Rams 49ers odds picks prediction spread over/under betting line

Los Angeles Rams at San Francisco 49ers odds, picks and predictions

Analyzing Monday’s Los Angeles Rams at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

The Los Angeles Rams (2-1) and San Francisco 49ers (1-2) will meet Monday night for the final game of Week 4. It’s a pivotal early-season divisional matchup in the NFC West. Kickoff from Levi’s Stadium will be at 8:15 p.m. ET (ESPN). Below, we analyze Tipico Sportsbook‘s lines around the Rams vs. 49ers odds, and make our expert NFL picks and predictions.

The Rams are coming off a win over the Arizona Cardinals in Week 3, beating their division rivals 20-12. It was their 2nd straight win after an opening blowout loss to the Buffalo Bills. The offense is still trying to find its groove, but the defense held Arizona out of the end zone.

The 49ers will look to make it 7 wins in their last 8 games against the Rams. They had a 6-game winning streak over Los Angeles before losing in the divisional round in January, proving to have the Rams’ number in these annual matchups. San Francisco comes in with Jimmy Garoppolo at QB after losing Trey Lance for the year to an ankle injury.

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Rams at 49ers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 2:26 p.m. ET.

Money line (ML): Rams +105 (bet $100 to win $105) | 49ers -125 (bet $125 to win $100)
Against the spread (ATS): Rams +1.5 (-107) | 49ers -1.5 (-115)
Over/Under (O/U): 42.5 (O: -115 | U: -107)

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Rams at 49ers key injuries

Rams

C Brian Allen (knee) out
CB David Long (groin) out
WR Van Jefferson (knee) out

49ers

LT Trent Williams (ankle) out

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Rams at 49ers picks and predictions

Prediction

Rams 21, 49ers 17

Money line

As previously mentioned, the 49ers have owned the Rams since 2018. They’ve gone 6-1 since then, but this is a game Los Angeles should be able to win – despite being on the road at Levi’s Stadium where it hasn’t won since 2018.

After seeing the 49ers struggle so badly against the Denver Broncos in Week 3, and watching the Rams shut down the Cardinals, I’m taking the RAMS (+105) to win outright.

Against the spread

It’s no surprise that the 49ers are favored at home against a team they’ve beaten 6 of the last 7 times, but the Rams feel like the better team coming into Week 4. And with how close many of these meetings have been over the last few years – 4 of the last 6 have been decided by 3 points or fewer – taking the points is the wiser move.

Bet the RAMS +1.5 (-107) to cover.

Over/Under

Neither of these offenses has looked very good this season. The Rams are 15th in points per game and the 49ers are 28th, so they have yet to find a rhythm on that side of the ball. Both teams boast impressive defenses, too, especially up front.

The total has gone Under in 4 of the last 5 meetings, and I think that’ll continue this week. Bet the UNDER 42.5 (-107).

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Los Angeles Rams at San Francisco 49ers odds, picks and prediction

Analyzing Monday’s Los Angeles Rams at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

The Los Angeles Rams (7-2) are on the road to visit the San Francisco 49ers (3-5) for Monday Night Football in Week 10. Kickoff from Levi’s Stadium will be at 8:15 p.m. ET. Below, we look at the Rams vs. 49ers odds and lines, and make our best NFL picks, predictions and bets.

The Rams are coming off their second loss of the season as they fell to the Tennessee Titans at home in lopsided fashion last Sunday night. The Rams had won four in a row coming into that game, all by at least nine points, but the Titans gave the Rams offense a lot of trouble and held them to only 16 points.

The 49ers have had a really disappointing season up to this point, dropping five of their last six games after starting the year 2-0. They were crushed 31-17 by the Arizona Cardinals in Week 9 despite the Cards being without both QB Kyler Murray and WR DeAndre Hopkins. QB Jimmy Garoppolo remains the starter but the 49ers are only 17th in scoring this season.

Rams at 49ers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 8:35 a.m. ET.

Money line: Rams -190 (bet $190 to win $100) | 49ers +155 (bet $100 to win $155)
Against the spread (ATS): Rams -3.5 (-108) | 49ers +3.5 (-112)
Over/Under (O/U): 50.5 (O: -108 | U: -112)

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Rams at 49ers key injuries

Rams

WR Robert Woods (knee) out
C Brian Allen (elbow) questionable
OLB Von Miller (ankle) questionable
CB Darious Williams (ankle) questionable
WR Ben Skowronek (thigh) questionable

49ers

DT Maurice Hurst (calf) out
DB Jimmie Ward (quad) questionable
CB Josh Norman (rib) questionable
S Tavon Wilson (foot) out
RB JaMycal Hasty (ankle) out

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Rams at 49ers odds, lines, predictions and picks

Prediction

Rams 31, 49ers 21

Money line

The 49ers are trending in the wrong direction, and fast. Their only wins have come against the Detroit Lions, Philadelphia Eagles and Chicago Bears, while also losing last week to the Murray-less Cardinals. The Rams looked out of sorts against the Titans but don’t expect another performance like that from the offensive line tonight.

So long as the Rams can contain WR Deebo Samuel and keep DE Nick Bosa off of QB Matthew Stafford, they’ll win this game.

Bet the RAMS (-190) to win outright.

Against the spread

The 49ers are a paltry 2-6 against the spread this season and have only covered once in their last six games. The Rams have lost their last four games to the 49ers but Robert Saleh is no longer in San Francisco and he was a thorn in Sean McVay’s side, so I expect a better offensive performance tonight.

The Rams will bounce back from last week’s loss to the Titans and get off to a strong start against the 49ers. Bet the RAMS -3.5 (-108) to cover.

Over/Under

The Over has been a solid pick for both of these teams this season. The total has gone Over five times for each team and with the Rams offense playing well all year, I think it’s a good bet again on Monday night.

Seeing as the Over has hit in each of the 49ers’ last four games and in five of the Rams’ nine contests this year, I like the OVER 50.5 (-108).

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First look: Los Angeles Rams at San Francisco 49ers odds and lines

Looking at Sunday’s Los Angeles Rams at San Francisco 49ers Week 10 NFL odds, lines and trends. Here’s what you need to know.

The Los Angeles Rams (7-2) travel to meet the San Francisco 49ers (3-5) for Monday Night Football in Week 10 at Levi’s Stadium in Santa Clara, Calif. Kickoff is scheduled for 8:15 p.m. ET. Below, we look at the Rams vs. 49ers odds and lines; check back for our NFL picks and predictions.

The Rams suffered a 28-16 loss at home Sunday night against the Tennessee Titans. Los Angeles has failed to cover its past three games overall.

The 49ers looked to be catching a break in Week 9 with the Arizona Cardinals missing QB Kyler Murray, WR DeAndre Hopkins and DE J.J. Watt. San Francisco still fell 31-17 at home, and it’s now 1-5 SU/ATS across the past six games overall.

Also see: All Week 10 odds and lines

Rams at 49ers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Tuesday at 7:15 a.m. ET.

Money line: Rams -205 (bet $205 to win $100) | 49ers +165 (bet $100 to win $165)
Against the spread (ATS): Rams -3.5, -115 (bet $115 to win $100) | 49ers +3.5, -105 (bet $105 to win $100)
Over/Under (O/U): 48.5, O: -115 (bet $115 to win $100) | U: -105 (bet $105 to win $100)

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2021 betting stats:

ML: L.A. Rams 7-2 | San Francisco 3-5
ATS: L.A. Rams 4-5 | San Francisco 2-6
O/U: L.A. Rams 5-3-1 | San Francisco 5-3

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Rams at 49ers head-to-head

The NFC West Division rivals meet twice each season. San Francisco won its first-ever visit to SoFi Stadium in Week 12 last season, winning 23-20 as five-point underdogs as the Under cashed. The 49ers also won the meeting at Levi’s Stadium, topping the Rams 24-16 in Week 6 as 2.5-point ‘dogs as the Under connected. San Francisco is 4-0 SU/3-1 ATS in the past four meetings.

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