Syracuse at Clemson odds, picks and predictions

Analyzing Wednesday’s Syracuse at Clemson odds and lines, with college basketball expert picks, predictions and best bets.

The Syracuse Orange (16-11, 9-7 ACC) face the Clemson Tigers (19-8, 11-5) Wednesday at Littlejohn Coliseum. Tip-off is at 7 p.m. ET (ACC  Network). Below, we analyze Tipico Sportsbook’s lines around the Syracuse vs. Clemson odds, and make our expert college basketball picks, predictions and bets.

The Orange were blown out 77-55 by Duke on Saturday as 1-point underdogs at home. Syracuse is 5-5 in its last 10 games.

The Tigers lost 83-73 to Louisville on Saturday despite being 10.5-point road favorites. Clemson has lost 4 of its last 5 games, but still owns the 4th-best conference record.

This is the only regular-season meeting between the Orange and the Tigers. The home team has won 7 straight meetings.

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Syracuse at Clemson odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:17 a.m. ET.

  • Moneyline (ML): Syracuse +145 (bet $100 to win $145) | Clemson -190 (bet $190 to win $100)
  • Against the spread (ATS): Syracuse +3.5 (-105) | Clemson -3.5 (-115)
  • Over/Under (O/U): 143.5 (O: -105 | U: -115)

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Syracuse at Clemson picks and predictions

Prediction

Clemson 77, Syracuse 71

Moneyline

AVOID.

Clemson should be able to secure the win at home, but taking the Tigers straight up at the current odds (-190) isn’t advised with how they’ve performed recently.

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Against the spread

CLEMSON -3.5 (-115) is the lean in this ACC showdown with the Tigers playing at home, where they are 13-1. Clemson convert 80% of their free throws, 2nd in the nation.

Clemson is 4-1 ATS in its last 5 home games and the home team is 6-1 ATS in the last 7 meetings between these programs.

Over/Under

OVER 143.5 (-105) seems like the ideal choice with Clemson likely being able to take advantage of Syracuse’s zone defense. The Tigers are making 36% of their 3-pointers (81st in the nation) and C PJ Hall should have success on the offensive glass.

The Orange are 6-1 to the Over in their last 7 road games and the Tigers have hit the Over in 4 straight games.

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