Indianapolis Colts at Buffalo Bills odds, picks and predictions

Analyzing Saturday’s Indianapolis Colts at Buffalo Bills odds and lines, with expert NFL picks and predictions.

The Indianapolis Colts face off against the Buffalo Bills Saturday in each team’s first preseason game. Kickoff from Highmark Stadium is set for 1 p.m. ET. Below, we analyze BetMGM Sportsbook’s lines around the Colts vs. Bills odds, and make our expert NFL picks and predictions.

The Colts finished last season with a dismal 4-12-1 overall record and they chased offensive talent and selected QB Anthony Richardson out of Flordia with the No. 4 overall pick in the 2023 draft. Indianapolis made other moves to increase their offensive firepower signing WR Isaiah McKenzie and RB Kenyan Drake.

There are still looming concerns around RB Jonathan Taylor heading into the 2023 campaign as the star running back remains on the PUP (physically unable to perform) list.

The Bills closed out the season with a 13-3 record and winning the AFC East, ultimately falling to the Cincinnati Bengals in the divisional round of the playoffs. Buffalo selected TE Dalton Kincaid out of Utah with the 25th pick in the draft, adding another weapon for QB Josh Allen.

Other notable offseason moves include defensive coordinator Leslie Frazier announcing he will be taking the year off, shocking players such as LB Von Miller, and leaving plenty of questions about how the defense will look in 2023. The Bills also re-signed DE Shaq Lawson to a one-year contract and signed S Taylor Rapp to a one-year contract.

[gambcom-standard rankid=”3011″ ]

[gambcom-standard rankid=”3012″ ]

Colts at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 2:43 p.m. ET,

  • Moneyline (ML): Colts -185 (bet $185 to win $100) | Bills +150 (bet $100 to win $150)
  • Against the spread (ATS): Colts  -3.5 (-110) | Bills +3.5 (-110)
  • Over/Under (O/U): 38 (O: -110 | U: -110)

WIN YOUR FANTASY FOOTBALL LEAGUE!
The Huddle has been turning players like you into winners for over 25 years. This season, it’s your turn. Custom fantasy football rankings, sleepers and tools are just a click away. Save 25% off the Internet’s best-kept secret. Subscribe now!

FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+

Colts at Bills picks and predictions

Prediction

Colts 24, Bills 20

Moneyline

BET COLTS (-185).

Bills coach Sean McDermott has already stated that Allen and WR Stefon Diggs will not play which is an indication we may not see many of the typical starters for Buffalo. However, on the defensive side of the ball, we may see S Damar Hamlin get some reps in what would be his first action since he went into cardiac arrest in early January.

Colts coach Shane Steichen has stated that Richardson will get the start. Expect to see Colts players playing deeper into the game than the Bills which should give them the edge.

Against the spread

PASS.

With many moving parts in Week 1 of the preseason, it will be difficult to have confidence in either side in this matchup. There is too much uncertainty for both sides, which is typical at this stage of the season. I recommend staying away from the spread.

Play our free daily Pick’em Challenge and win! Play now!

Over/Under

LEAN OVER 38 (-110).

With an ongoing battle between Richardson and QB Gardner Minshew, expect to see both QBs treat the game with an elevated seriousness. On the flip side, the Bills will be looking to use Week 1 of the preseason as a time to iron out kinks in their defense without a defensive coordinator.

For the Bills’ offense, while Allen will not see the field, backup QBs Kyle Allen and Matt Barkley certainly have the ability to hit receivers and find the end zone. That said, 38 points will require both offenses to find the end zone multiple times which is why sprinkling may be the best option.

[gambcom-standard rankid=”5″ ]

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow @seth_orlemann on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

Access more NFL coverage:

BetFTW | TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWireTitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]

Underdog corner: 3 best NFL picks and predictions for Week 11

Assessing the NFL betting odds and lines for Week 11, with three predictions and picks for the best underdog bets to make.

The Minnesota Vikings and New Orleans Saints came through for us and covered as underdogs in Week 10, while the Las Vegas Raiders fell far short.

That makes it eight winning weeks out of 10 here this season for an overall against-the-spread (ATS) record of 22-8 with 18 outright winners.

Here are our NFL underdog ATS picks and predictions of Week 11.

NFL underdog predictions: Week 11

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 5:06 p.m. ET.

Houston Texans +9.5 (+100) at Tennessee Titans

The AFC-leading Titans (8-2 straight up, 7-3 ATS) have won six in a row and covered in five of their last six with the last five coming against 2020 playoff teams.

But with a road game at the suddenly surging New England Patriots looming in Week 12, this is prime letdown spot for Tennessee.

Take the TEXANS +9.5 (+100) and QB Tyrod Taylor and to keep things close in a division game coming off a bye.

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

New Orleans Saints +2.5 (-105) at Philadelphia Eagles

Is the wrong team favored here? Here’s the case:

The Saints are a league-best 11-3 SU and 12-2 ATS as an underdog since 2018, including 3-1 and 4-0, respectively, this season.

The Eagles are 0-4 SU and 1-3 ATS at home this season.

We’ll bank on the league’s best run defense negating the league’s third-best rushing attack and go with the SAINTS +2.5 (-105), hitting the +110 money line as well.

Also see: All Week 11 odds and lines

WIN YOUR FANTASY FOOTBALL LEAGUE!

For 25 years, TheHuddle.com has been helping fantasy players just like you win. This year, it’s your turn! Custom player rankings, tools and more to give you the edge over your competition.

Use code SBW21 to take 20% OFF a new subscription. Join now!

Indianapolis Colts +7.5 (-117) at Buffalo Bills

This is a rematch of last January’s AFC Wild Card Game won 27-24 by the host Bills.

Buffalo didn’t cover as a touchdown favorite that day and has failed to cover in three of its previous four games this season heading into Sunday’s meeting.

Indy has won four of its last five – losing only to the Titans 34-31 in overtime in Week 8 – and figures to keep things tight in Orchard Park. Take the COLTS +7.5 (-117) catching more than a TD.

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

Follow @kenpomp on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

Access more NFL coverage:

TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWireTitansWire | VikingsWire | WashingtonFootballWire | DraftWire | TouchdownWire | TheListWire

Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]