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The San Diego Padres (15-18) host the Cincinnati Reds (16-14) for the finale of a 3-game series at Petco Park Wednesday. First pitch is set for 4:10 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Reds vs. Padres odds and make our expert MLB picks and predictions for the best bets.
Season series: Tied 1-1
San Diego lost Monday’s series opener 5-2 as a -109 pick ’em, but rebounded Tuesday with a 6-4 win as a -164 favorite, which snapped a 5-game skid. The 1st game cashed the Under (8), while Game 2 hit the Over (7).
The Padres are just 7-11 at home this season and have lost 4 of their last 5 at Petco. San Diego is 15-18 against the spread (ATS).
The Reds have been among the most fickle teams in the MLB, having traded off winning and losing in their last 5 games, going 2-3 straight up (SU). They 7-7 SU on the road and 17-13 ATS overall.
Reds at Padres projected starters
RHP Graham Ashcraft vs. RHP Joe Musgrove
Ashcraft (3-1, 4.40 ERA) makes his 6th start. He has a 1.29 WHIP, 2.2 BB/9 and 8.2 K/9 through 28 2/3 innings.
- Last start: No-decision, 6 1/3 IP, 1 ER, 7 H, 0 BB, 3 K in 2-1 loss at Texas Rangers Friday
- Reds are 3-2 in his 5 starts
- 2024 road splits: 1-1, 2.00 ERA (18 IP, 4 ER), 16 H, 3 HR, 3 BB, 16 K in 3 starts
- Career vs. Padres: 0-0, 1.42 ERA (12 2/3 IP, 2 ER), 0.95 WHIP, 10 K in 2 starts last season
Musgrove (3-3, 6.94 ERA) makes his 8th start. He has a 1.66 WHIP, 3.3 BB/9 and 6.9 K/9 through 35 innings.
- Last start: Loss, 3 2/3 IP, 7 ER, 8 H, 2 BB, 4 K in 9-3 home defeat to the Philadelphia Phillies Friday
- Padres are 4-3 in his 7 starts
- 2024 home splits: 2-3, 6.49 ERA (26 1/3 IP, 19 ER), 31 H, 8 HR, 7 BB, 22 K in 5 starts
- Career vs. Reds: 6-2, 3.83 ERA (54 IP, 23 ER), 1.06 WHIP, 8.5 K/9 in 10 outings (9 starts), including 3-0 in last 4 starts
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Reds at Padres odds
Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:39 a.m. ET.
- Moneyline (ML): Reds +116 (bet $100 to win $116) | Padres -136 (bet $136 to win $100)
- Run line (RL)/Against the spread: Reds +1.5 (-188) | Padres -1.5 (+155)
- Over/Under (O/U): 8 (O: -112 | U: -108)
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Reds at Padres picks and predictions
Prediction
Reds 5, Padres 4
Moneyline
BET REDS (+116).
The Reds haven’t put together many long stretches of wins or losses this season, and they are 9-4 SU following a loss, which they are coming off of Tuesday.
Ashcraft has also been far better on the road than at home while the opposite can be said for Musgrove, who is coming off one of his worst starts of the season.
The Padres are just 7-8 SU as home favorites this season. Couple their struggling pitcher with how disappointing they’ve been at home, and the Padres are worth fading. Back REDS (+116).
Run line/Against the spread
PASS.
The Reds +1.5 (-188) are far too expensive as run-line underdogs, while Musgrove and the Padres -1.5 (+155), who haven’t rewarded bettors at home, aren’t worth a play as favorites. AVOID a run-line play.
Over/Under
LEAN OVER 8 (-112).
The Reds are 16-13-1 O/U on the season and have gone Over in 2 of their last 4, scoring at least 4 runs in 3 of their last 4. The Reds are 4-1 O/U in Ashcraft’s 5 starts.
The Padres are 17-15-1 O/U on the season and have allowed at least 8 runs in 3 of their last 6 games, going 4-2 O/U in that span. They are 5-2 O/U in Musgrove’s 7 starts.
Considering those trends, back OVER 8 (-112).
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