San Francisco 49ers vs. Seattle Seahawks odds predictions pick betting line spread

The San Francisco 49ers (6-5) are on the road against the Seattle Seahawks (3-8) in Week 13 for a classic NFC West rivalry game. Kickoff is 4:25 p.m. ET at Lumen Field. Below, we look at the 49ers vs. Seahawks odds and lines, and make our best NFL picks, predictions and bets.

The 49ers have won three games in a row and four of their last five. They have scored 30 or more points while averaging 170 rushing yards across the four victories. Their one hiccup in the last five was a 31-17 loss to the Cardinals where they only mustered 39 rushing yards.

The Seahawks are a mess. They have lost three in a row and six of their last seven games. Since QB Russell Wilson returned from injured reserve they have scored a total of 28 points combined in three games. Wilson still has not won a home game this season.

49ers at Seahawks odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 8:30 p.m. ET.

Money line: 49ers -175 (bet $175 to win $100) | Seahawks +140 (bet $100 to win $140)
Against the spread (ATS): 49ers -3.5 (+100) | Seahawks +3.5 (-120)
Over/Under (O/U): 45.5 (O: -108 | U: -112)

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49ers at Seahawks key injuries

49ers

LB Dre Greenlaw (groin) out
WR Deebo Samuel (groin) out
RB Trey Sermon (ankle) out
LB Fred Warner (hamstring) doubtful
LB Marcell Harris (concussion) questionable

Seahawks

G Damien Lewis (elbow) doubtful
RB Rashaad Penny (hamstring) questionable
RB Alex Collins (abdomen) questionable
RB Travis Homer (calf) questionable

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49ers at Seahawks odds, lines, predictions and picks

Prediction

Seahawks 24, 49ers 23

Money line

Wilson’s finger injury was supposed to take four to eight weeks to recover and we enter the seventh week since he suffered the injury. It’s been clear that he’s not been 100% in the three games since he’s returned.

However, even with the struggles at home this season, the Seahawks beat the 49ers once this season and have done so 14 of the last 16 times they have played each other.

Rivalry games are always weird. With Samuel out and their linebackers banged up, this is the perfect week for an upset.

Take the SEAHAWKS (+140).

Against the spread

The Seahawks are 5-6 ATS this season but have failed to cover the spread in the three games since Wilson’s return.

The 49ers started the year 1-5 ATS but are 4-1 ATS in their last five games.

However, expecting the outright Seattle win, take the SEAHAWKS +3.5 (-120).

Over/Under

The Seahawks have only had one game this season hit the Over, an overtime game in Week 2.

The 49ers have had four of their last six games go Over the projected total.

This is the game the Seahawks come alive a little.

Take OVER 45.5 (-108).

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We were 1-2 here last week in Underdog Corner, hitting on the Miami Dolphins and coming up short with the Indianapolis Colts and Minnesota Vikings.
It was only our third losing week of the season, though, as our against-the-spread record stands at 25-11 (.694). A full 21 of those 25 underdog ATS winners have won outright as well.
That established, it’s on to our three selections for lucky Week 13.

NFL underdog predictions: Week 13

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 4:30 p.m. ET.

New Orleans Saints +4.5 (-110) vs. Dallas Cowboys

The Cowboys still have a two-game lead atop the NFC East but have dropped three of their last four contests and continue to battle COVID issues with head coach Mike McCarthy out for this Thursday night road game.

The struggle also is real for the Saints, who have lost four straight since a Halloween upset of the defending-champion Tampa Bay Buccaneers. But New Orleans’ health fortunes finally appear to be on the upswing with Taysom Hill set to take the reins at quarterback, and stud RB Alvin Kamara likely to play for the first time since Week 9.

Additionally, New Orleans has been one of the league’s best with 12-4 ATS/11-5 SU records as an underdog since 2018, so we’re banking on the SAINTS (+4.5) to keep it close in the Week 13 opener.

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Los Angeles Chargers +3.5 (-120) at Cincinnati Bengals

The Bengals have put together back-to-back double-digit wins to move to 7-4. But their other two-game win streaks this season have been followed by losses, and we could easily see that happening again with the whole city still celebrating the Bengals’ first season sweep of the hated Pittsburgh Steelers since 2009.

The up-and-down Chargers, meanwhile, were stymied in a 28-13 road loss to the Denver Broncos on Sunday to fall to 6-5.

The Bolts, though, have performed better as underdog (6-4 ATS) than favorite (7-9) over the last two seasons, so we’ll take CHARGERS (+3.5) catching the field goal-and-the-hook Sunday.

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Seattle Seahawks +3.5 (-120) vs. San Francisco 49ers

These are two NFC West rivals trending in completely different directions with the Niners having won and covered in four of their last five while the 3-8 Seahawks have dropped six of seven since beating the host 49ers 28-21 in Week 4.

But we’re banking on one last stand from Russell Wilson and Co., who have won 13 of the last 15 meetings (10-5 ATS) against San Francisco, who will be without injured do-it-all WR Deebo Samuel in this one.

Take the SEAHAWKS (+3.5) and the points at home.

Also see: All Week 13 odds and lines

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

Follow @kenpomp on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

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