Colts-Texans odds, picks and best bets [UPDATED]

Previewing the Colts at Texans Week 12 matchup, with NFL betting odds, picks and best bets

The Indianapolis Colts (6-4) and Houston Texans (6-4) are tied atop the AFC South and will meet in Week 12 for a game with huge playoff implications. The winner will be in the driver’s seat in the division, while the loser could fall out of the playoff picture.

Kickoff from NRG Stadium in Houston will be at 8:20 p.m. ET on Thursday night.

Colts at Texans: Week 12 preview, betting trends and notes


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  • The Texans were blown out by the Ravens on Sunday, losing 41-7 as 4.5-point underdogs. It was the third time this season they’ve failed to win a third straight game.
  • The Colts took care of the Jaguars in Week 11, winning 33-13 at home. It ended a two-game losing skid following losses to the Steelers and Dolphins.
  • The Colts are 6-0-1 ATS in their last seven road games against Houston. They’ve won three straight vs. the Texans, too, dating back to last December.
  • Houston is 14-4 straight up in its last 18 games against the AFC South.
  • The Colts are 6-0 ATS in their last six against the AFC South, and are 3-0 this season.
  • In their last 11 games against teams above .500, the Colts are 10-1 ATS.

Colts at Texans: Key injuries

Colts RB Marlon Mack left Sunday’s game with a hand injury and will miss the game. WR T.Y. Hilton (calf) and TE Eric Ebron (ankle) are expected to play. WR Parris Campbell (hand) is less certain.

Texans WR Will Fuller (hamstring) remains questionable.

Colts at Texans: Odds, betting lines and prediction

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 1 p.m. ET.

Prediction

Texans 24, Colts 21

Moneyline (?)

The Colts being without Mack is a big factor in this one. The Texans have the advantage of being at home, too, and they should bounce back from an embarrassing loss to the Ravens.

Bet the TEXANS (-189) to win outright on Thursday night. Deshaun Watson is a more dynamic quarterback than Jacoby Brissett and that’ll make a huge difference.

New to sports betting? A $10 wager on the Texans to win outright would return a profit of $5.29.

Against the Spread (?)

The Texans enter as 3.5-point favorites at home, despite losing by 34 points to the Ravens on Sunday. The Colts have been excellent against the spread when facing the Texans and the AFC South in recent years, going 3-0 against the division this year alone.

Bet the COLTS (-110) to cover the 3.5-point spread.

Over/Under (?)

Thursday night games typically lead to some sloppy play early in the contest, which could be the case this week. The Over/Under is set at 46.5 points, and in 12 of the Colts’ last 18 road games, the total has gone under.

Take the UNDER (-115) in this matchup as both teams will take a little while to knock off the short-week rust.

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