Houston Astros at San Francisco Giants odds, picks and predictions

Analyzing Wednesday’s Houston Astros at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The Houston Astros (31-37) and San Francisco Giants (33-35) meet Wednesday for the finale of a 3-game series. First pitch from Oracle Park is set for 3:45 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Astros vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 1-1

Houston beat San Francisco 3-1 in the 2nd game of the series Tuesday while cashing as a +103 road underdog. The Astros broke the 1-1 tie in the top of the 5th innings thanks to an error by 3B Matt Chapman. Tuesday’s win snapped a 2-game losing skid for Houston.

RHP Jordan Hicks picked up the loss for San Francisco, allowing 3 ER on 5 hits and 1 walk with 5 K’s in 4 2/3 innings. The Giants have lost 2 of their last 3 outings.

Astros at Giants projected starters

LHP Framber Valdez vs. RHP Logan Webb

Valdez (5-3, 3.53 ERA) makes his 11th start. He has a 1.15 WHIP, 2.5 BB/9 and 7.1 K/9 in 63 2/3 innings.

  • Last start: Win, 9 IP, 1 ER, 4 H, 1 BB, 8 K in 7-1 victory at Los Angeles Angels Friday
  • Career vs. San Francisco: 1-1, 3.27 ERA (11 IP, 4 ER), 1.27 WHIP, 11.5 K/9 in 2 starts

Webb (5-5, 2.92 ERA) makes his 15th start. He has a 1.20 WHIP, 2.1 BB/9 and 7.6 K/9 in 86 1/3 innings.

  • Last start: Win, 7 IP, 2 ER, 5 H, 0 BB, 6 K in 5-2 victory at Texas Rangers Friday
  • Career vs. Houston: 2-1, 3.18 ERA (17 IP, 6 ER), 1.18 WHIP, 5.8 K/9 in 3 starts

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Astros at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:30 a.m. ET.

  • Moneyline (ML): Astros -105 (bet $105 to win $100) | Giants -115 (bet $115 to win $100)
  • Run line (RL)/Against the spread (ATS): Astros -1.5 (+165) | Giants +1.5 (-200)
  • Over/Under (O/U): 7.5 (O: +100 | U: -120)

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Astros at Giants picks and predictions

Prediction

Giants 3, Astros 1

Moneyline

LEAN GIANTS (-115).

San Francisco is 3-1 in the last 4 meetings overall and 3-1 in the last 4 meetings at Oracle Park.

This is only a lean because the Astros enter as the slightly hotter team, going 6-4 in their last 10 games overall and 3-2 in their last 5 on the road, while the Giants are only 4-6 in their last 10 and 1-4 in their last 5 at home.

Run line/Against the spread

PASS.

I like the Giants to cover here as +1.5 (-200) underdogs, but the line is simply not worth the risk of betting on at this price. Bet on the moneyline and/or total instead.

Over/Under

BET UNDER 7.5 (-120).

The Under has hit in 4 of Houston’s last 5 road games and is 7-3 in its last 10 overall. For San Francisco, the Under is 4-1 in its last 5 outings. The Under has also hit in each of the last 4 Houston-San Francisco matchups overall and is 3-0 in the last 3 meetings in the Bay Area.

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Houston Astros at San Francisco Giants odds, picks and predictions

Analyzing Tuesday’s Houston Astros at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The Houston Astros (30-37) and San Francisco Giants (33-34) play the 2nd game of a 3-game set at Oracle Park Tuesday. First pitch is scheduled for 9:45 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Astros vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 1-0

The Astros lost 4-3 in 10 innings as -114 road favorites in the series opener Monday as the Under (8) hit. Houston has lost back-to-back games for the 1st time since a 3-game skid May 27-29.

RF Austin Slater hit a game-winning single for the Giants, who rallied back from a 2-run deficit in the 10th inning. San Francisco has won 4 of its last 5 games.

Astros at Giants projected starters

RHP Ronel Blanco vs. RHP Jordan Hicks

Blanco (5-2, 2.78 ERA) makes his 12th start. He has a 1.05 WHIP, 3.8 BB/9 and 8.2 K/9 in 64 2/3 IP.

  • Last start: Loss, 5 2/3 IP, 4 ER, 5 H, 2 BB, 2 K in 4-2 home setback vs. St. Louis Cardinals Wednesday
  • 2024 road stats: 4-0, 2.08 ERA (30 1/3 IP, 7 ER), 1.09 WHIP, 8.6 K/9 in 5 starts

Hicks (4-2, 2.82 ERA) makes his 14th start. He has a 1.19 WHIP, 3.1 BB/9 and 7.9 K/9 in 67 IP.

  • Last start: No-decision, 3 2/3 IP, 2 ER, 6 H, 4 BB, 7 K in 9-3 win at Arizona Diamondbacks Wednesday
  • 2024 home stats: 2-1, 2.52 ERA (39 1/3 IP, 11 ER), 0.99 WHIP, 5.7 K/9 in 7 starts

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Astros at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:26 p.m. ET.

  • Moneyline (ML): Astros -105 (bet $105 to win $100) | Giants -115 (bet $115 to win $100)
  • Run line (RL)/Against the spread (ATS): Astros -1.5 (+155) | Giants +1.5 (-190)
  • Over/Under (O/U): 8 (O: -105 | U: -115)

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Astros at Giants picks and predictions

Prediction

Astros 3, Giants 2

Moneyline

The ASTROS (-105) are 4-1 in their last 5 outings after a loss and should bounce back against the inconsistent Giants, who are 4-7 over their last 11 games. Blanco has yet to lose a decision on the road this season, and Hicks has allowed a total of 7 runs over his last 2 starts (9 IP).

BET ASTROS (-105).

Run line/Against the spread

San Francisco +1.5 (-190) will probably hit, but it’s hard to beat MLB long term betting into markets with this much vig.

PASS. Bet the ML and/or total instead.

Over/Under

Blanco has allowed 2 ER or fewer in all 4 road starts this season, and Hicks has given up 2 or fewer runs in 6 of his 7 appearances at Oracle Park. The Under has hit in 4 of 5 games for the Astros and 3 of 4 for San Francisco.

BET UNDER 8 (-115).

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Houston Astros at San Francisco Giants odds, picks and predictions

Analyzing Monday’s Houston Astros at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The Houston Astros (30-36) and San Francisco Giants (32-34) begin a 3-game interleague series at Oracle Park on Monday. First pitch is scheduled for 9:45 p.m. ET (MLB Network). Let’s analyze FanDuel Sportsbook’s lines around the Astros vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Giants won 2-1 in 2023

The Astros took 2 of 3 from the Los Angeles Angels over the weekend, winning a series for the 2nd straight time since June 3. Houston won the previous interleague series against the St. Louis Cardinals Monday through Wednesday, too.

On the road, Houston has struggled, going just 8-13 in the past 21 games not including a pair of neutral-site games in Mexico City on April 27-28.

The Under is 3-1 in the past 4 games for Houston, while going 12-3 in the past 15 outings. On the road, the total has gone low at a 8-1 clip in the past 9 tries.

For the Giants, they suffered a 7-2 loss in the interleague series finale at the Texas Rangers on Sunday, but San Francisco won the 1st 2 battles in that series. The Giants are just 3-7 in the past 10 games, however, and they’ve dropped the past 4 games at home, too.

Astros at Giants projected starters

RHP Spencer Arrighetti vs. LHP Kyle Harrison

Arrighetti (3-5, 5.79 ERA) makes his 11th start. He has a 1.67 WHIP, 5.0 BB/9 and 10.6 K/9 in 46 2/3 IP.

  • Last start: No-decision, 3 IP, 1 ER, 3 H, 3 BB, 4 K in an 8-5 home win vs. St. Louis Cardinals last Tuesday
  • 2024 road splits: 1-4, 7.54 ERA (22 2/3 IP, 19 ER), 1.90 WHIP, .309 opponents’ batting average (OBA), 4 HR, 14 BB, 29 K in 5 starts

Harrison (4-3, 4.18 ERA) makes his 14th start. He has a 1.39 WHIP, 3.0 BB/9 and 6.0 K/9 in 71 IP.

  • Last start: Loss, 6 IP, 4 R (3 ER), 8 H, 0 BB, 5 K in 8-5 road loss vs. Arizona Diamondbacks last Tuesday
  • 2024 home splits: 1-1, 4.65 ERA (31 IP, 16 ER), 1.45 WHIP, .286 OBA, 3 HR, 9 BB, 34 K in 6 starts

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Astros at Giants odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:26 a.m. ET.

  • Moneyline (ML): Astros -118 (bet $118 to win $100) | Giants +100 (bet $100 to win $100)
  • Run line (RL)/Against the spread (ATS): Astros -1.5 (+146) | Giants +1.5 (-176)
  • Over/Under (O/U): 8 (O: -122 | U: +100)

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Astros at Giants picks and predictions

Prediction

Giants 7, Astros 5

Moneyline

The GIANTS (+100) are a decent play at even-money in this interleague series opener at home.

Arrighetti has been awful for the Astros (-118), particularly on the road, and it won’t help that there is a jetstream blowing out to the left-center field power alley.

The Astros just can’t seem to develop any momentum or play with any consistency.

Run line/Against the spread

If you’re a little more on the conservative side, and just can’t play San Francisco straight up, backing GIANTS +1.5 (-176) isn’t priced out of line for a little bit of insurance.

The Giants have lost 4 in a row at home, so they’re anything but a slam-dunk play. Of course, Astros -1.5 (+146) are 6 games under .500 this season, and Arrighetti has an ERA north of 7 on the road.

Over/Under

OVER 8 (-122) is the best play on the board in this interleague series opener.

The wind will be blowing out from home plate to the left-center field power alley at an 8-11 mph clip.

While the Under has dominated for the Astros lately, the Over is 5-2 in Arrighetti’s past 7 starts.

For the Giants, the Over is 6-3 in the past 9 outings, and 9-4 in the previous 13 home contests. The total has gone high in 4 of the past 5 starts by the southpaw Harrison, too.

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Houston Astros at San Francisco Giants odds, picks and prediction

Analyzing Saturday’s Houston Astros at San Francisco Giants odds and lines, with MLB picks and predictions.

The San Francisco Giants (64-39) host the Houston Astros (64-40) Saturday for the second game of their three-game interleague set at Oracle Park. First pitch is scheduled for 4:05 p.m. ET. Let’s analyze BetMGM Sportsbook‘s lines around the Astros vs. Giants odds with MLB picks and predictions.

The Astros won the first game of the series 9-6 as 2B Jose Altuve went 3-for-6 with 2 home runs and 5 RBIs. Also, Houston’s lineup nuked San Francisco’s bullpen by plating 6 runs across 4 innings of work.

Season series: Astros lead 1-0.

RHP Zack Greinke makes his 22nd start for the Astros. He is 10-3 with a 3.48 ERA (126 2/3 IP, 49 ER), 1.12 WHIP, 1.8 BB/9 and 6.6 K/9.

  • Last outing: Win, 3-1, with 6 IP, 1 ER, 5 H, 2 BB and 4 K Sunday against the Texas Rangers.
  • vs. Giants on the current roster (177 PA): 2.02 FIP with a .212 batting average (BA), .240 wOBA, .289 expected slugging percentage (xSLG), 26.6 K% and 86.3 mph exit velocity (EV).

LHP Alex Wood is San Francisco’s projected starter. He is 9-3 with a 3.65 ERA (93 2/3 IP, 38 ER), 1.17 WHIP, 2.9 BB/9 and 9.8 K/9 through 17 starts.

  • Last outing: Win, 6-1, with 5 1/3 IP, 1 ER, 5 H, 2 BB and 8 K Sunday against the Pittsburgh Pirates.

MLB betting offers/promotions

BetMGM Sportsbook offers available in CO, IA, IN, MI, NJ, PA, TN, VA, WV and Washington D.C. New customer offers, terms and conditions apply.

  • Bet just $1 on either team’s money line, WIN $100 (in free bets) if either team hits a home run during the game. Bet now!
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Astros at Giants odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 10:30 a.m. ET.

  • Money line: Astros +100 (bet $100 to win $100) | Giants -120 (bet $120 to win $100)
  • Against the spread/ATS: Astros +1.5 (-200) | Giants -1.5 (+165)
  • Over/Under: 8.5 (O: -105 | U: -115)

Prediction

Astros 7, Giants 3

Money line (ML)

Let’s go with the hot hand and BET an ASTROS (+100) team that’s won eight of their last 10 games.

Since the All-Star Game, Houston’s lineup is 10th or better in wRC+, wOBA and WAR while San Francisco’s lineup ranks 19th or worse in each of those categories.

Also, Greinke has been more effective on the road this season and has always pitched well at San Francisco’s home ballpark. Greinke is 5-0 on the road with a 2.25 ERA (60 IP, 15 ER), 0.85 WHIP and 4.8 K/BB through nine starts.

For his career, Greinke is 6-0 with a 1.19 ERA (53 IP, 7 ER), 0.89 WHIP and 5.4 K/BB in eight starts at San Francisco’s ballpark.

TAKE the ASTROS (+100) for 1 unit.

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Run line/Against the spread (ATS)

Slight “LEAN” to the ASTROS -1.5 (+165) on the alternate line for a tiny wager, if at all, because Houston has clear edges in the starting pitching and hitting matchups and San Francisco’s bullpen is taxed from throwing a lot of pitches recently.

However, the Giants covered the spread in eight of their 12 games as home underdogs this season and the Astros bullpen has been the weakest facet of Houston’s game throughout the season.

The best play in this game is to stick with the Astros (+100) on the money line, but Houston is clearly the right side so I don’t hate SPRINKLING on ASTROS -1.5 (+165).

Over/Under (O/U)

PASS with a slight “lean” toward the Over 8.5 (-105) as a “contrarian play” against a majority of the market that’s taking the Under. Since that’s my only handicapping angle I’ll stay away from the total in Astros-Giants.

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Houston Astros at San Francisco Giants odds, picks and prediction

Analyzing Friday’s Houston Astros at San Francisco Giants odds and lines, with MLB picks and predictions.

The Houston Astros (63-40) kick off a three-game interleague set at the San Francisco Giants (64-38) Friday in Oracle Park. First pitch is scheduled for 9:45 p.m. ET. Let’s analyze BetMGM Sportsbook‘s lines around the Astros vs. Giants odds with MLB picks and predictions.

Houston has won seven of its last nine games, including three straight series victories. The Astros took two of three from the visiting Cleveland Indians (July 19-21), swept the Texas Rangers in three (July 23-25) and won two of three at the Seattle Mariners (Monday through Wednesday).

San Francisco won the rubber match of their three-game set with the Los Angeles Dodgers Wednesday. It was the Giants’ second series win against their long-time rivals in the past 10 games.

LHP Framber Valdez is Houston’s projected starter. Valdez is 6-2 with a 2.97 ERA (66 2/3 IP, 22 ER), 1.29 WHIP, 4.1 BB/9 and 8.1 K/9 in 11 starts.

  • Last outing: Win, 4-1, with 6 IP, 0 ER, 0 H, 6 BB and 4 K against the Texas Rangers Saturday.
  • 2021 road splits: 3-2 with a 2.94 ERA (33 2/3 IP, 11 ER), 1.10 WHIP and 2.6 K/BB rate in five starts.

RHP Kevin Gausman takes the hill for the Giants. Gausman is 9-4 with a 2.21 ERA (122 IP, 30 ER), 0.92 WHIP, 2.7 BB/9 and 10.3 K/9 in 20 starts.

  • Last outing: Loss, 10-2, with 4 1/3 IP, 6 ER, 8 H, 4 BB and 2 K Saturday vs. the Pittsburgh Pirates.
  • 2021 home splits: 4-2 with a 3.10 ERA (52 1/3 IP, 18 ER), 0.84 WHIP and 4.3 K/BB rate in eight starts.

MLB betting offers/promotions

BetMGM Sportsbook offers available in CO, IA, IN, MI, NJ, PA, TN, VA, WV and Washington D.C. New customer offers, terms and conditions apply.

  • Bet just $1 on either team’s money line, WIN $100 (in free bets) if either team hits a home run during the game. Bet now!
  • RISK-FREE FIRST BET. Place your first bet, if it loses you’ll get up to $600 in free bets. Bet now!

Astros at Giants odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 5:50 a.m. ET.

  • Money line: Astros +105 (bet $100 to win $105) | Giants -125 (bet $125 to win $100)
  • Against the spread/ATS: Astros +1.5 (-200) | Giants -1.5 (+165)
  • Over/Under: 7.5 (O: -115 | U: -105)

Prediction

Astros 6, Giants 5

Money line (ML)

“LEAN” to the ASTROS (+105) for a half unit because the Giants’ Gausman has looked shaky in recent starts. He’s allowed 8 earned runs in just 7 1/3 innings in his last two starts.

FanGraphs graded Gausman’s last start against the lowly Pirates a 19. The previous outing was a 32 against the Los Angeles Dodgers.

Also, San Francisco’s lineup is around league average against left-handed pitching in wRC+, OPS and wOBA but has the third-worst hard-contact rate. Houston’s lineup is clearly the top in MLB vs. right-handed pitching and ranks in the top 3 in wRC+, wOBA, OPS and BB/K rate.

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Run line/Against the spread (ATS)

PASS because the Astros +1.5 (-200) is way out of my price range despite Houston’s 8-4 ATS record as a road underdog this season. I only “lean” to the Astros outright and don’t like them enough to buy Houston’s overpriced insurance.

Over/Under (O/U)

BET the OVER 7.5 (-115) for 1 unit as my favorite play in this game because Houston is 9-2-1 O/U as a road underdog this year and San Francisco is 19-17-1 O/U as a home favorite.

Not only has Gausman regressed from his early-season dominance in the past two starts, but Valdez has control issues that could lead to San Francisco’s lineup putting up some crooked numbers in innings.

Valdez grades in the 26th percentile in BB%. He was pulled while flirting with a no-hitter during his last start because he walked 6 in 6 innings and threw 99 pitches.

If Valdez duplicates that performance against the Giants, he could be in trouble because San Francisco’s lineup has the highest BB/K rate vs. left-handed pitching and has hit the ninth-most home runs against lefties.

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Gannett may earn revenue from audience referrals to betting services. Newsrooms are independent of this relationship and there is no influence on news coverage. This information is for entertainment purposes only. We make no representations or warranties as to the accuracy, completeness, or reliability of any content.

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