First look: Clemson at Louisville odds and lines

Previewing the Clemson Tigers at Louisville Cardinals Week 10 matchup, with college football odds, trends and head-to-head records.

The Clemson Tigers (5-3, 4-2 ACC) pay a visit to Cardinal Stadium to take on the Louisville Cardinals (4-4, 2-3) Saturday at 7:30 p.m. ET. Below, we look at the Clemson vs. Louisville odds and lines; check back for our college football picks and predictions.

Clemson defeated Florida State 30-20 Saturday. The Tigers defense held the Seminoles to just 241 total yards and a combined 4-for-14 mark on third and fourth downs.

As shaky as the Clemson offense has been this season (114th FBS in total offense), the Tigers have been solid in stopping opponents. Clemson has held foes to 15.3 points per game, which ranks third nationally.

The Cardinals were on the downside of a 28-13 game at NC State Saturday. Louisville now returns home after losing three of its last four games overall. Dating back to 2020, the Cards are 5-1 in their last six home games.

Rankings courtesy of the AFCA Coaches Poll powered by USA TODAY Sports.

Clemson at Louisville odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 5:52 p.m. ET.

  • Money line: Clemson -200 (bet $200 to win $100) | Louisville +160 (bet $100 to win $160)
  • Against the spread (ATS): Clemson -3.5, -112 (bet $112 to win $100) | Louisville +3.5, -108 (bet $110 to win $108)
  • Over/Under (O/U): 46.5, O: -110 (bet $110 to win $100) | U: -110 (bet $110 to win $100)

Also see: Betting 101

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

2021 betting stats:

  • ML: Clemson 5-3 | Louisville 4-4
  • ATS: Clemson 1-7 | Louisville 4-4
  • O/U: Clemson 2-6 | Louisville 2-6

Clemson at Louisville head-to-head

The all-time series is led by the Tigers 6-0. They are 4-0 ATS over the last four meetings (2016-19).

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First look: Florida at South Carolina odds and lines

Previewing the Florida Gators at South Carolina Gamecocks Week 10 matchup, with college football odds, trends and head-to-head records.

The Florida Gators (4-4, 2-4 SEC) and South Carolina Gamecocks (4-4, 1-4) tangle in an SEC East clash Saturday in Columbia, S.C. The battle at Williams-Brice Stadium is scheduled for 7:30 p.m. ET. Below, we look at the Florida vs. South Carolina odds and lines; check back for our college football picks and predictions.

Florida has gone loss-bye-loss over the last three weeks. The losses were at LSU (49-42 Oct. 16) and to No. 1 Georgia (34-7 Saturday in Jacksonville). The top-ranked Bulldogs had three scoring drives of less than 50 yards and added a defensive touchdown, too.

The Gamecocks last played Oct. 23 when they lost at Texas A&M 44-14. South Carolina has averaged just 20.9 points per game this season, ranking 115th in the country. USC has been undone by numerous and costly turnovers of late and is minus-6 in that department over their last three games.

Rankings courtesy of the AFCA Coaches Poll powered by USA TODAY Sports.

Florida at South Carolina odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 5:24 p.m. ET.

  • Money line: Florida -1000 (bet $1,000 to win $100) | South Carolina +600 (bet $100 to win $600)
  • Against the spread (ATS): Florida -18.5, -110 (bet $110 to win $100) | South Carolina +18.5, -110 (bet $110 to win $100)
  • Over/Under (O/U): 53.5, O: -110 (bet $110 to win $100) | U: -110 (bet $110 to win $100)

Also see: Betting 101

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

2021 betting stats:

  • ML: Florida 4-4 | South Carolina 4-4
  • ATS: Florida 3-5 | South Carolina 3-4-1
  • O/U: Florida 3-5 | South Carolina 3-5

Florida at South Carolina head-to-head

UF has won three straight meetings and five of the last six against South Carolina. In a series that dates back to 1911, the Gators are 29-9-3. Against the spread, Florida is just 1-3-1 over the last five meetings.

The road team has found success in the alternating tussles in Columbia and Gainesville. The road squad is 6-1-1 ATS across the last six UF-USC games.

The Over is 4-0 in the last four meetings.

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First look: Indiana at Michigan odds and lines

Previewing the Indiana Hoosiers at Michigan Wolverines Week 10 matchup, with college football odds, trends and head-to-head records.

The Indiana Hoosiers (2-6, 0-5 Big Ten) and No. 10 Michigan Wolverines (7-1, 4-1) tussle in a Big Ten East Division contest Saturday night in Ann Arbor, Michigan. The game at Michigan Stadium will kick off at 7:30 p.m. ET. Below, we look at the Indiana vs. Michigan odds and lines; check back for our college football picks and predictions.

Rankings according to the AFCA Coaches Poll powered by USA TODAY Sports.

Indiana is coming off a road loss to Maryland and has lost four straight games for the first time since 2018.

The Hoosiers have endured scoring woes for most of the season and now — after a 38-35 setback against the Terrapins — have coughed up 92 points over the last two weeks. IU is 1-3 on the road; all three losses have come in Big Ten play.

The Wolverines return to the Big House after an unsuccessful trip to Spartan Stadium in Saturday’s intrastate battle at then-No. 7 Michigan State.

UM spit the bit on the 30-14 late-third-quarter lead, as coach Jim Harbaugh’s combined record against MSU and Ohio State fell to 3-9.

The Wolverines lost to the Spartans despite outgaining them, 552 yards to 395, and holding MSU to a 4-of-13 mark on third downs.

Indiana at Michigan odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 11:02 a.m. ET.

  • Money line: Indiana +650 (bet $100 to win $650) | Michigan -1100 (bet $1,100 to win $100)
  • Against the spread (ATS): Indiana +19.5, -112 (bet $112 to win $100) | Michigan -19.5, -108 (bet $108 to win $100)
  • Over/Under (O/U): 50.5, O: -115 (bet $115 to win $100) | U: -105 (bet $105 to win $100)

Also see: Betting 101

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

2021 betting stats:

  • ML: Indiana 2-6 | Michigan 7-1
  • ATS: Indiana 2-6 | Michigan 6-2
  • O/U: Indiana 3-5 | Michigan 4-4

Indiana at Michigan head-to-head

Michigan is 59-10 across 69 all-time meetings against IU. Among the 10 wins for the Hoosiers is a 38-21 win in Bloomington, Indiana last fall.

Indiana held UM to 357 yards in the game (13 on the ground) and controlled the game wire to wire. The victory was the Hoosiers’ first over Michigan since 1987. Indiana is 4-1-1 ATS over the last six series meetings.

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First look: Ohio State at Nebraska odds and lines

Previewing the Ohio State Buckeyes at Nebraska Cornhuskers Week 10 matchup, with college football odds, trends and head-to-head records.

The No. 5 Ohio State Buckeyes (7-1, 5-0 Big Ten) visit the Nebraska Cornhuskers (1-5, 3-6) Saturday in Lincoln, Nebraska. The Buckeyes and ‘Huskers will tee it off at noon ET at Memorial Stadium. Below, we look at the Ohio State vs. Nebraska odds and lines; check back for our college football picks and predictions.

Rankings courtesy the AFCA Coaches Poll powered by USA TODAY Sports.

Ohio State travels west after a 33-24 home win over the Penn State Nittany Lions Saturday night. The Buckeyes were undone by 10 penalties and were slow to get their top-flight offense on track against a solid PSU defense. But OSU would eventually get 152 rushing yards from freshman RB TreVeyon Henderson and grind out the two-score victory.

The Cornhuskers suffered its third consecutive setback with a 28-23 home loss to Purdue. Nebraska was held to just six points in the game’s second half. All six of the Huskers’ losses this season — and nine of the program’s last 10 since last fall — have been by one score.

Ohio State at Nebraska odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 10:57 a.m. ET.

  • Money line: Ohio State -600 (bet $600 to win $100) | Nebraska +420 (bet $100 to win $420)
  • Against the spread (ATS): Ohio State -14.5, -112 (bet $112 to win $100) | Nebraska +14.5, -108 (bet $108 to win $100)
  • Over/Under (O/U): 63.5, O: -108 (bet $108 to win $100) | U: -112 (bet $112 to win $100)

Also see: Betting 101

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

2021 betting stats:

  • ML: Ohio State 7-1 | Nebraska 3-6
  • ATS: Ohio State 4-3-1 | Nebraska 4-4-1
  • O/U: Ohio State 5-3 | Nebraska 4-4-1

Ohio State at Nebraska head-to-head

The Buckeyes beat the Cornhuskers, 52-17, last season and have won six straight in a nine-game all-time series (which OSU leads, 8-1). Ohio State outgained Nebraska, 491 yards to 370.

Since Nebraska joined the Big Ten in 2011, OSU is 6-1 straight-up and 6-1 ATS vs. the ‘Huskers. The Buckeyes have averaged 52.3 points per game over those half-dozen wins.

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First look: Tennessee at Kentucky odds and lines

Previewing the Tennessee Volunteers at Kentucky Wildcats Week 10 matchup, with college football odds, trends and head-to-head records.

The Tennessee Volunteers (4-4, 2-3 SEC) meet the No. 17 Kentucky Wildcats (6-2, 4-2) at Kroger Field in Lexington, Ky. Kickoff is scheduled for 7 p.m. ET. Below, we look at the Tennessee vs. Kentucky odds and lines; check back for our college football picks and predictions.

The Volunteers have dropped two straight games with losses against Ole Miss at home and Alabama on the road, and are 0-4 SU/ATS in four games against ranked opponents this season.

The Wildcats have dropped two straight games, both on the road, at Georgia and Mississippi State. The game against the Bulldogs was especially disappointing as UK had two weeks to prepare but still lost as 1-point dogs.

Rankings according to the AFCA Coaches Poll powered by USA TODAY Sports.

Tennessee at Kentucky odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 9:40 a.m. ET.

  • Money line: Tennessee +110 (bet $100 to win $110) | Kentucky -135 (bet $135 to win $100)
  • Against the spread (ATS): Tennessee +2.5, -112 (bet $112 to win $100) | Kentucky -2.5, -108 (bet $108 to win $100)
  • Over/Under (O/U): 58.5, O: -108 (bet $108 to win $100) | U: -112 (bet $112 to win $100)

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

2021 betting stats:

  • ML: Tennessee 4-4 | Kentucky 6-2
  • ATS: Tennessee 3-5 | Kentucky 6-2
  • O/U: Tennessee 5-3 | Kentucky 5-3

Tennessee at Kentucky head-to-head

The Volunteers have dominated the all-time series 81-26-9, but the Wildcats have made some inroads lately. Kentucky won 34-7 in Knoxville last season on Oct. 17, 2020, and it is 2-2 SU in the last four meetings. Tennessee is still 7-2 ATS in the past nine meetings, with the Under 3-0 in the last three.

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First look: LSU at Alabama odds and lines

Previewing the LSU Tigers at Alabama Crimson Tide Week 10 matchup, with college football odds, trends and head-to-head records.

The LSU Tigers (4-4, 2-3 SEC) meet the No. 3 Alabama Crimson Tide (7-1, 4-1) at Bryant-Denny Stadium in Tuscaloosa, Ala. Kickoff is scheduled for 7 p.m. ET. Below, we look at the LSU vs. Alabama odds and lines; check back for our college football picks and predictions.

The Tigers were dropped 31-17 at Ole Miss last time out Oct. 23 prior to a bye. LSU is just 1-3 straight up and 3-1 against the spread across the past four outings, while the Over has hit in two of the previous three.

The Crimson Tide had a wake-up call at Texas A&M Oct. 9, losing 41-38. Since that loss, Alabama has outscored Mississippi State and Tennessee by a combined score of 101-33 in two wins and covers.

Rankings according to the AFCA Coaches Poll powered by USA TODAY Sports.

LSU at Alabama odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 9:16 a.m. ET.

  • Money line: LSU +1100 (bet $100 to win $1,100) | Alabama -3000 (bet $3,000 to win $100)
  • Against the spread (ATS): LSU +28.5, -108 (bet $108 to win $100) | Alabama -28.5, -112 (bet $112 to win $100)
  • Over/Under (O/U): 64.5, O: -117 (bet $117 to win $100) | U: -103 (bet $103 to win $100)

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

2021 betting stats:

  • ML: LSU 4-4 | Alabama 7-1
  • ATS: LSU 3-5 | Alabama 5-3
  • O/U: LSU 4-4 | Alabama 5-3

LSU at Alabama head-to-head

The Crimson Tide lead the all-time series 54-26-5. Alabama won last season’s meeting in Baton Rouge by a 55-17 score, and it has won nine of the previous 10 in the series. LSU won the most recent meeting in Tuscaloosa, however, an epic 46-41 win Nov. 9, 2019.

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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First look: Missouri at Georgia odds and lines

Previewing the Missouri Tigers at Georgia Bulldogs Week 10 matchup, with college football odds, trends and head-to-head records.

The Missouri Tigers (4-4, 1-3 SEC) meet the No. 1 Georgia Bulldogs (8-0, 6-0) at Sanford Stadium in Athens, Ga. Kickoff is scheduled for noon ET. Below, we look at the Missouri vs. Georgia odds and lines; check back for our college football picks and predictions.

The Tigers topped Vanderbilt on the road by a 37-28 count Saturday, and have alternated wins and losses in each of the past four outings. The Tigers have failed to cover in any of their eight games, the only FBS team yet to cover this season.

The Bulldogs rolled Florida 34-7 in Jacksonville in the team’s annual rivalry game. Georgia has allowed just 53 total points across eight victories, or 6.6 points per game. The Bulldogs have the best scoring defense in the nation, while ranking second in total yards, passing yards and rushing yards allowed per game.

Rankings according to the AFCA Coaches Poll powered by USA TODAY Sports.

Missouri at Georgia odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 8:53 a.m. ET.

  • Money line: Missouri +1700 (bet $100 to win $1,700) | Georgia -100000 (bet $100,000 to win $100)
  • Against the spread (ATS): Missouri +37.5, -105 (bet $105 to win $100) | Georgia -37.5, -115 (bet $115 to win $100)
  • Over/Under (O/U): 59.5, O: -110 (bet $110 to win $100) | U: -110 (bet $110 to win $100)

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

2021 betting stats:

  • ML: Missouri 4-4 | Georgia 8-0
  • ATS: Missouri 0-8 | Georgia 6-2
  • O/U: Missouri 6-2 | Georgia 3-5

Missouri at Georgia head-to-head

The Bulldogs have dominated this all-time series 9-1, including seven straight. Mizzou’s lone victory came at Sanford Stadium back on Oct. 12, 2013, a 41-26 victory. Last season, UGA won 49-14 in Columbia Dec. 12, 2020.

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First look: UCLA at Utah odds and lines

Previewing the UCLA Bruins at Utah Utes Week 9 matchup, with college football odds, trends and head-to-head records.

The UCLA Bruins (5-3, 3-2 Pac-12) and Utah Utes (4-3, 3-1) tangle in a Saturday night game in Salt Lake City. The Pac-12 tilt at Rice-Eccles Stadium is slated for a 10 p.m. ET start. Below, we look at the UCLA vs. Utah odds and lines; check back for our college football picks and predictions.

UCLA, which is coming off a 34-31 loss to Oregon, hits the road for a third game in four weeks. The Bruins, who allowed 296 passing yards to the Ducks, rank 125th in the nation in yielding 290.9 passing yards per contest. UCLA has won four straight games (straight-up and against the spread) on the road.

The Utes dropped a 42-34 game at Oregon State Saturday. Utah was outscored 28-10 in the second half. The loss snapped a three-game win streak. The Utes now return to Rice-Eccles Stadium where they have won five in a row and 16 of their last 17.

UCLA at Utah odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Tuesday at 9:10 a.m. ET.

  • Money line: UCLA +180 (bet $100 to win $180) | Utah -230 (bet $230 to win $100)
  • Against the spread (ATS): UCLA +6.5, -112 (bet $112 to win $100) | Utah -6.5, -108 (bet $110 to win $108)
  • Over/Under (O/U): 60.5, O: -112 (bet $112 to win $100) | U: -108 (bet $108 to win $100)

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

2021 betting stats:

  • ML: UCLA 5-3 | Utah 4-3
  • ATS: UCLA 5-3 | Utah 2-5
  • O/U: UCLA 4-4 | Utah 5-2

UCLA at Utah head-to-head

Utah has won four straight games against UCLA, outscoring the Bruins 190-75.

UCLA leads the all-time series 11-7. Against the spread, the road team is 6-2 across the last eight meetings.

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First look: Michigan at Michigan State odds and lines

Previewing the Michigan at Michigan State Week 9 matchup, with college football odds, trends and head-to-head records.

The No. 6 Michigan Wolverines (7-0, 4-0 Big Ten) and No. 7 Michigan State Spartans (7-0, 4-0) will lock horns in a rivalry battle Saturday in East Lansing. Kickoff in the top-10 tussle from Spartan Stadium is slated for noon ET. Below, we look at the Michigan vs. Michigan State odds and lines; check back for our college football picks and predictions.

Rankings courtesy of the AFCA Coaches Poll, powered by USA TODAY Sports.

Michigan drubbed Northwestern 33-7 Saturday. The Wolverines managed 30-plus points for a sixth time in seven games and 200 or more rushing yards (294) for a fifth time this fall. RB Blake Corum rushed for 119 yards in the victory and already has 729 yards on the season. UM’s 253.3 rushing yards per game rank fifth in FBS.

The Spartans defeated Indiana 20-15, despite compiling just 241 yards on offense. MSU struggled in taking 12 penalties for 134 yards in the contest. At 68.1 yards per game, Michigan State is the 17th-most penalized team in FBS. RB Kenneth Walker III is a legitimate candidate for “First Half Heisman”: the dynamic junior back needs just 3 yards to reach 1,000 rushing yards on the season, and he already has 10 total touchdowns.

Michigan at Michigan State odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Tuesday at 8:30 a.m. ET.

  • Money line: Michigan -205 (bet $205 to win $100) | Michigan State +165 (bet $100 to win $165)
  • Against the spread (ATS): Michigan -4.5, -108 (bet $108 to win $100) | Michigan State +4.5, -112 (bet $112 to win $100)
  • Over/Under (O/U): 50.5, O: -117 (bet $117 to win $100) | U: -103 (bet $103 to win $100)

Also see: Betting 101

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

2021 betting stats:

  • ML: Michigan 7-0 | Michigan State 7-0
  • ATS: Michigan 6-1 | Michigan State 5-1-1
  • O/U: Michigan 3-4 | Michigan State 3-4

Michigan at Michigan State head-to-head

Michigan and Michigan State are meeting as top-10 teams for the first time since 1964. Saturday’s game will mark the 114th meeting between the the intrastate foes.

UM leads the series, 71-37-5. But the Spartans have held sway in the series over the last 13 years. MSU is 9-4 against the Wolverines since 2008.

Michigan State won last year’s game, 27-24.

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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First look: North Carolina at Notre Dame odds and lines

Previewing the North Carolina at Notre Dame Week 9 matchup, with college football odds, trends and head-to-head records.

The North Carolina Tar Heels (4-3) pay a visit to South Bend, Ind., to take on the No. 11 Notre Dame Fighting Irish (6-1) on Saturday night. The contest at Notre Dame Stadium is slated to kick off at 7:30 p.m. ET. Below, we look at the North Carolina vs. Notre Dame odds and lines; check back for our college football picks and predictions.

Rankings courtesy the AFCA Coaches Poll powered by USA TODAY Sports.

North Carolina is playing in its first true road game since a season-opening 17-10 loss at Virginia Tech Sept. 3. The Tar Heels are just 4-7 on the road in Mack Brown’s tenure as head coach (2019-present). UNC is looking to avenge a 31-17 loss to Notre Dame last season. The Tar Heels led that game, 17-14, late in the first half, but they produced just 58 yards over six drives after halftime.

Notre Dame is coming off a 31-16 win over USC Saturday. The Irish led that game, 24-3, heading into the fourth quarter. They went a combined 9-for-13 in converting third-and fourth-down opportunities. That’s an area where UND has struggled for much of the season: the team’s 38.1% rate of converting third downs ranks 84th in the nation.

North Carolina at Notre Dame odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Tuesday at 7:55 a.m. ET.

  • Money line: North Carolina +140 (bet $100 to win $140) | Notre Dame -175 (bet $175 to win $100)
  • Against the spread (ATS): North Carolina +3.5, -112 (bet $112 to win $100) | Notre Dame -3.5, -108 (bet $108 to win $100)
  • Over/Under (O/U): 62.5, O: -112 (bet $112 to win $100) | U: -108 (bet $108 to win $100)

Also see: Betting 101

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2021 betting stats:

  • ML: North Carolina 4-3 | Notre Dame 6-1
  • ATS: North Carolina 3-4 | Notre Dame 4-3
  • O/U: North Carolina 4-3 | Notre Dame 4-3

North Carolina at Notre Dame head-to-head

Notre Dame is 19-1 over 20 all-time games against North Carolina. (A 2008 UNC win was vacated.)

The road team is 5-0 ATS over the last five series contests.

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