the White Sox (+215) are a horrific team which loses more than 3 times the amount of games they win.

PASS, and look to the run line instead.

Run line/Against the spread

The GIANTS -1.5 (+120) are a much better play at plus-money on the run line.

San Francisco barely covered 5-3 in Monday’s series opener, but Matt Chapman’s homer in the 6th inning made a huge difference. San Francisco has won 3 in a row, and each victory has come by 2 or more runs. So, if you like the Giants to win, you should also like them to get the job done on the run line.

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Over/Under

OVER 7.5 (-128) is the lean, but go with a half-unit play at most.

You’ll be going against the trends a bit, as the Under is 4-1-1 in the past 6 games for San Francisco. However, the Over is 3-2 in Ray’s 5 starts with the Giants so far this season.

For the White Sox, the Under is 2-0-1 in the past 3 outings, but the White Sox have allowed 27 runs in the past 5 contests, or 5.4 runs per game. Look for San Francisco to do most of the heavy lifting.

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Chicago White Sox at San Francisco Giants odds, picks and predictions

Analyzing Monday’s Chicago White Sox at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The Chicago White Sox (30-95) and San Francisco Giants (63-63) open a 3-game series in San Francisco on Monday. First pitch for the opener is at 9:45 p.m. ET from Oracle Park. Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting, Giants won 2-1 in 2023

The White Sox are coming off a 2-0 shutout loss to the Houston Astros on Sunday, losing 2 out of 3 games. They have lost 2 in a row and only have 3 wins in their last 31 games.

The Giants are coming off a 4-2 road win over the Oakland A’s on Sunday in 10 innings, splitting the 2-game series. They are 2-5 in their last 7 games.

White Sox at Giants projected starters

RHP Jonathan Cannon vs. LHP Kyle Harrison

Cannon (2-6, 4.02 ERA) makes his 14th start and 16th appearance. He has a 1.30 WHIP, 2.6 BB/9 and 6.1 K/9 in 80 2/3 IP.

  • Last start: Loss, 4 2/3 IP, 3 ER, 5 H, 3 BB, 4 K in 4-1 home loss to New York Yankees on Tuesday
  • Sox have lost 6 of his last 7 starts
  • Facing Giants for 1st time

Harrison (6-5, 4.14 ERA) makes his 22nd start. He has a 1.31 WHIP, 2.9 BB/9 and 8.4 K/9 in 111 IP.

  • Last start: No decision, 5 IP, 3 ER, 6 H, 2 BB, 6 K in 5-4 home loss to Atlanta Braves on Tuesday
  • Has 7.43 ERA in 3 August starts
  • Facing White Sox for 1st time

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

White Sox at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:07 a.m. ET.

  • Moneyline (ML): White Sox +200 (bet $100 to win $200) | Giants -250 (bet $250 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (-105) | Giants -1.5 (-115)
  • Over/Under (O/U): 8 (O: -105 | U: -115)

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White Sox at Giants picks and predictions

Prediction

Giants 5, White Sox 2

Moneyline

At this point, why would anyone bet the White Sox to win? They lost 21 straight games and are 3-28 in their last 31 games. They have baseball’s worst road record at 12-51. They have lost 6 of Cannon’s last 7 starts.

The Giants are 36-27 at home.

But betting the Giants at -250 isn’t worth the action.

PASS.

Run line/Against the spread

Fourteen of Chicago’s last 17 losses have been by 2 or more runs. The Sox are 26-36 ATS as road dogs.

Eight of the Giants’ last 9 wins have been by multiple runs.

BET GIANTS -1.5 (-115).

Over/Under

The White Sox have scored 2 or fewer runs in 5 of their last 7 games while the Giants have allowed 2 or fewer runs in 3 straight games and in their last 4 wins.

BET UNDER 8 (-115).

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