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The Pitt Panthers (1-4, 0-2 ACC) welcome the Louisville Cardinals (6-0, 3-0) to Acrisure Stadium Saturday. Kickoff is set for 6:30 p.m. ET (CW Network). Below, we analyze BetMGM Sportsbook’s lines around the Louisville vs. Pitt odds, and make our expert college football picks and predictions.
Louisville, No. 15 in the US LBM Coaches Poll powered by USA TODAY Sports, beat the No. 21 Notre Dame Fighting Irish Saturday, winning the prime-time Week 6 matchup 33-20 and covering as a 6-point home underdog. Louisville is 0-2-1 against the spread (ATS) away from home yet 2-0-1 ATS in its last 3 games. QB Jack Plummer leads the way offensively with 1,551 passing yards and 12 TDs.
Pitt had a byle in Week 6 after losing to Virginia Tech 38-21 on the road in Week 5 as a 3-point road favorite. It is 0-4-1 ATS this season and 0-2-1 ATS at home this season. QB Phil Jurkovec has been the main weapon on offense, totaling 818 passing yards and 7 total TDs. Pitt has lost both conference games this season by double figures.
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Louisville at Pitt odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 12:51 a.m. ET.
- Moneyline (ML): Louisville -300 (bet $300 to win $100) | Pitt +240 (bet $100 to win $240)
- Against the spread (ATS): Louisville -7.5 (-110) | Pitt +7.5 (-110)
- Over/Under (O/U): 44.5 (O: -110 | U: -110)
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Louisville at Pitt picks and predictions
Prediction
Louisville 31, Pitt 17
Moneyline
PASS.
The Cardinals are the real deal, and they should win with ease on the road against a Pitt team that’s both struggled at home and against conference opponents. At -300 though, there’s no value on the favorite.
Against the spread
BET LOUISVILLE -7.5 (-110).
Louisville has been great on both sides of the ball. It sits 49th in the nation in opponents’ yards per play at 5.3. It has allowed 20 or fewer points in all but 2 games and has double-digit wins in 4 of 6 games. The Cardinals have only played 1 true road game (2 were at neutral sites) and pushed that in a 13-10 favorite at NC State. The Cardinals have topped 30 points in 4 of 6 games.
Pitt sits 73rd in opponents’ 3rd-down conversation rate, so it may struggle to keep the Cardinals’ offense off the field. The Panthers are 0-2-1 ATS at home and lost 41-24 in its last home game against the No. 12 UNC Tar Heels. Expect a similar game and for the Cards to dominate on the road. Take LOUISVILLE -7.5 (-110).
Over/Under
LEAN OVER 44.5 (-110).
The Panthers are 4-1 O/U this season as they have allowed 25-plus points in 3 of 5 games and have allowed 38 or more in 2 straight games. Pitt has scored 20-plus points in 4 of 5 games as well, so it should be able to get on the board often.
The Cardinals have a strong offense and should be able to abuse the Panthers’ weak defense. Louisville is 2-3-1 O/U this season and has scored 102 points over its last 3 games.
Take OVER 44.5 (-110).
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