Boston Red Sox at Chicago White Sox odds, picks and predictions

Analyzing Friday’s Boston Red Sox at Chicago White Sox odds and lines, with MLB expert picks, predictions and best bets.

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The Chicago White Sox (15-48) welcome the Boston Red Sox (32-31) to Guaranteed Rate Field Friday for the 2nd game of their 4-game series. First pitch is set for 8:10 p.m. ET (MLB Network). Let’s analyze FanDuel Sportsbook’s lines around the Red Sox vs. White Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: Red Sox lead 1-0

The White Sox have lost 14 straight games with just 3 of those coming by 1 run and 8 of them coming at home. Chicago dropped the 1st game of the series 14-2 Thursday. Boston used two 4-run innings to jump ahead and never looked back. The White Sox are 26-37 against the spread (ATS) on the season and sit 5th in the AL Central.

The Red Sox, who are 18-13 on the road this season, have won 2 straight, splitting a series with the Atlanta Braves prior to their Thursday win. Boston has won 4 of its last 6. Despite an above-.500 record, the Red Sox sit 3rd in the AL East and are just 28-35 ATS on the season.

Red Sox at White Sox projected starters

RHP Cooper Criswell vs. LHP Garrett Crochet

Criswell (3-2, 3.92 ERA) makes his 10th start. The rookie has a 1.19 WHIP, 2.1 BB/9 and 8.5 K/9 in 43 2/3 IP.

  • Last start: Win, 5 IP, 1 ER, 4 H, 1 BB, 5 K in 6-3 home victory over Detroit Tigers Saturday
  • 2024 road splits: 1-1, 4.82 ERA (18 2/3 IP, 10 ER), 1.29 WHIP, 1 HR, 7.7 K/9 in 4 starts
  • Career vs. White Sox: 0-0, 3.38 ERA (2 2/3 IP, 1 ER), 3 H, 2 BB, 3 K in 1 relief appearance of 8-7 home victory with Tampa Bay Rays April 21, 2023

Crochet (5-5, 3.49 ERA) makes his 14th start. He has a 0.93 WHIP, 1.9 BB/9 and 12.0 K/9 in 69 2/3 IP.

  • Last start: No-decision, 6 IP, 1 ER, 5 H, 1 BB, 8 K in 4-3 road loss in 10 innings to Milwaukee Brewers Saturday
  • 2024 home splits: 3-3, 2.50 ERA (39 2/3 IP, 11 ER), 0.86 WHIP, 3 HR, 13.8 K/9 in 5 starts
  • Career vs. Red Sox: 0-1, 3.00 ERA (3 IP, 1 ER), 2.00 WHIP, 12.0 K/9 in 4 relief appearances

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Red Sox at White Sox odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:03 a.m. ET.

  • Moneyline (ML): Red Sox -110 (bet $110 to win $100) | White Sox -106 (bet $106 to win $100)
  • Run line (RL)/Against the spread (ATS): Red Sox -1.5 (+142) | White Sox +1.5 (-172)
  • Over/Under (O/U): 7.5 (O: -118 | U: -104)

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Red Sox at White Sox picks and predictions

Prediction

White Sox 5, Red Sox 4

Moneyline

BET WHITE SOX (-106).

The White Sox have lost 14 straight, so the books making this the moneyline odds is alarming.

However, it is because of Crochet’s play. The White Sox are 5-8 when he takes the mound, but he has gone at least 5 innings and allowed 2 or fewer earned runs in 7 straight games. The White Sox are 4-2 in his last 6 starts. Chicago has scored 14 runs in its last 3 games.

Meanwhile, the Red Sox have allowed 23 runs in Criswell’s last 4 starts and have lost 4 of their last 8 games. Boston is just 7-8 over its last 15 road games.

The White Sox have their bats heating up with a strong option on the mound. Expect them to snap their losing streak, and bet WHITE SOX (-106).

Run line/Against the spread

PASS.

There’s no great option on the run line. The White Sox are far too expensive as run-line underdogs. A bettor would pay almost twice the potential return for a team that’s struggled over the last few weeks.

On the flip side, the Red Sox are too risky as run-line favorites given Crochet’s strong play as of late. Ultimately, avoid a run-line play.

Over/Under

BET OVER 7.5 (-118).

The White Sox have gone Over in 4 straight games and are 5-0-1 O/U in their last 6. Chicago has scored at least 3 runs in 5 of its last 6 games and at least 5 in 3 of its last 6.

The Red Sox have gone north of the total in 5 of their last 6 games as well and allowed at least 8 runs in 2 of their last 4. Boston has been solid offensively, scoring at least 6 runs in 4 of its last 6 games.

Considering the trends for both sides, back OVER 7.5 (-118).

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Boston Red Sox at Chicago White Sox odds, picks and predictions

Analyzing Thursday’s Boston Red Sox at Chicago White Sox odds and lines, with MLB expert picks, predictions and best bets.

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The Boston Red Sox (31-31) and Chicago White Sox (15-47) open up a 4-game series Thursday. First pitch from Guaranteed Rate Field is scheduled for 8:10 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Red Sox vs. White Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: 1st meeting; White Sox won 4-2 in 2023

The Red Sox are just 5-7 in their last 12 games, although they were able to split a 2-game set against the visiting Atlanta Braves recently. Boston was victorious 9-0 Wednesday afternoon as a -110 favorite. SP Nick Pivetta allowed only 1 hit in 7 innings with 9 strikeouts, while 3B Rafael Devers drove in 3 with 2 HRs and CF Jarren Duran tripled and homered.

The White Sox lost to the crosstown rival Cubs by a score of 7-6 both Tuesday and Wednesday, making it 13 straight losses for the Windy City’s AL club. The White Sox own the worst record in MLB, and manager Pedro Grifol’s time as manager may be running out according to Ken Rosenthal of The Athletic.

Red Sox at White Sox projected starters

RHP Tanner Houck vs. RHP Jake Woodford

Houck (5-5, 1.85 ERA) makes his 13th start. He has a 0.96 WHIP, 1.7 BB/9 and 8.7 K/9 in 78 innings.

  • Last start: Win, 7 IP, 1 ER, 3 H, 2 BB, 6 K in 7-3 home victory vs. Detroit Tigers Friday
  • Has allowed only 1 HR this season; HR/9 (0.12) and HR/FB % (2.0%) are lowest in MLB
  • Career vs. White Sox: 0-3, 5.93 ERA (13 2/3 IP, 9 ER), 1.68 WHIP, 5.3 K/9 in 4 games (3 starts)

Woodford (0-1, 6.23 ERA) makes his 2nd start. He has a 1.62 WHIP, 4.2 BB/9 and 8.3 K/9 in 4 1/3 innings.

  • Last start: Loss, 4 1/3 IP, 3 ER, 5 H, 2 BB, 4 K in 7-2 home setback vs. Toronto Blue Jays May 28.
  • Triple-A Charlotte stats: 1-3, 5.26 ERA (49 2/3 IP, 29 ER), 1.39 WHIP, 3.1 BB/9, 7.6 K/9 in 10 starts

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Red Sox at White Sox odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 3:27 p.m. ET.

  • Moneyline (ML): Red Sox -235 (bet $235 to win $160) | White Sox +194 (bet $100 to win $194)
  • Run line (RL)/Against the spread (ATS): Red Sox -1.5 (-146) | White Sox +1.5 (+122)
  • Over/Under (O/U): 8.5 (O: -122 | U: +100)

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Red Sox at White Sox picks and predictions

Prediction

Red Sox 5, White Sox 3

Moneyline

PASS.

Way too much juice to lay with Boston (-235) on its own, although you can always consider it in a parlay. I would rather take a shot on the White Sox ML Friday with SP Garrett Crochet taking the bump against a Red Sox lineup that leads MLB in K% vs. LHP.

Run line/Against the spread

BET RED SOX -1.5 (-146).

The White Sox have lost 17 of their last 18 games and closer RP Michael Kopech described their situation as “not fun.” — surprise, surprise.

Neither is the idea of backing the White Sox, even getting a run and a half. Devers enters Thursday action ranked in the top 8 in the AL in homers (13 — 8th) and OBP (.380 — 6th).

The Red Sox have a clear advantage in both the hitting and pitching departments and they should win by multiple runs. Plus, RF Tyler O’Neill just returned Wednesday from a 10-day IL stint for knee inflammation.

Over/Under

BET UNDER 8.5 (+100).

Over the last month, both teams are in the bottom 6 in terms of walk percentage (White Sox 7.0%, Red Sox 7.1%), plus Houck has issued only 4 free passes over his last 20 innings. DH Eloy Jimenez is still out for Chicago and 1B Andrew Vaughn is hitting .211, so I would not expect this White Sox lineup to do much damage.

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Boston Red Sox at Chicago White Sox odds, picks and predictions

Analyzing Friday’s Boston Red Sox at Chicago White Sox odds and lines, with MLB expert picks, predictions and best bets.

The Boston Red Sox (39-37) and Chicago White Sox (32-44) meet Friday for the opener of a 3-game series. First pitch from Guaranteed Rate Field is set for 8:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Red Sox vs. White Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting of 2023; Chicago won 4-2 last season

Boston lost 6-0 Thursday as a +122 road underdog vs. the Minnesota Twins. The Red Sox dropped back-to-back games on Wednesday and Thursday to split the 4 game series. Boston won 6 straight games from June 14-20, including the first 2 road games at Minnesota, and now sits at 18-19 on the road this season.

The White Sox lost 6-3 as -108 home favorites Wednesday vs. the Texas Rangers, losing the series 2-1. Chicago is 3-7 in its last 10 contests and has lost 4 of its last 5 games to fall to 18-19 at home on the season.

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Red Sox at White Sox projected starters

RHP Brayan Bello vs. RHP Lucas Giolito

Bello (4-4, 3.49 ERA) makes his 12th start. He has a 1.30 WHIP, 3.0 BB/9 and 8.6 K/9 through 59 1/3 IP.

  • Last outing: Win, 7 IP, 1 ER, 4 H, 3 BB, 8 K in a 6-2 home win Sunday vs. New York Yankees
  • First career start vs. Chicago

Giolito (5-4, 3.54 ERA) makes his 16th start. He has a 1.24 WHIP, 2.9 BB/9 and 9.3 K/9 through 86 1/3 IP.

  • Last outing: No-decision, 5 IP, 2 ER, 8 H, 3 BB, 5 K in a 4-3 road win Saturday vs. Seattle Mariners
  • Career vs. Boston: 1-1, 5.63 ERA (24 IP, 15 ER), 28 H, 14 BB, 29 K across 5 starts

Red Sox at White Sox odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 5:40 a.m. ET.

  • Moneyline (ML): Red Sox -115 (bet $115 to win $100) | White Sox -105 (bet $105 to win $100)
  • Run line (RL)/Against the spread (ATS): Red Sox -1.5 (+145) | White Sox +1.5 (-175)
  • Over/Under (O/U): 8.5 (O: -105 | U: -115)

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Red Sox at White Sox picks and predictions

Prediction

White Sox 4, Red Sox 2

Moneyline

LEAN WHITE SOX (-105).

The Red Sox are the hotter team as they enter off wins in 6 of their last 8 games, but Chicago has got the better of Boston in recent meetings. The White Sox won 4 of 6 matchups in 2022, and the Red Sox are 1-5 in Bello’s last 6 series-opening starts, according to covers.com.

Run line/Against the spread

PASS.

The White Sox at +1.5 (-175) should be a pretty safe bet, but the line here is not worth the juice. Bet on the moneyline and/or O/U instead.

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Over/Under

LEAN UNDER 8.5 (-115).

The Under is 3-2-1 in Chicago’s last 6 outings and 5-2 in the past 7 Boston-Chicago meetings. The Under is also 6-0 in Chicago’s last 6 series openers and 4-0 in Giolito’s last 4 starts vs. the AL East, all per covers.com.

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Boston Red Sox at Chicago White Sox odds, picks and predictions

Analyzing Wednesday’s Boston Red Sox at Chicago White Sox odds and lines, with MLB expert picks and predictions.

The Boston Red Sox (20-22) meet the Chicago White Sox (21-21) Wednesday for the second game of their 3-game series at Guaranteed Rate Field. First pitch is scheduled for 8:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Red Sox vs. White Sox odds with MLB picks and predictions.

Boston beat the brakes off Chicago 16-3 Tuesday in the series opener. The Red Sox’s lineup roughed up White Sox SP Dylan Cease for 7 runs on 2 homers and 8 hits over 3 innings and hit 4 home runs and 5 doubles for the game.

Season series: Chicago leads 3-1 but Boston has a plus-8 run differential in those meetings.

Red Sox at White Sox projected starters

LHP Rich Hill vs. RHP Lucas Giolito

Hill is 1-1 with a 3.90 ERA, 1.27 WHIP, 2.4 BB/9 and 6.9 K/9 through 30 IP over 7 starts.

  • Last start: No-decision with 2 IP, 4 ER, 6 H, 1 HR, 1 BB and 2 K in Boston’s 12-6 home win vs. the Seattle Mariners Thursday.
  • vs. White Sox on the current roster: 7.66 FIP with a .257/.353/.523 expected batting average (xBA), wOBA (xwOBA) and slugging percentage (xSLG) slash line, 18.2 K% and 87.7 mph exit velocity (EV) in 44 plate appearances (PA).

Giolito is 2-1 with a 2.84 ERA, 1.23 WHIP, 3.1 BB/9 and 12.5 K/9 in 31 2/3 IP over 6 starts.

  • Last start: No-decision with 5 IP, 2 ER, 7 H, 1 HR, 2 BB and 7 K in Chicago’s 6-2 loss at the Kansas City Royals last Wednesday.
  • 2021 vs. the Red Sox: Loss, 11-4, April 19 in Boston with 1 IP, 7 ER, 8 H, 2 HR, 2 BB and 0 K.
  • vs. Red Sox on the current roster: 6.98 FIP with a .271/.344/.439 xBA-xwOBA-xSLG slash line, 21.7 K% and 86.6 mph EV in 46 PA.

Red Sox at White Sox odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:15 p.m. ET.

  • Money line (ML): Red Sox +133 (bet $100 to win $133) | White Sox -165 (bet $165 to win $100)
  • Run line (RL)/Against the spread (ATS): Red Sox +1.5 (-160) | White Sox -1.5 (+130)
  • Over/Under (O/U): 7.5 (O: -120 | U: -105)

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Red Sox at White Sox picks and predictions

Prediction

White Sox 7, Red Sox 4

Money line

LEAN WHITE SOX (-165) because I’m not in love with this price but Chicago’s lineup nukes lefties and Giolito is a “top-of-the-rotation” guy whereas Hill is a “bottom-of-the-rotation” innings eater. The White Sox are 2nd in wRC+ (126) and 3rd in wOBA (.337) vs. lefties, per FanGraphs.

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Run line/Against the spread

PASS.

Chicago is 5-10 RL as a home favorite, Boston is 11-5 RL as a road underdog and 6 of the last 10 Red Sox-White Sox have been 1-run games.

Over/Under

BET the OVER 7.5 (-120) but let’s wait until closer to the first pitch because money is coming in on the Under and we might be able to get a better price later.

Chicago’s lineup nukes lefties and Boston’s has been scalding hot recently. The Red Sox are 1st in wRC+ (156), wOBA (.388), hard-hit rate (43.6%), barrel rate (12.0%) and WAR (4.7) over the last 2 weeks, according to FanGraphs.

Also, neither starter has impressive pitching peripherals thus far and both bullpens have regressed year over year.

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Boston Red Sox at Chicago White Sox odds, picks and prediction

Analyzing Saturday’s Boston Red Sox at Chicago White Sox odds and lines, with MLB expert picks and predictions.

The Boston Red Sox (80-63) meet the Chicago White Sox (81-60) Saturday for the second game of a three-game series at Guaranteed Rate Field. First pitch is scheduled for 7:10 p.m. ET. Let’s analyze the lines around the Red Sox vs. White Sox odds with MLB picks and predictions.

Chicago won the series opener Friday 4-3 as White Sox starting LHP Carlos Rodon had 5 IP with 1 ER, 3 H, 0 BB and 7 K and the Red Sox were unable to climb out of the 4-0 hole they were in after the fourth inning.

Season series: White Sox lead 3-2.

RHP Connor Seabold is projected to start in his first major-league debut for the Red Sox. Seabold is 2-3 with a 3.61 ERA (47 1/3 IP, 19 ER), 1.06 WHIP, 3.0 BB/9 and 10.6 K/9 over 10 starts in the minors this season for two Boston affiliates.

RHP Dylan Cease is Chicago’s projected starter. Cease is 11-7 with a 3.87 ERA (148 2/3 IP, 64 ER), 1.22 WHIP, 3.6 BB/9 and 11.9 K/9 in 28 starts.

  • Last outing: Loss, 6-0, with 5 IP, 3 ER, 4 H, 3 BB and 9 K Sunday at the Kansas City Royals.
  • Cease earned a no-decision in an April 17 start in Boston with a stat line of 4 2/3 IP, 2 ER, 6H, 3 BB and 6 K in a 7-4 loss.
    • vs. Red Sox on the current roster: 7.01 FIP with a .417 batting average, .451 wOBA, .604 expected slugging percentage, 19.2 K% and 87.5 mph exit velocity in 26 plate appearances.

Red Sox at White Sox odds, lines, picks and prediction

MLB odds provided by Tipico Sportsbook; access USA TODAY Sports for a full list. Odds last updated at 12:41 p.m. ET.

  • Money line: Red Sox +155 (bet $100 to win $155) | White Sox -190 (bet $190 to win $100)
  • Against the spread/ATS: Red Sox +1.5 (-135) | White Sox -1.5 (+110)
  • Over/Under: 9.5 (O: -105 | U: -120)

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Prediction

White Sox 7, Red Sox 3

Money line (ML)

“LEAN” to the WHITE SOX (-190) because they have an edge in starting and relief pitching and hitting. Albeit Chicago’s hitting edge is real slight but should get a little boost since the White Sox are facing a rookie in his MLB debut.

Chicago is 22 games above .500 as a home favorite and Boston is 21-22 as a road underdog. However, the White Sox are just 24-28 overall against winning teams and Cease’s pitching peripherals vs. the Red Sox are worrisome.

If I’m betting Chicago’s money line, I’m risking 1 unit rather than betting 1 unit. If your standard wager is $100, put that on WHITE SOX (-190) to earn a $52 profit.

Another way to get down on Chicago’s money line is to add it as a parlay leg with the Milwaukee Brewers’ money line.

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Run line/Against the spread (ATS)

Slight “LEAN” to the WHITE SOX -1.5 (+110) for a tiny wager, if at all, because I much prefer the plays discussed above. But both sides of the market are betting Chicago’s run line, which has caused oddsmakers to lessen the payout.

Plus, the White Sox’s bullpen ranks atop most advanced pitching categories following the All-Star Game and Boston’s bullpen has been a below-average unit over that same time span.

Another hesitation I have with Chicago’s run line is Boston’s 29-14 ATS record as a road underdog and that includes the series opener’s outcome.

Over/Under (O/U)

“LEAN” to the OVER 9.5 (-105) for a half unit because both sides of the market are barreling into the Over, which is why sportsbooks have the total up from the flat-9 opener.

More importantly, both lineups can mash and there are reasons to like how each stacks up against their respective opposing starter.

Boston is 21-22 O/U as a road underdog and Chicago is 26-33-3 O/U as a home favorite.

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Boston Red Sox at Chicago White Sox odds, picks and prediction

Analyzing Friday’s Boston Red Sox at Chicago White Sox odds and lines, with MLB expert picks and predictions.

The Chicago White Sox (80-60) host the Boston Red Sox (80-62) Friday for the opener of a three-game series at Guaranteed Rate Field. First pitch scheduled for 8:10 p.m. ET. Let’s analyze the lines around the Red Sox vs. White Sox odds with MLB picks and predictions.

Season series: Tied 2-2.

RHP Tanner Houck gets the nod for the White Sox. Houck is 0-3 with a 3.26 ERA (49 2/3 IP, 18 ER), 1.15 WHIP, 2.2 BB/9 and 11.2 K/9 in 10 starts and two relief appearances.

  • Last outing: No-decision in Boston’s 4-3 win over the Cleveland Indians Saturday with a stat line of 5 IP, 0 ER, 3 H, 0 BB and 7 K.
  • Houck lost April 18 to the White Sox 3-2 with 4 1/3 IP, 3 ER, 7 H, 0 BB and 2 K.
  • vs. White Sox on the current roster (10 PA): .200 batting average (BA), .212 wOBA, .552 expected slugging percentage (xSLG), 10.0 K% and 81.8 mph exit velocity (EV).

LHP Carlos Rodon is Chicago’s projected starter. Rodon is 11-5 with a 2.41 ERA (119 2/3 IP, 32 ER), 0.98 WHIP, 2.4 BB/9 and 12.6 K/9 in 21 starts.

  • Last outing: Win, 6-3, with 5 IP, 1 ER, 5 H, 1 BB and 5 K against the Pittsburgh Pirates Sept. 1.
  • vs. Red Sox on the current roster: .377 BA, .506 wOBA, .581 xSLG, 15.5 K% and 91.4 mph EV in 58 PA.

Red Sox at White Sox odds, lines, picks and prediction

MLB odds provided by Tipico Sportsbook; access USA TODAY Sports for a full list. Odds last updated at 11:48 a.m. ET.

  • Money line: Red Sox +130 (bet $100 to win $130) | White Sox -160 (bet $160 to win $100)
  • Against the spread/ATS: Red Sox +1.5 (-155) | White Sox -1.5 (+125)
  • Over/Under: 8.5 (O: -108 | U: -112)

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Prediction

White Sox 6, Red Sox 2

Money line (ML)

“LEAN” to the WHITE SOX (-160) for a half unit only because Chicago outright is on the fringe of my price range in this spot and I wouldn’t hate putting it into a parlay with another favorite for a plus-money payout.

The White Sox are 12 games above-.500 against righty starters and 22 games above-.500 at home, while the Red Sox are just 4-13 overall as road underdogs against a left-handed starter and just 36-33 on the road.

I’m willing to say the hitting matchup is a wash even though I think the White Sox have more talent in their lineup, but Chicago has a major edge in the pitching department.

Rodon lingered in the AL Cy Young race this year and Tipico has Rodon priced with the fifth-best odds (+1500) to win the award. Also, Chicago’s bullpen has been amazing recently while Boston’s has been mediocre. White Sox relievers rank atop the majors in xFIP, SIERA and K-BB% over the last 30 days, whereas the Red Sox is below-average in each metric

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Run line/Against the spread (ATS)

PASS because the White Sox -1.5 (+125) is below my buy price of +150 in this spot because the Red Sox have covered two-thirds of their contests as road underdogs (28-14 ATS).

Another reason why I don’t like Chicago’s value here is that both teams have been equally mediocre over the past 10 and 30 games.

Over/Under (O/U)

Slight “LEAN” to the UNDER 8.5 (-112) for a tiny wager because I much prefer the White Sox’s money line than the total in this game.

However, each team has played more to the Under in their respective location-based splits, Chicago is 7-13-1 O/U in Rodon’s 21 starts and Boston is 3-7 O/U in games Houck starts.

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