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The Cleveland Guardians (81-62) and Chicago White Sox (33-111) open a 3-game series Monday. First pitch from Guaranteed Rate Field is set for 7:40 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Guardians vs. White Sox odds and make our expert MLB picks and predictions for the best bets.
Season series: Tied 5-5
The Guardians were blanked 4-0 on Sunday against the LA Dodgers, suffering the series loss. Cleveland won the opener 3-1, before dropping the past 2 games by a combined score of 11-2. The Under (8.5) easily cashed Sunday, and the total has gone low at a 6-0-2 rate in the past 8 outings.
The White Sox are actually 2-2 in the past 4 games, pounding the Boston Red Sox at Fenway Park on Sunday by a 7-2 score as the Under (10.5) cashed. The offense has picked up the pace, averaging 5.3 runs per game (RPG) in the past 4 outings. However, the Under is 2-1 in the past 3 games, and 8-4 across the previous 12 outings.
Guardians at White Sox projected starters
LHP Joey Cantillo vs. TBD
Cantillo (0-3, 7.71 ERA) makes his 5th career start and 6th appearance. He has a 1.61 WHIP, 4.3 BB/9 and 7.2 K/9 in 18 2/3 innings.
- Last start: Loss, 4 IP, 7 ER, 6 H (2 HR), 3 BB, 5 K in 8-1 road setback vs. New York Yankees Aug. 21
- Last appearance: No-decision, 1 2/3 IP, 0 ER, 0 H, 0 BB, 1 K in relief appearance last Monday vs. Kansas City Royals
- 2024 road splits: 0-2, 9.00 ERA, 13 IP, 13 ER, 6 HR, 1.85 WHIP, .294 opponents’ batting average (OBA), 9 BB, 10 K in 3 starts
- Has never faced White Sox
No Chicago pitcher announced at time of publishing.
Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.
Guardians at White Sox odds
Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:17 a.m. ET.
- Moneyline (ML): Guardians -240 (bet $240 to win $100) | White Sox +198 (bet $100 to win $198)
- Run line (RL)/Against the spread (ATS): Guardians -1.5 (-140) | White Sox +1.5 (+116)
- Over/Under (O/U): 8.5 (O: -128 | U: +104)
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Guardians at White Sox picks and predictions
Prediction
Guardians 5, White Sox 2
Moneyline
The Guardians (-240) will set you back almost 2 1/2 times your potential return, and that’s just too much risk for not enough reward, even against the lowly White Sox (+198).
Cleveland is looking to snap back on track after suffering 2 of 3 losses in LA in a marquee series with the Dodgers.
But, if you like the Guardians, back it on the run line instead.
PASS.
Run line/Against the spread
The GUARDIANS -1.5 (-140) are much better priced on the run line, with much less risk. Still, the White Sox +1.5 (+116) have been a major thorn in the side of Cleveland this season, as the teams have split the previous 10 games. In fact, games against the 81-win Guardians account for 15% of the victories this season for the White Sox, which makes very little sense. Be careful.
However, with the White Sox yet to announce a pitcher, it’s a good idea to back Cleveland, although Cantillo isn’t exactly a stud.
Over/Under
UNDER 8.5 (+104) is worth playing lightly at plus-money.
The Under has cashed at an 8-4 pace in the past 12 games for the White Sox, while the Guardians have cashed low at a 6-0-2 pace in the previous 8 outings. The Under went low in 3 of 4 games in the most recent series in Chicago back on May 9-12, too.
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