San Francisco 49ers vs. Tennessee Titans odds lines money line against the spread Over Under

Thursday Night Football prop bets and picks: The streaking 49ers meet the sinking Titans

The Titans are spiraling. The 49ers are surging.

The San Francisco 49ers are the NFC’s hottest team.

Once 2-4 and left for dead in the ultra-competitive NFC West, Kyle Shanahan has boosted himself off a potential head coaching hot seat and piloted his team into the thick of the playoff race. The Niners are a major player in the Wild Card hunt and still have an outside shot at a division title. Though their dream of hosting a playoff game in the Santa Clara stadium no one seems to enjoy is a longshot, San Francisco has the chops to ruin someone else’s January on the road.

The Tennessee Titans are moving in the opposite direction. They won their first two games after losing All-World running back Derrick Henry to a foot injury, but have fallen back to earth in a 1-3 stretch since. Tennessee held the Steelers to 168 total yards last Sunday and still managed to blow a 13-3 lead thanks to four turnovers and a passing offense devoid of reliable talent without AJ Brown or Julio Jones in the lineup (and, if we’re being honest, sometimes with Jones *in* the lineup, too).

The Titans can stop that spiral in a primetime game that once looked like a penciled-in “W” but now has the Niners as a 3.5-point road favorite. Can Tennessee get its ducks in a row in time to fend off the Colts’ push for an AFC South title? Or is Nashville just the next stop for Shanahan’s hype train to the postseason?

Let’s talk about it. All odds via Tipico.

San Francisco 49ers at Tennessee Titans odds, picks and prediction

Analyzing Thursday’s San Francisco 49ers at Tennessee Titans odds and lines, with expert NFL picks, predictions and best bets.

The San Francisco 49ers (8-6) travel to meet the Tennessee Titans (9-5) for Thursday Night Football in Week 16 at Nissan Stadium in Nashville. Kickoff is scheduled for 8:20 p.m. ET. Below, we look at the 49ers vs. Titans odds and lines, and make our best NFL picks, predictions and bets.

The 49ers are coming off a convincing 31-13 victory against the Atlanta Falcons in Week 15. San Francisco has scored 23 or more points in each of the past six games, while going 5-1 SU/ATS.

The Titans suffered a disappointing 19-13 loss at Pittsburgh in Week 15, and they’re now 1-3 SU/ATS across the past four outings while hitting the Under in three of the games. The offense is averaging just 14.8 PPG across the past four contests. However, they should be getting their top receiver, A.J. Brown, back from injury.

49ers at Titans odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:30 a.m. ET.

Money line: 49ers -170 (bet $170 to win $100) | Titans +135 (bet $100 to win $135)
Against the spread (ATS): 49ers -3.5 (+102) | Titans +3.5 (-125)
Over/Under (O/U): 43.5 (O: -117 | U: -103)

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

49ers at Titans key injuries

49ers

RB Dre Greenlaw (groin) questionable
RB Elijah Mitchell (knee) questionable
LB Azeez Al-Shaair (elbow) questionable
S Jaquiski Tartt (ankle) questionable

Titans

RB D’Onta Foreman (ankle) questionable
WR Julio Jones (hamstring) questionable
OT Taylor Lewan (back) questionable

Let’s Make This Interesting

Place your legal sports bets online in New Jersey and Colorado with Tipico Sportsbook, a trusted, global sports-betting leader. Iowa, get ready, Tipico is coming to your state soon! New customer offer: Deposit $10 or more, get $100 in instant bet credits! 21+, see Tipico.com for Terms and Conditions. Bet now!

49ers at Titans odds, lines, predictions and picks

Prediction

49ers 24, Titans 21

Money line

The 49ERS (-170) are just slightly more than I care to wager on a money line team, but if you want to avoid laying the three and a hook, the price isn’t terribly out of line. The Titans (+135) are banged up, but they’re at home, and it’s going to be a close game.

Against the spread

The TITANS +3.5 (-125) are worth a look catching three and a hook at home. Tennessee has posted a 5-2 ATS mark in the past seven games as an underdog, and the Titans have won three straight games overall against NFC teams.

Over/Under

The slight lean is to OVER 43.5 (-117), but it’s going to be close. San Francisco has scored 23 or more points in five consecutive outings, but Tennessee has really struggled lately. The Titans have 20 or fewer points on offense in four straight, while allowing just 17.3 PPG across the past six.

Also see: All Week 16 odds and lines

Bet legally online with a trusted partner: Tipico Sportsbook, Sportsbook Wire’s official sportsbook partner in CO, NJ and, soon, IA. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

Follow Kevin J. Erickson on Twitter and SportsbookWire on Twitter and like us on Facebook.

Access more NFL coverage:

Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]

First look: Tennessee Titans at San Francisco 49ers odds and lines

Looking at Thursday’s Tennessee Titans at San Francisco 49ers Week 16 NFL odds, lines and trends. Here’s what you need to know.

The Tennessee Titans (9-5) host the San Francisco 49ers (8-6) Thursday for their Week 16 showdown at Nissan Stadium with the kickoff scheduled for 8:20 p.m. ET. Below, we look at the 49ers vs. Titans odds and lines; check back for our NFL picks and predictions.

San Francisco bullied the Atlanta Falcons in a 31-13 victory at home in Week 15, easily covering as a 9.5-point favorite. The 49ers gained 10 more first downs, 122 more total yards and held the Falcons to 1-for-5 on red-zone trips.

San Francisco’s ground game accumulated 162 rushing yards on 32 attempts with RB Jeff Wilson Jr.‘s 110 yards leading the group.

Tennessee gave up 16 unanswered, second-half points in its 19-13 loss to the Pittsburgh Steelers in Week 15. The Titans had nearly double the total yards (318-168) and double the time of possession (39:08-20:52) but sunk due to their minus-4 turnover differential.

Also see: All Week 16 odds and lines

49ers at Titans odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 10:55 a.m. ET.

Money line: 49ers -180 (bet $180 to win $100) | Titans +145 (bet $100 to win $145)
Against the spread (ATS): 49ers -3.5, -103 (bet $103 to win $100) | Titans +3.5, -117 (bet $117 to win $100)
Over/Under (O/U): 44.5, O: -110 (bet $110 to win $100) | U: -110 (bet $110 to win $100)

Also see: Betting 101

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

2021 betting records:

ML: 49ers 8-6 | Titans 9-5
ATS: 49ers 7-7 | Titans 8-6
O/U: 49ers 7-7 | Titans 7-7

49ers at Titans head-to-head

This will be the first meeting between these two teams since the Titans hired head coach Mike Vrabel in 2018. San Francisco beat Tennessee 25-23 at home in Niners head coach Kyle Shanahan’s first year on the job (2017).

Since 2018, the Titans are 7-5 ATS as home underdogs, 9-7 ATS vs. NFC teams, 12-9-1 ATS after a loss and 2-1 overall (2-1 ATS) on Thursdays.

In the Shanahan era, the 49ers are 8-7 ATS as road favorites, 12-8 ATS vs. NFC teams, 20-17 ATS following a win and 2-2 overall (2-2 ATS) on Thursdays.

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

Follow Geoff Clark on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

Access more NFL coverage:

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]