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The LA Rams (7-6) and San Francisco 49ers (6-7) will meet for the second time this season on Thursday night for a pivotal Week 15 game at Levi’s Stadium in Santa Clara. Kickoff is set for 8:15 p.m. ET (Prime Video). Let’s analyze BetMGM Sportsbook’s NFL odds around the Rams vs. 49ers odds, and make our expert NFL picks and predictions.
The Rams beat the 49ers 27-24 in Week 3 as a 6-point road underdog as the Over 44.5 cashed.
The Rams crept above .500 for the first time this season when they beat the Buffalo Bills 44-42 as 3.5-point underdogs on Sunday. It was the highest-scoring game of the season, featuring 12 total TDs, 902 yards and 0 turnovers. Los Angeles has won 2 straight games and is second in the NFC West.
The 49ers also came away with a win in Week 14, steamrolling the Chicago Bears at home 38-13. The 49ers had 452 total yards of offense compared to only 162 for the Bears, a dominant victory from start to finish. The 49ers are still 2 games back of the Seahawks for the division lead, but a win will keep them in the mix for another division title.
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Rams at 49ers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Wednesday at 2:37 p.m. ET.
- Moneyline (ML): Rams +130 (bet $100 to win $130) | 49ers -155 (bet $155 to win $100)
- Against the spread (ATS): Rams +3 (-120) | 49ers -3 (+100)
- Over/Under (O/U): 49.5 (O: -110 | U: -110)
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Rams at 49ers key injuries
Rams
- CB Cobie Durant (chest) questionable
- C Beaux Limmer (knee) questionable
- WR Demarcus Robinson (shoulder) questionable
49ers
- DE Nick Bosa (hip/oblique) questionable
- RB Isaac Guerendo (foot) questionable
- OT Trent Williams (ankle) questionable
- LB Dre Greenlaw (Achilles) questionable
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Rams at 49ers picks and predictions
Prediction
Rams 27, 49ers 24
Moneyline
The Rams already beat the 49ers once this year and now they’re going for the season sweep of their rivals. Their win over the Bills on Sunday was far more impressive than San Francisco’s victory against the Bears, even if it was only by 2 points.
The offense is just about fully healthy, which will be a problem for the 49ers’ banged-up defense. And with San Francisco down to either its third- or fourth-string running back, a rushing attack that’s given the Rams fits over the years will be shorthanded.
With QB Matthew Stafford playing lights out in recent weeks, the Rams will take down their rival on the road Thursday. BET RAMS (+130) to win outright.
Against the spread
With the spread sitting at the key number of +3, it’s not a bad idea to sprinkle a bit on the Rams to cover just in case they lose a close one to the 49ers. However, I’d rather just play the ML and bet Los Angeles to win its third straight game.
LEAN RAMS +3 (-120).
Over/Under
The Rams nearly went over the total by themselves last week against the Bills, putting up 44 points on their own. Their defense has struggled to stop anyone in recent weeks, giving up 560 rushing yards in their last three games, so the 49ers should be able to score on the LA defense.
The Rams, meanwhile, seemingly found something on offense against Buffalo. And with WR Puka Nacua playing perhaps better than he ever has, the Rams’ passing attack will give the 49ers’ secondary trouble.
BET OVER 49.5 (-110).
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