Boston Red Sox at Chicago White Sox odds, picks and predictions

Analyzing Wednesday’s Boston Red Sox at Chicago White Sox odds and lines, with MLB expert picks and predictions.

The Boston Red Sox (20-22) meet the Chicago White Sox (21-21) Wednesday for the second game of their 3-game series at Guaranteed Rate Field. First pitch is scheduled for 8:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Red Sox vs. White Sox odds with MLB picks and predictions.

Boston beat the brakes off Chicago 16-3 Tuesday in the series opener. The Red Sox’s lineup roughed up White Sox SP Dylan Cease for 7 runs on 2 homers and 8 hits over 3 innings and hit 4 home runs and 5 doubles for the game.

Season series: Chicago leads 3-1 but Boston has a plus-8 run differential in those meetings.

Red Sox at White Sox projected starters

LHP Rich Hill vs. RHP Lucas Giolito

Hill is 1-1 with a 3.90 ERA, 1.27 WHIP, 2.4 BB/9 and 6.9 K/9 through 30 IP over 7 starts.

  • Last start: No-decision with 2 IP, 4 ER, 6 H, 1 HR, 1 BB and 2 K in Boston’s 12-6 home win vs. the Seattle Mariners Thursday.
  • vs. White Sox on the current roster: 7.66 FIP with a .257/.353/.523 expected batting average (xBA), wOBA (xwOBA) and slugging percentage (xSLG) slash line, 18.2 K% and 87.7 mph exit velocity (EV) in 44 plate appearances (PA).

Giolito is 2-1 with a 2.84 ERA, 1.23 WHIP, 3.1 BB/9 and 12.5 K/9 in 31 2/3 IP over 6 starts.

  • Last start: No-decision with 5 IP, 2 ER, 7 H, 1 HR, 2 BB and 7 K in Chicago’s 6-2 loss at the Kansas City Royals last Wednesday.
  • 2021 vs. the Red Sox: Loss, 11-4, April 19 in Boston with 1 IP, 7 ER, 8 H, 2 HR, 2 BB and 0 K.
  • vs. Red Sox on the current roster: 6.98 FIP with a .271/.344/.439 xBA-xwOBA-xSLG slash line, 21.7 K% and 86.6 mph EV in 46 PA.

Red Sox at White Sox odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:15 p.m. ET.

  • Money line (ML): Red Sox +133 (bet $100 to win $133) | White Sox -165 (bet $165 to win $100)
  • Run line (RL)/Against the spread (ATS): Red Sox +1.5 (-160) | White Sox -1.5 (+130)
  • Over/Under (O/U): 7.5 (O: -120 | U: -105)

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Red Sox at White Sox picks and predictions

Prediction

White Sox 7, Red Sox 4

Money line

LEAN WHITE SOX (-165) because I’m not in love with this price but Chicago’s lineup nukes lefties and Giolito is a “top-of-the-rotation” guy whereas Hill is a “bottom-of-the-rotation” innings eater. The White Sox are 2nd in wRC+ (126) and 3rd in wOBA (.337) vs. lefties, per FanGraphs.

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Run line/Against the spread

PASS.

Chicago is 5-10 RL as a home favorite, Boston is 11-5 RL as a road underdog and 6 of the last 10 Red Sox-White Sox have been 1-run games.

Over/Under

BET the OVER 7.5 (-120) but let’s wait until closer to the first pitch because money is coming in on the Under and we might be able to get a better price later.

Chicago’s lineup nukes lefties and Boston’s has been scalding hot recently. The Red Sox are 1st in wRC+ (156), wOBA (.388), hard-hit rate (43.6%), barrel rate (12.0%) and WAR (4.7) over the last 2 weeks, according to FanGraphs.

Also, neither starter has impressive pitching peripherals thus far and both bullpens have regressed year over year.

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