First look: Notre Dame at USC odds and lines

Looking at Saturday’s Notre Dame at USC college football odds, lines and trends. Here’s what you need to know.

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The No. 5 Notre Dame Fighting Irish (10-1) and the USC Trojans (6-5) meet Saturday at the Los Angeles Memorial Coliseum. Kickoff is scheduled for 3:30 p.m. ET (CBS). Below, we look at Notre Dame vs. USC odds from BetMGM Sportsbook’s college football odds before making our expert college football picks and predictions later in the week.

The Fighting Irish pounded previously unbeaten Army at Yankee Stadium Saturday, 49-14, easily covering as a 14-point favorite as the Over (44.5) cashed in a battle of ranked teams.

Notre Dame has won 9 straight games, while covering 7 in a row, since that stunning 16-14 loss to Northern Illinois back on Sept. 7. The Over has cashed in 3 of the past 4 games for Notre Dame, while going 5-2 in the past 7 games.

USC held off rival UCLA Saturday at the Rose Bowl, securing bowl eligibility as a result. USC has covered consecutive games for the first time since Sept. 1-7 when it had wins over LSU and Utah State to start the season.

The Under has cashed in 3 straight games for the Trojans, and the 13 points allowed to UCLA were the fewest USC has given up since Sept. 7, a shutout win over Utah State.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

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Notre Dame at USC odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college football odds. Lines last updated Monday at 9:33 a.m. ET.

  • Moneyline (ML): Notre Dame -250 (bet $250 to win $100) | USC +200 (bet $100 to win $200)
  • Against the spread: Notre Dame -7.5 (-110) | USC +7.5 (-110)
  • Over/Under (O/U): 51.5 (O: -110 | U: -110)

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2024 betting stats

  • ML: Notre Dame 10-1 | USC 6-5
  • ATS: Notre Dame 9-2 | USC 7-4
  • O/U: Notre Dame 6-5 | USC 5-6

Notre Dame vs. USC head-to-head

Notre Dame leads the all-time series 49-37-5, including a 48-20 win last season in South Bend.

USC won the most recent game at home, 38-27, but that is the only victory for the Trojans in the past 6 tries since Oct. 21, 2017.

USC does hold a slight 5-4 ATS edge in the past 9 meetings since Nov. 29, 2014, while the Over has cashed in each of the past 2 meetings and 6 of the previous 9 outings.

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First look: Notre Dame at USC odds and lines

Looking at Saturday’s Notre Dame at USC NCAA Football odds, lines and trends. Here’s what you need to know.

The No. 15 Notre Dame Fighting Irish (8-3) and No. 5 USC Trojans (10-1) clash in a rivalry battle Saturday evening. Kickoff at Los Angeles Memorial Coliseum is scheduled for 7:30 p.m. ET (ABC). Below, we look at Notre Dame vs. USC from Tipico Sportsbook; check back for all our college football picks and predictions.

Notre Dame covered a 19.5-point spread in blanking Boston College 44-0 Saturday. Junior RB Logan Diggs had 122 rushing yards to pace an Irish ground game that pounded out 281 yards, its 2nd-most this season. The win marked UND’s 5th in a row.

The 7th-ranked (CFP) Trojans topped current No. 18 UCLA 48-45 (covering a 2-point spread) Saturday night. QB Caleb Williams threw for a season-high 470 yards in leading Southern Cal to its 4th-straight conquest. USC had 649 total yards in the game and was buoyed by a plus-3 in turnovers.

Rankings courtesy the AFCA Coaches Poll powered by USA TODAY Sports.

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Notre Dame at USC odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 1:50 p.m. ET.

  • Moneyline: Off the board
  • Against the spread (ATS): Notre Dame +5.5 (-110) | USC -5.5 (-110)
  • Over/Under (O/U): 62.5 (O: -110 | U: -110)

2022 betting stats

  • ML: Notre Dame 8-3 | USC 10-1
  • ATS: Notre Dame 6-5 | USC 7-4
  • O/U: Notre Dame 6-5 | USC 8-3

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Notre Dame vs. USC head-to-head

UND won last year’s meeting 31-6 (Oct. 23, 2021) and has won 4 in a row in this series, which dates back to 1926. In 89 all-time meetings, the Fighting Irish lead 48-36-5.

Saturday’s contest will be the 1st series game in Los Angeles since 2018. The rivals have split the last 6 games in Southern California.

Since 2011, each side is 5-5 against the number. The Under has hit in 3 straight meetings and is 6-4 since 2011.

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