Jacksonville Jaguars at Buffalo Bills odds, picks and predictions

Analyzing Monday’s Jacksonville Jaguars at Buffalo Bills odds and lines, with expert NFL picks and predictions.

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The Jacksonville Jaguars (0-2) and the Buffalo Bills (2-0) meet for a Week 3 game Monday. Kickoff at Highmark Stadium is set for 7:30 p.m. ET (ESPN). Let’s analyze BetMGM Sportsbook’s NFL odds around the Jaguars vs. Bills odds, and make our expert NFL picks and predictions.

The Jaguars lost 18-13 at home to the Cleveland Browns last week. Jacksonville has had issues on offense, averaging just 15.0 points per game (PPG) in 2 games, while allowing just 19.0 PPG.

QB Trevor Lawrence has completed just 51.0% of his pass attempts for 382 yards, 1 TD and 0 INT in 2 outings, while RB Travis Etienne leads the team with just 96 rushing yards, although he has 2 scores.

The Bills have scored 31 or more points in both games. That includes a 31-10 win at the Miami Dolphins last Thursday as a 2.5-point underdog as the Under (49.5) cashed.

The weather forecast for Western New York is rather ominous, although things have improved in the past couple of days. The forecast is calling for a 40% chance of precipitation, with showers off and on throughout the game. Winds will be blowing from 8-11 MPH, too, perhaps limiting the aerial attack with the slippery conditions.

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Jaguars at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Sunday at 4:07 p.m. ET.

  • Moneyline (ML): Jaguars +200 (bet $100 to win $220) | Bills -250 (bet $250 to win $100)
  • Against the spread (ATS): Jaguars +5.5 (-110) | Bills -5.5 (-110)
  • Over/Under (O/U): 45.5 (O: -110 | U: -110)

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Jaguars at Bills key injuries

Jaguars

  • RB Tank Bigsby (shoulder) questionable
  • TE Evan Engram (hamstring) out
  • OT Cam Robinson (knee) questionable
  • DB Darnell Savage (quadriceps) questionable

Bills

  • LB Terrel Bernard (pectoral) out
  • CB Taron Johnson (forearm) out

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Jaguars at Bills picks and predictions

Prediction

Bills 24, Jaguars 17

Moneyline

The Bills (-250) will cost you 2 1/2 times your potential return, and that’s quite risky despite the fact Buffalo has won both its games, while the Jaguars (+200) have lost both outings.

Jacksonville could easily have won both of its 1st 2 games, losing each by a single score. This is a pesky team with some impressive skill-position players and an above-average defense. It won’t be an easy game for the home side.

PASS.

Against the spread

The BILLS -5.5 (-110) are the lean, but go very, very lightly.

Buffalo covered handily last week in Miami in Week 2, but it failed to cover at home against Arizona despite a 34-28 victory. You can expect a similar result here, especially if it is a soggy game with plenty of running.

The Jaguars +5.5 (-110) have the tools to hang with the Bills if the aerial game is limited by the weather, especially if RB Tank Bigsby is healthy enough to join Etienne in the backfield.

Over/Under

UNDER 45.5 (-110) is a solid play in the 1st of this MNF double dip.

We’re going to have a wet track, and that might mean more running, and less aerials. A ground-based offensive attack keeps the clock running, which is beneficial to Under bettors.

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Jacksonville Jaguars vs. Buffalo Bills odds, picks and predictions

Analyzing Sunday’s Jacksonville Jaguars vs. Buffalo Bills odds and lines, with expert NFL picks and predictions.

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The Jacksonville Jaguars (2-2) and Buffalo Bills (3-1) meet Sunday at Tottenham Hotspur Stadium in London. Kickoff is set for 9:30 a.m. ET (NFL Network). Below, we analyze FanDuel Sportsbook’s lines around the Jaguars vs. Bills odds, and make our expert NFL picks and predictions.

Jacksonville will be playing its second game in a row in London after defeating Atlanta 23-7 as a 3-point favorite last Sunday. Jacksonville was the home team in the contest which took place at Wembley Stadium. It will be the designated road team against the Bills in this game.

The Bills are coming off 3 wins of at least 28 points. Their most recent was a 48-20 win as 3-point favorites over the Miami Dolphins last Sunday. The win put them in 1st place in the AFC East, heading into London.

After 4 turnovers in Week 1, QB Josh Allen has improved each week. This culminated last Sunday with 21-of-25 passing for 320 yards and 4 TDs. Allen has gotten into MVP form, and this has allowed the Bills to make easy work of recent opponents.

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Jaguars vs. Bills odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:12 p.m. ET.

  • Moneyline (ML): Jaguars +198 (bet $100 to win $198) | Bills -240 (bet $240 to win $100)
  • Against the spread (ATS): Jaguars +5.5 (-110) | Bills -5.5 (-110)
  • Over/Under (O/U): 48.5 (O: -110 | U: -110)

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Jaguars vs. Bills key injuries

Jaguars

  • WR Jamal Agnew (quad) questionable
  • CB Christian Braswell (hamstring) out
  • WR Zay Jones (knee) questionable
  • LB Devin Lloyd (thumb) out

Bills

  • OLB Von Miller (ACL) questionable
  • DE Greg Russo (foot) out
  • CB Tre’Davious White (Achilles) out

Jaguars vs. Bills picks and predictions

Prediction

Bills 31, Jaguars 2

Moneyline

PASS.

Neither side is worth making a wager on. Buffalo is too high at -240 and Jacksonville does not offer enough value at +198.

Against the spread

BET BUFFALO -5.5 (-110).

Buffalo has won its past 3 games by an average of 30 points. In this time, it has only allowed 33 points to its opponents while the offense has failed to score under 37 points.

WR Stefon Diggs and Allen have put any off-season strife behind them, and the connection in the pass game is as strong as ever.

While the injury to White is concerning, Jacksonville is dealing with several injuries at the WR position. This will make it difficult for the Jags to take advantage of the missing All-Pro.

Despite Jacksonville already having played in London and being there for a week, Buffalo is the better team. 5.5 points is not enough, and if the number stays below 7, Buffalo is the side.

Over/Under

BET OVER 48.5 (-110).

While many of the games played in London have gone Under, these games are normally played at Wembley Stadium — a grass field made specifically for soccer. This game will be played at the new Tottenham Hotspur Stadium. A stadium built with input from the NFL to make it more conducive to NFL games. It has a field turf surface and in the 2 matchups it hosted in 2022, both games went Over.

With the offense of Buffalo averaging 41 points in the past 3 games, it could get this game to go Over by itself. But Jacksonville will score a bit as well. This total should be closer to 52. With it being so low, take OVER 48.5 (-110).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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