The Notre Dame Fighting Irish and Ohio State Buckeyes meet at Ohio Stadium Saturday to open their seasons. Kickoff is scheduled for 7:30 p.m. ET (ABC). Below, we analyze Tipico Sportsbook‘s lines around the Notre Dame vs. Ohio State odds, and make our expert college football picks and predictions.
The Fighting Irish kick off the Marcus Freeman era as coach after Chip Kelly bolted for the open LSU job during the offseason. Freeman is a Dayton, Ohio, native and he also played football for the Buckeyes.
Ohio State leads the all-time series 4-2, winning the last 4 meetings. Notre Dame’s last win in the series was Oct. 31, 1936.
The Buckeyes have posted a 5-2-1 ATS mark in their last 8 games in September, but they’re just 1-4 ATS in their last 5 non-conference games.
Notre Dame is ranked No. 5 and Ohio State is ranked No. 2 in the AFCA Coaches Poll powered by USA TODAY Sports.
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Notre Dame at Ohio State odds
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:15 a.m. ET.
- Money line (ML): Notre Dame +520 (bet $100 to win $520) | Ohio State -750 (bet $750 to win $100)
- Against the spread (ATS): Notre Dame +16.5 (-112) | Ohio State -16.5 (-108)
- Over/Under (O/U): 59.5 (O: -105 | U: -115)
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Notre Dame at Ohio State picks and predictions
Prediction
Ohio State 38, Notre Dame 24
Money line
Ohio State (-750) will cost you 7 and a half times your potential return, and that’s rather risky, especially against a fellow top-5 team. Notre Dame is breaking in a new quarterback and playing its first regular-season game under Freeman, but they’re still quite formidable.
AVOID.
Against the spread
NOTRE DAME +16.5 (-112) is worth a look, as more than 2 touchdowns is quite a large spread for a battle of teams ranked 5th or higher.
In addition, the Irish have posted an impressive 4-1-1 ATS mark in their last 6 games against Big Ten teams, and cashed in their final 4 road games in 2021.
Over/Under
OVER 59.5 (-105) is worth a look in all Ohio State games until further notice.
The Buckeyes led the nation with 45.5 PPG and 551.6 total yards per game last season, and Heisman Trophy favorite QB C.J. Stroud and the offense are expected to be quite strong yet again.
The Irish cashed the Over in 4 of the final 5 road outings in 2021, and the Over is 7-2 in the previous 9 tries against Big Ten opponents.
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