WATCH: Seattle Seahawks at Indianapolis Colts, Week 1, Key Facts, Stats

See betting lines, statistical trends and relevant facts for the 2021 NFL season opener between the Seattle Seahawks and Indianapolis Colts.

The Indianapolis Colts host the Seattle Seahawks Sunday to open their respective seasons. The Colts lost their last seven season openers, but the Seahawks lost each of their last three road openers as favorites.

Seattle is the favorite, but Indianapolis won eight of its last nine home games against NFC opponents, including three of four as a home underdog. Go to Tipico Sportsbook for the most updated odds.

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Minnesota Vikings at Cincinnati Bengals odds, picks and prediction

Analyzing the Minnesota Vikings at Cincinnati Bengals Week 1 odds and lines, with expert NFL picks, predictions and best bets.

The Cincinnati Bengals open their 2021 season at home as they play host to the Minnesota Vikings at 1 p.m. ET Sunday. Below, we look at the Vikings vs. Bengals odds and lines, and make our best NFL picks, predictions and bets.

The Vikings made the playoffs every odd-numbered year since head coach Mike Zimmer was hired (and missed the postseason every even-numbered year). Last season, injuries and organizational arrogance of letting key defensive players leave or get cut led Minnesota to dig an early hole for itself that it never rebounded from.

The Vikings have the requisite offensive talent in RB Dalvin Cook, WRs Justin Jefferson and Adam Thielen, and QB Kirk Cousins to put up a lot of points, but it is the defense that will be needed to get the Vikings back to the playoffs and they’ve added a lot of veterans to accomplish that.

The Bengals get QB Joe Burrow back after an impressive, but injury-shortened rookie season. He has weapons in RB Joe Mixon, and WRs Tyler Boyd, Tee Higgins and Ja’Marr Chase. However, defense has been the problem in Cincinnati for years and head coach Zac Taylor hasn’t changed the culture of losing in two seasons.

The Bengals have a record of 6-25-1 under Taylor and the hot seat under him is as flammable as it is with any coach in the league. Winning now is a job requirement or Taylor will be shown the door.

Vikings at Bengals odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 10:25 p.m. ET.

  • Money line: Vikings -170 (bet $170 to win $100) | Bengals +135 (bet $100 to win $135)
  • Against the spread (ATS): Vikings -3.5 (+100) | Bengals +3.5 (-125)
  • Over/Under (O/U): 46.5 (O: -117 | U: -103)

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Vikings at Bengals key injuries

Vikings

  • OT Christian Darrisaw (groin) out
  • LB Anthony Barr (knee) out

Bengals

  • CB Trae Waynes (hamstring) out

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Vikings at Bengals odds, lines, predictions and picks

Prediction

Vikings 27, Bengals 24

Money line

This is a difficult bet because the Vikings have the better personnel and with the team as healthy as it will be all season, they should win. The -170 is just a lot to give up for a road team without a recent pedigree.

If I was going to roll the dice with a small bet, I would take the Bengals at +135 because it should be a close game; however, AVOID THIS BET and bet on the spread and O/U.

Against the spread

It’s hard enough to bet against the Bengals straight up, but 3.5 points is giving a lot for a Minnesota team with an extremely suspect offensive line. It’s a line that routinely kills drives with penalties and Cincinnati’s ability to put up points – a 10-point deficit can turn to three in a hurry against a prevent defense late in the game – makes 3.5 points too many to give away.

Roll with the BENGALS +3.5 (-125)

Over/Under

Both teams have dismal offensive lines, which can lead to field position games, but both sides also have a defense that can get beaten over the top.

The Vikings and Bengals had the 27th and 26th ranked defenses in 2020, disrespectively, and you don’t jump from there to a top 10 defense the next season. It’s a sign of deep systematic problems that only get worse with injuries. There will be enough big plays in this game to get it to the OVER 46.5 (-117).

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WATCH: Arizona Cardinals at Tennessee Titans, Week 1, Key Facts, Stats

See betting lines, statistical trends and relevant facts for the 2021 season opener between the Arizona Cardinals and the Tennessee Titans.

The Arizona Cardinals kick off their season on the road, facing the Tennessee Titans. The road team won eight of the last nine season openers for the Titans, and Arizona will look to continue that trend in 2021. Tennessee is favored in this one, but the Cardinals have high hopes for DE J.J. Watt to make an immediate impact for the team. Go to Tipico Sportsbook for the most updated odds.

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WATCH: Los Angeles Chargers At Washington Football Team, Week 1, Key Facts, Stats

See betting lines, statistical trends and relevant facts for the 2021 NFL season opener between L.A. Chargers and Washington Football Team.

The NFL’s defensive rookie of the year last season was DE Chase Young of the Washington Football Team. The offensive rookie of the year was Los Angeles Chargers QB Justin Herbert.

They face off in Week 1 of the 2021 season. With each team having an award winner on the opposite side of the ball, perhaps it is fitting the betting line shifted during the week. Here’s another set of neutralizing facts: Washington has lost five of its past six home openers while the Chargers lost five of their last six September road games against NFC opponents. Go to Tipico Sportsbook for the most updated odds.

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Jacksonville Jaguars at Houston Texans odds, picks and prediction

Analyzing the Jacksonville Jaguars at Houston Texans Week 1 odds and lines, with expert NFL picks, predictions and best bets.

The Jacksonville Jaguars and Houston Texans meet Sunday at NRG Stadium in Houston. Kickoff is scheduled for 1 p.m. ET and the game is televised on CBS. Below, we look at the Jaguars at Texans odds and lines, and make our best NFL picks, predictions and bets.

The Jaguars selected QB Trevor Lawrence No. 1 overall in the 2021 NFL Draft. To no one’s surprise, he was tabbed as the starter by new head coach Urban Meyer, and each will make their NFL debuts Sunday.

One player who will not debut for a long time is fellow first-round pick RB Travis Etienne, as he is out for the season due to surgery to repair a Lisfranc injury.

The Texans turn to QB Tyrod Taylor as their starting signal caller, and QB Deshaun Watson will be inactive after an offseason of tumult and an ongoing investigation due to off-field issues. Like Meyer, David Culley makes his NFL head coaching debut in this one.

Jaguars at Texans odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 10:05 p.m. ET.

  • Money line: Jaguars -180 (bet $180 to win $100) | Texans +145 (bet $100 to win $145)
  • Against the spread (ATS): Jaguars -3.5 (-105) | Texans +3.5 (-120)
  • Over/Under (O/U): 46.5 (O: -108 | U: -112)

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Jaguars at Texans key injuries

Jaguars

  • No notable injuries

Texans

  • LB Kevin Pierre-Louis (thigh) questionable
  • QB Deshaun Watson (not injury related) out

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Jaguars at Texans odds, lines, predictions and picks

Prediction

Jaguars 27, Texans 20

Money line

The Jaguars (-180) will cost you nearly two times your potential return, and that’s risky business on a team opening on the road after a 1-15 season in 2020.

I don’t care how bad the Texans are supposed to be, the Jaguars are still the Jaguars.

AVOID, and look to the spread instead.

Against the spread

JAGUARS -3.5 (-105) is the more reasonable play with much less risk. I am still concerned about the hook, as I don’t usually like to bet favorites laying 3.5 or 7.5.

However, with Taylor under center, and no real immediate threats among the skill position players for Houston, I think Lawrence, Meyer and company have a successful Week 1 trip to the Gulf Coast.

Over/Under

The lean is to OVER 46.5 (-108), ever so slightly. It’s worth a small-unit play only. I don’t think Jacksonville blows out Houston by any means, but the Jags have plenty of offensive weapons to score a fair share of points.

The back end of the Texans defense is particularly in shambles, and I think Lawrence goes over the top for at least two long scoring plays to help Over bettors.

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WATCH: New York Jets At Carolina Panthers, Week 1, Key Facts, Stats

See betting lines, statistical trends and relevant facts for the 2021 NFL season opener between the Carolina Panthers and New York Jets.

The New York Jets went 2-14 last season, which was the second-worst record in franchise history; however, their 2021 season opener does offer intrigue as they go with first-round pick Zach Wilson at quarterback while former Jets signal-caller Sam Darnold gets the start for the Carolina Panthers.

The Jets failed to cover the line in eight of their past nine September games, and as you might suspect, Carolina favored in this one. Go to Tipico Sportsbook for the most updated odds.

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WATCH: Minnesota Vikings At Cincinnati Bengals, Week 1, Key Facts, Stats

See betting lines, statistical trends and relevant facts for the 2021 NFL season opener between the Cincinnati Bengals and Minnesota Vikings

The Minnesota Vikings won four of their past five season openers. This season begins on the road against the Cincinnati Bengals, who lost four of their past five home openers.

However, the return of second-year QB Joe Burrow from a knee injury may shift the negative trends of Cincinnati’s recent history. That makes an intriguing situation with Minnesota favored in this one. Go to Tipico Sportsbook for the most updated odds.

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Los Angeles Chargers at Washington Football Team odds, picks and prediction

Analyzing the Los Angeles Chargers at Washington Football Team Week 1 odds and lines, with expert NFL picks, predictions and best bets.

The Los Angeles Chargers and Washington Football Team meet Sunday at FedExField in Landover, Md. Kickoff is scheduled for 1 p.m. ET and the game is televised on CBS. Below, we look at the Chargers vs. Washington odds and lines, and make our best NFL picks, predictions and bets.

Chargers QB Justin Herbert begins his first full season under center after taking over the job early in 2020 and going on to win Offensive Rookie of the Year.

L.A. went just 1-4 straight up in five trips east of the Mississippi River, including a visit to the New Orleans Saints in Week 5, but they were a solid 3-2 against the spread in those games.

Washington had a rough preseason, going 1-2 SU and 0-3 ATS, but those games do not count. They went just 3-5 at home last season but posted a solid 5-3 ATS mark, including a 3-1 ATS record against the AFC. WFT also hit the Under in its final six regular-season home games.

Chargers at Washington odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 9:40 p.m. ET.

  • Money line: Chargers +102 (bet $100 to win $102) | Washington -125 (bet $125 to win $100)
  • Against the spread (ATS): Chargers +1.5 (-107) | Washington -1.5 (-115)
  • Over/Under (O/U): 44.5 (O: -115 | U: -105)

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Chargers at Washington key injuries

Chargers

  • RB Austin Ekeler (hamstring) questionable

Washington

  • WR Curtis Samuel (groin) out

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Chargers at Washington odds, lines, predictions and picks

Prediction

Washington 24, Chargers 20

Money line

Sign me up for WASHINGTON (-125) and a little Fitzmagic to start the 2021 season.

I don’t like the fact the Chargers will either be without Ekeler or he’ll be somewhat limited. I expect the Bolts will be forced to go to the air a little more, and Washington was No. 2 in the NFL against the pass last season. WFT won its home opener last season against Philadelphia, and I think it starts out strong Sunday, too.

Against the spread

WASHINGTON -1.5 (-115) isn’t much different against the number than the money line, but if you want to save a few pennies, lay the point and a half.

Washington will be missing a big-play option in Samuel on the outside, but WR Terry McLaurin is a beast, and he’ll make the first start of QB Ryan Fitzpatrick successful. TE Logan Thomas is an underrated option in the pass game, too.

As mentioned above, RB Justin Jackson might be forced into a larger role if Ekeler is inactive or limited and the Chargers could have an unbalanced attack with more air work. Washington is a no-fly zone, as it really put the clamps on opposing pass attacks last season.

Over/Under

The lean is to UNDER 44.5 (-105), which Washington saw frequently down the stretch in home games in 2020.

The Under is a perfect 6-0 in the last six regular-season home games for WFT and also a perfect 6-0 in the past six games in September for Los Angeles.

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Seattle Seahawks at Indianapolis Colts odds, picks and prediction

Analyzing the Seattle Seahawks at Indianapolis Colts Week 1 odds and lines, with expert NFL picks, predictions and best bets.

The Seattle Seahawks and Indianapolis Colts meet Sunday at Lucas Oil Stadium in Indianapolis. Kickoff is scheduled for 1 p.m. ET and the game is televised on FOX. Below, we look at the Seahawks vs. Colts odds and lines, and make our best NFL picks, predictions and bets.

The Seahawks went 4-1 straight up last season when playing east of the Mississippi River, but they were just 2-3 against the spread. This game is in Indianapolis, which observes Eastern Daylight Time. The Under was also 3-2 in those five games.

The Colts get a spot of good news, as QB Carson Wentz is not on the injury report ahead of Sunday’s game. After missing time due to a foot injury and COVID-19 issues, he is ready. So he will debut, and with the exception of WR T.Y. Hilton (neck), on the short-term injured reserve list, the Colts skill position players are at full strength.

Seahawks at Colts odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 9:20 p.m. ET.

  • Money line: Seahawks -155 (bet $155 to win $100) | Colts +125 (bet $100 to win $125)
  • Against the spread (ATS): Seahawks -2.5 (-130) | Colts +2.5 (+105)
  • Over/Under (O/U): 49.5 (O: -108 | U: -112)

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Seahawks at Colts key injuries

Seahawks

  • No notable players

Colts

  • CB Xavier Rhodes (calf) out
  • Quenton Nelson (foot, back) out

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Seahawks at Colts odds, lines, predictions and picks

Prediction

Seahawks 27, Colts 24

Money line

Betting the SEAHAWKS (-155) on the money line isn’t a bad play and isn’t too terribly expensive. I think this will be a one-score game, coming down to a late field goal perhaps. As such, rather than worrying about the spread, just play the game straight up.

Against the spread

The SEAHAWKS -2.5 (-130) are quite expensive laying the two and a half, so it’s better to play the money line; however, if you are dead-set on not paying the little bit of extra juice, I think Seattle wins this one by a field goal and covers.

I’ll take Seahawks QB Russell Wilson any day of the week up against Wentz, especially as the latter is still jelling with his new teammates.

Over/Under

The lean is OVER 49.5 (-108), but it’s only worth a small-unit wager. New Seahawks offensive coordinator Shane Waldron plans to use the short and intermediate pass routes a lot more, and more passing is good news for Over bettors.

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WATCH: Pittsburgh Steelers At Buffalo Bills, Week 1, Key Facts, Stats

See betting lines, statistical trends and relevant facts for the 2021 NFL season opener between the Pittsburgh Steelers and Buffalo Bills.

The Buffalo Bills reached the AFC championship game last season for the first time since 1993, and taking care of business at home was a key to their success.

Including the playoffs, the Bills have won seven consecutive home games. They also have a nine-game winning streak as home favorites, and they are favored for their season opener against the visiting Pittsburgh Steelers. Go to Tipico Sportsbook for the most updated odds.

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