San Francisco Giants at Arizona Diamondbacks odds, picks and predictions

Analyzing Wednesday’s San Francisco Giants at Arizona Diamondbacks odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (79-79) and Arizona Diamondbacks (87-71) close out their 3-game series and their season series Wednesday. First pitch from Chase Field is at 9:40 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s MLB odds around the Giants vs. Diamondbacks odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 6-6

The Giants have won the 1st 2 games of the series (6-3 and 11-0) and have a 5-game winning streak. They shut out Arizona on Tuesday night behind starter Logan Webb. (6 IP, 0 ER, 4 H, 1 BB, 4 K).

The Diamondbacks have lost 3 in a row and hold a half-game lead over the Atlanta Braves for the final NL Wild Card berth. They are tied in the loss column with them. They are a half-game behind the New York Mets for the 2nd Wild Card spot.

Giants at Diamondbacks projected starters

RHP Mason Black vs. RHP Zac Gallen

Black (1-4, 5.88 ERA) makes his 8th start and 9th career appearance. He has a 1.52 WHIP, 2.7 BB/9 and 7.5 K/9 in 33 2/3 IP.

  • Last start: Win, 5 2/3 IP, 0 R, 4 H, 1 BB, 4 K in 2-1 road win over Kansas City Royals Friday
  • Facing Arizona for 1st time

Gallen (13-6, 3.74 ERA) makes his 28th start. He has a 1.29 WHIP, 3.3 BB/9 and 9.2 K/9 in 142 IP.

  • Last start: Win, 5 IP, 4 ER, 7 H, 1 BB, 5 K in 7-4 road win over Milwaukee Brewers Friday
  • Is 3-0 with 3.00 ERA in 4 September starts
  • Vs. the Giants: Is 1-1 with 4.09 ERA in 2 starts in 2024 and 5-5 with 4.15 ERA in 15 career starts

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Giants at Diamondbacks odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of MLB odds. Lines last updated at 9:21 a.m. ET.

  • Moneyline (ML): Giants +185 (bet $100 to win $185) | Diamondbacks -225 (bet $225 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-110) |Diamondbacks -1.5 (-110)
  • Over/Under (O/U): 8.5 (O: -110 | U: -110)

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Giants at Diamondbacks picks and predictions

Prediction

Diamondbacks 7, Giants 3

Moneyline

The Diamondbacks have not been swept in a series at home yet this season. And while the Giants are 7-1 on their current road trip, Black has allowed 4 or more runs in 4 of his 8 appearances this season.

Arizona has won Gallen’s last 4 starts and should win, but don’t bet the moneyline at -225

PASS.

Run line/Against the spread

Sixteen of the Diamondbacks’ last 18 wins have been by 2 or more runs. Five of the last 6 wins by Arizona when Gallen pitches have been by 2 or more runs. Five of their 6 wins over the Giants this season have been by 2 or more runs.

BET DIAMONDBACKS -1.5 (-110).

Over/Under

Eight of their 12 meetings this season have had totals of more than 8 runs and 6 of the Diamondbacks’ last 8 games have had 9 or more total runs.

BET OVER 8.5 (-110).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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San Francisco Giants at Arizona Diamondbacks odds, picks and predictions

Analyzing Wednesday’s San Francisco Giants at Arizona Diamondbacks odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (76-75) wrap up a 2-game road series against the Arizona Diamondbacks (80-72) Wednesday. First pitch from Chase Field is at 3:40 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Diamondbacks odds and make our expert MLB picks and predictions for the best bets.

Season series: tied 6-6

The Giants lost the opener 8-4 Tuesday despite scoring 2 runs in the top of the 1st inning. They have lost 4 of their last 5 games and are 6-11 in their last 17, falling 3 games behind the final NL Wild Card spot.

The Diamondbacks have won 4 in a row. They are currently the No. 2 NL Wild Card, half a game up on the Chicago Cubs and 3 games behind the Philadelphia Phillies for the top NL Wild Card.

Giants at Diamondbacks projected starters

RHP Logan Webb vs. RHP Merrill Kelly

Webb (10-12, 3.31 ERA) makes his 32nd start. He has a 1.06 WHIP, 1.3 BB/9 and 8.2 K/9 through 201 IP.

  • Last start: No-decision, 8 IP, 1 ER, 4 H, 0 BB, 6 K in 3-2 road loss vs. Colorado Rockies Friday
  • 2-0 with 2.57 ERA in 3 starts vs. Arizona this season

Kelly (11-7, 3.45 ERA) makes his 28th start. He has a 1.21 WHIP, 3.5 BB/9 and 9.7 K/9 through 159 IP.

  • Last start: Loss, 5 IP, 7 ER, 6 H, 4 BB, 7 K in 11-1 road loss vs. New York Mets Thursday
  • 6-5 with 3.48 ERA and 1.20 WHIP in 17 career starts vs. Giants

Play our free daily Pick’em Challenge and win! Play now!

Giants at Diamondbacks odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:27 a.m. ET.

  • Moneyline (ML): Giants -115 (bet $115 to win $100) | Diamondbacks -105 (bet $105 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants -1.5 (+150) | Diamondbacks +1.5 (-185)
  • Over/Under (O/U): 7.5 (O: -120 | U: +100)

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Giants at Diamondbacks picks and predictions

Prediction

Diamondbacks 4, Giants 2

Moneyline

Kelly has 2 bad starts (7 ER allowed in each) in his last 11 turns, but he allowed 2 ER or fewer 7 times along that span. The Diamondbacks are 4-2 in his last 6 outings.

The Giants have lost 5 of Webb’s last 6 starts and have lost 10 of their last 11 road games overall.

BET DIAMONDBACKS (-105).

Run line/Against the spread

The Giants have not covered the spread in their last 8 games and are 2-15 ATS in their last 17.

The Diamondbacks are 4-0 ATS in their last 4 games. Three of their last 4 wins have been by 2 or more runs and 4 of their 6 wins over the Giants have been by 2 or more runs, so while betting them at +1.5 isn’t profitable, you might consider a small wager on an alternate line of DIAMONDBACKS -1.5 (+185).

Over/Under

Four of Webb’s last 5 and 7 of his last 9 starts have not reached 8 total runs.

Half of the 12 games between the 2 teams have stayed under 8 total runs.

BET UNDER 7.5 (+100).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Jess Root on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

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