San Francisco Giants vs. Chicago Cubs odds predictions pick betting line spread

San Francisco Giants at Chicago Cubs odds, picks and predictions

Analyzing Wednesday’s San Francisco Giants at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (36-38) and Chicago Cubs (35-39) wrap up a 3-game set at Wrigley Field Wednesday. First pitch is scheduled for 2:20 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Giants vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 1-1

After a 7-6 series-opening win, the Giants lost 5-2 as +105 underdogs Tuesday as the Under (9.5) hit. San Francisco has lost 3 of its last 5 games.

Cubs CF Cody Bellinger hit a go-ahead RBI single in the 8th inning, breaking a 2-2 tie. The win snapped a 2-game skid for Chicago, which cashed as a -114 favorite.

Giants at Cubs projected starters

TBD vs. RHP Kyle Hendricks

The Giants had not yet named a starter. RHP Spencer Howard (0-1, 4.02 ERA) started Friday after RHP Logan Webb‘s spot in the rotation and could be an option for the series finale. Howard has a 1.66 WHIP, 4.0 BB/9 and 5.7 K/9 in 2 starts and 2 relief appearances.

Howard last start: Loss, 2 1/3 IP, 4 ER, 7 H, 4 BB, 1 K in Friday’s 8-6 home defeat vs. Los Angeles Angels
Howard 2024 road stats: 0-0, 2.89 ERA (9 1/3 IP, 3 ER), 1.07 WHIP, 4.8 K/9 in 1 start and 1 relief appearance

Hendricks (0-4, 8.20 ERA) makes his 8th start and 13th appearance. He has a 1.71 WHIP, 3.0 BB/9 and 6.2 K/9 in 45 IP.

Last outing: No-decision, 4 1/3 relief IP, 0 R, 2 H, 0 BB, 1 K in 3-0 home loss vs. St. Louis Cardinals Friday
Last start: Loss, 4 2/3 IP, 7 ER (8 R), 11 H, 0 BB, 4 K in 9-3 home setback vs. Pittsburgh Pirates May 17
2024 home stats: 0-2, 7.36 ERA (22 IP, 18 ER), 1.77 WHIP, 7.4 K/9 in 3 starts and 3 relief appearances
Career vs. Giants (regular season): 6-2, 2.36 ERA (76 1/3 IP, 20 ER), 0.94 WHIP, 7.2 K/9 in 12 starts, including 1-0 with 2.70 ERA (13 1/3 IP, 4 ER) in 2 starts last year

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Giants at Cubs odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:21 a.m. ET.

Moneyline (ML): Giants +102 (bet $100 to win $102) | Cubs -120 (bet $120 to win $100)
Run line (RL)/Against the spread (ATS): Giants -1.5 (+152) | Cubs +1.5 (-184)
Over/Under (O/U): 11.5 (O: +104 | U: -128)

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Giants at Cubs picks and predictions

Prediction

Giants 5, Cubs 4

Moneyline

The GIANTS (+102) would be my lean with Hendricks starting for the Cubs. While the uncertainty at starting pitcher for San Francisco definitely gives me pause, in no scenario do I want to bet the Cubs with Hendricks on the mound unless I’m getting plus money.

LEAN GIANTS (+102).

Run line/Against the spread

It’s tough for me to feel confident in the run line either way without a starting pitcher confirmed for San Francisco. However, the Cubs have lost by multiple runs in Hendricks’ last 6 outings.

I would still PASS on the run line, though, until the Giants officially announce a starter. Bet the ML and/or total instead.

Over/Under

While Hendricks has allowed 4 ER or more in 6 of his 7 starts this season, this number seems a bit too high. The Cubs offense has been underperforming recently, and the Under is 10-1 in their last 11 games.

BET UNDER 11.5 (-128).

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San Francisco Giants at Chicago Cubs odds, picks and predictions

Analyzing Tuesday’s San Francisco Giants at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (36-37) and Chicago Cubs (34-39) play the 2nd game of a 3-game set Tuesday. First pitch from Wrigley Field is scheduled for 8:05 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 1-0

The Giants won 7-6 as +103 underdogs in the series opener Monday as the Over (10) hit.

Giants 2B Thairo Estrada hit a go-ahead 3-run HR in the 9th inning, the Cubs’ 16th blown save this year (2nd-most in MLB). LF Heliot Ramos and C Patrick Bailey also hit HRs for San Francisco, which came back from a 3-run, 8th-inning deficit.

Giants at Cubs projected starters

RHP Logan Webb vs. LHP Justin Steele

Webb (6-5, 3.02 ERA) makes his 15th start. He has a 1.20 WHIP, 1.9 BB/9 and 7.6 K/9 in 92 1/3 innings.

Last start: Win, 6 IP, 3 ER, 7 H, 0 BB, 5 K in 5-3 home victory against Houston Astros Wednesday
2024 road splits: 2-3, 4.06 ERA (44 1/3 IP, 20 ER), 1.35 WHIP, 8.9 K/9 in 8 starts

Steele (0-3, 3.22 ERA) makes his 10th start. He has a 1.09 WHIP, 2.3 BB/9 and 8.6 K/9 in 50 1/3 innings.

Last start: No-decision, 6 IP, 0 R, 3 H, 1 BB, 5 K in 3-2 road loss to Tampa Bay Rays Thursday
2024 home splits: 0-2, 4.15 ERA (21 2/3 IP, 10 ER), 1.34 WHIP, 7.9 K/9 in 4 starts

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Giants at Cubs odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:35 a.m. ET.

Moneyline (ML): Giants -115 (bet $115 to win $100) | Cubs -105 (bet $105 to win $100)
Run line (RL)/Against the spread (ATS): Giants -1.5 (+140) | Cubs +1.5 (-165)
Over/Under (O/U): 9.5 (O: -110 | U: -110)

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Giants at Cubs picks and predictions

Prediction

Giants 3, Cubs 0

Moneyline

The Giants are 5-1 since May following a series-opening win, while the Cubs are coming off a heartbreaking home loss and dealing with a struggling bullpen.

LEAN GIANTS (-115).

Run line/Against the spread

While I like the Giants Tuesday, both teams have had their fair share of 1-run scores. I would PASS here and stick with the moneyline.

Over/Under

The Cubs have the best Under record after a loss this season at 23-13-2 (63.9%). Steele also hasn’t given up more than 1 run in each of his last 4 starts.

Webb hasn’t been as dominant lately, giving up 7 or more hits and 3-plus runs in 2 of his last 3 starts. However, the Cubs are batting just .214 with RISP, the 3rd-lowest mark in MLB, which will give the Giants plenty of opportunities to get out of a jam.

BET UNDER 9.5 (-110).

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San Francisco Giants at Chicago Cubs odds, picks and predictions

Analyzing Tuesday’s San Francisco Giants at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (70-68) meet the Chicago Cubs (74-64) for the 2nd game of a 3-game series Tuesday. First pitch from Wrigley Field is at 7:40 p.m. ET (TBS). Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: Cubs lead 3-1

Cubs LHP Justin Steele is an NL Cy Young candidate and yesterday’s performance was one of his best this season. The left-hander dominated the San Francisco Giants with a career-high 12 K with just 2 H over 8 scoreless IP en route to a 5-0 Chicago victory.

The Giants RHP Logan Webb had a solid day on the mound as well, holding the Cubs to just 1 run until the 7th inning. Webb left after pitching 6 2/3 IP with 3 ER allowed on 5 H and 1 BB with 4 K.

Cubs RF Seiya Suzuki scored the game-winning run in the 2nd inning with a solo home run, and he batted in the final run of the game, a fielder’s choice in the 8th inning.

Giants at Cubs projected starters

RHP Ryan Walker vs. RHP Kyle Hendricks

Walker (4-2, 2.16 ERA) makes his 12th start and 39th appearance. He has a 1.24 WHIP, 2.7 BB/9 and 11.0 K/9 through 50 IP.

Last start: No-decision, 1 2/3 IP, 1 ER, 1 H, 2 BB, 3 K in 7-3 loss vs. Atlanta Braves on Aug. 26
2023 road stats: 2-1, 2.18 ERA (20 2/3 IP, 5 ER) in 2 starts and 13 relief appearances
Career vs. Cubs: 0-0, 2.45 ERA (3 2/3 IP, 1 ER) in 2 relief appearances

Hendricks (5-7, 3.59 ERA) makes his 20th start. He has a 1.13 WHIP, 1.6 BB/9 and 6.0 K/9 through 110 1/3 IP.

Last start: No decision, 6 IP, 0 ER, 4 H, 2 BB, 6 K in 3-2 win vs. Milwaukee Brewers Wednesday
2023 home stats: 2-4, 4.31 ERA (54 1/3 IP, 26 ER) in 10 starts
Career vs. Giants: 6-2, 2.03 ERA (71 IP, 16 ER) in 11 starts

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Giants at Cubs odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:34 a.m. ET.

Moneyline (ML): Giants +125 (bet $100 to win $125) | Cubs -150 (bet $150 to win $100)
Run line (RL)/Against the spread (ATS): Giants +1.5 (-150) | Cubs -1.5 (+125)
Over/Under (O/U): 10.5 (O: -105 | U: -115)

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Giants at Cubs picks and predictions

Prediction

Giants 4, Cubs 2

Moneyline

Walker most likely won’t be pitching long into this game as he usually throws a couple of innings and is pulled before facing the same batter twice. However, he’s been dominant during his short stints. In the past 28 days he has allowed just 1 ER across 10 2/3 IP through 4 starts and 6 relief appearances.

Once Walker gets pulled the Giants’ bullpen is not easy to score against. They collectively post a 3.73 ERA and a league-high 605 K.

Combine that with the Giants’ 20-11 record against the NL Central, I like the value of the underdog.

LEAN GIANTS (+125).

Run line/Against the spread

The Giants post a 23-17 record when they are road underdogs (a 57.5% hit rate), while the Cubs cover 46.7% of the time when they are home favorites.

The line is chalky but if you like the moneyline play and also want some insurance then BET GIANTS +1.5 (-150).

Over/Under

The Giants are one of the better Under teams this season. They have the 3rd best Under rate in MLB and after a loss (58.5%, 38-27-2).

The Cubs have recently trended toward the Under, cashing it in 7 of their last 8 games. The books see a high-scoring game, putting the line at 10.5, but I expect another low-scoring affair.

LEAN UNDER 10.5 (-115).

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San Francisco Giants at Chicago Cubs odds, picks and predictions

Analyzing Monday’s San Francisco Giants at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (70-67) and Chicago Cubs (73-64) open up a 3-game set at Wrigley Field Monday. First pitch is at 2:20 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: Cubs lead 2-1

The Giants enter this one on a 3-game skid after losing 3 of 4 at the San Diego Padres from Thursday to Sunday. San Francisco is just 8-12 and 12-18 over the last 20 and 30 games, respectively, and is in a 4-way tie for the final NL Wild Card spot.

The Cubs are securely in the 2nd NL Wild Card spot, 3 games up on those 4 teams tied for the final spot. They have gone 6-4, 12-8 and 19-11 over the last 10, 20 and 30 games, respectively. It has been a banner year for the Cubbies thus far, and they have arguably their best starter going Monday.

Giants at Cubs projected starters

RHP Logan Webb vs. LHP Justin Steele

Webb (9-11, 3.49 ERA) makes his 29th start. He has a 1.10 WHIP, 1.3 BB/9 and 8.4 K/9 in 180 1/3 innings.

Last start: Loss, 6 IP, 2 ER, 7 H, 0 BB, 6 K Wednesday against Cincinnati Reds
2 career starts vs. Cubs: 2-0, 4.85 ERA, 1.15 WHIP, 11 K in 13 IP

Steele (15-3, 2.69 ERA) makes his 26th start. He has a 1.17 WHIP, 1.9 BB/9 and 8.8 K/9 in 144 innings.

Last start: Win, 6 IP, 0 ER, 6 H, 1 BB, 8 K Tuesday against the Milwaukee Brewers
2 career starts vs. Giants: 0-2, 4.15 ERA, 2.08 WHIP, 10 K in 8 2/3 IP

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Giants at Cubs odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:34 a.m. ET.

Moneyline (ML): Giants +115 (bet $100 to win $115) | Cubs -140 (bet $140 to win $100)
Run line (RL)/Against the spread (ATS): Giants +1.5 (-165) | Cubs -1.5 (+135)
Over/Under (O/U): 9 (O: -105 | U: -115)

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Giants at Cubs picks and predictions

Prediction

Cubs 6, Giants 4

Moneyline

Steele hasn’t lost in his last 8 starts and is 11-2 with a 2.46 ERA at home this season. There is a lot to like on the Cubs’ side. The Giants have scored 3 runs or fewer in 6 of 10 games. After scoring 7 against the Padres Thursday, they plated just 4 runs the next 3 games.

Steele and the CUBS (-140) roll.

Run line/Against the spread

The Cubs are just 34-34 on the RL at home, and it’s too volatile to lean either way in this one.

PASS.

Over/Under

The wind will be a factor as it is blowing out to left-center at 11 mph. There are a lot of Under trends to use caution with, though. The Giants are 4-6 O/U over the last 10, and Chicago is 3-7 O/U during the same stretch. The Over is just 2-8 in the last 10 meetings. The wind blowing out at Wrigley changes things, though.

LEAN OVER 9 (-105).

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San Francisco Giants at Chicago Cubs odds, picks and prediction

Analyzing Friday’s San Francisco Giants at Chicago Cubs odds and lines, with MLB expert picks and predictions.

The San Francisco Giants (90-50) hold the best record in baseball entering their weekend series against the Chicago Cubs (65-76). The two teams will open up their three-game set Friday with a 2:20 p.m. ET first pitch at Wrigley Field. Let’s analyze the lines around the Giants vs. Cubs odds with MLB picks and predictions.

Giants RHP Dominic Leone (3-3, 1.55 ERA) makes his 45th appearance and second start. He has a 1.11 WHIP, 4.4 BB/9 and 8.4 K/9 through 40 2/3 IP.

Leone has recorded more than three outs just once all year, and that was back in June, so this sets up as a bullpen game where several relievers will be used.
Behind Leone’s shiny ERA are some marginal skills and good fortune. He boasts a 1/5 K/BB over his last six appearances and has benefited greatly this season from a .217 BABIP and 4.9% HR/FB rate.

Cubs RHP Kyle Hendricks (14-6, 4.65 ERA) makes his 29th start. He has a 1.36 WHIP, 2.1 BB/9 and 6.6 K/9 through 160 2/3 IP.

Hendricks got off to a rough start this season but got hot for an extended stretch and his ERA sat at 3.68 just a month ago. He has been hit hard in five starts since though, allowing 28 ER and 7 HR across 26 IP.
Has put up a 5.56 ERA and 6.7 K/9 while allowing 17 HR in 81 IP (1.9 HR/9) through 15 home starts.

Giants at Cubs odds, lines, picks and prediction

MLB odds provided by Tipico Sportsbook; access USA TODAY Sports for a full list. Odds last updated at 12:30 p.m. ET.

Money line: Giants -155 (bet $155 to win $100) | Cubs +125 (bet $100 to win $125)
Against the spread/ATS: Giants -1.5 (+102) | Cubs +1.5 (-125)
Over/Under: 9.5 (O: -107 | U: -115)

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Prediction

Giants 6, Cubs 5

Money line (ML)

Both teams are playing well heading into this game. The Cubs have won eight of their last nine games, while the Giants have won four in a row and sport the league’s second-best road record at 45-27.

Hendricks is striking batters out at a career-low rate and has been pitching very poorly lately. It’s tough to have much confidence in him and he’s probably one to bet against until we see a rebound performance.

A small play on GIANTS (-155) looks like the side to take.

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Run line/Against the spread (ATS)

The San Francisco offense should put some runs on the board against Hendricks, who has had some blowups lately. However, the Cubs aren’t likely to be shut down by Leone and company, either.

Odds are this one stays pretty close throughout, so the call here is to PASS on the run line.

Over/Under (O/U)

The Giants are fourth in runs per game on the road and are facing a pitcher that is going through a very rough stretch. On the other side, the Cubs have scored 78 runs over their last 13 games (6.0 per game) and will square off against a host of relievers working an inning or two throughout the game.

Look for enough runs to push this total OVER 9.5 (-107)

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