[gambcom-standard rankid=”4141″ ]
The San Francisco 49ers (5-6) try to salvage their season against the Buffalo Bills (9-2) on Sunday Night Football. Kickoff from Highmark Stadium is set for 8:20 p.m. ET (NBC). Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Bills odds, and make our expert NFL picks and predictions.
The Niners’ season is on life support in the basement of the NFC West. The good news is they’re just 1 win under the division-leading Seattle Seahawks. The bad news is they have to leapfrog 3 teams to take the West crown. The 49ers have lost 2 straight after a 38-10 defeat in the Frozen Tundra of Green Bay last week. QB Brandon Allen threw for 199 yards, 1 TD and 1 INT. QB Brock Purdy (shoulder) is expected back for this one.
The Bills exit their bye week after outclassing the Kansas City Chiefs 30-21. QB Josh Allen went 27-for-40 for 262 yards, 1 TD and 1 INT, but his 26-yard rushing touchdown was the eventual game-winner. RB James Cook amassed just 20 yards on 9 carries, but 2 of those ended in the end zone. Buffalo has won 6 straight.
Play our free daily Pick’em Challenge and win! Play now!
49ers at Bills odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 2:40 p.m. ET.
- Moneyline (ML): 49ers +225 (bet $100 to win $225) | Bills -275 (bet $275 to win $100)
- Against the spread (ATS): 49ers +6 (-110) | Bills -6 (-105)
- Over/Under (O/U): 44.5 (O: -110 | U: -110)
WIN YOUR FANTASY FOOTBALL LEAGUE!
The Huddle has been turning players like you into winners for over 25 years. This season, it’s your turn. Custom fantasy football rankings, sleepers and tools are just a click away. Save 25% off the Internet’s best-kept secret. Subscribe now!
[gambcom-standard rankid=”4132″ ]
49ers at Bills key injuries
49ers
- DE Nick Bosa (hip, oblique) out
- CB Deommodore Lenoir (knee) out
- QB Brock Purdy (shoulder) probable
- OT Trent Williams (knee) out
Bills
- WR Keon Coleman (wrist) questionable
- TE Dalton Kincaid (knee) out
- LB Matt Milano (biceps) questionable
FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+
49ers at Bills picks and predictions
Prediction
49ers 20, Bills 17
Moneyline
This game is going to be ugly in the best kind of way. Heavy snowfall is expected with strong winds and a gametime temperature of 27 degrees. The Bills have run away with the AFC East, and this one means so much more to San Francisco than Allen and Co. The absence of Kincaid, who is great on underneath and short-yardage routes is also key.
Yes, the Niners are a warm-weather team. Purdy played 4 years at Iowa State, which is susceptible to cold temps. Purdy, RB Christian McCaffrey and TE George Kittle can’t be counted out here. In a battle of fortitude, the Niners need it more. I’m taking my shot on 49ERS +225.
Against the spread
If you aren’t completely on board with my bold prediction, I still think 49ERS +6 (-110) is a good bet. The conditions will keep the ball out of the air for the most part. San Francisco’s backs, particularly Jordan Mason, match up well with Buffalo’s.
Over/Under
This is an Under game. With the forecast, I’m really surprised the total hasn’t slipped below 40. Heavy snow, cold temps and wind make for an UNDER 44.5 (-110) cash.
[gambcom-standard rankid=”6305″ ]
Want to play some games of your own? Play for free at the best social casinos and enjoy lots of slots, blackjack, video poker, roulette and more. You can even earn real prizes!
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.
Follow Ryan Dodson on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.
Access more NFL coverage:
BetFTW | TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWire | TitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire
[lawrence-newsletter]
[lawrence-auto-related count=3 category=1367]